„CP-47,497“ – Versionsunterschied
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{{Infobox Chemikalie |
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|IUPAC_name = 2-[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl)phenol |
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| Strukturformel = [[Datei:CP-47,497.svg]] |
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| image = CP-47,497.svg |
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| width= 240 |
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| CAS_number= 70434-82-1 |
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| Wirkstoffgruppe = [[Cannabinoide|Cannabinoidmimetikum]] |
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| Wirkmechanismus = [[Cannabinoid-Rezeptor]] [[Cannabinoid-Rezeptor 1|CB<sub>1</sub>]][[Agonist (Pharmakologie)|Agonist]] |
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| C=21 | H=34 | O=2 |
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| molecular_weight = 318.492 g/mol |
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| smiles = Oc1cc(C(C)(C)CCCCCC)ccc1C(CCC2)CC2O |
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| Molare Masse = 318.492 g·mol<sup>−1</sup> |
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| Quelle GefStKz = <ref>In Bezug auf ihre Gefährlichkeit wurde die Substanz von der EU noch nicht eingestuft, eine verlässliche und zitierfähige Quelle hierzu wurde noch nicht gefunden.</ref> |
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'''CP 47,497''' |
'''CP 47,497''' is a drug which is a [[cannabinoid]] receptor agonist, developed by [[Pfizer]] in the 1980s. It has [[analgesic]] effects and is used in scientific research. It is a potent CB<sub>1</sub> agonist with a [[Dissociation constant|Ki]] of 2.1nM.<ref>Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. ''Biopolymers''. 2003;71(2):169-89. PMID 12767117</ref><ref>Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168. Springer. ISBN 3-540-22565-X</ref><ref>Little PJ, Compton DR, Johnson MR, Melvin LS, Martin BR. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. ''Journal of Pharmacology and Experimental Therapeutics'' 1988; 247:1046–1051.</ref> |
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On the 19th of January 2009, the University of Freiburg in Germany announced that an undisclosed [[analog (chemistry)|analog]] of CP 47,497 is the main active ingredient in the herbal mixture [[Spice (drug)|Spice]].<ref>Hauptwirkstoff von „Spice“ identifiziert, University of Freiburg http://www.pr.uni-freiburg.de/pm/2009/pm.2009-01-19.19/</ref> |
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{{cannabinoid-stub}} |
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== Einzelnachweise == |
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==References== |
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{{cannabinoids}} |
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[[Kategorie:Synthetische Droge]] |
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[[Category:Cannabinoids]] |
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Version vom 21. Januar 2009, 21:33 Uhr
CP 47,497 is a drug which is a cannabinoid receptor agonist, developed by Pfizer in the 1980s. It has analgesic effects and is used in scientific research. It is a potent CB1 agonist with a Ki of 2.1nM.[1][2][3]
On the 19th of January 2009, the University of Freiburg in Germany announced that an undisclosed analog of CP 47,497 is the main active ingredient in the herbal mixture Spice.[4]
References
- ↑ Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers. 2003;71(2):169-89. PMID 12767117
- ↑ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168. Springer. ISBN 3-540-22565-X
- ↑ Little PJ, Compton DR, Johnson MR, Melvin LS, Martin BR. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.
- ↑ Hauptwirkstoff von „Spice“ identifiziert, University of Freiburg http://www.pr.uni-freiburg.de/pm/2009/pm.2009-01-19.19/