Ying Ge

Ying Ge
Alma mater	Cornell University (PhD) University of Peking (BS)
Scientific career
Institutions	University of Wisconsin-Madison Wyeth
Thesis	Top down characterization of proteins by electron capture dissociation and blackbody infrared radiative dissociation mass spectrometry (2002)

Ying Ge is a Chinese-American biologist and Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the Board of Directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.

Early life and education

Ge was born in China. She attended Peking University for her undergraduate studies, where she studied chemistry. After graduating in 1997 Ge moved to the United States, where she joined Cornell University as a doctoral student. Here she started to work on mass spectrometry, using electron-capture dissociation to study proteins. She worked under the supervision of Tadhg Begley and Fred McLafferty. After completing her doctorate, Ge worked as a research scientist at Wyeth.

Research and career

Ge joined the University of Wisconsin–Madison as an assistant scientist, where she oversaw the mass spectrometry programme. She became an Associate Professor in 2015, and full Professor in 2019.

Ge develops high-resolution mass spectrometry proteomics to better understand cardiac disease. To image the very large proteins of human heart tissue, Ge combines fourier-transform ion cyclotron resonance (FT–ICR) mass spectrometry with electron-capture dissociation. She has worked to create a top-down disease proteomic platform that allows for the separation, detection and characterisation of

Awards and honours

2016 Georges Guiochon Faculty Fellowship

2018 H. I. Romnes Faculty Fellowship

2020 American Society for Mass Spectrometry Biemann Medal

2020 Analytical Scientist Power List

Select publications

• Smith, Lloyd M; Kelleher, Neil L (2013-02-27). "Proteoform: a single term describing protein complexity". Nature Methods. 10 (3): 186–187. doi:10.1038/nmeth.2369. ISSN 1548-7091.

• {Ge, Ying; Lawhorn, Brian G.; ElNaggar, Mariam; Strauss, Erick; Park, Joo-Heon; Begley, Tadhg P.; McLafferty, Fred W. (2002-01-01). "Top Down Characterization of Larger Proteins (45 kDa) by Electron Capture Dissociation Mass Spectrometry". Journal of the American Chemical Society. 124 (4): 672–678. doi:10.1021/ja011335z. ISSN 0002-7863.

• {Horn, David M.; Ge, Ying; McLafferty, Fred W. (2000-10-01). "Activated Ion Electron Capture Dissociation for Mass Spectral Sequencing of Larger (42 kDa) Proteins". Analytical Chemistry. 72 (20): 4778–4784. doi:10.1021/ac000494i. ISSN 0003-2700.

• Sze, Siu Kwan; Ge, Ying; Oh, HanBin; McLafferty, Fred W. (2002-02-19). "Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue". Proceedings of the National Academy of Sciences. 99 (4): 1774–1779. doi:10.1073/pnas.251691898. ISSN 0027-8424. PMID 11842225.