Jayasena is both a given name and a surname. Notable people with the name include:
- Jayasena (fl. 12th century), Indian monk
- Jayasena Dissanayake (fl. 1996–1998)), Sri Lankan politician
- Hemantha Jayasena (born 1971), Sri Lankan-born Italian cricketer
- Henry Jayasena (1931–2009), Sri Lankan actor
- J. P. Jayasena (1921–1990), Ceylonese politician
- L. B. Jayasena (1920–?), Sri Lankan politician
- Ranmith Jayasena (born 2000), Sri Lankan cricketer
- Sumedha Jayasena (born 1952), Sri Lankan politician
This page or section lists people that share the same given name or the same family name.
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