Second Creek or Secondcreek may refer to:
- Second Creek (Adelaide), a tributary of the River Torrens, Adelaide, South Australia
- Second Creek (Greenbrier River), a stream in West Virginia
- Second Creek (Mississippi), a tributary of the Homochitto River
- Second Creek (Pocatalico River), a stream in Kanawha County, West Virginia
- Second Creek (Uwharrie River tributary), a stream in Randolph County, North Carolina
- Secondcreek, West Virginia, an unincorporated community
This disambiguation page lists articles about distinct geographical locations with the same name.
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