File:Penicillin inhibition.svg
Original file (SVG file, nominally 1,157 × 1,813 pixels, file size: 1.34 MB)
Captions
Captions
Summary
[edit]DescriptionPenicillin inhibition.svg |
English: Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme) and subsequent suicide inhibition by penicillin.
1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.) 2. The PBP binds the peptide side chains and forms the cross-link with the expulsion of one D-Alanine from one peptide side chain. (See PBP_catalysis.svg for details.) 3. The PBP dissociates from the wall once the cross-link has been formed. 4. Penicillin is added to the system. It enters the active site of the PBP and reacts with the serine group that is important in its enzymatic activity. 5. The beta-lactam ring of penicillin (represented here as the top of the "P") is irreversibly opened during the reaction with the PBP. Penicillin remains covalently linked to the PBP and permanently blocks the active site.Italiano: Diagramma raffigurante la formazione di legami incrociati nella parete cellulare batterica da parte di una proteina legante la penicillina e inibizione suicidia della penicillina .
1. La parete cellulare batterica è costituito da filamenti di subunità ripetute N -acetil-glucosammina (NAG) e acido N-acetilmuramico (NAM). Le subunità NAM portano corte catene peptidiche attaccate. (La composizione esatta è variabile. L'alanina prossimale è solitamente una L-Ala e la due distali sono di solito D-Ala.) 2. La proteina lega le catene laterali peptidiche e forma la reticolazione con l'espulsione di una D-alanina da una catena laterale. 3. La proteina dissocia dalla parete una volta formato il reticolo. 4. Se penicillina viene aggiunto al sistema, essa entra nel sito attivo della proteina e reagisce con il gruppo serina il quale è importante per lattività enzimatica. 5. L'anello beta-lattamico della penicillina (qui rappresentato in rosso sulla "P") è irreversibilmente aperto durante la reazione con il proteina e rimanendo covalentemente ne blocca permanentemente il sito attivo. |
||
Date | |||
Source | Own work | ||
Author | Mcstrother | ||
Other versions |
[edit]
|
||
SVG development InfoField | This diagram was created with Inkscape, or with something else.
|
Licensing
[edit]- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 00:39, 10 September 2011 | 1,157 × 1,813 (1.34 MB) | Mcstrother (talk | contribs) | Corrected errors in mechanism of cross-linking. | |
04:03, 3 May 2011 | 1,157 × 1,813 (1.09 MB) | Mcstrother (talk | contribs) | Changed all fonts from "Sans" to "Liberation Sans" to fix overlap issues. | ||
03:42, 10 April 2011 | 1,157 × 1,813 (1.09 MB) | Mcstrother (talk | contribs) | Changed color of carbohydrate chain. | ||
06:42, 7 March 2011 | 1,157 × 1,813 (1.08 MB) | Mcstrother (talk | contribs) | {{Information |Description ={{en|1=Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme) and subsequent suicide inhibition by penicillin. 1. The bacterial cell wall consists of strands o |
You cannot overwrite this file.
File usage on Commons
The following 8 pages use this file:
File usage on other wikis
The following other wikis use this file:
- Usage on ar.wikipedia.org
- Usage on bg.wikipedia.org
- Usage on bn.wikipedia.org
- Usage on diq.wikipedia.org
- Usage on en.wikipedia.org
- Usage on gl.wikipedia.org
- Usage on he.wikipedia.org
- Usage on it.wikipedia.org
- Usage on ko.wikipedia.org
- Usage on ml.wikipedia.org
- Usage on sr.wikipedia.org
- Usage on tr.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Short title | Penicillin inhibition |
---|---|
Width | 1157.0914 |
Height | 1813.1825 |