CTP synthetase
| CTP synthase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CTPS | ||||||
| NCBI gene | 1503 | ||||||
| HGNC | 2519 | ||||||
| OMIM | 123860 | ||||||
| PDB | 1s1m | ||||||
| RefSeq | NM_001905 | ||||||
| UniProt | P17812 | ||||||
| Other data | |||||||
| EC number | 6.3.4.2 | ||||||
| Locus | Chr. 1 p34.1 | ||||||
| |||||||
CTP synthase (or CTP synthetase) is an enzyme involved in pyrimidine biosynthesis.
It intraconverts UTP and CTP. The source of the amine/amino group in CTP is glutamine.
CTP synthase is activated by GTP, a purine. This acts to balance the relative amounts of purine and pyrimidine nucleotides.
CTP synthase is inhibited by reversible by CTP and irreversible for example by the glutamine analogon DON.[1]
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CTP (Note nitrogen in upper right. Ignore rotation.)
References
- ^ Ahluwalia GS et al. Metabolism and action of amino acid analog anti-cancer agents ”, in Pharmac. Ther. (1990) 46: 243-271
External links
- CTP+synthetase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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