سایکلین دی۱
سایکلین دی۱ (انگلیسی: Cyclin D1) یک پروتئین است که در انسان توسط ژن «CCND1» کُدگذاری میشود. ژن مذکور بر روی بازوی بلند کروموزوم ۱۱ (باند 11q13) واقع است و در حدود ۱۳٬۳۸۸ جفت باز طول دارد و ۲۹۵ پروتئین را کُدگذاری میکند.[۴][۵]
اهمیت بالینی
[ویرایش]تولید بیش از حد این پروتئین در مراحل آغازین سرطان و پیشرفت تومور مشاهده شدهاست[۶] و میتواند از طریق رشد بدون حمایت تکیهگاه سلولی و همچنین رگسازی وابسته به تولید فاکتور رشد اندوتلیال عروقی، منجر به سرطانزایی شود.[۷] تولید زیاد این سایکلین دی۱ همچنین سبب کاهش بیان ژنی Fas شده و در نتیجه مقاوت به شیمیدرمانی پیش میآید و سلولهای سرطانی در برابر آپوپتوز محافظت میشوند.[۷]
تولید بیش از حد این پروتئین با بقای کمتر بیماران سرطانی و افزایش متاستاز در ارتباط است.[۸][۹] چنین افزایشی در میزانِ این پروتئین در سرطانهای زیر یافت شدهاست:
- سرطان ریه از نوع سلول غیر کوچک (۳۰–۴۶٪)[۱۰][۱۱]
- سرطانهای بافت پوششی سر و گردن (۳۰–۵۰٪)[۱۲][۱۳][۱۴]
- سرطان لوزالمعده (۲۵٪)[۱۵]
- سرطان مثانه (۱۵٪)[۱۶]
- آدنوم هیپوفیز (۴۹–۵۴٪)[۱۷][۱۸]
- سرطان پستان(۱۳٪)[۱۹][۲۰][۲۱]
بیشتولیدی سایکلین دی۱ بهویژه در «سرطانهای پستان نوع ER+» قویاً تأیید شدهاست[۲۱] و عدم تنظیم آن با بروز مقاومت به هورموندرمانی در این سرطانها مرتبط است.[۲۲][۲۳][۲۴]
جابهجایی کروموزومی جایگاه ژنی سایکلین دی۱ در حدود ۱۵ – ۲۰٪ از موارد مولتیپل میلوما یافت شدهاست.[۲۵][۲۶]
از روشهای رنگآمیزی ایمونوهیستوشیمی آنتیبادیهای سایکلین دی۱ برای تشخیص لنفوم سلول منتل استفاده میشود. همچنین پیشنهاد شده تا از آن بهعنوان یک نشانگر زیستی برای تشخیص سرطان پستان استفاده شود.[۲۷]
جستارهای وابسته
[ویرایش]منابع
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