Gift of Life Marrow Registry
 | This article contains close paraphrasing of a non-free copyrighted source, https://www.giftoflife.org/about/history (Copyvios report). (October 2023) |
| Company type | Non-profit |
|---|---|
| Industry | Health care |
| Founded | Boca Raton, Florida, USA (1991) |
| Headquarters | Boca Raton, USA |
Key people | Jay Feinberg, Founder & CEO Stephen Siegel, Chairman William Begal, Chairman Emeritus |
| Website | www.giftoflife.org |
The Gift of Life Marrow Registry is a non-profit organization founded in 1991 and headquartered in Boca Raton, Florida that operates a public blood stem cell and bone marrow registry while facilitating transplants for children and adults battling life-threatening illnesses, including leukemia, lymphoma, other cancers and genetic diseases.[1]
The registry contains over 470,000 potential donors, and has found more than 31,000 donor matches and facilitated over 5,000 transplants since its inception.[2]
History
[edit]Gift of Life was founded following a successful bone marrow registration campaign to save the life of Jay Feinberg, a 22-year-old analyst with the Federal Reserve.[3][4]
Feinberg was diagnosed with leukemia in 1991. Since tissue type is inherited, like eye or hair color, a patient's best chance of finding a genetic match lies with those of similar ethnic background. For Feinberg, those were donors of Eastern European Jewish descent. After four years of searching, a match was found with a 16 year-old girl from Illinois, saving Feinberg's life.[5]
At that time, the worldwide registry was not representative of all ethnic groups. Feinberg felt an urgent need to add diversity to the registry, creating the Gift of Life Marrow Registry.[6]
Background
[edit]Only 30 percent of patients with diseases treatable with a blood stem cell/bone marrow transplant can find a suitable donor among their family members. The remaining 70 percent must rely on the generosity of an unrelated donor to save their lives. There are more than 90 stem cell and marrow donor registries in 56 countries.[7]
Gift of Life was the first registry in the world to human leukocyte antigen tissue type stem cell and marrow donors on a mass scale at donor drives using buccal swabs.
Collection of Stem Cells
[edit]Peripheral Blood Stem Cells (PBSC):[8] It is possible to collect stem cells from the peripheral blood rather than the bone marrow. In order to collect a sufficient quantity of stem cells, injections of a medication called filgrastim must be administered. This mobilizes stem cells to travel from the bone marrow into the circulating blood. The stem cells are collected through a procedure called apheresis, the same process used to collect several other types of blood components. A cell separating machine filters out the stem cells, which can then be infused into the recipient. Today, PBSC is requested approximately 90 percent of the time.
Bone Marrow:[9] Marrow is found in the hollow cavities of the body's large bones. Donation involves withdrawing 2-3 percent of the donor's total marrow from the iliac crest of the hip, posterior aspect of the donor's pelvic bone. There is no cutting or stitching. The procedure involves a needle aspiration, performed using an anesthetic. Typically, the donor enters a medical center’s outpatient facility in the morning and goes home in the afternoon. Today, bone marrow is requested approximately 10 percent of the time.
There are clinical reasons why one cellular source may be more beneficial for the patient over the other. The transplant physician requests one source based on the patient's circumstances. If a donor declines to donate via one method, the transplant center may or may not be able to accept the other, based on the clinical needs of the patient.
Gift of Life – NMDP Collection Center
[edit]In April 2019, Gift of Life opened the Dr. Miriam and Sheldon G. Adelson Gift of Life - NMDP Collection Center in collaboration with NMDP at its Florida headquarters.[10] The Collection Center primarily collects blood stem cells from donors for transplant into a patient. The stem cells are taken by a courier to the patient’s transplant center.[citation needed]
Center for Cell and Gene Therapy
[edit]Gift of Life opened a Center for Cell and Gene Therapy at its Boca Raton location in November 2020.[11] The facility houses a Cellular Therapy Laboratory and BioBank. High complexity testing (hematology and flow cytometry), processing (Sepax 2) and cryopreservation are performed at this location.[12]
Other United States Registries
[edit]The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1986 and based in Minneapolis,[13] that operates a registry of volunteer donors and cord blood units. In May 2004, the Gift of Life Marrow Registry and NMDP formed an associate donor registry relationship together.[citation needed]
DKMS, a German bone marrow registry, also operates a large U.S. bone marrow registry.[14]
References
[edit]- ^ "Financials". www.giftoflife.org. Retrieved 2019-11-20.
- ^ "Home page - Gift of Life Marrow Registry". www.giftoflife.org. Retrieved 28 March 2024.
- ^ "Cancer battle spurs entrepreneur to start donor registry". Reuters. 2011-07-13. Retrieved 2019-11-20.
- ^ Stone, Judy. "What You Need To Know On World Bone Marrow Day". Forbes. Retrieved 2019-11-20.
- ^ "Cancer battle spurs entrepreneur to start donor registry". Reuters. 2011-07-13. Retrieved 2021-12-18.
- ^ Goldman, Ari L. (1991-12-16). "Day of Hope for Those Dying of Leukemia". The New York Times. ISSN 0362-4331. Retrieved 2023-02-24.
- ^ "WMDA Organisation data (Public Access)". share.wmda.info. World Marrow Donor Association (WMDA). Retrieved 2024-03-29.
- ^ "Donation Frequently Asked Questions". bloodcell.transplant.hrsa.gov. Retrieved 2016-06-26.
- ^ "Donation Frequently Asked Questions". bloodcell.transplant.hrsa.gov. Retrieved 2016-06-26.
- ^ "StackPath". www.hpnonline.com. 22 April 2019. Retrieved July 17, 2020.
- ^ "Gift of life marrow registry announces new center for cell and gene therapy – the Boca Raton Tribune – Stem Cell Clinic". www.stemcellclinic.net. 22 November 2020. Retrieved November 26, 2020.
- ^ "Cell Therapy".
- ^ Confer, D.; Robinett, P. (August 2008). "The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation". Bone Marrow Transplantation. 42 (1): S3–S5. doi:10.1038/bmt.2008.102. ISSN 1476-5365. PMID 18724295.
- ^ "Together, we delete blood cancer". www.dkms.org. Retrieved 2023-02-24.
Further reading
[edit]- Dell’Antonia, Kj (January 5, 2015). "Charities That Inspire Kids: Gift of Life Bone Marrow Foundation". The New York Times. Retrieved June 25, 2016.
- Dorfman, Steve (June 24, 2016). "Gift Of Life". The Palm Beach Post. Retrieved June 25, 2016.
- Abo, Jessica (November 16, 2012). "Celebrating the Gift of Life and How to Give It". The Huffington Post. Retrieved June 25, 2016.
- "Maccabeats Return To Raise Money For Bone Marrow Foundation". The Huffington Post. December 21, 2011. Retrieved June 25, 2016.
- Goldberg, Eleanor (February 2, 2012). "Carrying On Ayelet's Fight For Life". The Huffington Post. Retrieved June 25, 2016.
- "Bone-marrow donors give a 'huge gift of hope'". WCVB. March 28, 2016. Retrieved June 25, 2016.
- "Saving a Life is Easier Than You Think". The Huffington Post. May 19, 2015.
- "Equal Opportunity for Those Needing Bone Marrow Transplants". The Huffington Post. March 22, 2016.