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CN105675896A - Dismountable multipurpose reagent strip assembly - Google Patents

Dismountable multipurpose reagent strip assembly Download PDF

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Publication number
CN105675896A
CN105675896A CN201610149393.1A CN201610149393A CN105675896A CN 105675896 A CN105675896 A CN 105675896A CN 201610149393 A CN201610149393 A CN 201610149393A CN 105675896 A CN105675896 A CN 105675896A
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CN
China
Prior art keywords
strip
shaped
reagent
reagent strip
storehouse
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Granted
Application number
CN201610149393.1A
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Chinese (zh)
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CN105675896B (en
Inventor
王兴
张旭中
李世林
张鹏远
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Tianjin one Rui biological Polytron Technologies Inc
Original Assignee
TIANJIN YIRUI BIOLOGICAL ENGINEERING Co Ltd
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Priority to CN201610149393.1A priority Critical patent/CN105675896B/en
Publication of CN105675896A publication Critical patent/CN105675896A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Packages (AREA)

Abstract

The invention relates to a dismountable multipurpose reagent strip assembly. The reagent strip assembly comprises a reagent strip support and a sample bin, a reagent bin, a detection bin and a consumable bin which are mounted on the reagent strip support, the reagent strip support comprises a reagent strip upper panel, the reagent strip upper panel comprises sample position holes, consumable position holes, multiple reagent position holes and detection position holes, a strip-shaped frame is integrally manufactured below the reagent strip upper panel, an inner space of the strip-shaped frame is partitioned into multiple independent spaces, and each independent space corresponds to the corresponding hole in the reagent strip upper panel; the sample bin, the reagent bin, the detection bin and the consumable bin each comprises a barrel-shaped bin body on the lower portion and a bin rim at the edge of an opening in the upper portion, and each barrel-shaped bin body is inserted in the corresponding independent space formed by partitioning the middle area of the strip-shaped frame. By means of the dismountable multipurpose reagent strip assembly, production, packaging, replacement and combination can be conducted at will in automation design, and the reagent strip assembly is adapted to experiments of different detection modes without increasing cost.

Description

A kind of dismountable multiplex reagent strip assembly
Technical field
The invention belongs to biochemical immunity testing equipment technical field, particularly a kind of dismountable multiplex reagent strip assembly.
Background technology
In biochemistry detection field, the packaging means of test kit is substantially all bottled. Open during use bottle cap take out liquid, it may also be useful to after cover bottle cap again. In order to reduce the quantity of bottle, the component of reagent is all that the dosage divided with many people is packed. Open successively after bottle takes liquid according to the order of experiment during manual operation and cover lid again. This kind of mode waste of manpower, efficiency is not high.
Along with the development of technology, the equipment of automatization is by a large amount of uses, and at this moment people start to carry out processing and testing with mechanical manipulator. But the packaging of test kit does not carry out big change, being still bottled reagent, many people are packaged. Need when entering automatic equipment manually to open bottle cap, by manually covering bottle cap after experiment terminates. This kind of mode has 2 obvious shortcomings, first, reagent component bottle must be opened for a long time, owing to bottle cap will be opened when automatic equipment put into by reagent, and the equipment of automatization needs the operating time, namely use less than reagent also can expose in atmosphere, so some component exposes for a long time can As time goes on produce offset of performance in atmosphere. 2nd, the component cannotd be used up may will be wasted due to collocation problem, because some component just can not utilize again once open, if be not finished, can not preserve.
In order to address these problems, some self-reacting devices have devised the reagent strip that can simultaneously hold the required all components of experiment, also on the support of a bar shaped, set the position, hole of a lot of reagent component exactly, various component is put into Kong Weizhong according to demand, and closes with aluminium-foil paper. These components are single parts, can not cause waste, and time only to need to use in foil sealing, ability consumptive material punctures aluminium-foil paper and draws, and can not allow reagent exposure in atmosphere. Solve the problem that reagent bottle there will be.
Although using conveniently, but this kind of reagent strip encounters difficulty on the convenient degree produced and handiness. First run into and need to carry out injection moulding production, once it is determined that the position, hole of reagent wells position sample just can not have changed, if need to carry out variation will mold again, can greatly increase production cost like this.
Secondly, conventional reagent strip is just integrated with reagent component, sample areas and surveyed area that experiment needs, but not integrated for consumptive material, consumptive material part will be added in the design of automatization like this, add the difficulty of automation design.
3rd owing to needing integrated a variety of reagent component in single reagent strip, and the processing mode of each component and preserving type are likely different, but only one, container, and add another component again after first being added a kind of component when producing, until all components all add just can carry out sealer operation, if the improper preservation of the component at this moment added at first easily goes wrong, the complete processing of reagent strip can be very complicated.
Summary of the invention
It is an object of the invention to the technical problem that the detection mode for domestic use occurs, it is proposed to a kind of dismountable multiplex reagent strip assembly.
The present invention solves its technical problem and takes following technical scheme to realize:
A kind of dismountable multiplex reagent strip assembly, sample storehouse, agent bin, detection storehouse and the consumptive material storehouse comprising reagent strip support He being arranged on reagent strip support,
Wherein, reagent strip support includes reagent strip top panel further, reagent strip top panel is made up of the strip panel that two-strip structure is identical, the connection center line of two strip panels is shaped with the bar shaped segmentation perforation at multiple interval, strip panel is shaped with bending V-type push rod from left to right successively downwards, the chute board inwardly caved in both sides and both sides are wider than the mounting plate of chute board, have sample bit hole on a mounting board from left to right successively, hole, consumptive material position, multiple hole, reagent position of order arrangement and detecting position hole, right-hand member at each strip panel is integrally shaped with extension and width to the right and is narrower than the strongback of strip-shaped surface plate, the location bolt that the first system of right-hand end at strongback has width identical with strip panel, strip framework integrally it is shaped with in the lower section of the mounting plate part of each strip panel, the internal space of strip framework separates into multiple separate space by some next doors, each separate space is corresponding with each position of opening on mounting plate,
Meanwhile, being integrally shaped with slideway edge in the both sides, lower section of strip panel middle slideway Board position, the outside on two slideway edges is identical with the mounting plate part width of strip panel, and slideway aligns along bottom with the bottom of strip framework;
Meanwhile, the spacing edge of del integrally it is shaped with in the lower section of reagent strip top panel both sides.
Wherein, described sample storehouse, agent bin, detection storehouse and consumptive material storehouse include the edge, storehouse at bottom bucket shape warehouse and warehouse upper opening edge, bucket shape warehouse is inserted in the separate space separated in strip framework, and storehouse is along being stuck in mounting plate perforate corresponding to each separate space.
And, described sample storehouse specifically comprises bottom drum shape warehouse, is integrally shaped with edge on the storehouse on matching ring and matching ring top outside the upper shed of drum shape warehouse, and on storehouse, the edge on edge is shaped with hand and tears breach.
And, described agent bin and detection storehouse include the four prism type warehouse of a bottom adduction, integrally being shaped with square openings edge outside the upper shed of four prism type warehouse, two opposition side surface upper part at four prism type warehouse are integrally shaped with the square card button of two outwardly convexs.
And, bottom the warehouse in described detection storehouse, connect bucket at the bottom of a rectangular parallelepiped.
And, described consumptive material storehouse comprises the identical cylindrical warehouse of two structures, two cylindrical warehouses are arranged in parallel by a union lever connection, are integrally shaped with the rectangle fillet edge connecting two warehouses at the upper shed edge of two cylindrical warehouses, are shaped with hand at the edge on fillet edge and tear breach.
Advantage and the positively effect of the present invention be:
1, the present invention compares the position that already present single part reagent strip adds required consumptive material, it is possible to save the problem of consumptive material position and replacing in automation design.
2, manner is changed into from fixing mode in the position, component hole of single part reagent strip by the present invention, it is possible to carry out arbitrarily producing, pack, change and combining, very convenient. This kind of mode can allow single part reagent strip be suitable for various different reagent and experiment and need not increase cost.
3, in the present invention, cuvette also can carry out arbitrary combination and replacing, it is possible to is adapted to the experiment of different detection mode, and does not increase extra cost.
4, the container of the various component of the present invention is produced with independent mould, is applicable to batch production filling with operating.
Accompanying drawing explanation
Fig. 1 is the main TV structure schematic diagram of reagent strip support in the present invention;
Fig. 2 is the vertical view of Fig. 1;
Fig. 3 is the perspective view of reagent strip support in the present invention;
Fig. 4 is the structural representation of sample storehouse in the present invention;
Fig. 5 is the structural representation in agent bin and detection storehouse in the present invention;
Fig. 6 is the left view of Fig. 5;
Fig. 7 is another kind of structural representation detecting storehouse in the present invention;
Fig. 8 is the structural representation in consumptive material storehouse in the present invention.
Embodiment
The invention process being further described below, following examples are descriptive, are not limited, can not limit protection scope of the present invention with this.
A kind of dismountable multiplex reagent strip assembly, sample storehouse, agent bin, detection storehouse and the consumptive material storehouse comprising reagent strip support He being arranged on reagent strip support,
Wherein, as shown in the figures 1 and 2, reagent strip support includes reagent strip top panel 5 further, reagent strip top panel is made up of the rectangle strip panel that two-strip structure is identical, the connection center line of two rectangle strip panels is shaped with the bar shaped segmentation perforation 8 at multiple interval, article two, rectangle strip panel can be broken into two with one's hands along this bar shaped segmentation perforation, form two independent reagent strip supports, it is shaped with the V-type push rod 1 bent successively downwards to right-hand member from rectangle strip panel left end, the chute board 3 that inwardly caves in both sides and both sides are wider than the mounting plate of chute board, have circular sample bit hole 4 on a mounting board from left to right successively, hole, rectangular consumptive material position 6, multiple square holes, reagent position 7 of order arrangement and rectangular detecting position hole 9, right-hand member at each rectangle strip panel is integrally shaped with extension and width to the right and is narrower than the strongback 10 of rectangular bars shape panel, the location bolt 11 that the first system of right-hand end at strongback has width identical with rectangle strip panel, as shown in figures 2 and 3, strip framework 13 integrally it is shaped with in the lower section of the mounting plate part of each rectangle strip panel, the internal space of strip framework separates into multiple separate space by some next doors 14, each separate space is corresponding with each position of opening on mounting plate,
Meanwhile, being integrally shaped with slideway along 2 in the both sides, lower section of rectangle strip panel middle slideway Board position, the outside on two slideway edges is identical with the mounting plate part width of rectangle strip panel, and slideway aligns along bottom with the bottom of strip framework;
Meanwhile, as shown in Figure 2, del integrally it is shaped with in the lower section of reagent strip top panel both sides spacing along 12.
In specific embodiment of the invention, strip framework: be the main integral part of reagent strip support, the perforate of all ingredients groove and the design of various Design assistant are all achieved on strip framework, are the main bodys of reagent strip support.
Rectangle strip panel: being the end face of strip framework, both sides lean out strip framework, main effect is the effect forming stiffening web, ensures the levelness of strip framework, guaranteed reagent,G.R. bar level.
Push rod: reagent strip needs level insertion automatic equipment, and push rod is the hand-held position of operator, operator's level push rod, the slow access arrangement of reagent strip.Push rod presents V-type, mainly makes push rod stressed area big, and operation strength is controlled, uses V-type design can also increase buffering in addition.
Location bolt: at the head of reagent strip, first insert self-reacting device, have reagent guide-track groove in automatic equipment, first location bolt inserts in reagent guide-track groove and moves forward in groove.
Slideway edge: at the afterbody of reagent strip, finally inserts self-reacting device, and after guide-track groove is also inserted in slideway edge, whole reagent strip has put into guide rail with regard to complete, will not have and slide up and down.
Spacing edge: locating bolt position more rearward, be a little edge outstanding on framework edge, just can be stuck in the corresponding groove of automatic equipment in automatic equipment internal slide at reagent strip, also will have good positioning before and after such reagent strip.
Wherein, as shown in Figure 4, described sample storehouse comprises bottom drum shape warehouse 19, is integrally shaped with along 16 on the storehouse on matching ring 18 and matching ring top outside the upper shed of drum shape warehouse, and on storehouse, the edge on edge is shaped with hand and tears breach 17; Warehouse is for carrying sample, matching ring is for carrying out shrink-fit with reagent strip support, whole sample storehouse is positioned, on storehouse, edge is a square bigger than coordinating loop diameter, effect be one can frame on reagent strip support, two is to provide more area for the upper shed of foil sealing drum shape warehouse, and it is along a vee below edge on storehouse that hand tears breach, upwards lift for craft and aluminium foil is torn, then can carry out adding sample operation.
Wherein, as shown in Fig. 5 or 6, described agent bin and detection storehouse include the four prism type warehouse 22 of a bottom adduction, integrally being shaped with square openings edge 20 outside the upper shed of four prism type warehouse, two opposition side surface upper part at four prism type warehouse are integrally shaped with the square card button 21 of two outwardly convexs; It it is a cubic cone bottom four prism type warehouse, raffinate can not be left during for drawing liquid, edge of opening is a square bigger than warehouse opening diameter, effect is, one can frame on reagent strip support, two is to provide more area for foil sealing, card button is for being fixed with reagent strip support, as shown in Figure 3, the top of card button can be detained on the lower arris 15 of hole, reagent position or detecting position bore edges on a mounting board, for fixing.
In specific embodiment of the invention, as shown in Figure 7, then bottom the warehouse in described detection storehouse, connect bucket 23 at the bottom of a rectangular parallelepiped, among structure be used for light-intensity method detection.
Wherein, as shown in Figure 8, described consumptive material storehouse comprises the identical cylindrical warehouse 27 of two structures, two cylindrical warehouses are arranged in parallel to be connected by a union lever 26, integrally it is shaped with the rectangle fillet connecting two warehouses at the upper shed edge of two cylindrical warehouses along 24, it is shaped with hand at the edge on fillet edge and tears breach 25;
Warehouse: 2 cylindrical containers, each container can hold the suction nozzle of a 200ul, and 2 warehouse tops link together, as the parts of a combination.
Fillet edge: be than 2 combinations after the bigger rectangle of warehouse diameter, effect is one can frame two be to provide more area for foil sealing on reagent strip support.
Hand tears breach: open below a vee for one of edge on storehouse, is torn by aluminium foil in the lump for manual upwards lifting, and then can carry out getting consumptive material operation.

Claims (5)

1. a dismountable multiplex reagent strip assembly, it is characterised in that: sample storehouse, agent bin, detection storehouse and the consumptive material storehouse comprising reagent strip support He being arranged on reagent strip support,
Wherein, reagent strip support includes reagent strip top panel further, reagent strip top panel is made up of the strip panel that two-strip structure is identical, the connection center line of two strip panels is shaped with the bar shaped segmentation perforation at multiple interval, strip panel is shaped with bending V-type push rod from left to right successively downwards, the chute board inwardly caved in both sides and both sides are wider than the mounting plate of chute board, have sample bit hole on a mounting board from left to right successively, hole, consumptive material position, multiple hole, reagent position of order arrangement and detecting position hole, right-hand member at each strip panel is integrally shaped with extension and width to the right and is narrower than the strongback of strip-shaped surface plate, the location bolt that the first system of right-hand end at strongback has width identical with strip panel, strip framework integrally it is shaped with in the lower section of the mounting plate part of each strip panel, the internal space of strip framework separates into multiple separate space by some next doors, each separate space is corresponding with each position of opening on mounting plate,
Meanwhile, being integrally shaped with slideway edge in the both sides, lower section of strip panel middle slideway Board position, the outside on two slideway edges is identical with the mounting plate part width of strip panel, and slideway aligns along bottom with the bottom of strip framework;
Meanwhile, the spacing edge of del integrally it is shaped with in the lower section of reagent strip top panel both sides.
Wherein, described sample storehouse, agent bin, detection storehouse and consumptive material storehouse include the edge, storehouse at bottom bucket shape warehouse and warehouse upper opening edge, bucket shape warehouse is inserted in the separate space separated in strip framework, and storehouse is along in the mounting plate perforate that to be stuck in strip framework each separate space corresponding.
2. dismountable multiplex reagent strip assembly according to claim 1, it is characterized in that: described sample storehouse specifically comprises bottom drum shape warehouse, integrally being shaped with edge on the storehouse on matching ring and matching ring top outside the upper shed of drum shape warehouse, on storehouse, the edge on edge is shaped with hand and tears breach.
3. dismountable multiplex reagent strip assembly according to claim 1, it is characterized in that: described agent bin and detection storehouse include the four prism type warehouse of a bottom adduction, integrally being shaped with square openings edge outside the upper shed of four prism type warehouse, two opposition side surface upper part at four prism type warehouse are integrally shaped with the square card button of two outwardly convexs.
4. dismountable multiplex reagent strip assembly according to claim 3, it is characterised in that: bottom the warehouse in described detection storehouse, connect bucket at the bottom of a rectangular parallelepiped.
5. dismountable multiplex reagent strip assembly according to claim 1, it is characterized in that: described consumptive material storehouse comprises the identical cylindrical warehouse of two structures, two cylindrical warehouses are arranged in parallel by a union lever connection, integrally it is shaped with the rectangle fillet edge connecting two warehouses at the upper shed edge of two cylindrical warehouses, it is shaped with hand at the edge on fillet edge and tears breach.
CN201610149393.1A 2016-03-16 2016-03-16 A kind of removably multi-purpose reagent bar assembly Active CN105675896B (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106281977A (en) * 2016-11-22 2017-01-04 安图实验仪器(郑州)有限公司 Be suitable to the double nucleic acid extraction box of diagnostic nucleic acid system
CN106367309A (en) * 2016-11-22 2017-02-01 安图实验仪器(郑州)有限公司 Single-row nucleic acid extraction box applicable to nucleic acid diagnostic systems
CN107966396A (en) * 2017-11-24 2018-04-27 中山市创艺生化工程有限公司 A kind of reagent bottle holder for cellanalyzer
CN109230449A (en) * 2018-08-22 2019-01-18 威海威高生物科技有限公司 Turn to sample rack
CN111948390A (en) * 2020-08-31 2020-11-17 浙江盛域医疗技术有限公司 Time-resolved fluoroimmunoassay kit for detecting t-PAI-C and application thereof

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US20030180191A1 (en) * 2000-09-18 2003-09-25 Hideyuki Suzuki Micro well array and method of sealing liquid using the micro well array
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CN103163290A (en) * 2011-12-09 2013-06-19 益思美诠生物科技(上海)有限公司 Reagent strip carrier device used for rapid immunoassay analyzer and use method thereof
CN105116143A (en) * 2015-08-12 2015-12-02 杭州创新生物检控技术有限公司 Multi-term respiratory tract pathogene detection kit and detection method thereof
CN205506847U (en) * 2016-03-16 2016-08-24 天津市一瑞生物工程有限公司 Multi -purpose reagent strips subassembly of detachable

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Publication number Priority date Publication date Assignee Title
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US20030180191A1 (en) * 2000-09-18 2003-09-25 Hideyuki Suzuki Micro well array and method of sealing liquid using the micro well array
CN202093021U (en) * 2011-04-27 2011-12-28 李志华 Five-item immunegold filtration assay rapid detecting card of Toxopasma, RubellaVirus, Cytomegalo Virus, and Herpes. Virus (TORCH)
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106281977A (en) * 2016-11-22 2017-01-04 安图实验仪器(郑州)有限公司 Be suitable to the double nucleic acid extraction box of diagnostic nucleic acid system
CN106367309A (en) * 2016-11-22 2017-02-01 安图实验仪器(郑州)有限公司 Single-row nucleic acid extraction box applicable to nucleic acid diagnostic systems
CN106367309B (en) * 2016-11-22 2019-01-04 安图实验仪器(郑州)有限公司 Single nucleic acid extraction box suitable for diagnostic nucleic acid system
CN106281977B (en) * 2016-11-22 2019-01-04 安图实验仪器(郑州)有限公司 Double nucleic acid extraction box suitable for diagnostic nucleic acid system
CN107966396A (en) * 2017-11-24 2018-04-27 中山市创艺生化工程有限公司 A kind of reagent bottle holder for cellanalyzer
CN109230449A (en) * 2018-08-22 2019-01-18 威海威高生物科技有限公司 Turn to sample rack
CN109230449B (en) * 2018-08-22 2024-03-12 威海威高生物科技有限公司 Steering sample rack
CN111948390A (en) * 2020-08-31 2020-11-17 浙江盛域医疗技术有限公司 Time-resolved fluoroimmunoassay kit for detecting t-PAI-C and application thereof

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Address after: 300457 the third floor of C8 building, C8 building, No. 80 Tian Da Science Park, Fourth Avenue, Binhai New Area

Patentee after: Tianjin one Rui biological Polytron Technologies Inc

Address before: 300457 the third floor of C8 building, C8 building, No. 80 Tian Da Science Park, Fourth Avenue, Binhai New Area

Patentee before: Tianjin Yirui Biological Engineering Co., Ltd.