Deoxyadenosine

Deoxyadenosine
Names
	IUPAC name (2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
	Other names 2′-Deoxyadenosine; α-Deoxyadenosine; dA
Identifiers
CAS Number	958-09-8 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:17256 ;
ChEMBL	ChEMBL416340 ;
ChemSpider	13135 ;
ECHA InfoCard	100.012.262
IUPHAR/BPS	5109;
MeSH	2'-deoxyadenosine
PubChem CID	636;
UNII	P582C98ULC ;
CompTox Dashboard (EPA)	DTXSID10883624 ;
	InChI InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 Key: OLXZPDWKRNYJJZ-RRKCRQDMSA-N ; InChI=1/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 Key: OLXZPDWKRNYJJZ-RRKCRQDMBK;
	SMILES n2c1c(ncnc1n(c2)[C@@H]3O[C@@H]([C@@H](O)C3)CO)N;
Properties
Chemical formula	C10H13N5O3
Molar mass	251.24192
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Deoxyadenosine (symbol dA or dAdo) is a deoxyribonucleoside. It is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2′ position of its ribose sugar moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with deoxythymidine (T) in double-stranded DNA.

In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).^[1]

References

^ Griffiths, Anthony J. F.; Wessler, Susan R.; Carroll, Sean B.; Doebly, John (2012). Introduction to Genetic Analysis (10th ed.). New York: W . H. Freeman and Company. ISBN 978-1-4641-0661-3.

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[1] Griffiths, Anthony J. F.; Wessler, Susan R.; Carroll, Sean B.; Doebly, John (2012). Introduction to Genetic Analysis (10th ed.). New York: W . H. Freeman and Company. ISBN 978-1-4641-0661-3.

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See also

References