JP2958366B2 - Stratum corneum removal detection device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a medical device such as a blood glucose measuring device,
The present invention relates to a stratum corneum removal detecting device that detects a state of stratum corneum removal performed prior to setting a body fluid extraction suction cell in a human body.

[Summary of the Invention]

The present invention, in the stratum corneum removal detection device, at least a pair of electrodes are arranged on the suction cell for bodily fluid extraction, and in a state where the pair of electrodes is in contact with the human body, a measuring means for measuring a resistance value between the two electrodes and By providing a display means for displaying the measurement result, the degree of removal of the stratum corneum can be easily detected by a change in the resistance value between the two electrodes, and the workability can be improved.

[Conventional technology]

Conventionally, blood glucose has been measured by directly collecting blood from the human body and examining it.

As a simple blood glucose meter, for example, a method is used in which a needle is punctured with a finger of a human body to make a wound, a small amount of blood adhered to the needle is transferred to a test paper, and a blood glucose level is measured from the blood adhered to the test paper. Has been adopted.

This simple blood glucose meter can measure subtle changes in blood glucose as compared to a urinary glucose test, and is used daily by many patients who need insulin injections. However, collecting blood by piercing the needle in this manner is performed by so-called invasion that causes pain to the subject. Also, for regular inspection after every meal or every 30 minutes,
For example, there is a problem in that the skin of the test site, for example, the skin of the fingertip is hardened or roughened, and the subject is significantly distressed.

On the other hand, there has been proposed a method of measuring a blood glucose level by collecting a body fluid and measuring a glucose level thereof without collecting blood. Since the glucose level of the body fluid has a correspondence with the blood glucose level of the blood, it is possible to easily measure the blood glucose level by collecting a small amount of the body fluid.

In the case of this method, for example, a part of the skin of the subject is removed to expose the dermis by removing a part of the stratum corneum, and when the suction is performed by, for example, contacting a funnel-shaped suction cell, the body fluid exudes. The blood glucose level is measured by collecting the sample and measuring the glucose level of oxygen contained therein.

Conventionally, the degree of removal of the stratum corneum has been judged visually based on the sense of the measurer. For this reason, when the stratum corneum is not sufficiently removed, it is difficult to obtain a body fluid, and it may take a long time to extract the body fluid or a large suction force, which may cause pain to the subject. In addition, if the dermis is also removed when removing the stratum corneum, the stratum corneum will be damaged during suction by the suction cell, damaging the capillaries, blood will be mixed into the body fluid, causing measurement failure, In addition, there was a problem of giving pain to the subject.

[Problems to be solved by the invention]

In order to solve the above-mentioned problem, the present invention performs detection and measurement of the quality of the removal of the stratum corneum to ensure the measurement of the blood sugar level and the like.

[Means for solving the problem]

A stratum corneum removal detecting device according to the present invention is shown in the block diagram of FIG.

In the present invention, as shown in FIG. 1, at least a pair of electrodes (2) is arranged in a body fluid extraction suction cell (1) in a stratum corneum removal detecting device (20), and the pair of electrodes (2) is It comprises a measuring means (3) for measuring a resistance value between the two electrodes (2) in a state of being in contact with a human body, and a display means (8) for displaying the measurement result.

[Action]

The above-described stratum corneum removal detection device (20) according to the present invention includes:
The electrode (2) is brought into contact with the human body with the suction cell (1) for extracting body fluid, and the resistance between the electrodes (2) is measured by the measuring means (3) to measure the resistance of the skin of the subject.

That is, in general, the electrical resistance value of the skin is about 1 to 5 MΩ on the stratum corneum, and this resistance value is about 1/100 or less on the dermis surface after removing the stratum corneum. After the removal operation, if the resistance value is measured by the device (20) of the present invention, it can be determined whether or not the stratum corneum has been removed based on the change in the resistance value.

Further, when the dermis surface is damaged, the resistance value is remarkably reduced, so that it is possible to judge the excessive removal of the stratum corneum, and it is possible to reliably measure the blood sugar level and the like.

〔Example〕

Hereinafter, a stratum corneum removal detecting device (20) according to the present invention will be described as a first example.
This will be described in detail with reference to the block diagram of FIG.

In FIG. 1, (1) is a schematic sectional view of a suction cell for bodily fluid extraction, for example, a flat funnel shape, a tube (11) connected to one narrow opening, and another wide opening. Is the contact surface (1A) with the skin. Then, for example, a pair of electrodes (2) is arranged in the body fluid extraction suction cell (1) such that the end surface (2A) faces substantially the same plane as the contact surface (1A). The resistance value between the electrodes (2) is measured by the measuring means (3). In the measuring means (3), for example, a resistance value between the electrodes (2) is detected by a bridge circuit (4) having a built-in DC power supply, and the electrical output is used as an analog / digital converter (hereinafter, A / D converter). (5)
A / D conversion is performed, and input to a central processing unit (hereinafter referred to as CPU) (6).

The CPU (6) stores a program (ROM) for performing a measurement operation to be described later (read only memory) (9)
And a RAM (random access memory) (10) for temporarily storing measured values. The output from the CPU (6) is digitally displayed on the display means (8) by the drive circuit (7). .

The stratum corneum removal detection device (2
An example of the measurement procedure 0) will be described in detail with reference to the flowcharts of FIGS.

For example, as shown in FIG. 2A, a body fluid extraction suction cell (1) is placed at the position of the skin test site where the keratin removal process is performed, and first, the electric resistance value on the skin before the removal of the keratin layer is measured. Measured by means (3). Since the electric resistance value on the skin changes depending on the mounted state, that is, the degree of pressing on the skin, in this case, the measurement is performed in a state where only the mounting is performed and suction is not performed.

As shown in FIG.
Store it in M (10).

Thereafter, as shown in FIG. 2C, the stratum corneum was removed from the test portion, and as shown in FIG. 2D, the resistance was set again with the body fluid extraction suction cell (1) placed on the test portion. Measure the value.

Then, as shown in FIG.
Is compared with the stored initial value, a logarithmic difference between the initial value and the measured value is calculated, for example, and a plurality of LEDs provided on the display means (8) are provided by the driving circuit (7). The degree of exfoliation of the stratum corneum due to a change in resistance value, for example, pass / fail is displayed externally according to the number of light emission of the (light emitting element).

With this display, as shown in FIG. 2F, the stratum corneum is removed again, or the stratum corneum removal detection is terminated, and the blood glucose level is measured by the body fluid extraction suction cell (1).

In this way, it is possible to reliably measure the degree of the removal of the stratum corneum without depending on the senses such as the visual observation of the measurer.

In the above-described example, the case where the body fluid extraction suction cell (1) is placed on the test part is described.
May be fixed in a state of being pressed on the skin, and the resistance value may be measured.

In the above example, first, the electrical resistance value on the stratum corneum is measured and set as an initial value, and this is compared with the electrical resistance value after the removal of the stratum corneum, and the degree of removal of the stratum corneum is observed. Because there is an individual difference in the electric resistance value on the skin, it is possible to make a more accurate judgment of the stratum corneum removal by such a relative comparison. In this case, various other program modes can be adopted, such as measuring the initial value only at the first time and then performing only the measurement after the removal of the stratum corneum.

〔The invention's effect〕

As described above, according to the stratum corneum removal detecting device (20) of the present invention, at least a pair of electrodes (2) is disposed in the body fluid extraction suction cell (1), and the pair of electrodes (2) is placed on the human body. In a state where the electrodes are in contact with each other, a measuring means (3) for measuring a resistance value between the two electrodes (2) and a display means (8) for displaying the measurement result are provided. By measuring the resistance value, the removal of the stratum corneum can be determined, and the measurement of the blood sugar level and the like can be reliably performed.

Further, when the dermis surface is damaged, the resistance value is remarkably reduced, so that it is possible to reliably determine the excessive removal of the stratum corneum.

As described above, according to the device of the present invention, it is possible to detect the removal of the stratum corneum, so that it is possible to avoid inhaling blood due to damage to the stratum corneum during body fluid extraction or to reduce the pain of the subject, It is useful for high-frequency blood glucose measurement.

[Brief description of the drawings]

FIG. 1 is a block diagram showing a stratum corneum removal detecting device according to the present invention, and FIG. 2 is a flowchart showing a measuring mode of the stratum corneum removing detecting device according to the present invention. (1) Suction cell for body fluid extraction, (1A) contact surface, (2)
Is an electrode, (2A) is an end face, (3) is a measuring means, (4) is a bridge circuit, (5) is an A / D converter, (6) is a CPU, (7)
Is a drive circuit, (8) is a display means, (9) is a ROM, (10)
Is a RAM, (11) is a tube, and (20) is a stratum corneum removal detection device.

──────────────────────────────────────────────────続 き Continued on the front page (58) Fields surveyed (Int. Cl. ⁶ , DB name) A61B 5/14 300 A61B 5/14 310 A61B 10/00 A61B 10/00 103 A61B 5/05

Claims (1)

(57) [Claims] At least a pair of electrodes are arranged in a body fluid extraction suction cell, and a measuring means for measuring a resistance value between the electrodes while the pair of electrodes is in contact with a human body; A device for detecting and removing a stratum corneum, comprising a display means for displaying.