CXCR1

CXCR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ILP, 1ILQ, 2LNL
Dynodwyr
Cyfenwau	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA, Interleukin 8 receptor, C-X-C motif chemokine receptor 1
Dynodwyr allanol	OMIM: 146929 HomoloGene: 68074 GeneCards: CXCR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • C-X-C chemokine receptor activity • interleukin-8 binding • G protein-coupled receptor activity • chemokine receptor activity • interleukin-8 receptor activity • signal transducer activity • C-C chemokine receptor activity • chemokine binding • C-C chemokine binding Cydrannau o'r gell • integral component of membrane • Cellbilen • secretory granule membrane • bilen • external side of plasma membrane Prosesau biolegol • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • receptor internalization • dendritic cell chemotaxis • GO:0072468 signal transduction • chemokine-mediated signaling pathway • interleukin-8-mediated signaling pathway • neutrophil degranulation • chemotaxis • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cytosolic calcium ion concentration • calcium-mediated signaling • neutrophil chemotaxis • cell chemotaxis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3577	n/a
Ensembl	ENSG00000163464	n/a
UniProt	P25024	n/a
RefSeq (mRNA)	NM_000634	n/a
RefSeq (protein)	NP_000625	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCR1 yw CXCR1 a elwir hefyd yn C-X-C motif chemokine receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCR1.

• C-C
• CD128
• CD181
• CKR-1
• IL8R1
• IL8RA
• CMKAR1
• IL8RBA
• CDw128a
• C-C-CKR-1

Llyfryddiaeth

• "CXC chemokine receptor 1 predicts postoperative prognosis and chemotherapeutic benefits for TNM II and III resectable gastric cancer patients. ". Oncotarget. 2017. PMID 27780937.
• "CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and ERK1/2 phosphorylation. ". Int J Oncol. 2016. PMID 26983663.
• "Impaired CXCR1-dependent oxidative defence in active tuberculosis patients. ". Tuberculosis (Edinb). 2015. PMID 26316141.
• "Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. ". Cell Host Microbe. 2013. PMID 24139401.
• "Single nucleotide polymorphisms in CXCR1 gene and its association with hepatitis B infected patients in Saudi Arabia.". Ann Hepatol. 2013. PMID 23396733.