POU2AF1

POU2AF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CQT
Dynodwyr
Cyfenwau	POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
Dynodwyr allanol	OMIM: 601206 HomoloGene: 4543 GeneCards: POU2AF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 protein binding • GO:0001104 transcription coregulator activity • RNA polymerase II core promoter sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • humoral immune response • transcription by RNA polymerase II • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5450	n/a
Ensembl	ENSG00000110777	n/a
UniProt	Q16633	n/a
RefSeq (mRNA)	NM_006235	n/a
RefSeq (protein)	NP_006226	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn POU2AF1 yw POU2AF1 a elwir hefyd yn POU class 2 associating factor 1 a POU domain class 2-associating factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn POU2AF1.

• BOB1
• OBF1
• OCAB
• OBF-1

Llyfryddiaeth

• "The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter. ". Eur J Immunol. 2003. PMID 14515270.
• "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization. ". Genomics. 1996. PMID 8617501.
• "Germline variation in the 3'-untranslated region of the POU2AF1 gene is associated with susceptibility to lymphoma. ". Mol Carcinog. 2017. PMID 28345816.
• "POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. ". J Immunol. 2016. PMID 26927796.
• "OCA-B regulation of B-cell development and function.". Trends Immunol. 2003. PMID 14552839.