ZNF473

ZNF473
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2EMB, 2EMC, 2EME, 2EOU, 2EOX, 2EOY, 2EOZ, 2YRH, 2YRJ, 2YSV, 2YTD, 2YTE, 2YTT, 2YU5
Identifikatori
Aliasi	ZNF473
Vanjski ID-jevi	OMIM: 617908 MGI: 2442697 HomoloGene: 18698 GeneCards: ZNF473
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.33 Početak 50,025,714 bp Kraj 50,053,414 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 B3 Početak 44,380,904 bp Kraj 44,400,474 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje iona metala • vezivanje sa DNK • nucleic acid binding • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • Cajal body • jedro • intracellular anatomical structure • nukleoplazma Biološki proces • termination of RNA polymerase II transcription • mRNA 3'-end processing by stem-loop binding and cleavage • GO:0009373 regulation of transcription, DNA-templated • histone mRNA metabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	25888	243963
Ensembl	ENSG00000142528	ENSMUSG00000048012
UniProt	Q8WTR7	Q8BI67
RefSeq (mRNK)	NM_001006656 NM_001308424 NM_015428	NM_001289836 NM_001289837 NM_001289838 NM_001289839 NM_178734
RefSeq (bjelančevina)	NP_001006657 NP_001295353 NP_056243	NP_001276765 NP_001276766 NP_001276767 NP_001276768 NP_848849
Lokacija (UCSC)	Chr 19: 50.03 – 50.05 Mb	Chr 7: 44.38 – 44.4 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein 473 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF473.

Aminokiselinska sekvenca

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAEEFVTLKD		VGMDFTLGDW		EQLGLEQGDT		FWDTALDNCQ		DLFLLDPPRP
NLTSHPDGSE		DLEPLAGGSP		EATSPDVTET		KNSPLMEDFF		EEGFSQEIIE
MLSKDGFWNS		NFGEACIEDT		WLDSLLGDPE		SLLRSDIATN		GESPTECKSH
ELKRGLSPVS		TVSTGEDSMV		HNVSEKTLTP		AKSKEYRGEF		FSYSDHSQQD
SVQEGEKPYQ		CSECGKSFSG		SYRLTQHWIT		HTREKPTVHQ		ECEQGFDRNA
SLSVYPKTHT		GYKFYVCNEY		GTTFSQSTYL		WHQKTHTGEK		PCKSQDSDHP
PSHDTQPGEH		QKTHTDSKSY		NCNECGKAFT		RIFHLTRHQK		IHTRKRYECS
KCQATFNLRK		HLIQHQKTHA		AKTTSECQEC		GKIFRHSSLL		IEHQALHAGE
EPYKCNERGK		SFRHNSTLKI		HQRVHSGEKP		YKCSECGKAF		HRHTHLNEHR
RIHTGYRPHK		CQECVRSFSR		PSHLMRHQAI		HTAEKPYSCA		ECKETFSDNN
RLVQHQKMHT		VKTPYECQEC		GERFICGSTL		KCHESVHARE		KQGFFVSGKI
LDQNPEQKEK		CFKCNKCEKT		FSCSKYLTQH		ERIHTRGVKP		FECDQCGKAF
GQSTRLIHHQ		RIHSRVRLYK		WGEQGKAISS		ASLIKLQSFH		TKEHPFKCNE
CGKTFSHSAH		LSKHQLIHAG		ENPFKCSKCD		RVFTQRNYLV		QHERTHARKK
PLVCNECGKT		FRQSSCLSKH		QRIHSGEKPY		VCDYCGKAFG		LSAELVRHQR
IHTGEKPYVC		QECGKAFTQS		SCLSIHRRVH		TGEKPYRCGE		CGKAFAQKAN
LTQHQRIHTG		EKPYSCNVCG		KAFVLSAHLN		QHLRVHTQET		LYQCQRCQKA
FRCHSSLSRH		QRVHNKQQYC		L

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol. Cell. Biol. 26 (17): 6702–12. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Pillai RS, Grimmler M, Meister G, et al. (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.