CN106726008A - A kind of valve and preparation method thereof - Google Patents
A kind of valve and preparation method thereof Download PDFInfo
- Publication number
- CN106726008A CN106726008A CN201710005019.9A CN201710005019A CN106726008A CN 106726008 A CN106726008 A CN 106726008A CN 201710005019 A CN201710005019 A CN 201710005019A CN 106726008 A CN106726008 A CN 106726008A
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- China
- Prior art keywords
- valve
- polyurethane
- supporting part
- prefabricated
- finished product
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/20—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Prostheses (AREA)
Abstract
The invention provides a kind of valve and preparation method thereof, including, support and leaflet；The valve that the support is arranged in the flexible leaflet as prepared by this method is molded by Best-Effort request coating method dip coating, so that leaflet is integrally formed with support, with service life higher, support is not good with blood directly contact antithrombotic effect in itself, valve can obtain aperture area in manufacturing process, ensure sufficient aperture area and reduce the disqualification rate of finished product, have production technology simple relative to prior art step simultaneously, controllability is stronger, beneficial to the batch production of valve.
Description
Technical field
The present invention relates to cardiac valves field, more particularly to a kind of valve and preparation method thereof.
Background technology
The artificial valve of current Clinical practice has two major classes, and one is mechanical prosthetic valve, is mainly made by pyrolytic carbon.With St-
Jude Medical and Carbomedics mechanical prosthetic valve are representative.Long service life is characterized in, but its leaflet is rigid leaflet sheet
Structure, leaflet folding sound is larger, because of blood compatibility reason, it is necessary to lifelong Anticoagulation of Warfarin, its thrombosis and bleeding
Risk has a strong impact on therapeutic effect and patients ' life quality.Two is biovalve, with valve made of cattle pericardium and porcine aortic valve as representative.
It is good with haemodynamics, it is not required to the advantage of long-term anti-freezing, but its calcification in vivo, decay, make its service life shorter, it is many
Number is adapted only to gerontal patient.
The content of the invention
For the drawbacks described above and problem of prior art, the purpose of the embodiment of the present invention be to provide a kind of long service life and
The good valve of antithrombotic effect.
In order to achieve the above object, the present invention provides following technical scheme：A kind of valve preparation method, including, following step
Suddenly：
S1：Cylindrical die is soaked in polyurethane solutions, using Best-Effort request coating method on cylindrical die surface
Prepare polyurethane inner membrance；
S2：Valve bracket is taken, the outer surface that valve bracket is set in polyurethane inner membrance is obtained into prefabricated valve semi-finished product, will
Prefabricated valve semi-finished product are soaked in polyurethane solutions, are coated in prefabricated valve surface of semi-finished using Best-Effort request coating method poly-
Urethane adventitia；The demoulding, obtains prefabricated valve；
S3：Moulding is arranged to prefabricated valve, valve finished product is obtained.
Wherein, the step S3 includes：
S301：Prefabricated valve includes supporting part and polyurethane film portion, by the unnecessary polyurethane film at the outlet end of supporting part
Excision, the polyurethane film at supporting part liquid inlet is inwardly overturn, and is stretched out from the outlet end of supporting part, and extending area forms annular
Open leaflet；
S302：The circumference trisection point of ring-shape open leaflet end is pasted by 5%THF solution and is fixed on supporting part
Outlet end, makes it be consistent with human heart valve closure state shape, obtains valve semi-finished product；
S303：Valve semi-finished product are placed in 80-90 DEG C of drying box, 8-12 hours is incubated, valve finished product is obtained.
Wherein, the step S2 includes：
After step coats polyurethane adventitia using Best-Effort request coating method in prefabricated valve surface of semi-finished, also including such as
Lower step：
S201：Reinforcement is taken, reinforcement is pasted on supporting part by binding agent, use Best-Effort request coating method supporting part
Surface forms reinforcement polyurethane adventitia.
Wherein, the polyurethane solutions mass concentration is 5-30%.
Wherein, the preparation method of the polyurethane solutions is：By in PU grain dissolutions to THF solution, stir, and it is quiet
Put 1-2h..
Wherein, the material of the support elects stainless steel as.
A kind of valve, including by the moulding poly- ammonia including annular frame supporting part and leaflet portion for obtaining of tubular polyurethane film
Ester valve, also including ring support, the ring support is embedded in the annular frame supporting part of the polyurethane valve.
Wherein, the tubular polyurethane film is coated on the ring support surface, from the liquid inlet of the ring support to
Outer extension；The extension of tubular polyurethane film is to upset, extreme circumferential trisection point and the annular inside the ring support
The outlet end of support is fixedly connected.
Wherein, the ring support surface sets reinforcement.
Wherein, the ring support surface is smooth mirror surface.
Valve as prepared by this method is by soaking lifting shaping so that leaflet is integrally formed with support, with higher
Service life, support is good with contacting blood antithrombotic effect, and valve can obtain aperture area in manufacturing process, it is ensured that
Sufficient aperture area simultaneously reduces the disqualification rate of finished product, while have production technology simple relative to prior art step, can
Control property is stronger, beneficial to the batch production of valve.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, without having to pay creative labor, may be used also
Other accompanying drawings are obtained with according to these accompanying drawings.
Fig. 1 is stereogram of the invention；
Fig. 2 is top view of the invention.
Specific embodiment
Below in conjunction with embodiments of the invention, technical scheme is clearly and completely described, it is clear that
Described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the implementation in the present invention
Example, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made is belonged to
The scope of protection of the invention.
Used as embodiment, a kind of valve preparation method takes cylindrical die, and the diameter of cylindrical die is less than valve bracket
Diameter, diameter elects 10-30mm, scope needed for covering is clinical as.The material of cylindrical die is preferably stainless steel, and surface is polished to
Minute surface, seamless and corner angle.Using Best-Effort request coating method, cylindrical die is soaked in polyurethane solutions, soaks 10 points
Clock, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, so as to prepare polyurethane inner membrance on cylindrical die surface.Wherein,
The mass concentration of polyurethane solutions is 5-30%, preferably 15%.Preparation method be by PU grain dissolutions in THF solution,
Stir, and stand 1-2h.Preferably, by PU grain dissolutions to THF solution, stir, stand 1.5 hours.Take valve
Membrane support, valve bracket is ring support, and the two ends of valve bracket are respectively liquid inlet and the outflow of blood supply liquid of the inflow of blood supply liquid
Outlet end, valve bracket is set in film outer surface in polyurethane, the polyurethane inner membrance outside the liquid inlet of valve bracket
Length is longer than the length of valve bracket.Prefabricated valve semi-finished product are obtained after the completion of suit.Using Best-Effort request coating method, will be prefabricated
Valve semi-finished product are soaked in polyurethane solutions, are soaked 5 minutes, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, so that
Polyurethane adventitia is coated in prefabricated valve surface of semi-finished.In be coated on for valve bracket by polyurethane adventitia and polyurethane inner membrance,
Valve bracket is set not expose, it is to avoid with blood directly contact, to lift antithrombotic property, increase the service life.Polyurethane film and
Under valve bracket gets on from cylindrical die, the demoulding obtains prefabricated valve.Moulding is arranged to prefabricated valve, human heart valve is formed
Film shape.So as to obtain valve finished product.
Arrange moulding concretely comprising the following steps:
Valve bracket position is supporting part in prefabricated valve, and remaining position is polyurethane film portion, by entering for supporting part
Polyurethane film excision at liquid end, will avoid valve bracket is exposed during excision.By the polyurethane at supporting part liquid inlet
Film is turned inside out to supporting part, and is stretched out from the outlet end of supporting part, and extending area is pruned, and makes extending area higher than branch
The outlet end 10-30mm of support part.Extending area forms ring-type and opens leaflet, and a diameter of valve in theory that ring-type opens leaflet is opened
Maximum gauge is put, the openings of sizes of valve can be measured in the process, filter out substandard product, reduce finished product not
Qualification rate, and cause that the big I of valve orifice is accurately measured.The end of ring-shape open leaflet, circumference trisection point are passed through
5%THF solution pastes the outlet end for being fixed on supporting part, it is consistent with human heart valve closure state shape, obtains valve
Semi-finished product.Valve semi-finished product are placed in 80-90 DEG C of drying box, preferably 80 DEG C, be incubated 8-12 hour, acquisition valve into
Product.
In one embodiment, prefabricated valve can also be reinforced by reinforcement, improves the service life of valve.Reinforcing side
Formula is to take reinforcement, and reinforcement is pasted on into supporting part by binding agent, and the selection of binding agent is existing binding agent, preferably,
THF solution.The prefabricated valve that will reinforce reinforcement using Best-Effort request coating method is soaked in polyurethane solutions, in supporting part
Surface forms reinforcement polyurethane adventitia.
Leaflet thickness is determined by soak time, number of times, can be 0.02mm to 2mm, depending on different parts valve to leaflet
Across valve pressure, pliability, the requirement of intensity.Valve sinus portion refers to the part between annular leaflet and support, made by the present invention
Leaflet pliability is high, open abundant, and blood can fully be squeezed out sinus portion when open, and blood is difficult to stop gathering in sinus portion, is difficult shape
Into thrombus.
Preferably, the outlet end of ring support is crown-shaped.
According to Fig. 1-2, a kind of valve as made by the above method, including is obtained by tubular polyurethane film is moulding
Polyurethane valve including annular frame supporting part and leaflet portion, also including ring support 2, the ring support 2 is embedded in institute
State in the annular frame supporting part of polyurethane valve 1.Wherein, the tubular polyurethane film is coated on the ring support surface,
Stretch out from the liquid inlet of the ring support；The extension of tubular polyurethane film overturns to inside the ring support, end
Circumference trisection point 3 is held to be fixedly connected with the outlet end of the ring support.Wherein, the ring support surface sets and strengthens
Muscle.Wherein, the ring support surface is smooth mirror surface.
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, and it is any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all contain
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (10)
1. a kind of valve preparation method, it is characterised in that including following steps：
S1：Cylindrical die is soaked in polyurethane solutions, is prepared on cylindrical die surface using Best-Effort request coating method
Polyurethane inner membrance；
S2：Valve bracket is taken, the outer surface that valve bracket is set in polyurethane inner membrance is obtained into prefabricated valve semi-finished product, will be prefabricated
Valve semi-finished product are soaked in polyurethane solutions, and polyurethane is coated in prefabricated valve surface of semi-finished using Best-Effort request coating method
Adventitia；The demoulding, obtains prefabricated valve；
S3：Moulding is arranged to prefabricated valve, valve finished product is obtained.
2. a kind of valve preparation method according to claim 1, it is characterised in that the step S3 includes：
S301：Prefabricated valve includes supporting part and polyurethane film portion, by the unnecessary polyurethane film excision at the outlet end of supporting part,
Polyurethane film at supporting part liquid inlet is inwardly overturn, is stretched out from the outlet end of supporting part, extending area forms ring-shape open
Leaflet；
S302：The circumference trisection point of ring-shape open leaflet end is pasted by 5%THF solution be fixed on supporting part go out liquid
End, makes it be consistent with human heart valve closure state shape, obtains valve semi-finished product；
S303：Valve semi-finished product are placed in 80-90 DEG C of drying box, 8-12 hours is incubated, valve finished product is obtained.
3. a kind of valve preparation method according to claim 1, it is characterised in that the step S2 includes：
After step coats polyurethane adventitia using Best-Effort request coating method in prefabricated valve surface of semi-finished, also including following step
Suddenly：
S201：Reinforcement is taken, reinforcement is pasted on supporting part by binding agent, using Best-Effort request coating method in supporting part table
Face forms reinforcement polyurethane adventitia.
4. a kind of valve preparation method according to claim 1, it is characterised in that the polyurethane solutions mass concentration is
5-30%.
5. a kind of valve preparation method according to claim 4, it is characterised in that the preparation method of the polyurethane solutions
For：By in PU grain dissolutions to THF solution, stir, and stand 1-2h.
6. a kind of valve preparation method according to claim 1, it is characterised in that the material of the support is stainless steel.
7. a kind of valve, including by the moulding polyurethane including annular frame supporting part and leaflet portion for obtaining of tubular polyurethane film
Valve, it is characterised in that also including ring support, the ring support is embedded the annular frame support in the polyurethane valve
In portion.
8. a kind of valve according to claim 7, it is characterised in that the tubular polyurethane film is coated on the annular branch
Frame surface, stretches out from the liquid inlet of the ring support；The extension of tubular polyurethane film to the ring support inside
Upset, extreme circumferential trisection point is fixedly connected with the outlet end of the ring support.
9. a kind of valve according to claim 8, it is characterised in that the ring support surface sets reinforcement.
10. a kind of valve according to claim 8, it is characterised in that the ring support surface is smooth mirror surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710005019.9A CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710005019.9A CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106726008A true CN106726008A (en) | 2017-05-31 |
| CN106726008B CN106726008B (en) | 2019-01-22 |
Family
ID=58951018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710005019.9A Active CN106726008B (en) | 2017-01-04 | 2017-01-04 | A kind of valve and preparation method thereof |
Country Status (1)
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| CN (1) | CN106726008B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107320218A (en) * | 2017-06-23 | 2017-11-07 | 董念国 | Pulmonary artery intervenes valve support and pulmonary artery intervenes the preparation method of valve |
| CN113599023A (en) * | 2021-07-16 | 2021-11-05 | 复旦大学附属中山医院 | Intervention type artificial heart valve |
| WO2024041251A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Valve material, method for preparing same and use thereof |
| WO2024041250A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Polymer valve material, preparation method for integrally molding same, and use thereof |
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| US4575442A (en) * | 1982-12-27 | 1986-03-11 | Ewald Hennig | Making heart valves |
| CN1223560A (en) * | 1996-06-24 | 1999-07-21 | 阿迪亚姆医药技术有限及两合公司 | Cardiac valve prosthesis |
| CN1244107A (en) * | 1997-01-24 | 2000-02-09 | 奥特克欧洲有限公司 | Heart valve prosthesis |
| WO2001041679A1 (en) * | 1999-12-08 | 2001-06-14 | Aortech Europe Limited | Hearth valve prosthesis and method of manufacture |
| US20020082689A1 (en) * | 2000-12-21 | 2002-06-27 | Chinn Joseph Andrew | Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends |
| US20030125804A1 (en) * | 2001-12-28 | 2003-07-03 | Kruse Steven D. | Fatigue test for prosthetic stent |
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| US6953332B1 (en) * | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| WO2006000763A2 (en) * | 2004-06-23 | 2006-01-05 | The University Court Of The University Of Glasgow | Biocompatible layered structures and methods for their manufacture |
| US20060241744A1 (en) * | 2003-03-20 | 2006-10-26 | Aortech International Plc | Valve |
| US20110257739A1 (en) * | 2010-04-16 | 2011-10-20 | Abiomed, Inc. | Percutaneous valve deployment |
| CN103384505A (en) * | 2011-02-18 | 2013-11-06 | D·J·威特利 | Heart valve |
| CN104799975A (en) * | 2015-04-20 | 2015-07-29 | 杭州嘉和众邦生物科技有限公司 | Artificial bioprosthetic heart valve and production method thereof |
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2017
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Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575442A (en) * | 1982-12-27 | 1986-03-11 | Ewald Hennig | Making heart valves |
| CN1223560A (en) * | 1996-06-24 | 1999-07-21 | 阿迪亚姆医药技术有限及两合公司 | Cardiac valve prosthesis |
| CN1244107A (en) * | 1997-01-24 | 2000-02-09 | 奥特克欧洲有限公司 | Heart valve prosthesis |
| WO2001041679A1 (en) * | 1999-12-08 | 2001-06-14 | Aortech Europe Limited | Hearth valve prosthesis and method of manufacture |
| CN1449267A (en) * | 2000-10-09 | 2003-10-15 | 阿迪亚姆生命科学股份公司 | Cardiac valve prosthesis, especially mitral cardiac valve and method for producing the same |
| US6953332B1 (en) * | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| US20020082689A1 (en) * | 2000-12-21 | 2002-06-27 | Chinn Joseph Andrew | Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends |
| US20030125804A1 (en) * | 2001-12-28 | 2003-07-03 | Kruse Steven D. | Fatigue test for prosthetic stent |
| US20060241744A1 (en) * | 2003-03-20 | 2006-10-26 | Aortech International Plc | Valve |
| WO2006000763A2 (en) * | 2004-06-23 | 2006-01-05 | The University Court Of The University Of Glasgow | Biocompatible layered structures and methods for their manufacture |
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| CN107320218A (en) * | 2017-06-23 | 2017-11-07 | 董念国 | Pulmonary artery intervenes valve support and pulmonary artery intervenes the preparation method of valve |
| CN107320218B (en) * | 2017-06-23 | 2019-08-16 | 武汉唯柯医疗科技有限公司 | Pulmonary artery intervenes the preparation method of valve bracket and pulmonary artery intervention valve |
| CN113599023A (en) * | 2021-07-16 | 2021-11-05 | 复旦大学附属中山医院 | Intervention type artificial heart valve |
| WO2024041251A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Valve material, method for preparing same and use thereof |
| WO2024041250A1 (en) * | 2022-08-22 | 2024-02-29 | 杭州启明医疗器械股份有限公司 | Polymer valve material, preparation method for integrally molding same, and use thereof |
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