CN108175544A - 3D printing self-locking anatomical form artificial vertebral body and manufacture craft - Google Patents
3D printing self-locking anatomical form artificial vertebral body and manufacture craft Download PDFInfo
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- CN108175544A CN108175544A CN201810071948.4A CN201810071948A CN108175544A CN 108175544 A CN108175544 A CN 108175544A CN 201810071948 A CN201810071948 A CN 201810071948A CN 108175544 A CN108175544 A CN 108175544A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2/4425—Intervertebral or spinal discs, e.g. resilient made of articulated components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of 3D printing self-locking anatomical form artificial vertebral body, including upper centrum and hypocentrum；The upper centrum and hypocentrum are connected by protrusion and groove；The surface of the upper centrum and hypocentrum is provided with cellular trabecular bone structure.The contact surface of upper centrum and hypocentrum is provided with the physiologic radian for meeting backbone with centrum contact position.Trabecular bone structure is irregular space network.Artificial vertebral body provided by the invention is that the product mix of the two pieces 3D printing of split is applied in combination more convenient to the phenomenon that being used together, be not in slippage.Length can be processed according to the lesion height of patient, centrum contact position, and can control angular dimension between centrum and centrum, reduce the incidence of sedimentation, enhance stability, restore lordosis.By cellular microcellular structure, promote bone fusion, best backbone physiology mechanism stable and bearing capacity are provided, finally realize bone fusion.
Description
Technical field
The present invention relates to artificial vertebral body technical field of structures, particularly a kind of 3D printing self-locking anatomical form artificial vertebral body.
Background technology
In the resection operation of original spinal vertebral, it is metal or other materials that doctor machines its raw material by implantation
The artificial vertebral body of material replaces human spine, restores the reconstruction of backbone, to obtain the recovery of patient spine function.Vertebra artificial vertebral body
It is mainly used for the lesion of tuberculosis of spine, vertebral tumor.Backbone artificial vertebral body is shown in that Fig. 1, Fig. 1 are backbone artificial vertebral body schematic diagram；Packet
Include centrum and hypocentrum；Common product is machined by forging titanium alloy material, existing artificial vertebral body and titanium cage product
Mostly forged titanium alloy machines, and assembles and uses through scattered part, and the operative approach mode of these products is anterior approach, can be caused
Patient organ's institutional framework changes, it is impossible to the postoperative better recovery of patient be made to cause very big puzzlement；Though after being implanted into human body
So stability is restored, but bone and bone cannot merge completely, perform poor on strength and stiffness, easily slipping causes treatment to be lost
It loses, compensatory movement, which occurs, in adjacent segment to be increased, and leads to the stress concentration at the position, and intervertebral disc degeneration accelerates, articuli intervertebrales are answered
Power increases, and in turn results in the spinal canal stenosis of Fusion levels or adjacent segment, secondary spondylolisthesis and pseudarthrosis are formed, especially existed
Multi-segmental spinal fusion becomes apparent from fixing.
Existing product is all that doctor, producer are divided into product according to surgical experience product type suitable for most of patient
Number, such as find that product is not consistent with the lesion of patient in use, doctor can break patient spine according to the model of prosthese
It is bad, can be patient spine function reduction in this way.
Invention content
The purpose of the present invention is to propose to a kind of 3D printing self-locking anatomical form artificial vertebral bodies；This artificial vertebral body is beaten by 3D
Artificial vertebral body structure is printed to replace original backbone artificial vertebral body structure.
The purpose of the present invention is achieved through the following technical solutions：
3D printing self-locking anatomical form artificial vertebral body provided by the invention, including upper centrum and hypocentrum；The upper centrum
It is connected with hypocentrum by protrusion and groove；The surface of the upper centrum and hypocentrum is provided with cellular bone trabecula knot
Structure.
Further, the contact surface of the upper centrum and hypocentrum is provided with the physiologic curve for meeting backbone with centrum contact position
Degree.
Further, the trabecular bone structure is irregular space network.
Further, the upper centrum and hypocentrum are by the way that titanium alloy powder is passed through laser high temperature with 3D printing technique
It is sintered a kind of separate assembling artificial vertebral body of the cellular bone trabecula pattern formed.
Further, there are one through-holes for the upper centrum and the setting of hypocentrum centre.
Further, using fire hydrant barb locking structure, the fire hydrant barb lock between the upper centrum and hypocentrum
Fast knot structure includes upper end cap and lower endcaps；
The end face of the upper end cap is provided with the cylinder of protrusion, and the end faces of the lower endcaps is provided with matched recessed with cylinder
Slot, the cylinder of the upper surface are used to be inserted into the groove of lower endcaps and rotate fixation.
The present invention also provides a kind of 3D printing self-locking anatomical form artificial vertebral body manufacture crafts, specifically include following step
Suddenly：
1) three-dimensional imaging is carried out by the CT data of patient, patient's lesion centrum and neighbouring section anatomical structure is connected
Continuous tomoscan obtains the medical digital normal data of medical radioactive diagnosis and treatment diagnostic device Docom；
2) CT scan layer data with the form of Docom is exported, inputs the software of Mimics10.01, through framing,
Threshold segmentation, dynamic partition are handled per tomographic image by selective editing and loophole, removal redundant data, smoothing processing, finally
The threedimensional model established comprising sick vertebra adjacent to anatomical structure is calculated through 3D, is as a result exported with STL forms；
3) height of lesion centrum, Zhou Jing, the thickness of front and rear edge cortex of bone, internal gap structure, neighbouring is calculated
Pedicle widths, height, pedicle of vertebral arch axis and the vertebral sagittal of centrum, the angle of cross section；
4) threedimensional model established according to CT computer aided techniques；
5) it cleans：The incidence angles degree of water jet need to be provided to different product, is converted by the rotation of workpiece and nozzle
Angle is to realize the comprehensive cleaning to workpiece.
Further, 4) threedimensional model established according to CT computer aided techniques in the step, is as follows：
Selective laser fusion technology is up to fusing point 1688 ± 4 ° of the moulding artificial vertebral body into porous " cellular " of titanium,
In, the elasticity modulus of titanium alloy centrum is 3.25 ± 1.08GPa, porous " cellular " artificial vertebral body, pore size control
At 100 μm.
Further, the cleaning is further included is cleaned using ultrasonic oscillation.
By adopting the above-described technical solution, the present invention has the advantage that：
Artificial vertebral body provided by the invention is the principle root to being used together by the product mix of the two pieces 3D printing of split
According to the structure that the rotation of fire hydrant is locked, the scope of application is the illnesss such as tumor of spine, tuberculosis of spine；It is readily modified as with this product
The mode of operative approach is Via Posterior Spinal Approach, and two kinds of product groups are combined together the phenomenon that being not in postoperative slippage, lock
Dead effect is more secured.Centrum length can be processed according to the lesion height of patient, centrum contact position, and can control centrum
The angular dimension between centrum reduces the incidence of sedimentation, enhances stability, restores lordosis.Pass through cellular micropore
Structure promotes bone fusion, provides best backbone physiology mechanism stable and bearing capacity, finally realize bone fusion.
Other advantages, target and the feature of the present invention will be illustrated in the following description to a certain extent, and
And to a certain extent, based on will be apparent to those skilled in the art to investigating hereafter, Huo Zheke
To be instructed from the practice of the present invention.The target and other advantages of the present invention can by following specification realizing and
It obtains.
Description of the drawings
The description of the drawings of the present invention is as follows.
Fig. 1 is backbone artificial vertebral body schematic diagram.
Fig. 2 is the artificial vertebral body of 3D printing entirety.
Fig. 3 is 3D printing self-locking anatomical form artificial vertebral body exploded view.
Fig. 4 is 3D printing self-locking anatomical form artificial vertebral body exploded sectional view.
Fig. 5 is the artificial vertebral body upper end schematic diagram of 3D printing.
Fig. 6 is artificial vertebral body vertical view.
Fig. 7 is two protrusions and two grooves that machining is formed.
Fig. 8 netted is honeycomb structure, other are entity structure.
Fig. 9 is shaft side figure.
Figure 10 a represent rule and have the porous overall structure of good visual connectivity in a plurality of directions.
Figure 10 b represent rule and have the porous penetrating effect of forward direction of good visual connectivity in a plurality of directions.
Figure 10 c represent rule and have the porous oblique penetrating effect of good visual connectivity in a plurality of directions.
Figure 11 a represent the poor porous overall structure of irregular and visual permeability.
Figure 11 b represent the poor porous penetrating effect of forward direction of irregular and visual permeability.
Figure 11 c represent the poor porous oblique penetrating effect of irregular and visual permeability.
In figure, 1 is upper centrum, and 2 be hypocentrum, and 3 be centrum main body, and 4 be screw, and 5 be cellular, and 6 be entity.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples.
Embodiment 1
As shown in Fig. 2, Fig. 2 is the artificial vertebral body of 3D printing entirety；Artificial vertebral body provided in this embodiment is by split
To being used together, the scope of application is the illnesss such as tumor of spine, tuberculosis of spine for the product mix of two pieces 3D printing；With this product
The mode of operative approach is readily modified as Via Posterior Spinal Approach, and two kinds of product groups are combined together the phenomenon that being not in slippage, group
It closes using more convenient.
Artificial vertebral body provided in this embodiment is to carry out three-dimensional imaging by the CT data of patient, by CAD
Meet human spine model, and processing is customized to spinal vertebral with 3D printer；Length can be according to the lesion height of patient
Degree, centrum contact position are processed, and can control angular dimension between centrum and centrum, reduce the incidence of sedimentation, increase
Stiff stability restores lordosis.
The material of the artificial vertebral body of 3D printing is this by meeting the Ti6Al4V titanium alloy powders of ASTM F1580-12 standards
The existing good biocompatibility of material, can be chronically implanted human body, and have preferable fatigue resistance, postoperative to nor affect on MR inspections
It looks into；Material powder can be made into cellular microcellular structure through laser high temperature sintering, quenching, formation honeycomb shape, this centrum,
Bone trabecula in similar human body bone, has this bone trabecula, the osteocyte of adjacent normal vertebra can be grown into wherein, side bee
Socket bore shape grows into convenient for peripheral vessels, promotes bone fusion, provides best backbone physiology mechanism stable and bearing capacity, final real
Existing bone fusion.
The centrum main body of 3D printing, surface are cellular trabecular bone structure；Bone trabecula is cortex of bone in cancellous bone
Extension, i.e. bone trabecula are connected with cortex of bone, in irregular space network in ossis, such as luffa sample or sea
Continuous shape plays hematopoiesis support tissue, has this structure that bone tissue is made constantly to grow and reconstruct, to adapt to place position work(
Needs on energy；Knockdown centrum is suitable for doing posterior approach spinal nerve and not being destroyed, between upper and lower spinous process and spinous process into
Row places centrum；Centrum top and bottom can be printed according to the angle of centrum, and product is made to meet backbone with centrum contact position
Physiologic radian, the important physiological function of centrum after reconstruction restore backbone physiology height, stress conduction and distribution, restore ridge
Column function；
There are four the threaded holes that can twist screw in centrum main body, and the angle in hole is 35 °, and screw is tapping screw, effect
It is integrally fixed between two centrums up and down.
There are one through-holes for centrum medium design, it is therefore an objective to and broken bone is implanted into, bone and knitting can fully be made to rise into centrum, so as to
It realizes and is merged between real bone and bone；
Centrum internal structure is connected by tibet cinnamon bark, and is printed around centrum with the cylinder of six roots of sensation entity, is passed through
Repeated Compression experiment is carried out using mechanical pressure machine, the part compression stiffness numerical value of this structure is significantly larger than connectionless muscle and reality
The part of body cylinder, the pressure bigger that centrum is made to be born in human spine in this way ensure that centrum is not collapsed；
Vertebral rim position carries out physical print, and the discovery when carrying out compression experiment to part, vertebral rim does not carry out reality
There is the phenomenon that scaling-off and abrasion in the part of body printing, and the feelings of any damage do not occur using the part of physical print for edge
Condition occurs, and physical print is contacted in contact for face, uniform force, and the cellular contact of 3D printing is point contact, by
Power is uneven, causes to wear and scaling-off；
Two centrum combinations up and down provided in this embodiment are that the structural evolution locked according to fire hydrant barb is formed, this
Upper and lower two centrums do not fall out in the case that structure can make backbone stress, prevent reconstruction failure after spinal operation.The upper vertebra
It is locked between body and hypocentrum using fire hydrant barb locking structure, the fire hydrant barb including upper end cap and lower endcaps；Institute
The end face for stating upper end cap is provided with the cylinder of protrusion, the end faces of the lower endcaps be provided with the matched groove of cylinder, it is described on
The cylinder of end face is locked for being inserted into the groove of lower endcaps and rotating.
There are two the cylinder of protrusion, the end bottom of the lower endcaps is provided with matches with two cylinders for the upper end cap setting
Two groove structures closed, when two raised cylinders of upper surface are inserted into the groove of lower face and are revolved by clockwise direction
Turn, until it cannot rotate.
Embodiment 2
Artificial vertebral body provided in this embodiment passes through 3D printing；The material of artificial vertebral body is by titanium alloy powder, through laser height
Temperature sintering, quenching, form honeycomb shape, this centrum is characterized in that, can be made into cellular microcellular structure, similar
Bone trabecula in human body bone has this bone trabecula, and the osteocyte of adjacent normal vertebra can be grown into wherein, finally realize bone
Fusion.
Bone trabecula is extension of the cortex of bone in cancellous bone, i.e. bone trabecula is connected with cortex of bone, in ossis
In irregular space network, such as luffa sample or spongy, play hematopoiesis support tissue, there is this structure to make bone
Tissue constantly growth and reconstruction, to adapt to the needs of place position functionally.This metal be porous connection, be body fluid porous
Transhipment inside implantation material provides possibility, this process can activate the rising into so as to cause highly porous metal of bone tissue
On the one hand the development of implantation material, porous design improve the compatibility of implantation material and bone tissue, on the other hand promote vitronectin and
Fibronectin is in alloy surface and internal deposition, and BMP-2 and fibronectin can improve the adherency of the cell of titanium alloy surface,
So as to increase the growth of the adherency of osteocyte, proliferation, differentiation, while bone tissue in gap can strengthen being implanted into material and bone it
Between mechanical stability.
Titanium alloy powder is formed into a kind of cellular bone trabecula form by laser high temperature sintering with 3D printing technique
Separate assembling artificial vertebral body, the form of this combination passes through from the design of fire hydrant composite structure by upper and lower two centrums
It after two protrusions coordinate with groove, is rotated by epicentral aperture, makes two centrums combinations, this honeycomb fluking type pattern
Vertebral body structure can be substituted because of the patient of spinal lesion excision centrum, make patient spine vertebral bone and bone be attached and rise into,
Promote bone fusion, so as to restore the function of backbone.New product be Bone Ingrowth type product, suitable for carry out spinal fusion when support
Backbone provides Initial stability, supports normal Bony union process, and it is Thoracolumbar disk to be applicable in position.
As shown in Fig. 5 to Fig. 8, Fig. 5 is the artificial vertebral body upper end of 3D printing, and process is laser sintered, annealing；Fig. 6 is overlooks
See 6 entity reinforcing ribs, effect is to ensure the compressive strength of centrum；Fig. 7 is that two protrusions that machining is formed and two are recessed
Slot；Fig. 8 netted is honeycomb structure, other are entity structure；Fig. 9 is shaft side figure.
The manufacture craft of the present embodiment is as follows：
It is printed first with 3D printer according to graphics pattern, the netted honeycomb for printing, other are entity；
2) with machining center be processed the entity of part；
3) position of processing is polished with polishing machine, effect is that the position frictional force for contacting surface reduces；
4) clean, be divided into it is thick wash with two steps of fine purifiation, then with supersonic wave cleaning machine part is cleaned, makes part bee
The titanium alloy powder of nest internal residual is shaken off.
The 3D printing self-locking anatomical form artificial vertebral body manufacture craft, specifically includes following steps：
1) carry out three-dimensional imaging by the CT data of patient, be exactly to patient's lesion centrum and neighbouring section anatomical structure into
The continuous tomoscan of row obtains its Docom (medical radioactive diagnosis and treatment diagnostic device) medical digital normal data, wherein scanning thickness is
1mm, voltage 120kv；
2) CT scan layer data with the form of Docom is exported, inputs the software of Mimics10.01, through framing,
Threshold segmentation (a kind of image Segmentation Technology based on region), dynamic partition are passed through per tomographic image at selective editing and loophole
Reason, removes redundant data, and smoothing processing most calculates the threedimensional model established comprising sick vertebra adjacent to anatomical structure, as a result through 3D afterwards
It is exported with STL forms；
3) height of lesion centrum, Zhou Jing, the thickness of front and rear edge cortex of bone, internal gap structure, neighbouring is calculated
Pedicle widths, height, pedicle of vertebral arch axis and the vertebral sagittal of centrum, the angle of cross section；
4) threedimensional model established according to CT computer aided techniques, with selective laser fusion technology, is up to fusing point
1688 ± 4 ° of the moulding artificial vertebral body into porous " cellular " of titanium, wherein, the elasticity modulus of titanium alloy centrum is (3.25
± 1.08) GPa, porous " cellular " artificial vertebral body, pore size are controlled at 100 μm.
5) it cleans：
1. high pressure water impact cleans
During cleaning is impacted, the incidence angles degree of water jet need to be provided for different product, passes through workpiece
Rotation and nozzle convert angle to realize the comprehensive cleaning to workpiece, so as to avoid injection pressure uneven and cleaning blind area,
Further to remove a small amount of free metal powder particle remaining in perforated grill.
2. ultrasonic oscillation cleans
Since ultrasonic transducer frequency is inversely proportional with wavelength, wavelength size is related with bubble diameter size, and bubble diameter
It is related with its bubble impact ability.Usual frequency is low, and wavelength is big, and bubble diameter is big, and internal impact ability is high.Manufacturing enterprise should be true
The ultrasonic transducer of appropriate frequency is determined, further to remove minimal amount of residual powder.
There are two types of common 3D printing porous structures, and one kind is rule and has good visual perforation in a plurality of directions
Property porous structure (as shown in Figure 10 a-c), Figure 10 a-c is rules and have good visual connectivity in a plurality of directions
Porous structure figure, 10a represent the overall structure of rule, and 10b represents the penetrating effect of forward direction of rule, and 10c represents the oblique of rule
Penetrating effect；Such as Invasive lumbar fusion device, centrum prosthese, bone defect filler have the porous structure of larger thickness；Another kind is not
Rule and the visually poor porous structure of permeability (as illustrated in figs. 11a-c), Figure 11 a-c are poor for irregular and visual permeability
Porous structure figure, 11a represents irregular overall structure, and 11b represents the irregular penetrating effect of forward direction, and 11c represents not advise
Oblique penetrating effect then；The usually smaller porous layer of thickness or without thoroughly penetrating product porous surface, such as acetabular bone
Cup outside synosteosis interface (its substrate is solid metal), such structural thickness are usually no more than visual penetrating depth.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to compared with
The present invention is described in detail in good embodiment, it will be understood by those of ordinary skill in the art that, it can be to the skill of the present invention
Art scheme is modified or replaced equivalently, and without departing from the objective and range of the technical program, should all be covered in the present invention
Protection domain in.
Claims (9)
1.3D prints self-locking anatomical form artificial vertebral body, it is characterised in that：Including upper centrum and hypocentrum；The upper centrum is under
Centrum is connected by protrusion and groove；The surface of the upper centrum and hypocentrum is provided with cellular trabecular bone structure.
2. 3D printing self-locking anatomical form artificial vertebral body as described in claim 1, it is characterised in that：The upper centrum and lower vertebra
The contact surface of body is provided with the physiologic radian for meeting backbone with centrum contact position.
3. 3D printing self-locking anatomical form artificial vertebral body as described in claim 1, it is characterised in that：The trabecular bone structure is
Irregular space network.
4. 3D printing self-locking anatomical form artificial vertebral body as described in claim 1, it is characterised in that：The upper centrum and lower vertebra
Body is a kind of cellular trabecular pattern by the way that titanium alloy powder to be passed through to the formation of laser high temperature sintering with 3D printing technique
The separate assembling artificial vertebral body of formula.
5. 3D printing self-locking anatomical form artificial vertebral body as described in claim 1, it is characterised in that：The upper centrum and lower vertebra
There are one through-holes for setting among body.
6. 3D printing self-locking anatomical form artificial vertebral body as described in claim 1, it is characterised in that：The upper centrum and lower vertebra
Upper end cap and lower endcaps are included using fire hydrant barb locking structure, the fire hydrant barb locking structure between body；
The end face of the upper end cap is provided with the cylinder of protrusion, the end faces of the lower endcaps be provided with the matched groove of cylinder,
The cylinder of the upper surface is used to be inserted into the groove of lower endcaps and rotate fixation.
7.3D prints self-locking anatomical form artificial vertebral body manufacture craft, it is characterised in that：Specifically include following steps：
1) three-dimensional imaging is carried out by the CT data of patient, is continuously broken to patient's lesion centrum and neighbouring section anatomical structure
Layer scanning obtains the medical digital normal data of medical radioactive diagnosis and treatment diagnostic device Docom；
2) CT scan layer data with the form of Docom is exported, the software of Mimics10.01 is inputted, through framing, threshold value
Segmentation, dynamic partition handle by selective editing and loophole per tomographic image, remove redundant data, smoothing processing, most afterwards through 3D
The threedimensional model established comprising sick vertebra adjacent to anatomical structure is calculated, is as a result exported with STL forms；
3) height of calculating lesion centrum, Zhou Jing, the thickness of front and rear edge cortex of bone, internal gap structure, neighbouring centrum
Pedicle widths, height, pedicle of vertebral arch axis and vertebral sagittal, cross section angle；
4) threedimensional model established according to CT computer aided techniques；
5) it cleans：The incidence angles degree of water jet need to be provided to different product, angle is converted by the rotation of workpiece and nozzle
To realize the comprehensive cleaning to workpiece.
8. 3D printing self-locking anatomical form artificial vertebral body manufacture craft as described in claim 1, it is characterised in that：4) step
The threedimensional model established according to CT computer aided techniques in rapid, is as follows：Selective laser fusion technology, to molten
The moulding artificial vertebral body into porous " cellular " of titanium that up to 1688 ± 4 ° of point, wherein, the elasticity modulus of titanium alloy centrum
For 3.25 ± 1.08GPa, porous " cellular " artificial vertebral body, pore size is controlled at 100 μm.
9. 3D printing self-locking anatomical form artificial vertebral body manufacture craft as described in claim 1, it is characterised in that：The cleaning
It further includes and is cleaned using ultrasonic oscillation.
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Application publication date: 20180619 |