CN102300600B - Microtubular - Google Patents

Abstract

A kind of microtubular, including the coil being formed at interior lining.This coil is covered by a series of oversheath sections, and the hardness that the hardness of described sections closes on sections relative to near-end reduces.Preferably, these sections have angled end, to allow each sections can be inserted into and be combined into the sections before it.Oversheath eventually terminates at the microtubular far-end of the sections with lowest hardness.

Description

Microtubular

This application claims December in 2008 that submit to, entitled " Microcatheter ", Serial No. No.61/ on the 10th The priority of the U.S. Provisional Application of 121,525, its entire content is incorporated in this.

Technical field

This patent disclosure relates generally to armarium and the method manufacturing this equipment.More particularly, it relates to microtubular with And performing to get involved the manufacture method of the microtubular used in medical operating.

Background technology

Microtubular diagnoses for the various situations to occurring at vascular remote, height bending and disease With the medical operating disposed.Typically, in first position, microtubular is incorporated in patient's vascular system, and subsequently by suffering from Forward, the far-end until microtubular arrives desired target location to the vascular of person.

Microtubular process forward generally includes and applies power near its far-end.Therefore, slightly lead when of the prior art one When pipe deeper enters in vascular system, just it is difficult to suitably promote and the far-end of mobile operation microtubular.In this respect, it is desirable to A kind of have higher promotion ability and the microtubular of trace ability.Promotion ability is generally understood as when minimizing or not considering curved During folding, power is sent to from the near-end of microtubular the ability of the far-end of microtubular.Trace ability is generally understood as guiding microtubular to lead to Cross the ability of the vascular system of bending.

Although microtubular of the prior art is typically capable of performing they preplanned missions in the patient, but the still phase Hope the conduit performance with improvement, the trace ability such as improved and promotion ability.

Summary of the invention

According to a preferred embodiment of the present invention, a kind of microtubular includes the coil being formed within lining.This coil Being covered by a series of oversheath sections or transition sections, the hardness that the hardness of described sections closes on sections relative to near-end reduces. Preferably, these sections have angled end, so that each sections can be inserted into and be combined into the sections before it. Oversheath eventually terminates at the microtubular far-end of the sections with lowest hardness.

Accompanying drawing explanation

The aspects, features and advantages of the these and other of the embodiment of the present invention are by can following from the embodiment of the present invention Explanation embodies and illustrates, with reference to accompanying drawing, wherein:

Figure 1A illustrates the side cross-sectional view of the microtubular according to the preferred embodiment of the present invention；

Figure 1B illustrates the enlarged drawing of the microtubular remote area of the Figure 1A from region 1B acquirement；

Fig. 1 C illustrates the cross-sectional view of the microtubular of Figure 1A that 1C along the line obtains；

Fig. 2 A illustrates the microtubular in Figure 1A with curved distal region；

Fig. 2 B illustrates the remote area of the microtubular obtained from region 2B, partly removes oversheath；

Fig. 3 illustrates the different instances sections of the oversheath forming microtubular according to the preferred embodiment of the present invention；

Fig. 4 illustrates the different instances sections of the oversheath forming microtubular according to the preferred embodiment of the present invention；

Fig. 5 A illustrates the side-looking of two oversheath sections of the oblique angled end with opposed or relative orientation Figure；

Fig. 5 B illustrates the side view of two oversheath sections of the oblique angled end with similar orientation；And

Fig. 5 C illustrates the side perspective view of the sheath sections with oblique angled end regions.

Detailed description of the invention

Let us now refer to the figures the specific embodiment to the present invention to be described.But, the present invention can be by many different Form implement, embodiment described here should not be construed as limited to；And be to provide these embodiments so that The disclosure becomes detailed and complete, and will express the scope of the present invention to those of ordinary skill in the art all sidedly.In the accompanying drawings Term used in the detailed description of illustrated embodiment is not intended to limit the present invention.In the accompanying drawings, identical numeral Represent identical parts.

Other restriction, all terms as used herein (including technical term and scientific terminology) is only had to have and this The implication that implication that field those of ordinary skill is generally understood is identical.Being further to be understood that, term (such as generally makes The term defined in dictionary) should be construed to that there is the implication consistent in the context of correlation technique with them, do not understand It is interpreted as Utopian or the most formal understanding, unless literary composition is particularly limited to.

Figure 1A illustrates the preferred embodiment of microtubular 100, and microtubular 100 includes the length being connected to conductor housing parts 102 The duct member 101 of shape.The near-end 108 of duct member 101 is connected to the far-end of conductor housing 102, and is also covered by strain removing part 106 Lid.In duct member 101, at least one central lumen is connected with the passage in conductor housing 102, thus forms catheter channel 104. In the embodiment of this example, guide line 112 positions through passage 104, from the far-end 110 of duct member out.

Conductor housing 102 is attached to close end 108 preferably by DYMAX adhesive of medical or similar binding agent.Strain Elimination portion 106 can be installed on conductor housing 102 by the interconnection technique rubbing, bonding or be similar to.

As best shown in Figure 1B and 1C, passage 104 is formed by the liner 114 being wound with coil 124.Coil 124 is coated with The oversheath 116 formed by multiple different sections.The hardness of each section of oversheath 116 is preferably lower than the hard of the section of its near-end Degree.In this respect, oversheath 116 is typically increase towards the flexibility of far-end 110 relative to near-end 108.

As shown in Figure 2 A, oversheath preferably includes the hydrophilic coating along one part length.Preferably, this coating distance The remote end about 100-120cm of microtubular 100.

View shown in cross-sectional view as shown in Figure 1B and Fig. 2 B, far-end 110 includes being combined in coil layer 124 and outer Two radiopaque labellings 118 and 120 between sheath 116.In the layout of an example, labelling 120 is positioned at conduit 100 Remote end or near the remote end of conduit 100, and labelling 118 is located close at labelling band 120 about 3cm.As Figure 1B is optimal Shown in, region that is that these labellings 118 and 120 are provided that projection or that rise, these regions can be used for fixing implantation equipment, such as Support.

In one example, from strain relief 106 to the far-end measuring of distal part 110, microtubular 100 is about 150cm. Central lumen 104 has the internal diameter of about 0.0165 to 0.017 inch.Distal part 110 preferably includes about 40cm length (about Region 1.9French).Nearly portion 108 preferably includes the region of about 2.4French.Oversheath 116 about 0.025 inch.

Liner 114 is preferably made up of politef, PTFE or other similar materials, and has and arrive 0.0005 Wall thickness in 0.007 inch range.Preferably, liner 114 be " contraction " or stretching to reduce wall thickness.This stretching is the most optional The molecular structure of selecting property ground directional material, thus give extra Performance Characteristics.Such as, relative to similar, there is identical thickness The material not stretched of degree, this stretching can increase bursting strength and/or increase compliance or pliability.

In this respect, the less part of microtubular 100 be used for liner 114, and the thickness of other parts can increase and Do not increase the external diameter of microtubular 100 or reduce the internal diameter of microtubular 100.In other words, stretching liner 114 allow liner 114 with There is between microtubular other parts (such as oversheath 116) different thickness ratios.

Such as, it is of about 0.0165 to 0.017 inch range and external diameter is of about the 10 of 0.025 inch and is at intracavity diameter In system microtubular, when obtaining desired results of property, the thickness ratio greater than about 70% of oversheath 116 and liner 114, more preferably Ground is about 78%.

Preferably, by applying heat and tension force to liner 114 so that liner 114 is stretched with before assembly.Such as, Can be applied to the temperature between about 250 to 600 on liner 114 apply with the speed of 0.5 to 12 inch per minutes simultaneously Tension force between 50g to 750g.In another example, liner 114 can at room temperature use similar or higher power and class As or faster speed stretch.

In a preferred embodiment, liner 114 can have uniform thickness along its length.At another preferred embodiment In, the thickness of liner 114 towards proximally increasing, thus can give extra bursting strength.

Coil layer 124 is preferably formed by the thread round conductor of external diameter about 0.001 inch.The pitch of coil 124 is excellent It is selected in the range of about 0.002 to 0.004 inch.In the embodiment of some microtubulars 100, coil 124 may also be formed as There is tighter pitch.

In an example, oversheath 116 is had the polyether block amide of various hardness by multistage, and Pebax be combined with each other And form (such as, thermal or glue bond).As illustrated in Fig. 5 C, the first sheath segment 116A includes deflection or angled End 116D.It is to say, segment end 116D not with along sections 116A ground length axis 116E vertical.Preferably, this Individual angle can be in the range of relative to axis 116E about 5-75 degree.

As shown in Figure 5A, sections 116A is angularly combined in sheath segment 116B.Angularly cut ends 116D orientation For making it be in the position of relative rotation relative to angled cut ends 116C.It is to say, end 116D and 116C Angle be arranged as formed triangle or trapezoidal.

Preferably, first sections 116A and 116B by facing toward angled cut ends by angled cut ends 116D 116C places and combines.Subsequently, heat-shrinkable tube is placed on two sections 116A and 116B.Finally, heat is applied so that thermal contraction Pipe is diametrically shrinking, and promotes sections 116A to enter sections 116B.The heat of heat-shrinkable tube and power result in sections 116A and 116B Combine.Finally, heat-shrinkable tube can remove from sheath segment.

As illustrated in Fig. 5 B, sections 116A may also be oriented as so that angled cut ends 116D and angled end 116C is in same direction and orientation.Although two sections are shown as having angled end, it is also possible to imagination Only one of which sections can include angularly or the end of deflection.Angularly combining as described in the example of Fig. 5 A and 5B can Reduce bending, by keeping providing extra axial strength while flexibility it may happen that this bending.

Preferably, oversheath 116 has 7 sections, and each sections has than near-end adjacent to the lower hardness of its sections. In this respect, oversheath 116 becomes more pliable and tougher towards far-end 110.

Seeing Fig. 3, the oversheath 116 of example is shown as having different sections.Sections 150 represents the joint at near-end 108 Section, and sections 162 represents the sections at far-end 110.In an example, sections constitutes as follows:

Sheath segment number	Material	Length (about)	Internal diameter (about)	External diameter (about)
					150	Grilamid L25	85cm	0.026 inch	0.035 inch
152	Pebax 72	5cm	0.026 inch	0.035 inch
					154	Pebax 63D1	5cm	0.026 inch	0.033 inch
156	Pebax 55D1	5cm	0.026 inch	0.032 inch
					158	Pebax 45D2	20cm	0.026 inch	0.031 inch
160	Pebax 45D1	15cm	0.026 inch	0.030 inch
					162	Pebax 35D	15cm	0.026 inch	0.029 inch

Seeing Fig. 4, the oversheath 116 of an example is shown as having different sections.Sections 164 represents at near-end 108 Sections, and sections 176 represents the sections at far-end 110.In an example, sections constitutes as follows:

Sheath segment number	Material	Length (about)	Internal diameter (about)	External diameter (about)
					164	Grilamid L25	84cm	0.026 inch	0.035 inch
166	Pebax 72	5cm	0.026 inch	0.034 inch
					168	Pebax 63D1	5cm	0.026 inch	0.033 inch
170	Pebax 55D1	35cm	0.026 inch	0.032 inch
					172	Pebax 45D2	10cm	0.026 inch	0.031 inch
174	Pebax 45D1	15cm	0.026 inch	0.030 inch
					176	Pebax 35D	1cm	0.026 inch	0.029 inch

Will be consequently realised that the suitable alternative of Pebax and Grilamid is known in the art, and can correspondingly adopt With.It is also appreciated that the wall thickness of liner 114 and oversheath 116 can change, thus it is potentiated and enhanced some characteristics, the most micro- The desired trace ability of conduit 100, promotion ability, internal diameter and/or external diameter, with the operation of implementation plan.

End crystallized ability and the terminal end shape of enhancing that some embodiments of the present invention offer microtubular 100 is higher are protected Hold.About end crystallized ability, microtubular 100 is configured to straight (that is, non-preformed) configuration, and it is before the use by doctor Steamed form is desired shape.Conduit 100 can use means widely known in the art to carry out steamed form.Microtubular The terminal end shape of 100 is remained above 55%.In a preferred embodiment, terminal end shape remains 58%, and is preferable to carry out at another In example, terminal end shape remains 67%.

Keep by using thinner liner 114 to improve terminal end shape, this liner allow to combine more heavy wall, can shape Oversheath 116.Terminal end shape holding can also have tightly by being combined between liner 114 and shapable oversheath 116 The coil 124 of close pitch strengthens.Tight knot away from coil 124 to be arranged to pivot about liner 114 concentric so that microtubular 100 Shapable part (i.e. distal portion 110) will not seriously be affected by that straightening force of coil 124.This is with microtubular of the prior art Be contrasted, microtubular of the prior art use pigtail or the coil configuration of more long-pitch, with to microtubular end apply The mode of that straightening force is at microtubular deformable segment deployment line or other filament.

Although according to specific embodiment with should be used for describing the present invention, but those of ordinary skill in the field are at this Under teaching, in the spirit without departing from the present invention for required protection or the situation of the scope beyond the present invention for required protection Under, further embodiment and deformation can be obtained.It is, therefore, to be understood that provide accompanying drawing and explanation by way of example at this, with It is easy to the understanding of the present invention, and should not be considered as limiting the scope of the present invention.

Claims (15)

1. a microtubular, including:

Having the elongated pipe of multiple sections, the hardness of each sections is less than the hardness of near-end neighbouring section, and neighbouring section enters one Step includes mutually being in the end of the deflection of relative position of rotation, the end of wherein said deflection by the heat of heat-shrinkable tube and Power is pushed into and is attached in neighbouring section；

Coil, is positioned at the lower section of described elongated pipe, and has the pitch in 0.002 to 0.004 inch range；And

Being arranged in the internal lining pipe below described coil, described internal lining pipe is stretching, in order to optionally orient its material Molecular structure.

2. microtubular as claimed in claim 1, also includes the hydrophilic coating being arranged on described elongated pipe, described hydrophilic painting Layer is apart from the far-end 100-120cm of described elongated pipe.

3. microtubular as claimed in claim 1, each in wherein said multiple sections combines with mutually including an angle.

4. microtubular as claimed in claim 1, wherein said internal lining pipe is made up of PTFE, and has 0.0005 to 0.007 Thickness in inch range.

5. it is sized to enter a microtubular for patient's vascular system, including:

First tube segment, has a first axle along its length, and relative to described first axle have first non-perpendicular partially The first of gyration angularly end；And

Second tube segment, has the second axis along its length, and relative to described second axis have second non-perpendicular partially The second of gyration angularly end；

Wherein said first non-perpendicular deflection angle and described second non-perpendicular deflection angle are with relative to each other opposite orientation Mode is arranged, and

Wherein, the described first angled end is pushed into and is attached to described second pipe by heat and the power of heat-shrinkable tube In sections, form elongated pipe；Described elongated pipe have described elongated pipe proximally and distally near the passage of opening.

6. microtubular as claimed in claim 5, wherein said elongated pipe also includes multiple tube segment, the plurality of tube segment It is at least partially disposed at least in another of the plurality of tube segment；Each of the plurality of tube segment includes at least one Individual angled end.

7. microtubular as claimed in claim 5, wherein said elongated pipe also includes multiple tube segment, the plurality of tube segment Each be made up of the material with different hardness.

8. microtubular as claimed in claim 7, wherein said elongated pipe is arranged in the joint with 0.002 to 0.004 inch On coil.

9. a microtubular, including:

Having the elongated tubular sheath of the first thickness, described tubular sheath includes that multiple sections, the plurality of sections have phase It is in the angled end of deflection of relative position of rotation mutually；And,

There is the tubular liner of the second thickness, be arranged in described elongated tubular sheath；

Wherein, described elongated tubular sheath has the external diameter of 0.025 inch；And,

Wherein, the ratio between described first thickness and described second thickness is more than 70%；

The angled end of wherein said deflection is pushed into by heat and the power of heat-shrinkable tube and is attached in neighbouring section.

10. microtubular as claimed in claim 9, the described ratio between wherein said first thickness and described second thickness is 78%。

11. microtubulars as claimed in claim 9, also include the line being wound around, are arranged in described elongated tubular sheath and described Between tubular liner.

12. microtubulars as claimed in claim 9, wherein said tubular liner includes the material being stretched.

13. microtubulars as claimed in claim 9, wherein said tubular liner includes PTFE.

14. microtubulars as claimed in claim 9, wherein said elongated tubular sheath is saved by the sheath of multiple angled combinations Section is constituted.

15. microtubulars as claimed in claim 9, wherein said tubular liner includes the PTFE material of stretching.