Talk:Nasal administration

Title of this article

I think this article should be re-titled "Intranasal administration." There was once an article titled "Intranasal route," which was recently merged with the article on insufflation. (The latter article has very little information on intranasal delivery.)

My reason for recommending this change is that the substances are delivered into the nose (specifically the nasal cavity), as opposed to topical application to the surface of the nose for transdermal delivery. In addition, the research literature on central nervous system (CNS, brain and spinal cord) delivery refers to "intranasal" administration of drugs, or delivery via the "intranasal" route.

For disclosure, I am a co-author on some papers on this subject, and I have presented research on this subject at conferences as first author, and in our publications and presentations (from my lab group), we always used the term "intranasal." (So maybe that's a bias.) Any thoughts on this matter? Dcs002 (talk) 00:51, 26 September 2009 (UTC)

Olfactory transfer

A big thank you to whomever wrote this section! Very complete and nicely written, but now it's in need of update. I will update it soon (when I have more time). Thare have now been several human studies demonstrating therapeutic benefits of central drug delivery via the intranasal route, including a number of peptides, most notably (IMO) in Alzheimer patients and in patients with mild cognitive impairment (MCI, a sort of pre-Alzheimer or pre-dementia condition) who were given insulin intranasally. Unfortunately, none of these treatments is in widespread clinical use yet as they will need to go through the FDA approval process first, as will the special vortex spray devices or atomizers required to bring the drugs as high in the nasal cavity as the olfactory epithelium. That might be expedited in the case of insulin in Alzheimer patients due to the tremendous benefit shown (actual improvement instead of slowing degeneration of the brain, and actual neural regeneration observed in animal models), and because insulin is readily available at a lower cost than other Alzheimer medications, such as Aricept and Namenda. Dcs002 (talk) 00:51, 26 September 2009 (UTC)

Nasal vaccine for dogs

Copy paste 4. Feb 2022 from here:

https://en.wikipedia.org/wiki/Kennel_cough#Vaccines

Kennel cough is an upper respiratory infection affecting dogs.

There are multiple causative agents, the most common being the bacterium Bordetella bronchiseptica (found in 78.7% of cases in Southern Germany), followed by canine parainfluenza virus (37.7% of cases), and to a lesser extent canine coronavirus (9.8% of cases).

Several intranasal vaccines have been developed that contain canine adenovirus in addition to B. bronchiseptica and canine parainfluenza virus antigens. Studies have thus far not been able to determine which formula of vaccination is the most efficient. Adverse effects of vaccinations are mild, but the most common effect observed up to 30 days after administration is nasal discharge.

Question: what would happen if this vetenary vaccine is given to humans?

--91.159.188.74 (talk) 19:49, 4 February 2022 (UTC)

The article talk page is not a general discussion forum. Speculation on human use of veterinary medicines is outside the scope of this article and this talk page. You should ask a medical expert if you are thinking of trying this, not an anonymous online forum. Dcs002 (talk) 02:04, 29 July 2022 (UTC)

List of possible drugs, conditions

Each one needs a citation to be justified for inclusion. 2603:6000:D70A:BC00:1C69:20E9:6115:D11D (talk) 14:32, 19 July 2022 (UTC)

I'm not sure what list you're referring to, but citations are needed for controversial content or content that is likely to be contested. Could you be more specific with your concern? Dcs002 (talk) 02:06, 29 July 2022 (UTC)

Mechanistic routes of drug absorption claimed to be dominated by transcellular (fast) and paracellular (slow).

"Subsequent to a drug’s passage through the mucus, there are numerous mechanisms for absorption through the mucosa. These include transcellular or simple diffusion across the membrane, paracellular transport via movement between cell and transcytosis by vesicle carriers. Several mechanisms have been proposed, but paracellular and transcellular routes dominate [50].

Paracellular transport is slow and passive. There is an inverse correlation between intranasal absorption and the molecular weight of water-soluble compounds. Poor bioavailability was reported for drugs with a molecular weight greater than 1000 Daltons [48].

The second mechanism involves transport through a lipoidal route that is also known as the transcellular process and is responsible for the transport of lipophilic drugs that show a rate dependency on their lipophilicity. Drugs also cross cell membranes by an active transport route via carrier-mediated means or transport through the opening of tight junctions [50]." GrahamxReed (talk) 02:58, 18 April 2024 (UTC)

References