U-45 may refer to one of the following German submarines:
- SM U-45, was a Type U 43 submarine launched in 1915 and that served in the First World War until sunk on 12 September 1917
- During the First World War, Germany also had these submarines with similar names:
- SM UB-45, a Type UB II submarine launched in 1916 and sunk on 6 November 1916
- SM UC-45, a Type UC II submarine launched in 1916 and sunk on 17 September 1917; raised on 11 April 1918; re-entered service on 24 October 1918; surrendered on 24 November 1918
- During the First World War, Germany also had these submarines with similar names:
- German submarine U-45 (1938), a Type VIIB submarine that served in the Second World War until sunk on 14 October 1939.
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This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.