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Protein-coding gene in the species Homo sapiens
CNGA1 Identifiers Aliases CNGA1 , CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1External IDs OMIM : 123825 ; MGI : 88436 ; HomoloGene : 55432 ; GeneCards : CNGA1 ; OMA :CNGA1 - orthologs Wikidata
Cyclic nucleotide-gated channel alpha 1 , also known as CNGA1 , is a human gene encoding an ion channel protein.[ 5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[ 6] In rod photoreceptors , however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[ 7] [ 8] [ 9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[ 10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.
^ a b c GRCh38: Ensembl release 89: ENSG00000198515 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067220 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji; Matsuo, Hisayuki (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature . 342 (6251): 762–766. Bibcode :1989Natur.342..762K . doi :10.1038/342762a0 . hdl :11858/00-001M-0000-002B-B7A4-3 . ISSN 0028-0836 . PMID 2481236 . S2CID 4254661 .
^ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit" . Neuron . 36 (5): 891–896. doi :10.1016/s0896-6273(02)01099-1 . ISSN 0896-6273 . PMID 12467592 . S2CID 15365006 .
^ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry" . Nature . 420 (6912): 193–198. Bibcode :2002Natur.420..193Z . doi :10.1038/nature01201 . ISSN 0028-0836 . PMC 2877395 . PMID 12432397 .
^ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors" . Neuron . 36 (5): 881–889. doi :10.1016/s0896-6273(02)01098-x . ISSN 0896-6273 . PMID 12467591 . S2CID 17176092 .
^ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature . 362 (6422): 764–767. Bibcode :1993Natur.362..764C . doi :10.1038/362764a0 . ISSN 0028-0836 . PMID 7682292 . S2CID 4350775 .
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Dryja TP, Finn JT, Peng YW, McGee TL, Berson EL, Yau KW (October 1995). "Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa" . Proceedings of the National Academy of Sciences of the United States of America . 92 (22): 10177–81. Bibcode :1995PNAS...9210177D . doi :10.1073/pnas.92.22.10177 . PMC 40759 . PMID 7479749 .
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Griffin CA, Ding CL, Jabs EW, Hawkins AL, Li X, Levine MA (April 1993). "Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization" . Genomics . 16 (1): 302–3. doi :10.1006/geno.1993.1187 . PMID 7683629 .
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Paloma E, Martínez-Mir A, García-Sandoval B, Ayuso C, Vilageliu L, Gonzàlez-Duarte R, Balcells S (October 2002). "Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa" . Journal of Medical Genetics . 39 (10): 66e–66. doi :10.1136/jmg.39.10.e66 . PMC 1734976 . PMID 12362048 .
Cheng CH, Yew DT, Kwan HY, Zhou Q, Huang Y, Liu Y, Chan WY, Yao X (October 2002). "An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA" . Molecular Biology of the Cell . 13 (10): 3696–705. doi :10.1091/mbc.E02-03-0127 . PMC 129976 . PMID 12388767 .
Zhong H, Molday LL, Molday RS, Yau KW (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry" . Nature . 420 (6912): 193–8. Bibcode :2002Natur.420..193Z . doi :10.1038/nature01201 . PMC 2877395 . PMID 12432397 .
Zheng J, Trudeau MC, Zagotta WN (December 2002). "Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit" . Neuron . 36 (5): 891–6. doi :10.1016/S0896-6273(02)01099-1 . PMID 12467592 . S2CID 15365006 .
Kang K, Bauer PJ, Kinjo TG, Szerencsei RT, Bönigk W, Winkfein RJ, Schnetkamp PP (April 2003). "Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs" (PDF) . Biochemistry . 42 (15): 4593–600. doi :10.1021/bi027276z . PMID 12693957 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .