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awesome-spatial-omics Awesome

This wants to be a community maintained repository for collecting single-cell spatial omics resources to stay updated with this fast-growing field.

Any contribution is really appreciated.

At the moment we distinguish these main sections:

  • Spatial Omics Technologies
    • Spatial Transcriptomics
    • Spatial Multi Modal
    • Others (if any)
  • Spatial Omics Methods & Tools
    • Spatial Transcriptomics Methods & Tools
    • Spatial Multi Modal Methods & Tools
    • Others (if any)

This repo is inspired to the Mike Love's Awesome Multi Omics and the Sean Davis' Awesome Single Cell ones.

Spatial Omics Technologies

This section is referred to all the technologies that can be collected regarding the spatial omics field, each of this subsections could collect two main families of this technologies, spot-based and molecular-based.

Spatial Transcriptomics

Spot-Based
2016 10x Visium Allows the detection of transcripts at spatial spot level Ståhl et al.
2019 HDST High-definition spatial transcriptomics with 2-μm resolution Vickovic et al.
Molecular-based
2014 seqFISH Allows the detection of transcripts at spatial level Lubeck et Al.
2015 MERFISH Multiplexed smFISH with error-robust barcodes Chen et al.

Spatial MultiModal

Year Title Description Reference
YYYY 10x Spatial Proteomics co-detection Allows the co-detection of proteins and transcripts at spatial level Ref
2020 High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue detection of transcripts and proteins on a chip-placed tissue slice Liu et al 2020

Others (if any)

Year Title Description Reference
2021 Spatially mapped single-cell chromatin accessibility spatial ATAC Thornton et al. 2021

Spatial Omics Methods & Tools

This section is intended not only for papers, but also for packages, methods, approaches or guidelines for Spatial Omics data analysis and integration. Following subsection will be subsequently divided by argument while collecting them.

Spatial Transcriptomics Methods & Tools

Year Title Language Description Reference
2021 Giotto R Toolbox for integrative analysis and visualization of spatial expression data Dries et al. 2021

Spatial Multi Modal Methods & Tools

Others (if any)

Year Title Language Description Reference
2020 MISTy R Multiview Intercellular SpaTial modeling framework for knowledge extraction and analysis of highly multiplexed, spatially resolved omics data. Tanevski et al.

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