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MX2021003711A - Métodos para identificar pares de receptor de antígeno activador (acar)/receptor de antígeno quimérico inhibidor (icar) para su uso en terapias contra el cáncer. - Google Patents

Métodos para identificar pares de receptor de antígeno activador (acar)/receptor de antígeno quimérico inhibidor (icar) para su uso en terapias contra el cáncer.

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Publication number
MX2021003711A
MX2021003711A MX2021003711A MX2021003711A MX2021003711A MX 2021003711 A MX2021003711 A MX 2021003711A MX 2021003711 A MX2021003711 A MX 2021003711A MX 2021003711 A MX2021003711 A MX 2021003711A MX 2021003711 A MX2021003711 A MX 2021003711A
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Mexico
Prior art keywords
antigen receptor
icar
acar
chimeric antigen
pairs
Prior art date
Application number
MX2021003711A
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English (en)
Inventor
Gideon Gross
Dvir Dahary
Yael Sagi
Adi Sharbi-Yunger
William J Gibson
Merav Beiman
Original Assignee
Immpact Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Immpact Bio Ltd filed Critical Immpact Bio Ltd
Publication of MX2021003711A publication Critical patent/MX2021003711A/es

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Abstract

La presente invención proporciona un método para identificar un par de dianas que comprende i) un receptor de antígeno quimérico inhibidor (iCAR) o un receptor de antígeno quimérico protector (pCAR) capaz de impedir o atenuar la activación no deseada de una célula inmunitaria efectora, en donde la diana de iCAR o pCAR se dirige a un epítopo polimórfico extracelular diana, y ii) un receptor de antígeno quimérico activador (aCAR), en donde el aCAR se dirige a un epítopo no polimórfico la de superficie celular diana de una proteína, así como métodos de fabricación y uso de dichos pares en el tratamiento del cáncer.
MX2021003711A 2018-09-28 2019-09-27 Métodos para identificar pares de receptor de antígeno activador (acar)/receptor de antígeno quimérico inhibidor (icar) para su uso en terapias contra el cáncer. MX2021003711A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862738895P 2018-09-28 2018-09-28
US201962847830P 2019-05-14 2019-05-14
PCT/IB2019/001108 WO2020065406A2 (en) 2018-09-28 2019-09-27 Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies

Publications (1)

Publication Number Publication Date
MX2021003711A true MX2021003711A (es) 2021-08-11

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MX2021003711A MX2021003711A (es) 2018-09-28 2019-09-27 Métodos para identificar pares de receptor de antígeno activador (acar)/receptor de antígeno quimérico inhibidor (icar) para su uso en terapias contra el cáncer.

Country Status (11)

Country Link
US (1) US20200316120A1 (es)
EP (1) EP3856236B1 (es)
JP (1) JP2022508554A (es)
KR (1) KR20210088559A (es)
CN (1) CN113453705A (es)
AU (1) AU2019348877A1 (es)
BR (1) BR112021006100A2 (es)
CA (1) CA3114736A1 (es)
IL (1) IL282019A (es)
MX (1) MX2021003711A (es)
WO (1) WO2020065406A2 (es)

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