TAB1

TAB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2J4O, 2POM, 2POP, 2YDS, 2YIY, 4AY5, 4AY6, 4GS6, 4KA3, 4L3P, 4L53, 4O91, 5DIY, 5JGA, 5JGD
Dynodwyr
Cyfenwau	TAB1, 3'-Tab1, MAP3K7IP1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Dynodwyr allanol	OMIM: 602615 HomoloGene: 4461 GeneCards: TAB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding • catalytic activity • kinase activator activity • GO:0010577 enzyme activator activity • GO:0032403 protein-containing complex binding • mitogen-activated protein kinase p38 binding • protein kinase activator activity Cydrannau o'r gell • endosome membrane • cytosol • nuclear speck • GO:0009327 protein-containing complex • cnewyllyn cell Prosesau biolegol • cardiac septum development • lung development • GO:0016576 protein dephosphorylation • heart morphogenesis • stimulatory C-type lectin receptor signaling pathway • in utero embryonic development • MyD88-dependent toll-like receptor signaling pathway • coronary vasculature development • Fc-epsilon receptor signaling pathway • JNK cascade • aorta development • positive regulation of NF-kappaB transcription factor activity • I-kappaB kinase/NF-kappaB signaling • transforming growth factor beta receptor signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of MAP kinase activity • protein deubiquitination • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10454	n/a
Ensembl	ENSG00000100324	n/a
UniProt	Q15750	n/a
RefSeq (mRNA)	NM_153497 NM_006116	n/a
RefSeq (protein)	NP_006107 NP_705717	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TAB1 yw TAB1 a elwir hefyd yn TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TAB1.

• 3'-Tab1
• MAP3K7IP1

Llyfryddiaeth

• "TAK1-binding protein 1 is a pseudophosphatase. ". Biochem J. 2006. PMID 16879102.
• "Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. ". Int J Clin Exp Pathol. 2015. PMID 26884850.
• "TAB1: a target of triptolide in macrophages. ". Chem Biol. 2014. PMID 24462677.
• "The critical role of TAK1 in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. ". Am J Pathol. 2012. PMID 22525462.
• "Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.". PLoS One. 2011. PMID 22216226.