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DE69519921D1 - IMIDAZOLIDINE DERIVATIVES AND THEIR USE - Google Patents

IMIDAZOLIDINE DERIVATIVES AND THEIR USE

Info

Publication number
DE69519921D1
DE69519921D1 DE69519921T DE69519921T DE69519921D1 DE 69519921 D1 DE69519921 D1 DE 69519921D1 DE 69519921 T DE69519921 T DE 69519921T DE 69519921 T DE69519921 T DE 69519921T DE 69519921 D1 DE69519921 D1 DE 69519921D1
Authority
DE
Germany
Prior art keywords
groups
group
alkyl
esterified
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69519921T
Other languages
German (de)
Other versions
DE69519921T2 (en
Inventor
Harukazu Fukami
Motoo Sumida
Shinjiro Niwata
Saki Kakutani
Masayuki Saitoh
Hiroshi Shibata
Yoshinobu Kiso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of DE69519921D1 publication Critical patent/DE69519921D1/en
Publication of DE69519921T2 publication Critical patent/DE69519921T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

The invention relates to an imidazolidine derivative represented by the following general formula (1): <CHEM> wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C1-4 alkyl groups, C1-4 alkoxy groups, C1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.
DE69519921T 1994-07-29 1995-07-26 IMIDAZOLIDINE DERIVATIVES AND THEIR USE Expired - Fee Related DE69519921T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20786794 1994-07-29
JP33370694 1994-12-07
PCT/JP1995/001485 WO1996004248A1 (en) 1994-07-29 1995-07-26 Imidazolidine derivative and use thereof

Publications (2)

Publication Number Publication Date
DE69519921D1 true DE69519921D1 (en) 2001-02-22
DE69519921T2 DE69519921T2 (en) 2001-06-13

Family

ID=26516513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69519921T Expired - Fee Related DE69519921T2 (en) 1994-07-29 1995-07-26 IMIDAZOLIDINE DERIVATIVES AND THEIR USE

Country Status (7)

Country Link
US (1) US5691335A (en)
EP (1) EP0721944B1 (en)
AT (1) ATE198743T1 (en)
AU (1) AU3086095A (en)
DE (1) DE69519921T2 (en)
ES (1) ES2155134T3 (en)
WO (1) WO1996004248A1 (en)

Families Citing this family (42)

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US5912261A (en) * 1994-12-20 1999-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Carboxyalkyl heterocyclic derivatives
US6197806B1 (en) 1995-12-20 2001-03-06 Nippon Zoki Pharmaceutical Co., Ltd. Eliminating agent for activated oxygen and free radicals
JPH10182460A (en) * 1996-12-27 1998-07-07 Nippon Zoki Pharmaceut Co Ltd 3-deoxyglucosone generation inhibitor
US20050267148A1 (en) * 1998-07-15 2005-12-01 Teijin Limited Benzimidazole derivative
KR100903531B1 (en) * 1998-07-15 2009-06-23 데이진 가부시키가이샤 Thiobenzimidazole derivatives
KR100381214B1 (en) * 1998-08-10 2003-09-22 주식회사 엘지생명과학 Imidazolidine-2,4-dione derivatives useful as anticancer agents and preparation method thereof
KR20010074838A (en) * 1998-08-20 2001-08-09 요시다 쇼지 Preventives or remedies for eye circulatory failure
HUP0103387A3 (en) * 1998-08-21 2002-07-29 Daiichi Asubio Pharma Co Ltd Quinazoline derivatives preparation thereof, medicament containing them and their intermediates
AU754989B2 (en) 1998-11-16 2002-11-28 Nippon Zoki Pharmaceutical Co., Ltd. A therapeutic agent for intractable vasculitis
EP1136488A4 (en) * 1998-12-01 2002-06-12 Meiji Seika Kaisha Sf2809-i, ii, iii, iv, v and vi substances exhibiting chymase-inhibiting activities
WO2001030388A1 (en) * 1999-10-25 2001-05-03 Senju Pharmaceutical Co., Ltd. Tension-relieving agents for ciliary muscle
KR20010100004A (en) 1999-11-01 2001-11-09 도리이 신이치로 Inhibitors against vascular lipid deposition containing chymase-inhibiting substances
US6300503B1 (en) * 1999-12-17 2001-10-09 Dixie Chemical Company Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same
AU3413501A (en) 2000-02-22 2001-09-03 Daiichi Asubio Pharma Co., Ltd. Preventive or therapeutic drugs for various eosinophilia-related diseases containing chymase inhibitors as the active ingredient
US6500835B2 (en) 2000-02-22 2002-12-31 Suntory Limited Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient
KR20010109356A (en) * 2000-02-22 2001-12-08 도리이 신이치로 Preventive or therapeutic drugs for dermatitises containing chymase inhibitors as the active ingredient
JP4711523B2 (en) 2001-02-13 2011-06-29 日本臓器製薬株式会社 Hypoalbuminemia improving agent
US6919365B2 (en) * 2001-04-11 2005-07-19 Senju Pharmaceutical Co., Ltd. Imidazolidinedione derivatives and use thereof as drugs
RU2005105340A (en) * 2002-07-30 2005-07-20 Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик, С.А.С. (Fr) APPLICATION OF CHEMISE INHIBITORS FOR PREVENTION OR TREATMENT OF DAMAGE TO ARTIOVENOUS IMPLANTS
FR2845383B1 (en) * 2002-10-04 2004-12-31 Fournier Lab Sa COMPOUNDS DERIVED FROM 2-THIOHYDANTOIN AND THEIR USE IN THERAPEUTICS
FR2845384B1 (en) * 2002-10-04 2004-12-31 Fournier Lab Sa COMPOUNDS DERIVED FROM 2-THIOHYDANTOIN AND THEIR USE IN THERAPEUTICS
JP2006510600A (en) * 2002-10-04 2006-03-30 ラボラトワール フルニエ エス・アー Compounds derived from 2-thiohydantoin and their use in therapy
US20060217421A1 (en) 2003-05-09 2006-09-28 Hajimu Kurumatani Fortifier
US7361767B2 (en) * 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7423155B2 (en) 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
CA2550447A1 (en) 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en) 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7544756B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
SI2368550T1 (en) 2006-03-27 2013-11-29 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
MX2008012492A (en) 2006-03-29 2008-12-12 Univ California Diarylthiohydantoin compounds.
JP5535925B2 (en) 2007-10-26 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Diarylhydantoin compounds as androgen receptor modulators
JP5587914B2 (en) 2009-01-30 2014-09-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Azaquinazolinediones useful as chymase inhibitors
DK3124481T3 (en) 2010-02-16 2018-05-07 Aragon Pharmaceuticals Inc ANDROGEN RECEPTOR MODULATORS AND APPLICATIONS THEREOF
IL312316A (en) 2012-09-26 2024-06-01 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (en) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc Androgen receptor modulator and uses thereof
CN105873919A (en) * 2013-11-08 2016-08-17 拜耳医药股份有限公司 Substituted uracils as chymase inhibitors
TWI726969B (en) 2016-01-11 2021-05-11 比利時商健生藥品公司 Substituted thiohydantoin derivatives as androgen receptor antagonists
KR102384668B1 (en) * 2016-06-14 2022-04-07 브리스톨-마이어스 스큅 컴퍼니 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonist
ES2844184T3 (en) * 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hydroxy-3-sulfonylpyridine-2 (1H) -ones as APJ receptor agonists
WO2019023448A1 (en) * 2017-07-26 2019-01-31 Emory University Nadph oxidase inhibitors and uses thereof
KR20200070334A (en) 2017-10-16 2020-06-17 아라곤 파마슈티컬스, 인코포레이티드 Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1207391B (en) * 1962-05-30 1965-12-23 Degussa Process for the preparation of 3-benzoyl-5, 5-dimethylhydantoins
US4166124A (en) * 1970-05-15 1979-08-28 U.S. Philips Corporation Insecticidal 2,6-dihalobenzoyl urea derivatives
JPS5371073A (en) * 1976-12-03 1978-06-24 Sumitomo Chem Co Ltd 1-cyclic alkyl carbonyl-3(3,5-dihalogenophenyl)hydantoin derivs., process fo r their preparation and fungicides for agriculture and horti culture contg. the same as active constituents
JPS5855468A (en) * 1981-09-25 1983-04-01 Sumitomo Chem Co Ltd 5-chlorohydantoin derivative, its preparation and insecticide containing said derivative as active component
US4474796A (en) * 1983-02-04 1984-10-02 Sumitomo Chemical Company, Limited Insecticidal substituted hydantoins
JPH068281B2 (en) * 1985-09-19 1994-02-02 持田製薬株式会社 Hydantoin derivative and aldo-reductase inhibitor containing the same as active ingredient

Also Published As

Publication number Publication date
EP0721944A1 (en) 1996-07-17
AU3086095A (en) 1996-03-04
US5691335A (en) 1997-11-25
DE69519921T2 (en) 2001-06-13
ATE198743T1 (en) 2001-02-15
EP0721944A4 (en) 1997-01-02
ES2155134T3 (en) 2001-05-01
EP0721944B1 (en) 2001-01-17
WO1996004248A1 (en) 1996-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAICHI SUNTORY PHARMA CO., LTD., TOKIO/TOKYO, JP

8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI ASUBIO PHARMA CO., LTD., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee