JP2003225298A - Adhesive plaster - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an adhesive plaster which has excellent safety and can speed up the healing of a skin lesion region by having an action for accelerating the regeneration of the skin lesion region. <P>SOLUTION: This adhesive plaster is characterized in that a wound covering layer containing a hydrolytic shell membrane is provided on backing. Representative examples of the adhesive plaster are a poultice type adhesive plaster in which a layer of a hydrous gel paste containing the hydrolytic shell membrane is provided on the backing, and an adhesive plaster (a first-aid adhesive tape) in which a pad material undergoing impregnation with an adhesion of the hydrolytic shell membrane is stuck on the backing composed of a self-adhesive film and a self-adhesive sheet. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a plaster containing a hydrolyzed eggshell membrane in a wound covering part. The adhesive bandage of the present invention, the hydrolyzed eggshell membrane contained in the wound covering part has a regeneration promoting action on damaged skin, and also has an action to alleviate inflammation, so that the healing of damaged skin is promptly performed. Done.

[0002]

BACKGROUND OF THE INVENTION Human skin consists of a superficial epithelial layer and an underlying connective tissue dermis layer. The protein constituting the epithelial layer is mainly keratin, which has a protective effect on the skin, and the melanin (pigment) contained in the epithelial layer has a protective effect against ultraviolet rays. on the other hand,
The protein that constitutes the dermis layer is mainly collagen, and other components are elastin, albumin, globulin, and mucin. Damage to the skin due to injury,
When the damage reaches the dermis layer, the collagen constituting the dermis layer is also cut and destroyed.

[0003] First aid bandages in which a non-woven pad material is attached to an adhesive support have been widely used.
However, the conventional adhesive bandage is mainly used for protecting the damaged part, and the adhesive bandage itself has a low action of promoting the regeneration of the damaged part of the skin. From this point of view, there is a demand for a bandage that protects a skin-damaged part and promotes its regeneration to heal a wound early. If the area of skin damage is large or the degree of damage is large,
An adhesive bandage (so-called poultice type adhesive bandage) in which a hydrous gel plaster layer containing a medicinal component is provided on a support is used, but even in such an adhesive type patch adhesive bandage, regeneration of damaged skin is possible. There is a need for something that can promote wound healing and heal wounds early.

The eggshell membrane is a membrane located inside the eggshell of the eggs of birds such as chicken eggs, and consists of two inner and outer shells. The outer eggshell membrane adheres to the inner surface of the eggshell, and the inner eggshell membrane wraps the egg white. The eggshell membrane is composed of a tough fibrous protein, and is mainly composed of opokeratin and opomesin. It is reported that the eggshell membrane has a function of promoting the regeneration of the skin, but the eggshell membrane is insoluble in water, so that it is difficult to impregnate the pad material of the first-aid bandage, and also the type of poultice type. Even in a bandage, it is difficult to make it uniformly contained in the hydrous gel plaster layer.

[0005]

DISCLOSURE OF THE INVENTION An object of the present invention is to provide a bandage that not only protects a damaged part of the skin but also promotes regeneration of the damaged skin and can heal the wound early. That is.

[0006]

[Means for Solving the Problems] In order to achieve the above object, the present inventor has conducted extensive studies. As a result, they have found that a hydrolyzate of eggshell membranes (hydrolyzed eggshell membranes) has an excellent skin regeneration promoting action even after hydrolysis and an inflammation relieving action. Furthermore, since the hydrolyzed eggshell membrane is water-soluble, the present inventor can easily impregnate and attach it to a pad material of an emergency adhesive bandage forming a wound covering layer in the form of an aqueous solution or the like, and a patch type adhesive bandage. It was found that it can be evenly mixed in the hydrous gel plaster of, thereby providing a bandage that has not only a protective effect on the damaged part but also a regeneration promoting effect on damaged skin, and based on these findings, Completed the invention.

That is, the present invention is (1) a bandage characterized in that a wound covering layer containing a hydrolyzed eggshell membrane is provided on a support.

According to the present invention, (2) the wound dressing layer is a layer composed of a hydrous gel plaster containing a hydrolyzed eggshell membrane; (3) the hydrous gel plaster;
(2) The adhesive plaster of (2) which is an acryl-based hydrogel plaster; and (4) (2) or which contains a hydrolyzed eggshell membrane in a proportion of 0.5% by mass or more based on the mass of the hydrogel gel. It is a bandage of (3).

The present invention further provides (5) the bandage according to the above (1), wherein the wound coating layer is a layer made of a bad material which is obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying the wound coating layer;
And (6) the adhesive plaster according to (5) above, wherein the concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane impregnated in the pad material is 2 to 20% by mass.

The present invention also provides (7) a wound coating layer comprising a film-forming agent, a bactericidal agent, an anti-inflammatory / analgesic agent, a fragrance, a cooling agent,
The adhesive plaster according to any of (1) to (6) above, further containing one or more of a moisturizer, an antiseptic, and a vitamin.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below. The hydrolyzed eggshell membrane used in the present invention is obtained by hydrolyzing a membrane (outer eggshell membrane and / or inner eggshell membrane) inside the eggshell of an avian egg with a proteolytic enzyme, acid, alkali or the like. In the present invention, a water-soluble or water-dispersible hydrolyzed egg shell membrane is preferably used as the hydrolyzed egg shell membrane, and specific examples thereof include "EM Protein" manufactured by Kewpie Co., Ltd. Name) etc. can be mentioned.

The present invention includes any of the plasters in which a wound coating layer containing a hydrolyzed eggshell membrane is provided on a support. Among them, as a representative of the adhesive bandage of the present invention, (A) an adhesive bandage (a so-called poultice type adhesive bandage) in which a layer made of a hydrous gel shell containing a hydrolyzed eggshell membrane is provided as a wound covering layer on a support (Hereinafter, this may be referred to as "Band plaster A"); and (B) A bandage in which a pad material, which is obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying, is provided as a wound covering layer on the support. (A so-called first-aid bandage type) (hereinafter, this may be referred to as "a bandage B");

Therefore, first, the adhesive plaster A will be described. The adhesive bandage A is a hydrogel shell containing a hydrolyzed eggshell membrane applied in layers on a support to form a wound coating layer, and the surface thereof may be releasable from a film or sheet (eg, polyethylene film) if necessary. Etc.). When the adhesive bandage A is used, the releasable film or sheet covering the surface of the adhesive bandage A is peeled off, and the hydrous gel shell layer containing the hydrolyzed eggshell membrane (wound covering layer) is used as in the case of various conventionally known poultices. ) Is used by abutting and affixing to the damaged part.

As the hydrous gel plaster forming the wound covering layer in the plaster A, any hydrous gel plaster conventionally used in so-called poultices (puppo type adhesive plasters) can be used. , Polyacrylic acid, acrylic hydrogel mainly composed of water-soluble acrylic polymer such as sodium polyacrylate, hydrogel gel mainly composed of cellulose derivative such as sodium carboxymethyl cellulose, and mainly sodium alginate Examples thereof include a hydrated gel plaster, a hydrated gel plaster mainly containing gelatin, and a hydrated gel plaster obtained by blending polyvinyl alcohol with a superabsorbent polymer compound and / or a hydrophilic polymer compound. Among them, in the adhesive plaster A, an acrylic hydrogel plaster is preferably used as the hydrogel plaster. The water content of the hydrous gel plaster constituting the wound coating layer of the adhesive bandage A can be appropriately adjusted according to the type of the hydrous gel plaster, the application of the adhesive bandage A, and the like.
Generally, the water content of the hydrogel plaster is preferably 50% by mass or more.

As the support for the adhesive bandage A,
Any support can be used as long as it is a support conventionally used in so-called poultices (poultice type plasters), for example, non-woven fabric, woven fabric, knitted fabric, paper, plastic film, two or more of the above-mentioned materials. Examples thereof include a laminated sheet combined with each other.

The content of the hydrolyzed eggshell membrane in the hydrous gel plaster constituting the wound covering layer can be adjusted according to the application of the adhesive bandage A, etc. Based on the total weight of the hydrous gel plaster, 0.5% by mass or more is preferable from the viewpoint of the effect of promoting regeneration of the damaged part of the skin, etc., and is 2 to 30% by mass, particularly 8 to 15% by mass. It is more preferable from the viewpoints of the effect of promoting regeneration of a damaged skin portion, cost, feeling of use and the like.

The water-containing gel plaster layer constituting the wound covering layer of the adhesive bandage A is, in addition to the hydrolyzed eggshell membrane, if necessary, a film-forming agent, a bactericidal agent, an anti-inflammatory / analgesic agent, other medicinal ingredients, a fragrance, It may contain one or more of other components such as a cooling agent, a moisturizing agent, an antiseptic, a vitamin and a coloring agent. Examples of the film-forming agent include, but are not limited to, carboxymethyl chitin and other organic polymers, and examples of the bactericidal agent include acrinol, benzethonium chloride, and benzalkonium chloride. Can be mentioned. In addition, as an anti-inflammatory / analgesic agent, for example,
Dipotassium glycyrrhizinate, hydrocortisone acetate,
Lidocaine hydrochloride and the like can be mentioned. Further, examples of the moisturizer include polyhydric alcohols such as butylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, propanediol, glycerin, maltitol, and xylitol.

The amount of the water-containing gel plaster layer applied to the plaster A is not particularly limited, but in general, the support is 100 cm.
^The amount of hydrogel plaster applied per ² is about 5 to 20 g,
Particularly, about 8 to 15 g is preferable from the viewpoints of ease of production of the adhesive plaster A, handleability of the adhesive plaster A, effect of promoting regeneration on a skin-damaged part, cost, and feeling of use.

The method for producing the adhesive plaster A is not particularly limited, and the adhesive plaster A can be produced by the same method as has been conventionally used for a plaster type adhesive plaster. For example, it can be formed by applying a hydrolyzed eggshell membrane and a hydrous gel plaster containing other components as necessary on a support with a spray coating device, a roll coater or the like. When the water content of the hydrous gel plaster layer in the adhesive plaster A produced thereby is a predetermined value, the surface of the hydrous gel plaster layer is released as it is without performing a drying treatment. It may be covered with a flexible film or the like and then wrapped with an appropriate packaging material. Further, when the water content of the hydrous gel plaster layer in the adhesive bandage A produced above is higher than a predetermined value, the surface of the hydrous gel plaster layer is optionally dried after drying to a predetermined water content. It may be covered with a releasable film or the like and then wrapped with an appropriate packaging material.

Since the adhesive bandage A of the present invention obtained above contains a hydrolyzed eggshell membrane having a skin regeneration promoting action in the hydrous gel plaster layer forming the wound covering layer, it can regenerate damaged skin. It can promote and heal wounds early. In addition, since the hydrolyzed eggshell membrane contained in the hydrous gel plaster layer also has an action of relieving inflammation, it is possible to relieve the inflammation of the damaged skin portion and promote the regeneration of the skin.

Next, the plaster B of the present invention will be described.
Adhesive bandage B is obtained by impregnating a pad material with a liquid containing a hydrolyzed eggshell membrane and then drying it, and pasting it onto an adhesive support, which is typically called a wound tape or the like. The first-aid bandages are available.

The liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated may be any liquid that is safe after drying. For example, an aqueous solution or aqueous dispersion containing the hydrolyzed eggshell membrane or a hydrolyzed eggshell membrane may be used. Examples thereof include a solution or dispersion of a mixed solvent of water and alcohol contained therein, and among them, an aqueous solution containing a hydrolyzed eggshell membrane is preferable. The concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated can be appropriately adjusted, but is generally about 2 to 20% by mass, particularly about 8 to 15% by mass. However, it is preferable from the viewpoints of the effect of promoting regeneration of the damaged part of the skin, cost, feeling of use, and the like. Further, the impregnation amount of the liquid containing the hydrolyzed eggshell membrane into the pad material can be adjusted according to the type of pad material, the bulk density, the thickness, the use of the bandage B, etc.
Generally, it is 100 with respect to the mass of the pad material before impregnation.
It is preferable that the content is from about 500% by mass from the viewpoint of the skin regenerating effect of the adhesive bandage B, cost, and feeling of use.

The liquid containing the hydrolyzed eggshell membrane with which the pad material is impregnated is, together with the hydrolyzed eggshell membrane, a film-forming agent, a bactericide, an antiphlogistic / analgesic, other medicinal ingredients, a fragrance, and a cooling agent, if necessary. One or more of other components such as agents, moisturizers, preservatives, vitamins, coloring agents and the like can be contained. As the other components, for example, those similar to those mentioned above in the case of the adhesive bandage A can be used.

The type and form of the pad material is not particularly limited, and the same material as that conventionally used in a first aid bandage can be used.
Examples thereof include paper, woven fabric, and knitted fabric, and among them, nonwoven fabric or paper is preferable because it is excellent in impregnation property and retention property of the liquid containing the hydrolyzed eggshell membrane. The thickness of the pad material is not particularly limited, and may be the same as that in a conventional first-aid bandage, etc., and generally 0.2 to 1.5.
A thickness of about mm, particularly about 0.2 to 1.0 mm is preferably adopted.

Next, the pad material impregnated with the liquid containing the hydrolyzed eggshell membrane is dried. The drying method and conditions are not particularly limited, and any drying method and conditions that do not cause modification or alteration of the pad material and the components impregnated therein may be used. The dried pad material containing the hydrolyzed eggshell membrane is cut into an appropriate size and attached to the adhesive surface of an adhesive sheet or an adhesive film forming a support. The pad material containing the hydrolyzed eggshell membrane may be directly stuck on the support, but in order to prevent the pad material from adhering to the skin damage part, the surface of the pad material (at least the skin of the pad material It is preferable that the contacting surface portion) is covered with a releasable mesh body (mesh-shaped film or the like) and then attached to a support made of an adhesive sheet or an adhesive film. If the pad material of the adhesive bandage B adheres to the skin damage part, when the adhesive bandage B is peeled off, the surface part of the skin damage part will be peeled off while sticking to the pad material, and the skin part that is healing at all It is not desirable because it will be damaged. The type of the releasable mesh body that covers the surface of the pad material is not particularly limited, and the same releasable mesh body that has been conventionally used for covering the pad material such as the first aid bandage can be used. .

The type and form of the support to which the pad material containing the hydrolyzed eggshell membrane, preferably the pad material covered with the releasable mesh, is attached is not particularly limited, and it is used in conventional first-aid bandages and the like. It is possible to use an adhesive sheet or an adhesive film based on a flexible plastic sheet or film, which is similar to that described above. As in the case of conventional first-aid bandages, it is preferable that the support be provided with a large number of small holes for ventilation.

If necessary, the surface of the adhesive bandage B obtained above may be covered with a release paper or a release film as in the case of a conventional first-aid bandage, and then wrapped. The adhesive bandage B of the present invention is characterized in that the pad material contacted with the skin-damaged part contains a hydrolyzed eggshell membrane that promotes skin regeneration.
It can promote the regeneration of damaged skin and heal wounds early. Moreover, since the hydrolyzed eggshell membrane contained in the pad material also has an action of relieving inflammation, it is possible to relieve the inflammation of the skin-damaged part and promote the regeneration of the skin.

[0028]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples.

Example 1 (1) After mixing the components shown in Table 1 below, the mixture was sufficiently stirred at room temperature (15 minutes) to prepare a hydrogel plaster.

[0030]

[Table 1]

(2) The hydrous gel plaster containing the hydrolyzed eggshell membrane obtained in (1) above was applied onto a nonwoven fabric (width 50 cm, basis weight 200 g / m ² ) 10 using a roll coater.
After coating with a coating amount of g / 100 cm ^2, the surface of the water-containing gel plaster layer is covered with a polyethylene release film, and length × width =
The adhesive bandage A of the present invention was manufactured by cutting into a size of 15 cm × 10 cm.

Example 2 (1) The components shown in Table 2 below were mixed to prepare an aqueous solution containing a hydrolyzed eggshell membrane.

[0033]

[Table 2]

(2) The aqueous solution containing the hydrolyzed eggshell membrane obtained in (1) above is treated with a cellulose nonwoven fabric (paper).
(Thickness 0.3 mm, width 50 cm, basis weight 120 g / m ² )
Was applied and impregnated at a rate of 2.5 g per 100 cm ² of the nonwoven fabric, and then dried at 105 ° C. (3) After cutting the dried nonwoven fabric containing the hydrolyzed eggshell membrane obtained in (2) above to a width of 1 cm, the cut nonwoven fabric is covered (wrapped) with a releasable mesh sheet, and then the length thereof is adjusted. The pad material (width x length = 1 cm x 2 cm) containing a hydrolyzed eggshell membrane was produced by cutting into 2 cm. (4) The pad material obtained in (3) above is used as a support (flexible plastic film having a pressure-sensitive adhesive layer on one surface) provided with a large number of small holes for ventilation (width × length = 1.5 cm).
(7 cm) was attached and attached to the central portion of the adhesive layer side, and then the adhesive surface side was covered with release paper in the same manner as a conventional first-aid bandage to produce adhesive bandage B.

Comparative Example 1 Using the same components as in Example 2 except that the hydrolyzed egg shell membrane was not used, the same procedure as in Example 2 was carried out, and the pad material portion contained the hydrolyzed egg shell membrane. Made a non-adhesive plaster.

<Test Example 1> Ten adult males were used as test subjects, and two scratches were formed on the inside of the lower arm of each test subject using a paper file to lightly rub to the extent that blood was blotted to form a wound,
The adhesive bandage B produced in Example 2 was applied to one of the wounds, and the adhesive bandage produced in Comparative Example 1 was applied to the other wound and left as it was for 5 days. After 5 days, both bandages were peeled off, the healing state of the wound was visually observed, and the corresponding number of people was examined according to the evaluation criteria shown in Table 3 below. The results are shown in Table 4 below.

[0037]

[Table 3]

[0038]

[Table 4]

As can be seen from the results shown in Table 4 above, the adhesive plaster of Example 2 of the present invention containing a hydrolyzed eggshell membrane in the wound covering layer (pad material) has the action of promoting regeneration of the damaged skin area. In comparison with the adhesive plaster of Comparative Example 1 in which the pad material portion does not contain a hydrolyzed eggshell membrane, it has an effect of accelerating wound healing.

[0040]

INDUSTRIAL APPLICABILITY Since the hydrolyzed eggshell membrane contained in the wound covering layer has the action of promoting the regeneration of damaged skin and the action of alleviating inflammation, the bandage of the present invention is not damaged. Can promote healing of the skin. Since the hydrolyzed eggshell membrane used in the adhesive bandage of the present invention is derived from the edible eggshell membrane, the adhesive bandage of the present invention is also excellent in safety.

Claims (7)

[Claims] 1. A bandage comprising a support and a wound covering layer containing a hydrolyzed eggshell membrane. 2. The plaster according to claim 1, wherein the wound covering layer is a layer made of a hydrogel plaster containing a hydrolyzed eggshell membrane. 3. The adhesive plaster according to claim 2, wherein the hydrous gel plaster is an acrylic hydrogel plaster. 4. The adhesive plaster according to claim 2, which contains the hydrolyzed egg shell membrane in a proportion of 0.5% by mass or more based on the mass of the hydrous gel plaster. 5. The plaster according to claim 1, wherein the wound covering layer is a layer made of a bad material obtained by impregnating a liquid containing a hydrolyzed eggshell membrane and then drying. 6. The concentration of the hydrolyzed eggshell membrane in the liquid containing the hydrolyzed eggshell membrane impregnated in the pad material is 2 to 20% by mass.
The adhesive bandage according to claim 5. 7. A wound coating layer comprising a film-forming agent, a bactericidal agent, and an anti-inflammatory agent.
The method according to claim 1, further comprising one or more of analgesics, fragrances, cooling agents, moisturizers, preservatives and vitamins.
The adhesive plaster according to any one of 1 to 6.