Cinitapride (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiemetic agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain.[1][2] It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.[3][4]
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| Trade names | Cintapro, Pemix |
| Routes of administration | Oral |
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| Formula | C21H30N4O4 |
| Molar mass | 402.495 g·mol−1 |
| Chirality | Racemic mixture |
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Uses
editIt is indicated for the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying. It may be also used in the management of nausea and vomiting.
Synthesis
editCinitapride is the amide formed by reacting methyl 4-amino-2-ethoxy-5-nitrobenzoate (1) with the 4-aminopiperidine derivative (2).[5][6]
References
edit- ^ Robert M, Salvà M, Segarra R, et al. (July 2007). "The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole". Drug Metabolism and Disposition. 35 (7): 1149–56. doi:10.1124/dmd.106.010835. PMID 17437965. S2CID 1284844.
- ^ Fernández AG, Massingham R (January 1985). "Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs". Life Sciences. 36 (1): 1–14. doi:10.1016/0024-3205(85)90280-2. PMID 2981378.
- ^ Alarcón-de-la-Lastra Romero C, López A, Martín MJ, la Casa C, Motilva V (April 1997). "Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds". Pharmacology. 54 (4): 193–202. doi:10.1159/000139487. PMID 9211565.
- ^ Alarcón de la Lastra C, La Casa C, Martin MJ, Motilva V (March 1998). "Effects of cinitapride on gastric ulceration and secretion in rats". Inflammation Research. 47 (3): 131–6. doi:10.1007/s000110050301. PMID 9562338. S2CID 25620004. Archived from the original on 1999-08-27. Retrieved 2010-02-27.
- ^ GB patent 1574419, Inglesias, J.B; Soto, J.P; Noverola, A.V; Mauri, J.M, "Piperidine compounds", issued 1980-09-03, assigned to Anphar SA
- ^ "Cinitapride". Thieme. Retrieved 2024-07-02.
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