CN113855860B - Method and equipment for preparing artificial bone block - Google Patents
Method and equipment for preparing artificial bone block Download PDFInfo
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- CN113855860B CN113855860B CN202111220881.4A CN202111220881A CN113855860B CN 113855860 B CN113855860 B CN 113855860B CN 202111220881 A CN202111220881 A CN 202111220881A CN 113855860 B CN113855860 B CN 113855860B
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- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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Abstract
The application discloses a preparation method of an artificial bone block, which comprises the following steps: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate; extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates; immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture; adding a second blood to the first mixture to form a second mixture; after the second mixture is solidified, obtaining the solidified second mixture as an artificial bone piece. In the embodiment of this application, through in immersing the bone meal in liquid autologous concentrated growth factor, increased the stability of bone grafting, through the blood that adds art district in the mixture to bone meal and liquid autologous concentrated growth factor, realized the rapid solidification of bone meal.
Description
Technical Field
The application relates to a medical material preparation technology, in particular to a preparation method and equipment of an artificial bone block.
Background
Alveolar bone defects are a common problem in oral implant surgery. Classical guided bone regeneration surgery is an effective means to solve this problem. During this procedure, a heterogeneous bone material is implanted into the bone defect area and covered with a biofilm.
Practice shows that the stability of the bone grafting material has important influence on the bone grafting effect. At present, the bone grafting material commonly used in clinic mainly comprises granular bones, the bone powder granules are loose and are not suitable for fixed forming, the bone grafting material is easy to disperse and run off in the operation process, and the bone grafting material is easy to shift when more bleeding occurs to influence the bone grafting stability. In practice, liquid autologous concentrated Growth factors, abbreviated as liquid cgf (concentrated Growth factors), are usually used to soak bone powder, and the autologous concentrated Growth factors can promote the proliferation and differentiation of osteoblasts and the osteogenesis; at the same time, the bone meal particles can be solidified and molded. However, the bone meal is soaked in the liquid autologous concentrated growth factor, so that the bone meal coagulation time is long, and different blood components of different patients can cause the condition that the bone meal cannot be coagulated, thereby influencing the clinical use.
Disclosure of Invention
The embodiment of the application provides a preparation method of an artificial bone block, and solves the problems of long bone powder solidification time and unstable bone grafting in the prior art.
The embodiment of the application provides a preparation method of an artificial bone block, which comprises the following steps: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate; extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates; immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture; adding a second blood to the first mixture to form a second mixture; after the second mixture is solidified, the solidified second mixture is obtained as an artificial bone piece.
Optionally, the extracting liquid autologous concentrated growth factor from the liquid autologous platelet aggregate comprises: and extracting the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate to be used as a liquid autologous concentrated growth factor for preparing the artificial bone block.
Optionally, the method further includes: venous blood of a patient is drawn as the first blood to be centrifuged, the patient being a patient to be implanted with the artificial bone piece.
Optionally, the method further includes: obtaining the dosage parameter of the bone powder according to the parameter of the artificial bone block to be implanted into the patient; weighing the bone powder for preparing the artificial bone block according to the dosage parameter of the bone powder;
the bone meal is immersed in the liquid autologous concentrated growth factor, and the method comprises the following steps: and immersing the bone powder for preparing the artificial bone block into the liquid autologous concentrated growth factor.
Optionally, the method further includes: drawing blood of a patient as the second blood added to the first mixture, the patient being the patient to be implanted with the artificial bone piece.
Optionally, the drawing blood from the patient comprises: drawing blood from the patient from a surgical area of the patient in which the artificial bone piece is to be implanted.
Optionally, the method further includes: obtaining the dosage parameter of the second blood according to the dosage parameter of the bone meal; and drawing the second blood according to the dosage parameter of the second blood.
Optionally, the method further includes: and performing reshaping treatment on the artificial bone block according to the parameters of the artificial bone block to be implanted into the patient to obtain the reshaped artificial bone block.
Optionally, the artificial bone piece is a bone piece to be implanted in an oral cavity of a patient.
Optionally, the adding a second blood to the first mixture comprises: adding a second blood to the first mixture for a preset time period after the first mixture is formed.
Optionally, the volume of the liquid autologous concentrated growth factor is 0.5 ml.
Optionally, the bone meal weighs 0.5 g.
Optionally, the adding a second blood to the first mixture comprises: a drop of second blood or two drops of second blood is added to the first mixture using a dropper.
The embodiment of the present application further provides an artificial bone block preparation apparatus, including: a housing, a centrifuge disposed within the housing, a mixture container disposed within the housing; a blood collection tube inlet for placing a blood collection tube filled with first blood into the centrifuge is formed in the housing; a second blood injection port for injecting a second blood into the mixture container is provided on the housing, and a second blood transfer tube for transferring the second blood is provided between the second blood injection port and the second blood inlet of the mixture container; a bone powder injection port for injecting bone powder into the mixture container is arranged on the shell, and a bone powder conveying pipe for conveying the bone powder is arranged between the bone powder injection port and the bone powder inlet of the mixture container; a liquid autologous concentrated growth factor conveying pipe for conveying liquid autologous concentrated growth factors is arranged between the centrifugal device and the mixture container;
wherein, a blood collection tube filled with first blood to be centrifugally treated is placed into the centrifugal device through the blood collection tube placement opening, bone meal is injected into the mixture container through the bone meal conveying tube, the centrifugal device carries out centrifugal treatment on the first blood to obtain liquid autologous platelet aggregate, liquid autologous concentrated growth factors are extracted from the liquid autologous platelet aggregate, the extracted liquid autologous concentrated growth factors are conveyed into the mixture container through the liquid autologous concentrated growth factor conveying tube, the bone meal in the mixture container is mixed with the liquid autologous concentrated growth factors to form a first mixture, second blood is injected into the mixture container through the second blood conveying tube, and the first mixture is mixed with the second blood to form a second mixture, after the second mixture solidifies, an artificial bone mass is formed.
Optionally, a liquid autologous concentrated growth factor detection device and a liquid autologous concentrated growth factor extraction device are arranged in the centrifugal device;
the liquid autologous concentrated growth factor detection device is used for detecting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates after the centrifugation device obtains the liquid autologous platelet aggregates, and sending a liquid autologous concentrated growth factor extraction instruction to the liquid autologous concentrated growth factor extraction device after the liquid autologous concentrated growth factors are detected;
the liquid autologous concentrated growth factor extraction device is used for extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates according to the extraction instruction.
Optionally, the liquid autologous concentrated growth factor detection device includes a first image collector and a first image analyzer;
the first image collector is used for collecting images of liquid autologous platelet aggregates and sending the images of the liquid autologous platelet aggregates to the image analyzer;
the first image analyzer is used for positioning the position of the junction part of the red liquid and the white liquid in the image of the liquid autologous platelet aggregate to obtain positioning information and sending the positioning information to the liquid autologous concentrated growth factor extraction device;
and the liquid autologous concentrated growth factor extraction device extracts the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate according to the positioning information.
Optionally, a transmission mechanism for transmitting the mixture container to the outside of the shell is further arranged in the shell;
the transmission mechanism transfers the mixture container to the outside of the housing after the artificial bone piece is formed.
Optionally, an artificial bone block detection device is arranged in the mixture container;
the artificial bone block detection device is used for sending a first transmission instruction for transmitting the mixture container to the outside of the shell to the transmission mechanism after the artificial bone block is detected;
the transmission mechanism is specifically configured to transfer the mixture container out of the housing according to the first transfer instruction.
Optionally, the artificial bone block detection device includes a second image collector and a second image analyzer;
the second image collector is used for collecting images in the mixture container and sending the images in the mixture container to the second image analyzer;
the second image analyzer is used for analyzing the image in the mixture container and sending the transmission instruction to the transmission mechanism if the image of the artificial bone block is detected in the image in the mixture container.
Optionally, the transmission mechanism is further configured to transmit the mixture container into the housing after obtaining a second transmission instruction for transmitting the mixture container into the housing.
Optionally, a moving trigger button assembly for triggering the movement of the mixture container is arranged on the housing;
the mobile trigger button assembly is used for responding to the trigger operation of the mobile trigger button assembly, judging the position of the mixture container, and sending a second conveying instruction for conveying the mixture container into the shell to the conveying mechanism if the mixture container is outside the shell.
Optionally, a moving trigger button assembly for triggering the movement of the mixture container is arranged on the housing;
the mobile trigger button assembly is used for responding to a trigger operation aiming at the mobile trigger button assembly, judging the position of the mixture container, and sending a first transmission instruction for transmitting the mixture container to the outside of the shell to the transmission mechanism if the mixture container is in the shell.
Compared with the prior art, the embodiment of the application has the following advantages:
the embodiment of the application provides a preparation method of an artificial bone block, which comprises the following steps: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate; extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates; immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture; adding a second blood to the first mixture to form a second mixture; after the second mixture is solidified, obtaining the solidified second mixture as an artificial bone piece.
In the embodiment of this application, through in immersing the bone meal in liquid autologous concentrated growth factor, increased the stability of bone grafting, through the blood that adds art district in the mixture to bone meal and liquid autologous concentrated growth factor, realized the rapid solidification of bone meal.
Drawings
FIG. 1 is a flow chart of a method for preparing an artificial bone block according to an embodiment of the present disclosure;
FIG. 2 is a schematic diagram of a first blood to be centrifuged according to an embodiment of the present disclosure;
fig. 3 is a schematic view of a liquid autologous platelet aggregate provided in an embodiment of the present application;
FIG. 4 is a schematic representation of a first mixture provided by an embodiment of the present application;
FIG. 5 is a schematic illustration of a second blood sample taken according to embodiments of the present application;
FIG. 6 is a schematic illustration of the addition of a second blood to the first mixture as provided by an embodiment of the present application;
FIG. 7 is a schematic representation of a second mixture provided by an embodiment of the present application;
FIG. 8 is a first schematic view of an apparatus for preparing an artificial bone block according to an embodiment of the present disclosure;
fig. 9 is a second schematic view of an apparatus for preparing an artificial bone block according to an embodiment of the present disclosure.
Detailed Description
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. This application is capable of implementation in many different ways than those herein set forth and of similar import by those skilled in the art without departing from the spirit of this application and is therefore not limited to the specific implementations disclosed below.
The embodiment of the application provides a preparation method of an artificial bone block, which comprises the following steps: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate; extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates; immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture; adding a second blood to the first mixture to form a second mixture; after the second mixture is solidified, the solidified second mixture is obtained as an artificial bone piece. In the embodiment of this application, through in immersing the bone meal in liquid autologous concentrated growth factor, increased the stability of bone grafting, through the blood that adds art district in the mixture to bone meal and liquid autologous concentrated growth factor, realized the rapid solidification of bone meal.
The process is described and illustrated in detail below by means of specific examples.
Fig. 1 is a flowchart of a method for preparing an artificial bone block according to an embodiment of the present disclosure, and please refer to fig. 1, the method includes the following steps:
s101: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate;
in the embodiment of this application, treat centrifugal processing's first blood and be patient's venous blood, the patient is for treating implant the patient of artifical bone piece, after extracting patient's venous blood, put into the centrifuging tube that matches with centrifuge with it, carry out blood centrifugation in putting into centrifuge with the centrifuge tube again, obtain venous blood after centrifugal processing, liquid autologous platelet aggregate promptly.
Fig. 2 is a schematic diagram of first blood to be centrifuged according to an embodiment of the present application, and fig. 3 is a schematic diagram of liquid autologous platelet aggregates according to an embodiment of the present application. Referring to fig. 2, venous blood of a patient is extracted as first blood 202 to be centrifuged, and the first blood 202 to be centrifuged is added to a centrifuge tube 201 matched to a centrifuge. Referring to fig. 3, the centrifuge tube 201 is placed in a centrifuge for blood centrifugation to obtain a liquid autologous platelet aggregate 301.
The steps of the method for obtaining the liquid autologous platelet aggregate 301 can be realized by an apparatus, please refer to fig. 8, which comprises a housing 800, a centrifuge 801, and a blood collection tube inlet 803. Wherein, the centrifuge 801 is disposed in the housing 800, the blood collection tube inlet 803 is disposed on the housing 800, and is used for placing the blood collection tube 819 into the centrifuge 801, wherein, a shielding object, such as a cover, which is matched and sealed with the blood collection tube inlet 803, can be disposed on the blood collection tube inlet 803, and is used for preventing dust from entering the device. The blood collection tube 819 containing the first blood is inserted into the centrifuge 801 through the blood collection tube insertion port 803, and the first blood to be centrifuged is centrifuged by the centrifuge 801 to obtain a liquid autologous platelet aggregate.
The blood collection tube 819 is a disposable blood collection tube, and the blood collection tube can be inserted into the centrifuge 801 through the blood collection tube insertion port 803, or the used blood collection tube can be removed from the casing 800 to replace the blood collection tube.
S102: extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates;
the autologous concentrated Growth factors, CGF (concentrated Growth factors) for short, are a new generation of Growth factors, contain concentrated Growth factors and fibrin, and have the unique property of improving and enhancing tissue regeneration. The autologous concentrated growth factor is prepared by taking venous blood of a patient as a raw material through a special separation method.
In an embodiment of the present application, the extracting liquid autologous concentrated growth factor from the liquid autologous platelet aggregate includes: and extracting the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate to be used as a liquid autologous concentrated growth factor for preparing the artificial bone block.
In specific operation, please refer to fig. 2 and fig. 3 continuously, when preparing the liquid autologous concentrated growth factor, firstly, the venous blood of the patient is extracted, and the venous blood of the patient is placed in a centrifuge tube 201 matched with a centrifuge, in order to prevent blood coagulation, the centrifuge tube 201 containing the first blood 202 to be centrifuged should be placed in the centrifuge as soon as possible for centrifugation, for example, blood centrifugation is performed within 2 minutes, and then the centrifuge is started, and the specific centrifugation process is as follows: the centrifuge was accelerated to 2700 rpm in 30 seconds, then the centrifuge was centrifuged at 2700 rpm for 2 minutes, 2400 rpm for 4 minutes, then at 2700 rpm for 2 minutes, and at 3000 rpm for 3 minutes, and finally the centrifuge was decelerated in 36 seconds and stopped. Standing the centrifuged centrifuge tube 201 filled with blood to obtain the liquid autologous platelet aggregate 301, wherein the liquid autologous platelet aggregate 301 is divided into three layers: (1) the upper layer is serum (platelet poor plasma lacking fibrinogen and coagulation factors) 302; (2) the lower layer is the red blood cell layer 304; (3) the middle layer is liquid fibrin which is provided with a large amount of platelets and growth factors, namely liquid autologous concentrated growth factors 303, wherein the liquid autologous concentrated growth factors 303 are divided into three layers, namely a white part 303-1 at the upper layer, a red part 303-3 at the lower layer and a part 303-2 where the red and the white are intersected at the middle layer. In this application embodiment, the part that red liquid and white liquid are bordered among the liquid autologous platelet aggregate is rich in growth factor, as the liquid autologous concentrated growth factor who is used for preparing artificial bone piece, please continue to refer to fig. 2, in this application embodiment, adopts the heparin tube extraction of 4 milliliters treat the centrifugal processing's first blood, after first blood centrifugal processing, the volume of taking out the liquid that is rich in growth factor from the heparin tube of 4 milliliters is 0.5 milliliter promptly liquid autologous concentrated growth factor, and the reserve is for use.
Please refer to fig. 8, the step of the method for extracting the liquid autologous concentrated growth factor 303 may be implemented by a liquid autologous concentrated growth factor detection device 811 and a liquid autologous concentrated growth factor extraction device 813 arranged in the centrifugal device 801, where the liquid autologous concentrated growth factor detection device 811 is configured to detect the liquid autologous concentrated growth factor from the liquid autologous platelet aggregate after the centrifugal device 801 obtains the liquid autologous platelet aggregate, and send a liquid autologous concentrated growth factor extraction instruction to the liquid autologous concentrated growth factor extraction device 813 after the liquid autologous concentrated growth factor is detected; the liquid autologous concentrated growth factor extracting device 813 is configured to extract the liquid autologous concentrated growth factor from the liquid autologous platelet aggregate according to the extracting instruction.
The liquid autologous concentrated growth factor detection device 811 comprises a first image collector 814 and a first image analyzer 815; the first image collector 814 is configured to collect an image of liquid autologous platelet aggregates, and send the image of liquid autologous platelet aggregates to the image analyzer 815; the first image analyzer 815 is configured to locate a position of a boundary portion between red liquid and white liquid in the image of the liquid autologous platelet aggregate, obtain location information, and send the location information to the liquid autologous concentrated growth factor extraction apparatus 813; the liquid autologous concentrated growth factor extraction device 813 extracts the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate according to the positioning information, and the junction part is used as the liquid autologous concentrated growth factor for preparing the artificial bone block.
With continued reference to fig. 8, during the blood centrifugation process, the cap of the blood collection tube 819 is in a closed state, after the centrifugation process is completed, the cap of the blood collection tube 819 can be automatically opened, and the liquid autologous concentrated growth factor extraction device 813 can extend into the blood collection tube 819 to extract the liquid autologous concentrated growth factor. After the liquid autologous concentrated growth factor is extracted by the liquid autologous concentrated growth factor extracting device 813, the extracted liquid autologous concentrated growth factor is transmitted to the mixture container 802 through the liquid autologous concentrated growth factor transmitting tube 809.
A disinfection device 804 is further arranged in the centrifugal device 801, and the disinfection device 804 is used for disinfecting equipment. In the operation of the sterilization treatment, ultraviolet sterilization or high-temperature and high-pressure sterilization may be used, and when ultraviolet sterilization is used, the ultraviolet sterilization is generally used for sterilizing devices that do not directly contact bone meal and blood. For example, the centrifugal device 801 may be subjected to ultraviolet sterilization, and specifically, may be subjected to ultraviolet sterilization using an ultraviolet lamp. To the equipment of direct contact bone meal and blood to and the equipment that needs used repeatedly, equipment is for dismantling non-disposable equipment, the disinfection mode adopts high temperature high pressure disinfection to handle, for example, bone meal conveying pipe 807 and second blood conveying pipe 808 are for can separating the equipment of casing 800, during the use, above-mentioned removable equipment need carry out high temperature high pressure disinfection through disinfecting equipment 804 and handle.
S103: immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture;
in the embodiment of the application, the bone powder can be artificial bone powder, and when the artificial bone block is prepared, the parameters of the artificial bone block are implanted according to the needs of a patient to obtain the dosage parameters of the bone powder; the parameters of the artificial bone block are parameters capable of expressing the size of the bone block, such as a length value, a width value and a height value of the bone block; the dosage parameter of the bone meal is the weight of the bone meal. Weighing the bone powder for preparing the artificial bone block according to the dosage parameter of the bone powder; in the examples of the application, the bone meal is weighed to be 0.5 g.
The bone meal is immersed in the liquid autologous concentrated growth factor, and the method comprises the following steps: and immersing the bone powder for preparing the artificial bone block into the liquid autologous concentrated growth factor. In specific implementation, referring to fig. 4, fig. 4 is a schematic diagram of a first mixture provided in the present embodiment, and a first mixture is formed by immersing 0.5 g of artificial bone powder 401 in 0.5 ml of liquid autologous concentrated growth factor, specifically, immersing the artificial bone powder in the red-white intersected portion 303-2 of the liquid autologous concentrated growth factor.
It should be noted that, in the oral implant surgery, alveolar bone defect is a common disease, and doctors need to implant artificial bone blocks of different sizes according to different damage degrees of alveolar bones of patients. In the embodiment of the application, the dosage parameter of the bone powder is obtained according to the parameter of the artificial bone block which is needed to be implanted by a patient, then 0.5 g of the bone powder is weighed and immersed in the reserved 0.5 ml of liquid autologous concentrated growth factor. The bone grafting material is made of the bone powder, so that the bone powder is easy to fix and form, the bone powder is not easy to disperse and lose in the operation process, the bone powder is not easy to shift when bleeding is more, and the stability of bone grafting is enhanced.
The above method steps of forming the first mixture can be implemented by an apparatus, please refer to fig. 8, wherein a bone meal injection opening 805 for injecting bone meal into the mixture container 802 is provided on the housing 800, wherein a shielding, such as a cover, for preventing dust from entering the apparatus can be provided on the bone meal injection opening 805 to match and seal with the bone meal injection opening 805. A bone meal conveying pipe 807 for conveying bone meal is arranged between the bone meal injection port 805 and the bone meal inlet of the mixture container 802; the bone meal is added into the mixture container 802 through a bone meal injection port 805, the bone meal is conveyed into the mixture container 802 through a bone meal conveying pipe 807, the liquid autologous concentrated growth factor is conveyed into the mixture container 802 through a liquid autologous concentrated growth factor conveying pipe 809, the bone meal and the liquid autologous concentrated growth factor are mixed in the mixture container 802, and the bone meal is immersed in the liquid autologous concentrated growth factor to form a first mixture.
It should be noted that the bone powder conveying pipe 807 is a telescopic pipe, when bone powder is required to be conveyed to the mixture container 802, the bone powder conveying pipe 807 is connected to the mixture container 802, and when the bone powder is conveyed, the bone powder conveying pipe 807 and the mixture container 802 can be disconnected at any time.
S104: adding a second blood to the first mixture to form a second mixture;
in an embodiment of the application, blood of a patient is drawn as the second blood added to the first mixture, the patient being the patient in whom the artificial bone piece is to be implanted. The drawing of blood from a patient comprises: drawing blood from the patient from a surgical area of the patient in which the artificial bone piece is to be implanted.
It should be noted that the second blood added to the first mixture in this step is the blood drawn from the surgical area of the patient where the artificial bone piece is to be implanted. This is because, generally, after bone meal is soaked in liquid autologous concentrated growth factor, the coagulation time is long, therefore, blood needs to be added into the bone meal to accelerate the coagulation, but different blood components of different patients may cause the condition of non-coagulation, which affects the clinical use, therefore, in the embodiment of the present application, blood is extracted from the operation area where the patient is to be implanted with the artificial bone block, the blood is called autologous blood, and the coagulation of the bone meal can be accelerated after the autologous blood of the patient is added into the first mixture.
In the embodiment of the application, the dosage parameter of the second blood is obtained according to the dosage parameter of the bone meal; and drawing the second blood according to the dosage parameter of the second blood. It should be noted that, according to different amounts of bone meal, the amount of blood extracted from the operative area to be implanted with the artificial bone mass of the patient is different, so that in specific implementation, the amount of the second blood is determined according to the amount of the bone meal. Drawing the second blood according to the dosage parameter of the second blood, wherein the second blood can be drawn from the operation area by using a dropper, or can be drawn by other methods, and then adding the second blood of the patient drawn by using the dropper into the first mixture.
In an embodiment of the present application, the adding of the second blood to the first mixture includes: adding a second blood to the first mixture for a preset time period after the first mixture is formed. Said adding a second blood to said first mixture comprising: a drop of second blood or two drops of second blood is added to the first mixture using a dropper.
It should be noted that the time for adding the second blood, i.e. the autologous blood, to the first mixture and the amount of added autologous blood can affect the coagulation effect of the bone meal. Therefore, in the embodiment of the present application, after obtaining autologous blood from the operation area of the patient, it is necessary to add the first mixture of bone meal and liquid autologous concentrated growth factor as soon as possible, and the amount of added autologous blood is one or two drops, depending on the amount of bone meal of 0.5 g. In specific implementation, 0.5 g of bone meal is immersed in 0.5 ml of liquid autologous concentrated growth factor, and then one drop or two drops of autologous blood containing red blood cells are added into the bone meal by a dropper, so that the bone meal can be rapidly solidified into blocks within 30 s.
In operation, fig. 5 is a schematic diagram of a second blood sample obtained according to an embodiment of the present disclosure; FIG. 6 is a schematic illustration of the addition of a second blood to the first mixture as provided by an embodiment of the present application; fig. 7 is a schematic illustration of a second mixture provided in an embodiment of the present application. Referring to fig. 5, the second blood added to the first mixture means that the second blood 502, i.e., autologous blood, is drawn from the operation area 501 where the artificial bone fragment is to be implanted by the dropper 503. Referring to fig. 6, a second blood 502 is added to the first mixture, and a second mixture is obtained after the second blood 502 is added.
The method steps of the second mixture formation can be implemented by providing a second blood injection port 806 on the housing 800 for injecting a second blood into the mixture container 802, with continued reference to fig. 8, wherein the second blood injection port 806 can be provided with a cover, such as a cap, thereon for sealing the second blood injection port 806 to prevent dust from entering the device. A second blood transfer tube 808 for transferring a second blood is disposed between the second blood injection port 806 and the second blood inlet of the mixture container 802; after the first mixture is formed, a second blood is added to the mixture container 802 through the second blood injection port 806, the second blood is transferred to the mixture container 802 through the second blood transfer tube 808, and the first mixture is mixed with the second blood to form a second mixture.
Wherein the second blood delivery tube 808 is a telescopic tube, when the second blood needs to be injected into the mixture container 802, the second blood delivery tube 808 is connected with the mixture container 802, and when the second blood injection is completed, the second blood delivery tube 808 and the mixture container 802 can be disconnected at any time.
S105: after the second mixture is solidified, the solidified second mixture is obtained as an artificial bone piece.
In the embodiment of the application, after autoblood is added into the first mixture by a dropper, a second mixture is obtained, and after the second mixture is solidified within 30s, the second mixture after solidification, namely the artificial bone block, is obtained. Referring to fig. 7, after the second mixture 701 is solidified, an artificial bone block is obtained, wherein the artificial bone block is to be implanted in the oral cavity of the patient. In specific implementation, the artificial bone block is shaped according to parameters of the artificial bone block to be implanted into a patient, and the shaped artificial bone block is obtained.
The artificial bone block obtained by the embodiment of the application can be cut and shaped, so that the artificial bone block is matched with the operative region. This is because, different patients, alveolar bone damage's degree is different, and is also different to the size and dimension demand of artificial bone piece, consequently, when specifically using, after obtaining artificial bone piece, need cut out artificial bone piece according to the artificial bone piece size of the concrete damage position of patient's alveolar bone and needs, make its requirement that can perfect match, laminating art district. After the artificial bone block prepared in the embodiment of the application is implanted into an operation area, the condition of dispersion can not occur, and the stability of bone grafting is increased.
The above-mentioned steps of the method for preparing the artificial bone fragment can be implemented by a device, referring to fig. 9, after the second mixture is solidified, obtaining the solidified second mixture as the artificial bone fragment. Wherein, a transmission mechanism 810 for transmitting the mixture container 802 out of the housing 800 is also arranged in the housing 800. An artificial bone block detection device 812 is arranged in the mixture container 802; the artificial bone fragment detection device 812 is configured to send a first transmission instruction to the transmission mechanism 810 to transmit the mixture container 802 to the outside of the housing 800 after detecting the artificial bone fragment; the transmission mechanism 810 is specifically configured to transmit the mixture container 802 out of the housing 800 according to the first transmission instruction.
The artificial bone block detection device 812 comprises a second image collector 816 and a second image analyzer 817; the second image collector 816 is configured to collect images in the mixture container 802, and send the images in the mixture container 802 to the second image analyzer 817; the second image analyzer 817 for analyzing the image in the mixture container 802, and sending the transmission instruction to the transmission mechanism 810 if the image of the artificial bone fragment is detected in the image in the mixture container 802. The transmission 810 transmits the mixture container 802 out of the housing 800 according to a first transmission instruction.
It should be noted that, when the transmission mechanism 810 transmits the mixture container 802 to the outside of the housing 800, the artificial bone fragment detection device 812 and the second image collector 816 and the second image analyzer 817 inside the artificial bone fragment detection device 812 may be transmitted to the outside of the housing 800 together with the mixture container 802, or may remain in the housing 800 without being moved with the mixture container 802, which is within the protection scope of the embodiments of the present application.
The transmission 810 is also used to transfer the mixture container 802 into the housing 800 after obtaining a second transfer instruction to transfer the mixture container 802 into the housing 800.
A moving trigger button assembly 818 is provided on the housing 800 for triggering movement of the mixture container 802; the moving trigger button assembly 818 is configured to determine a position of the mixture container 802 in response to a trigger operation on the moving trigger button assembly 818, and send a second transfer instruction to the transfer mechanism 810 for transferring the mixture container 802 into the housing 800 if the mixture container 802 is outside the housing 800.
A moving trigger button assembly 818 is provided on the housing 800 for triggering movement of the mixture container 802; the moving trigger button assembly 818 is configured to determine a position of the mixture container 802 in response to a trigger operation on the moving trigger button assembly 818, and send a first transfer instruction to the transfer mechanism 810 for transferring the mixture container 802 out of the housing 800 if the mixture container 802 is inside the housing 800.
The embodiment of the present application further provides an artificial bone block preparation apparatus, including: a housing, a centrifuge disposed within the housing, a mixture container disposed within the housing; a blood collection tube inlet for placing a blood collection tube filled with first blood into the centrifuge is formed in the housing;
a second blood injection port for injecting a second blood into the mixture container is provided on the housing, and a second blood transfer tube for transferring the second blood is provided between the second blood injection port and the second blood inlet of the mixture container;
a bone powder injection port for injecting bone powder into the mixture container is arranged on the shell, and a bone powder conveying pipe for conveying the bone powder is arranged between the bone powder injection port and the bone powder inlet of the mixture container;
a liquid autologous concentrated growth factor conveying pipe for conveying liquid autologous concentrated growth factors is arranged between the centrifugal device and the mixture container;
wherein, a blood collection tube filled with first blood to be centrifugally treated is placed into the centrifugal device through the blood collection tube placement opening, bone meal is injected into the mixture container through the bone meal conveying tube, the centrifugal device carries out centrifugal treatment on the first blood to obtain liquid autologous platelet aggregate, liquid autologous concentrated growth factors are extracted from the liquid autologous platelet aggregate, the extracted liquid autologous concentrated growth factors are conveyed into the mixture container through the liquid autologous concentrated growth factor conveying tube, the bone meal in the mixture container is mixed with the liquid autologous concentrated growth factors to form a first mixture, second blood is injected into the mixture container through the second blood conveying tube, and the first mixture is mixed with the second blood to form a second mixture, after the second mixture solidifies, an artificial bone mass is formed.
As shown in fig. 8, a centrifugal device 801, a mixture container 802 and a liquid autologous concentrated growth factor conveying pipe 809 are arranged inside the housing 800, wherein the liquid autologous concentrated growth factor conveying pipe 809 is arranged between the centrifugal device 801 and the mixture container 802 and is used for conveying liquid autologous concentrated growth factors.
The case 800 is provided with a blood collection tube inlet 803 for introducing a blood collection tube 819 containing first blood into the centrifuge.
A second blood injection port 806 for injecting a second blood into the mixture container 802 is provided in the case 800, and a second blood transfer tube 808 for transferring the second blood is provided between the second blood injection port 806 and the second blood inlet of the mixture container 802; the second blood transfer tube 808 is a telescopic tube, when the second blood needs to be injected into the mixture container 802, the second blood transfer tube 808 is connected with the mixture container 802, and when the second blood injection is completed, the second blood transfer tube 808 and the mixture container 802 can be disconnected at any time.
A bone powder injection port 805 for injecting bone powder into the mixture container 802 is arranged on the shell 800, and a bone powder conveying pipe 807 for conveying the bone powder is arranged between the bone powder injection port 805 and the bone powder inlet of the mixture container 802; the bone powder conveying pipe 807 is a telescopic pipe, when bone powder is required to be conveyed to the mixture container 802, the bone powder conveying pipe 807 is connected with the mixture container 802, and after the bone powder is conveyed, the bone powder conveying pipe 807 and the mixture container 802 can be disconnected at any time.
Specifically, in operation, the blood collection tube 819 containing first blood to be centrifuged is placed into the centrifuge 801 through the blood collection tube placement port 803, the centrifuge 801 centrifuges the first blood to obtain liquid autologous platelet aggregates, and liquid autologous concentrated growth factors are extracted from the liquid autologous platelet aggregates.
The process of extracting the liquid autologous concentrated growth factor is described in further detail below.
The centrifugal device 801 is internally provided with a liquid autologous concentrated growth factor detection device 811 and a liquid autologous concentrated growth factor extraction device 813, wherein the liquid autologous concentrated growth factor detection device 811 is used for detecting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates after the centrifugal device 801 obtains the liquid autologous platelet aggregates, and sending a liquid autologous concentrated growth factor extraction instruction to the liquid autologous concentrated growth factor extraction device 813 after the liquid autologous concentrated growth factors are detected; the liquid autologous concentrated growth factor extracting device 813 is configured to extract the liquid autologous concentrated growth factor from the liquid autologous platelet aggregate according to the extracting instruction.
It should be noted that the liquid autologous concentrated growth factor detection apparatus 811 includes a first image collector 814 and a first image analyzer 815; the first image collector 814 is configured to collect an image of the liquid autologous platelet aggregate, and send the image of the liquid autologous platelet aggregate to the image analyzer; the first image analyzer 815 is configured to locate a position of a boundary portion between red liquid and white liquid in the image of the liquid autologous platelet aggregate, obtain location information, and send the location information to the liquid autologous concentrated growth factor extraction apparatus 813; the liquid autologous concentrated growth factor extraction device 813 extracts the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate according to the positioning information, and the junction part is used as the liquid autologous concentrated growth factor for preparing the artificial bone block. From this, the extraction of the liquid autologous concentrated growth factor was completed.
The blood collection tube 819 is a disposable blood collection tube, and the blood collection tube can be inserted into the centrifuge 801 through the blood collection tube insertion port 803, or a used blood collection tube can be taken out of the case 800 to replace the blood collection tube. With continued reference to fig. 8, during the blood centrifugation process, the cap of the blood collection tube 819 is in a closed state, after the centrifugation process is completed, the cap of the blood collection tube 819 can be automatically opened, and the liquid autologous concentrated growth factor extraction device 813 can extend into the blood collection tube 819 to extract the liquid autologous concentrated growth factor. After the liquid autologous concentrated growth factor is extracted by the liquid autologous concentrated growth factor extracting device 813, the extracted liquid autologous concentrated growth factor is transmitted to the mixture container 802 through the liquid autologous concentrated growth factor transmitting tube 809.
A disinfection device 804 is further arranged in the centrifugal device 801, and the disinfection device 804 is used for disinfecting equipment. In the operation of the sterilization treatment, ultraviolet sterilization or high-temperature and high-pressure sterilization may be used, and when ultraviolet sterilization is used, the ultraviolet sterilization is generally used for sterilizing devices that do not directly contact bone meal and blood. For example, the centrifugal device 801 may be subjected to ultraviolet sterilization, and specifically, may be subjected to ultraviolet sterilization using an ultraviolet lamp. To the equipment of direct contact bone meal and blood to and the equipment that needs used repeatedly, equipment is for dismantling non-disposable equipment, the disinfection mode adopts high temperature high pressure disinfection to handle, for example, bone meal conveying pipe 807 and second blood conveying pipe 808 are for can separating the equipment of casing 800, during the use, above-mentioned removable equipment need carry out high temperature high pressure disinfection through disinfecting equipment 804 and handle.
After the extraction of the liquid autologous concentrated growth factor is completed, the extracted liquid autologous concentrated growth factor is transferred into the mixture container 802 through the liquid autologous concentrated growth factor transfer tube 809, and then the next stage is performed: and mixing the bone meal with the liquid autologous concentrated growth factor.
The bone meal is added into the mixture container 802 through a bone meal injection port 805, the bone meal is conveyed into the mixture container 802 through a bone meal conveying pipe 807, the liquid autologous concentrated growth factor is conveyed into the mixture container 802 through a liquid autologous concentrated growth factor conveying pipe 809, and the bone meal and the liquid autologous concentrated growth factor are mixed in the mixture container 802 to form a first mixture.
After the first mixture is formed, the following goes to the next stage: and (3) preparing the artificial bone block.
After the first mixture is formed, the second blood is introduced into the mixture container 802 through the second blood injection port 806, the second blood is transferred into the mixture container 802 through the second blood transfer tube 808, the first mixture is mixed with the second blood to form a second mixture, and after the second mixture is coagulated, an artificial bone block is formed.
In the embodiment of the present application, as shown in fig. 9, a transmission mechanism 810 for transmitting the mixture container 802 to the outside of the housing 800 is further provided in the housing 800. It should be noted that an artificial bone block detection device 812 is arranged in the mixture container 802; the artificial bone block detection device is used for sending a first transmission instruction for transmitting the mixture container 802 out of the shell 800 to the transmission mechanism 810 after the artificial bone block is detected; the transmission mechanism 810 is specifically configured to transmit the mixture container 802 out of the housing 800 according to the first transmission instruction.
After the artificial bone fragment detection device 812 detects the artificial bone fragment, a first transmission instruction for transmitting the mixture container 802 out of the housing 800 is sent to the transmission mechanism 810, at this time, the bone powder transmission pipe 807 and the second blood transmission pipe 808 are contracted, that is, the bone powder transmission pipe 807 and the second blood transmission pipe 808 are both disconnected from the mixture container 802, and then the transmission mechanism 810 transmits the mixture container 802 out of the housing 800 according to the first transmission instruction. After the mixture container 802 is transferred to the outside of the housing 800, the mixture container 802 may be opened, or the artificial bone pieces may be ejected from the mixture container 802 in other ways, which are not specifically limited herein, to obtain the artificial bone pieces.
It should be noted that the artificial bone block detection apparatus includes a second image collector 816 and a second image analyzer 817; the second image collector 816 is configured to collect images in the mixture container 802, and send the images in the mixture container 802 to the second image analyzer 817; the second image analyzer 817 for analyzing the image in the mixture container 802, and sending the transmission instruction to the transmission mechanism 810 if the image of the artificial bone fragment is detected in the image in the mixture container 802. The transmission 810 transmits the mixture container 802 out of the housing 800 according to a first transmission instruction.
In the present embodiment, the transmission mechanism 810 is further configured to transfer the mixture container 802 into the housing 800 after obtaining a second transfer instruction for transferring the mixture container 802 into the housing 800. It should be noted that when the transmission mechanism 810 receives a first transmission command for transmitting the mixture container 802 out of the housing 800, the liquid autologous concentrated growth factor transmission tube 809 is disconnected from the mixture container 802; when the transmission mechanism 810 receives a second transmission instruction for transmitting the mixture container 802 into the shell 800, the liquid autologous concentrated growth factor transmission pipe 809 is connected with the mixture container 802.
In the present embodiment, a moving trigger button assembly 818 is provided on the housing 800 for triggering movement of the mixture container 802; the moving trigger button assembly 818 is configured to determine a position of the mixture container 802 in response to a trigger operation on the moving trigger button assembly 818, and send a second transfer instruction to the transfer mechanism 810 for transferring the mixture container 802 into the housing 800 if the mixture container 802 is outside the housing 800.
A moving trigger button assembly 818 is provided on the housing 800 for triggering movement of the mixture container 802; the moving trigger button assembly 818 is configured to determine a position of the mixture container 802 in response to a trigger operation on the moving trigger button assembly 818, and send a first transfer instruction to the transfer mechanism 810 for transferring the mixture container 802 out of the housing 800 if the mixture container 802 is inside the housing 800.
The embodiment of the application provides a preparation method of an artificial bone block, which comprises the following steps: putting first blood to be centrifugally treated into a centrifuge for blood centrifugal treatment to obtain a liquid autologous platelet aggregate; extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates; immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture; adding a second blood to the first mixture to form a second mixture; after the second mixture is solidified, the solidified second mixture is obtained as an artificial bone piece.
In the embodiment of this application, through in immersing the bone meal in liquid autologous concentrated growth factor, increased the stability of bone grafting, through the blood that adds art district in the mixture to bone meal and liquid autologous concentrated growth factor, realized the rapid solidification of bone meal.
Although the present application has been described with reference to the preferred embodiments, it is not intended to limit the present application, and those skilled in the art can make variations and modifications without departing from the spirit and scope of the present application, therefore, the scope of the present application should be determined by the claims that follow.
In a typical configuration, a computing device includes one or more processors (CPUs), input/output interfaces, network interfaces, and memory.
The memory may include forms of volatile memory in a computer readable medium, Random Access Memory (RAM) and/or non-volatile memory, such as Read Only Memory (ROM) or flash memory (flash RAM). Memory is an example of a computer-readable medium.
Computer-readable media, including both non-transitory and non-transitory, removable and non-removable media, may implement information storage by any method or technology. The information may be computer readable instructions, data structures, modules of a program, or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), Static Random Access Memory (SRAM), Dynamic Random Access Memory (DRAM), other types of Random Access Memory (RAM), Read Only Memory (ROM), Electrically Erasable Programmable Read Only Memory (EEPROM), flash memory or other memory technology, compact disc read only memory (CD-ROM), Digital Versatile Discs (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices, or any other non-transmission medium that can be used to store information that can be accessed by a computing device. As defined herein, computer readable media does not include non-transitory computer readable media (transient media), such as modulated data signals and carrier waves.
Claims (19)
1. The preparation method of the artificial bone block is characterized by comprising the following steps:
drawing venous blood of a patient as first blood to be centrifuged, the patient being a patient to be implanted with the artificial bone mass;
putting the first blood to be centrifuged into a centrifuge for blood centrifugation to obtain a liquid autologous platelet aggregate;
extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates;
immersing the bone meal in the liquid autologous concentrated growth factor to form a first mixture;
adding a second blood to said first mixture to form a second mixture;
obtaining a solidified second mixture as an artificial bone piece after the second mixture is solidified;
wherein the second blood is autologous blood of the surgical area of the patient, and the second blood is blood extracted from the surgical area of the patient where the artificial bone block is to be implanted.
2. The method of claim 1, wherein the extracting liquid autologous concentrated growth factor from the liquid autologous platelet aggregate comprises:
and extracting the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate to be used as a liquid autologous concentrated growth factor for preparing the artificial bone block.
3. The method of preparing an artificial bone block according to claim 1, further comprising:
obtaining the dosage parameter of the bone powder according to the parameter of the artificial bone block to be implanted into the patient;
weighing the bone powder for preparing the artificial bone block according to the dosage parameter of the bone powder;
the bone meal is immersed in the liquid autologous concentrated growth factor, and the method comprises the following steps: and immersing the bone powder for preparing the artificial bone block into the liquid autologous concentrated growth factor.
4. The method of preparing an artificial bone block according to claim 1, further comprising:
obtaining the dosage parameter of the second blood according to the dosage parameter of the bone meal;
and drawing the second blood according to the dosage parameter of the second blood.
5. The method of preparing an artificial bone block according to claim 1, further comprising: and carrying out reshaping treatment on the artificial bone block according to the parameters of the artificial bone block to be implanted into the patient to obtain the reshaped artificial bone block.
6. The method of preparing an artificial bone piece according to claim 1, wherein the artificial bone piece is a bone piece to be implanted in a mouth of a patient.
7. The method of preparing an artificial bone block according to claim 1, wherein the adding of the second blood to the first mixture comprises: adding a second blood to the first mixture for a preset time period after the first mixture is formed.
8. The method of claim 1, wherein the volume of the liquid autologous concentrated growth factor is 0.5 ml.
9. The method of preparing an artificial bone block according to claim 1, wherein the bone powder has a weight of 0.5 g.
10. The method of preparing an artificial bone block according to claim 1, wherein the adding of the second blood to the first mixture comprises: a drop of second blood or two drops of second blood is added to the first mixture using a dropper.
11. An apparatus for preparing an artificial bone block, comprising: a housing, a centrifuge disposed within the housing, a mixture container disposed within the housing;
a blood collection tube inlet for placing a blood collection tube filled with first blood into the centrifuge is formed in the housing;
a second blood injection port for injecting a second blood into the mixture container is provided on the housing, and a second blood transfer tube for transferring the second blood is provided between the second blood injection port and the second blood inlet of the mixture container;
a bone powder injection port for injecting bone powder into the mixture container is arranged on the shell, and a bone powder conveying pipe for conveying the bone powder is arranged between the bone powder injection port and the bone powder inlet of the mixture container;
a liquid autologous concentrated growth factor conveying pipe for conveying liquid autologous concentrated growth factors is arranged between the centrifugal device and the mixture container;
wherein, a blood collection tube filled with first blood to be centrifugally treated is placed into the centrifugal device through the blood collection tube placement opening, bone meal is injected into the mixture container through the bone meal conveying tube, the centrifugal device carries out centrifugal treatment on the first blood to obtain liquid autologous platelet aggregate, liquid autologous concentrated growth factors are extracted from the liquid autologous platelet aggregate, the extracted liquid autologous concentrated growth factors are conveyed into the mixture container through the liquid autologous concentrated growth factor conveying tube, the bone meal in the mixture container is mixed with the liquid autologous concentrated growth factors to form a first mixture, second blood is injected into the mixture container through the second blood conveying tube, and the first mixture is mixed with the second blood to form a second mixture, after the second mixture solidifies, an artificial bone mass is formed.
12. The preparation equipment according to claim 11, wherein a liquid autologous concentrated growth factor detection device and a liquid autologous concentrated growth factor extraction device are arranged in the centrifugal device;
the liquid autologous concentrated growth factor detection device is used for detecting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates after the centrifugation device obtains the liquid autologous platelet aggregates, and sending a liquid autologous concentrated growth factor extraction instruction to the liquid autologous concentrated growth factor extraction device after the liquid autologous concentrated growth factors are detected;
the liquid autologous concentrated growth factor extraction device is used for extracting liquid autologous concentrated growth factors from the liquid autologous platelet aggregates according to the extraction instruction.
13. The preparation device according to claim 12, wherein the liquid autologous concentrated growth factor detection device comprises a first image collector and a first image analyzer;
the first image collector is used for collecting images of liquid autologous platelet aggregates and sending the images of the liquid autologous platelet aggregates to the image analyzer;
the first image analyzer is used for positioning the position of the junction part of the red liquid and the white liquid in the image of the liquid autologous platelet aggregate to obtain positioning information and sending the positioning information to the liquid autologous concentrated growth factor extraction device;
and the liquid autologous concentrated growth factor extraction device extracts the junction part of the red liquid and the white liquid from the liquid autologous platelet aggregate according to the positioning information.
14. The manufacturing apparatus of claim 11, wherein a transmission mechanism for transferring the mixture container out of the housing is further provided within the housing;
the transmission mechanism transfers the mixture container to the outside of the housing after the artificial bone piece is formed.
15. The manufacturing apparatus as set forth in claim 14, wherein an artificial bone block detecting device is provided in the mixture container;
the artificial bone block detection device is used for sending a first transmission instruction for transmitting the mixture container to the outside of the shell to the transmission mechanism after the artificial bone block is detected;
the transmission mechanism is specifically configured to transfer the mixture container out of the housing according to the first transfer instruction.
16. The preparation apparatus according to claim 15, wherein the artificial bone mass detection device comprises a second image collector and a second image analyzer;
the second image collector is used for collecting images in the mixture container and sending the images in the mixture container to the second image analyzer;
the second image analyzer is used for analyzing the image in the mixture container and sending the transmission instruction to the transmission mechanism if the image of the artificial bone block is detected in the image in the mixture container.
17. The manufacturing apparatus of claim 14, wherein the transmission mechanism is further configured to transfer the mixture container into the housing after obtaining a second transfer instruction to transfer the mixture container into the housing.
18. The preparation apparatus as claimed in claim 17, wherein a moving trigger button assembly for triggering movement of the mixture container is provided on the housing;
the movable trigger button assembly is used for responding to the trigger operation of the movable trigger button assembly, judging the position of the mixture container, and sending a second conveying instruction for conveying the mixture container into the shell to the transmission mechanism if the mixture container is outside the shell.
19. The preparation apparatus as claimed in claim 14, wherein a moving trigger button assembly for triggering movement of the mixture container is provided on the housing;
the movable trigger button assembly is used for responding to the trigger operation of the movable trigger button assembly, judging the position of the mixture container, and sending a first transmission instruction for transmitting the mixture container to the outside of the shell to the transmission mechanism if the mixture container is in the shell.
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| CN202111220881.4A CN113855860B (en) | 2021-10-20 | 2021-10-20 | Method and equipment for preparing artificial bone block |
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| CN202111220881.4A CN113855860B (en) | 2021-10-20 | 2021-10-20 | Method and equipment for preparing artificial bone block |
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Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1671662A4 (en) * | 2003-08-27 | 2010-12-15 | Makoto Ogiso | Structural body constituted of biocompatible material impregnated with fine bone dust and process for producing the same |
| US9138509B2 (en) * | 2007-09-14 | 2015-09-22 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
| CN101569762A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Method for preparing quick hemostatic dressing |
| CN102247638A (en) * | 2011-04-12 | 2011-11-23 | 四川大学 | Haemodynamics-based forecast self-adaptive injection device |
| EP2943207B1 (en) * | 2013-01-11 | 2017-10-18 | The Gid Group, Inc. | Method for processing cancellous bone material and related products, methods and uses |
| US9907882B2 (en) * | 2014-04-18 | 2018-03-06 | Warsaw Orthopedic, Inc. | Demineralized bone matrix with improved osteoinductivity |
| CN205626155U (en) * | 2015-12-14 | 2016-10-12 | 广州医科大学附属口腔医院 | Bone meal blending transportation ware |
| CN209317930U (en) * | 2018-12-08 | 2019-08-30 | 广州笛特敏生物科技有限公司 | Centrifuge is used in a kind of separation of rat blood grumeleuse |
| CN211460608U (en) * | 2019-12-06 | 2020-09-11 | 海南医学院 | Bone meal premixing and pressurizing filler for dentistry |
| CN112244008B (en) * | 2020-10-27 | 2021-05-18 | 山东爱瑞达国科医疗科技有限公司 | Preparation of concentrated growth factor kit from umbilical cord blood |
| CN112807132A (en) * | 2021-01-29 | 2021-05-18 | 北京医瑞斯科技有限公司 | Device and method for fusing autologous concentrated growth factors and artificial bone powder |
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