CN114432016A

CN114432016A - Conveying guide wire

Info

Publication number: CN114432016A
Application number: CN202210361326.1A
Authority: CN
Inventors: 杨新健; 朱勇男; 刘健; 张义森; 王坤; 张莹; 李艺影
Original assignee: Beijing Neurosurgical Institute
Current assignee: Beijing Neurosurgical Institute
Priority date: 2022-04-07
Filing date: 2022-04-07
Publication date: 2022-05-06

Abstract

The invention provides a delivery guide wire, which comprises a mandrel, wherein the mandrel comprises a deformable section, the deformable section is positioned between the far end and the near end of the mandrel, the delivery guide wire is used for delivering a self-expanding stent, the deformable section is positioned in the inner cavity of the self-expanding stent, and the unreleased deformable section in the self-expanding stent is in a line shape; the mandrel releases the self-expanding support, the self-expanding support expands and expands, the deformable section deforms to form a deformable body, and the relative position between the distal end of the mandrel and the distal end of the self-expanding support is kept and not moved forward in the expanding process of the self-expanding support. The invention has the advantages that: the relative position between the far end of the guide wire and the far end of the self-expanding stent can be kept from moving forwards when the stent is released, so that the far end of the guide wire is prevented from penetrating into a farther blood vessel, and the risk that the far end of the guide wire bends or punctures the blood vessel due to stress concentration is reduced; the spiral coil structure which is convolutely contracted and stays at the far end of the stent has certain radial supporting force, and can assist the self-expanding stent to expand.

Description

Conveying guide wire

Technical Field

The invention relates to the field of medical instruments, in particular to a delivery guide wire.

Background

The current latest interventional therapy apparatus for human intracranial vascular aneurysm is a stent, and an interception barrier is formed at the neck of the aneurysm in the blood vessel by the high surface tension between meshes of the stent, so that the effect of blood vessel reconstruction is realized. The stent needs to be delivered into the intracranial vessel through a delivery guide wire. The intracranial blood vessel of the human body is very tortuous and has more branches.

At present, in order to avoid pushing the far end of a guide wire into a blood vessel with a small diameter in the blood vessel or stress concentration in a bent and branched blood vessel to puncture, burst and puncture the blood vessel, the far end of the guide wire is designed to be very soft and form a certain angle, such as 45 degrees, 90 degrees, 135 degrees, 180 degrees and the like, although the designs can relieve the stress concentration of the guide wire in a tortuous blood vessel, in the actual operation process, key operations such as release of a vascular stent and the like need high concentration attention of an operator, so that the far end condition of the guide wire is easily ignored, the stress concentration of the far end of the guide wire at a certain position of the blood vessel can be caused by continuous forward pushing of the guide wire, when the concentrated stress exceeds a critical value of the blood vessel wall, the blood vessel can be punctured, bleeding is caused, and cerebral apoplexy is caused.

In addition, both the cut stent and the woven stent have the problem that the stent is broken in a tortuous blood vessel, the broken stent in the blood vessel easily causes thrombosis, blood flow of the blood vessel is influenced, and if the thrombosis is serious, stenosis, unsmooth blood flow and even blockage of the blood vessel can be caused. The conventional procedures encountered in neuro-interventional surgery are: after the stent is released, the delivery guide wire is withdrawn, a balloon is pushed into the microcatheter and penetrates through the interior of the stent, the microcatheter is withdrawn to release the balloon, the balloon is pressurized, the expanded balloon props up the broken stent, and the blood vessel is kept smooth, however, the series of operations are very time-consuming.

Like patent CN113274178A provides a vascular stent conveyer, including casing, adjust knob, seal wire and pipe, improve adjust knob's rotation accuracy, and then improve the degree of accuracy of the slip size of pipe, can also avoid the maloperation, improve vascular stent conveyer's factor of safety. But the patent technology does not reduce the risk that the far end of the guide wire punctures the blood vessel, and solves the problem of stent folding.

In view of the foregoing, it would be desirable to provide a delivery guidewire that overcomes the deficiencies of the prior art.

Disclosure of Invention

The invention aims to provide a delivery guide wire, which aims to solve the problems in the prior art and achieves the aim through the following technical scheme.

One embodiment of the present invention provides a delivery guidewire, the mandrel comprising a deformable section, the deformable section being located between the distal end and the proximal end of the mandrel, the delivery guidewire being for delivery of a self-expanding stent, the deformable section being located within a lumen of the self-expanding stent, the deformable section in the unreleased self-expanding stent being in the form of a wire; the mandrel releases the self-expanding support, the self-expanding support expands and expands, the deformable section deforms to form a deformable body, and the relative position between the distal end of the mandrel and the distal end of the self-expanding support is kept and not moved forward in the expanding process of the self-expanding support.

According to the invention, the conveying guide wire is provided, wherein the deformation body is of a spiral coil structure, a wavy line structure or a zigzag line structure.

According to the invention, the conveying guide wire is provided, wherein the spiral coil structure is a cylindrical structure with the same diameter at each position in the coil, or a shuttle-shaped structure with the large diameter of the middle coil and the small diameter of the coils at the two ends.

According to the delivery guide wire provided by the above one embodiment of the invention, the helical coil structure is a primary structure, the deformable section is convolutely curled to form the helical coil structure, and the number of turns of the helical coil is greater than or equal to 1.

The pushwire according to the above embodiment of the present invention, wherein the helical coil structure is a multi-stage structure, the helical coil structure comprises a first stage coil and a second stage coil, the mandrel of the deformable section is helically crimped to form the first stage coil, and the first stage coil is helically crimped to form the second stage coil.

According to the invention, the delivery guide wire is provided, wherein the maximum outer diameter of the spiral coil structure is smaller than or equal to the inner diameter of the self-expanding stent.

The pushwire according to one of the above embodiments of the present invention, wherein the mandrel further comprises a grinding segment located at the distal end of the mandrel.

According to the delivery guide wire provided by the above embodiment of the invention, the delivery guide wire further comprises a developing spring, and the developing spring is fixedly sleeved outside the grinding section.

The pushwire according to the above-described one embodiment of the present invention is provided, wherein the mandrel further comprises a push section at a proximal end of the mandrel for an operator to move the guidewire.

The pushwire according to the above-mentioned embodiment of the present invention, wherein the material of the mandrel is a deformable memory alloy.

According to the present invention, there is provided the delivery guidewire according to the above-mentioned one embodiment, wherein the unreleased self-expanding stent is crimped in the introducing sheath or the microcatheter.

According to the delivery guide wire provided by the embodiment of the invention, when the delivery guide wire is delivered to the self-expanding stent, the delivery guide wire is pressed and held in the introducing sheath or the micro-catheter, the mandrel passes through the inner cavity of the self-expanding stent, the deformable section is positioned in the inner cavity of the self-expanding stent, and the deformable section is in a line shape under the action of pressure; the external pressure that the deformable section received when carrying the guide wire and releasing from expanding the support reduces, and the deformable section is along with the operator pushes away the guide wire from the near-end and warp by oneself and forms the deformable body, and the whole length of guide wire shortens along with the formation of deformable body, and the relative position between the distal end of dabber and the support distal end that self-expands keeps not advancing in the process that self-expands the support and opens, and the radial force that the deformable section warp the production is assisted and is expanded the support and open.

Advantages of the delivery guidewire according to embodiments of the present invention are: when the stent is released in the blood vessel, the mandrel of the guide wire can automatically deform, and the relative position between the distal end of the guide wire and the distal end of the self-expanding stent can be kept from moving forwards when the stent is released, so that the distal end of the guide wire is prevented from penetrating into the blood vessel at a farther position, and the risk that the distal end of the guide wire bends or punctures the blood vessel due to stress concentration is reduced; the deformation body after the convolution and shrinkage has certain radial supporting force and can assist the self-expanding stent to expand.

Drawings

Other features, objects and advantages of the present application will become more apparent upon reading of the following detailed description of non-limiting embodiments thereof, made with reference to the accompanying drawings.

FIG. 1 shows a schematic view of a mandrel delivering a guidewire according to one embodiment of the present invention.

FIG. 2 shows a schematic view of a delivery guidewire and self-expanding stent crimped in a microcatheter according to one embodiment of the invention.

FIG. 3 shows a schematic representation of a delivery guidewire and self-expanding stent crimped in a microcatheter with a deflectable segment in the shape of a wire, according to one embodiment of the invention.

FIG. 4 shows a schematic representation of a delivery guidewire and self-expanding stent exiting a microcatheter with the transformable portion expanded open, according to one embodiment of the present invention.

Fig. 5 shows a spiral coil structure of a single-layer structure according to an embodiment of the present invention.

Fig. 6 shows a spiral coil structure of a multi-stage structure according to an embodiment of the present invention.

Reference numbers and part names: a is the far end of a mandrel, B is the near end of the mandrel, 1 is a deformable section, 2 is a grinding section, 3 is a pushing section, and 4 is a self-expansion support.

Detailed Description

The following description of the embodiments of the present application with reference to the drawings and examples will make it easy for those skilled in the art to understand the technical problems and technical solutions solved by the present application and the technical effects thereof through the contents described in the present specification. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. In addition, for convenience of description, only portions related to the related invention are shown in the drawings.

It should be noted that the structures, proportions, sizes, and other elements shown in the drawings are only used for understanding and reading the contents of the specification, and are not used for limiting the conditions under which the present application can be implemented, so they do not have the technical significance, and any structural modifications, changes in proportion, or adjustments of sizes, which do not affect the efficacy and achievement of the purposes of the present application, shall still fall within the scope of the technical content disclosed in the present application.

Reference to words such as "first," "second," "the," and the like do not denote a limitation of quantity, and may refer to the singular or the plural. The present application is directed to the terms "comprising," "including," "having," and any variations thereof, which are intended to cover non-exclusive inclusions; for example, a process, method, system, article, or apparatus that comprises a list of steps or modules (elements) is not limited to the listed steps or elements, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus. Reference to "connected," "coupled," and the like in this application is not intended to be limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

FIG. 1 shows a schematic view of a delivery guidewire according to one embodiment of the present invention. As shown in figure 1, the delivery guide wire comprises a mandrel, the mandrel comprises a deformable section 1, the deformable section 1 is positioned between the distal end A and the proximal end B of the mandrel, the delivery guide wire is used for delivering a self-expanding stent 4, the deformable section 1 is positioned in the inner cavity of the self-expanding stent 4, when the self-expanding stent 4 is not released, the self-expanding stent 4 is pressed and held in an introducing sheath or a micro-catheter 5, and the deformable section 1 is in a linear shape under the action of pressure; when the mandrel releases the self-expanding support 4, the self-expanding support 4 expands and expands, the pressure applied to the deformable section 1 is reduced, the deformable section 1 deforms by itself to form a deformed body, and the relative position between the distal end A of the mandrel and the distal end of the self-expanding support is kept and is not moved forward in the expanding process of the self-expanding support 4.

The pushwire according to the above-mentioned embodiment of the present invention, wherein the structure of the deformable body includes, but is not limited to, a helical coil structure, a wavy line structure, or a zigzag line structure.

According to the delivery guide wire provided by the above one embodiment of the invention, the distal end A of the mandrel refers to the end away from the operator of the guide wire; proximal end B of the mandrel refers to the end of the mandrel that is proximal to the guidewire operator and, in use, is located outside the vessel.

According to the delivery guide wire provided by the above one embodiment of the present invention, the maximum outer diameter of the spiral coil structure is equal to or less than the inner diameter of the self-expanding stent 4.

The pushwire according to the above-mentioned one embodiment of the present invention, wherein said mandrel further comprises a grinding segment 2, the grinding segment 2 being located at the distal end a of the mandrel. The grinding section 2 of the mandrel is thinned through grinding, so that the flexibility and the flexibility of the far end A of the guide wire are improved, stress concentration is reduced, damage to blood vessels is avoided, the guide wire can reach finer blood vessels, and blood vessel over-selection can be better realized at the position of a bifurcated blood vessel.

According to the invention, the delivery guide wire is provided, wherein the delivery guide wire further comprises a developing spring 6, and the developing spring 6 is fixedly sleeved outside the grinding section 2. The developing spring 6 has developing function and flexibility, and the material of the developing spring 6 includes, but is not limited to, a platinum-tungsten alloy wire or a platinum-iridium alloy wire.

The pushwire is provided according to one of the above embodiments of the present invention, wherein the mandrel further comprises a push section 3, the push section 3 is located at the proximal end B of the mandrel, and the push section 3 is used for the operator to move the guidewire. The near end of the mandrel is smooth, thick in diameter and firm, and is beneficial to being held and held by an operator, not easy to break and beneficial to transmitting near-end force.

The pushwire according to the above-mentioned embodiment of the present invention, wherein the material of the mandrel is a deformable memory alloy, including but not limited to NiTi alloy.

FIG. 2 shows a schematic view of a delivery guidewire and self-expanding stent crimped in a microcatheter according to one embodiment of the invention. FIG. 3 shows a schematic representation of a delivery guidewire and self-expanding stent crimped in a microcatheter with a deflectable segment in the shape of a wire, according to one embodiment of the invention. As shown in fig. 2-3, in which the delivery guidewire is crimped in the introducer sheath or microcatheter 5 during delivery of the self-expanding stent 4, the core of the delivery guidewire passes through the lumen of the self-expanding stent 4, the transformable portion 1 is positioned within the lumen of the self-expanding stent 4, and the transformable portion 1 is in the form of a wire under pressure.

FIG. 4 shows a schematic representation of a delivery guidewire and self-expanding stent exiting a microcatheter after expansion and deployment, according to one embodiment of the invention. As shown in figure 4, the external pressure on the deformable section 1 is reduced when the delivery guide wire is released from the self-expanding stent 4, the deformable section 1 deforms to form a deformed body by itself along with the pushing of the guide wire from the proximal end by an operator, the whole length of the guide wire becomes shorter along with the formation of the deformed body, the relative position between the distal end A of the mandrel and the distal end of the self-expanding stent is kept and does not move forwards in the expanding process of the self-expanding stent 4, and the expanding of the self-expanding stent 4 is assisted by the radial force generated by the deformation of the deformable section.

Fig. 5 shows a spiral coil structure of a single-layer structure according to an embodiment of the present invention. As shown in FIG. 5, the spiral coil structure is a single-layer structure, the deformable section 1 is convolutely curled to form the spiral coil structure, and the number of turns n of the spiral coil is greater than or equal to 1, preferably, greater than or equal to 1 and less than or equal to 10.

Fig. 6 shows a spiral coil structure of a multi-stage structure according to an embodiment of the present invention. As shown in fig. 6, in which the spiral coil structure is a multi-stage structure, the spiral coil structure includes a primary coil and a secondary coil, the mandrel of the transformable portion 1 is spirally wound to form the primary coil, and the spirally wound primary coil is again spirally wound to form the secondary coil. The shortening rate of the spiral coil structure of the multistage structure is 300% -1000%.

Advantages of the delivery guidewire according to embodiments of the present invention are: when the stent is released in the blood vessel, the mandrel of the guide wire can deform automatically, so that the relative position between the far end of the guide wire and the far end of the self-expanding stent can be kept from moving forwards when the stent is released, the far end of the guide wire is prevented from penetrating into the blood vessel at a farther position, and the risk that the far end of the guide wire bends or punctures the blood vessel due to stress concentration is reduced; the deformation body after the convolution and shrinkage has certain radial supporting force and can assist the self-expanding stent to expand.

While the present application has been described and illustrated with reference to particular embodiments thereof, these descriptions and illustrations do not limit the present application. It will be clearly understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof within the embodiments without departing from the true spirit and scope of the present application as defined by the appended claims. The illustrations may not necessarily be drawn to scale. There may be a difference between the technical reproduction in the present application and the actual device due to variables in the manufacturing process and the like. There may be other embodiments of the application that are not specifically illustrated. The specification and drawings are to be regarded in an illustrative rather than a restrictive sense. Modifications may be made to adapt a particular situation, material, composition of matter, method, or process to the objective, spirit and scope of the present application. All such modifications are intended to be within the scope of the claims appended hereto. Although the methods disclosed herein have been described with reference to particular operations performed in a particular order, it should be understood that these operations may be combined, sub-divided, or reordered to form equivalent methods without departing from the teachings of the present application.

Claims

1. A pushwire comprising a mandrel, wherein the mandrel comprises a deformable section, the deformable section is located between the distal end and the proximal end of the mandrel, the pushwire is for delivery to a self-expanding stent, the deformable section is located within the lumen of the self-expanding stent, and the deformable section in the unreleased self-expanding stent is in the form of a wire; the mandrel releases the self-expanding support, the self-expanding support expands and expands, the deformable section deforms to form a deformable body, and the relative position between the distal end of the mandrel and the distal end of the self-expanding support is kept and not moved forward in the expanding process of the self-expanding support.

2. The pushwire of claim 1, wherein said deformable body is a helical coil structure, a wavy wire structure, or a zigzag wire structure.

3. The pushwire of claim 2, wherein the helical coil structure is a cylindrical structure with a constant diameter at any position inside the coil, or a fusiform structure with a large diameter at the middle coil and small diameters at the two ends.

4. The pushwire of claim 2 wherein said helical coil structure is a single layer structure and said deformable section is convolutely crimped to form said helical coil structure, said helical coil having a number of turns greater than or equal to 1.

5. The pushwire of claim 2, wherein the helical coil structure is a multi-stage structure comprising a primary coil and a secondary coil, the mandrel of the deflectable segment being helically crimped to form the primary coil, the primary coil being helically crimped to form the secondary coil.

6. The pushwire of claim 2, wherein the helical coil structure has a maximum outer diameter that is less than or equal to an inner diameter of the self-expanding stent.

7. The pushwire of claim 1, wherein said mandrel further comprises a grinding segment, said grinding segment being located at a distal end of said mandrel.

8. The pushwire of claim 1, further comprising a visualization spring, wherein the visualization spring is fixedly sleeved outside the grinding segment.

9. The pushwire of claim 1, wherein the mandrel further comprises a push section at a proximal end of the mandrel for an operator to move the guidewire.

10. The pushwire of claim 1, wherein said mandrel is formed of a deformable memory alloy.

11. The delivery guidewire of claim 1, wherein the unreleased self-expanding stent is crimped within an introducer sheath or microcatheter.

12. The delivery guidewire of any one of claims 1-11, wherein the delivery guidewire is configured to be crimped within the introducer sheath or microcatheter during delivery of the self-expanding stent, the mandrel extending through a lumen of the self-expanding stent, and the deflectable segment being positioned within the lumen of the self-expanding stent, the deflectable segment being configured to deflect under pressure; the external pressure that the deformable section received when the delivery wire releases from expanding the support reduces, and the deformable section deforms along with the operator pushes away the wire deformation from the near-end and forms the deformable body, and the whole length of wire shortens along with the formation of deformable body, and the relative position between the distal end of dabber and the support distal end that self-expands keeps not advancing in the process that self-expands the support and opens, and the radial force that the deformable section deformation produced assists the support that self-expands to open.