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Ibuprofen/paracetamol

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Ibuprofen/paracetamol
Combination of
IbuprofenNonsteroidal anti-inflammatory drug
ParacetamolAnalgesic/antipyretic
Clinical data
Trade namesCombogesic, Advil Dual Action with Acetaminophen, Ibupane
Other namesAcetaminophen/ibuprofen
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic.[6] It is available as a generic medication.[9][10][11]

Medical uses

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Ibuprofen/paracetamol is indicated for the short term management of mild to moderate acute pain.[7]

There is evidence that paracetamol combined with ibuprofen provides pain relief better than either medication used alone.[12][13]

Adverse effects

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See also: Nonsteroidal anti-inflammatory drug § Adverse effects, Ibuprofen § Adverse effects, and Paracetamol § Adverse effects

Society and culture

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Brand names

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The combination is available as Combiflam,[11][14] Advil Dual Action with Acetaminophen,[15][16][17] Ibupane,[1] Nuromol and Combogesic.[7]

References

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  1. ^ a b c "Ibupane" (PDF). TGA eBS. Archived from the original on 29 October 2020. Retrieved 29 April 2023.
  2. ^ "Nuromol Dual Action Pain Relief 200mg/500mg tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  3. ^ "Nuromol Pain Relief 200mg/500mg Film Coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 15 June 2022. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  4. ^ "Nuromol public assessment report". GOV.UK. 16 August 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  5. ^ "Nuromol Dual Action Pain Relief 200mg/500mg tablets (ibuprofen/paracetamol): public consultation". GOV.UK. 13 May 2021. Archived from the original on 25 February 2023. Retrieved 24 February 2023.
  6. ^ a b "Advil Dual Action with Acetaminophen- ibuprofen, acetaminophen tablet, film coated". DailyMed. 1 December 2021. Archived from the original on 25 February 2023. Retrieved 25 February 2023.
  7. ^ a b c "Combogesic- acetaminophen and ibuprofen tablet, film coated". DailyMed. 9 March 2023. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
  8. ^ "Combogesic IV- acetaminophen and ibuprofen injection injection". DailyMed. 29 April 2024. Archived from the original on 7 July 2024. Retrieved 6 July 2024.
  9. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  10. ^ "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA). 30 May 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  11. ^ a b "Combiflam". drugs.com. Archived from the original on 5 February 2015. Retrieved 5 February 2015.
  12. ^ Ong CK, Seymour RA, Lirk P, Merry AF (April 2010). "Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain". Anesthesia and Analgesia. 110 (4): 1170–9. doi:10.1213/ANE.0b013e3181cf9281. PMID 20142348. S2CID 7948680.
  13. ^ Moore RA, Derry C (January 2013). "Efficacy of OTC analgesics". International Journal of Clinical Practice. Supplement. 67 (178): 21–5. doi:10.1111/ijcp.12054. PMID 23163544. S2CID 205184492.
  14. ^ "Combiflam". Sanofi India. 28 February 2023. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
  15. ^ "Advil Dual Action: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 26 September 2020. Retrieved 28 February 2020.
  16. ^ "Drug Approval Package: Advil Dual Action with Acetaminophen". U.S. Food and Drug Administration (FDA). 31 March 2020. Archived from the original on 3 March 2023. Retrieved 2 March 2023.
  17. ^ "FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States" (Press release). GSK Consumer Healthcare. 28 February 2020. Archived from the original on 29 February 2020. Retrieved 28 February 2020 – via PR Newswire.
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