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GB2550139B - Functional prediction of MSCs - Google Patents

Functional prediction of MSCs Download PDF

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Publication number
GB2550139B
GB2550139B GB1608086.3A GB201608086A GB2550139B GB 2550139 B GB2550139 B GB 2550139B GB 201608086 A GB201608086 A GB 201608086A GB 2550139 B GB2550139 B GB 2550139B
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United Kingdom
Prior art keywords
mscs
functional prediction
prediction
functional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1608086.3A
Other versions
GB2550139A (en
GB201608086D0 (en
Inventor
J Mallinson David
R Dunbar Donald
M Gourlay Elaine
Olijnyk-Dallis Daria
O Reid Jim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sistemic Scotland Ltd
Original Assignee
Sistemic Scotland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sistemic Scotland Ltd filed Critical Sistemic Scotland Ltd
Priority to GB1608086.3A priority Critical patent/GB2550139B/en
Publication of GB201608086D0 publication Critical patent/GB201608086D0/en
Priority to EP17722445.8A priority patent/EP3455367A1/en
Priority to CA3062963A priority patent/CA3062963A1/en
Priority to SG11201809902QA priority patent/SG11201809902QA/en
Priority to US16/300,249 priority patent/US11266687B2/en
Priority to PCT/EP2017/061096 priority patent/WO2017194561A1/en
Publication of GB2550139A publication Critical patent/GB2550139A/en
Priority to IL262884A priority patent/IL262884A/en
Application granted granted Critical
Publication of GB2550139B publication Critical patent/GB2550139B/en
Priority to US17/669,675 priority patent/US20220160774A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
GB1608086.3A 2016-05-09 2016-05-09 Functional prediction of MSCs Active GB2550139B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GB1608086.3A GB2550139B (en) 2016-05-09 2016-05-09 Functional prediction of MSCs
US16/300,249 US11266687B2 (en) 2016-05-09 2017-05-09 Functional prediction of cellular functions by means of microRNA expression profiling in mesenchymal stem cells
CA3062963A CA3062963A1 (en) 2016-05-09 2017-05-09 Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
SG11201809902QA SG11201809902QA (en) 2016-05-09 2017-05-09 Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
EP17722445.8A EP3455367A1 (en) 2016-05-09 2017-05-09 Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
PCT/EP2017/061096 WO2017194561A1 (en) 2016-05-09 2017-05-09 Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
IL262884A IL262884A (en) 2016-05-09 2018-11-08 Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
US17/669,675 US20220160774A1 (en) 2016-05-09 2022-02-11 Functional prediction of cellular functions by means of microrna expresssion profiling in mesenchymal stem cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1608086.3A GB2550139B (en) 2016-05-09 2016-05-09 Functional prediction of MSCs

Publications (3)

Publication Number Publication Date
GB201608086D0 GB201608086D0 (en) 2016-06-22
GB2550139A GB2550139A (en) 2017-11-15
GB2550139B true GB2550139B (en) 2020-07-29

Family

ID=56297386

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1608086.3A Active GB2550139B (en) 2016-05-09 2016-05-09 Functional prediction of MSCs

Country Status (1)

Country Link
GB (1) GB2550139B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113490503A (en) * 2019-05-21 2021-10-08 艾默生物医学股份有限公司 Use of mesenchymal stem cells for treating immune-related diseases
CN112053750A (en) * 2020-09-02 2020-12-08 成都域时信息科技有限公司 Method for quantitatively predicting cartilage repair rate after mesenchymal stem cell therapy based on machine learning of block chain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157678A2 (en) * 2014-04-10 2015-10-15 The Trustees Of The University Of Pennsylvania Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157678A2 (en) * 2014-04-10 2015-10-15 The Trustees Of The University Of Pennsylvania Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Blood, vol.124(21), 2014, Zhao et al, "Circulating mir-153 participates in occurrence of acute graft-versus-host disease..." *
Gastroenterology, Vol. 148(4) suppl. 1, Oikonomopoulos et al, "Inhibition of microRNA-29a in human bone marrow mesenchymal stem cells increases their immunomodulatory function", S723 *
Gastroenterology, vol. 150(4) suppl. 1, 2016, Oikonomopoulos et al, "IFN-gamma regulates the immunosuppressive properties of bone marrow mesenchymal stem cells in a microRNA-29a/STAT-3 dependent manner", S359 *
Haematologics vol. 99(s1) 2014, Zhao, "Circulating mir-586 participates in occurrence of acute graft-versus host disease..." S1365 *
PLOS one, vol. 8(4), 2013, Chen et al, "Identification of miR-27b as a novel signature..."e60492, available from doi:10.1371/journal.pone.0060492 *
Stem cells vol. 30, 2012, Liu et al, "MicroRNA-181a regulates local immune balance..." pages 1756-1770 *

Also Published As

Publication number Publication date
GB2550139A (en) 2017-11-15
GB201608086D0 (en) 2016-06-22

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