MS4A3

MS4A3
Identifiers
Aliases	MS4A3, CD20L, HTM4, membrane spanning 4-domains A3
External IDs	OMIM: 606498; MGI: 2158468; HomoloGene: 4472; GeneCards: MS4A3; OMA:MS4A3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,071,115 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	11,618,215 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; testicle; ; monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; placenta; ; appendix;
	Top expressed in
	tibiofemoral joint; ; granulocyte; ; fetal liver hematopoietic progenitor cell; ; bone marrow; ; lumbar spinal ganglion; ; gastrula; ; right ventricle; ; body of femur; ; embryo; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; integral component of membrane; membrane; endomembrane system; plasma membrane; specific granule membrane;
Biological process	regulation of cell cycle; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	932
	170813
	ENSG00000149516; ENSG00000284903
	ENSMUSG00000024681
	Q96HJ5
	Q920C4
	NM_001031666; NM_001031809; NM_006138
	NM_133246
	NP_001026836; NP_001026979; NP_006129
	NP_573509
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.^[5]^[6]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.^[6]

Interactions

MS4A3 has been shown to interact with CDKN3.^[7]

References

^ ^a ^b ^c ENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084.
^ ^a ^b "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
^ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2". J. Biol. Chem. 280 (17): 17235–42. doi:10.1074/jbc.M413437200. PMID 15671017.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. PMC 150822. PMID 11781350.
Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID 11486273. S2CID 21846867.
Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7524084-5] Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084.

[entrez-6] "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".

[pmid11781350-7] Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

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v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

Interactions

References

Further reading