JP6391066B2 - Ornithine-containing composition for improving body composition - Google Patents

Description

  The present invention relates to a composition for improving body composition comprising ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins as active ingredients.

  In the elderly, various life problems occur, and meals are one of them. In other words, in general, elderly people have difficulty in chewing, and their preference for light foods increases, resulting in a shortage of intake of foods rich in animal proteins such as meat and lipids. It will be. However, it is known that intake of these proteins and lipids is an essential nutritional component for maintaining and improving the health of the elderly. For example, a 10-year survey of a group of 70-year-old elderly people in a region analyzed the relationship between dietary habits and life expectancy, and showed that people who constantly consume oils and fats have longer lives (non-patented). Reference 1). In addition, as a result of a two-year survey on the dietary habits of 600 elderly people, people who consume more animal protein foods such as meat and milk and fats and oils are necessary to enjoy leisure activities and daily life such as creative activities. There is a report that a decline in living functions is suppressed (Non-patent Document 2).

  Thus, protein and lipid intake from the diet is particularly important for elderly people. In general, blood albumin concentration is an indicator of whether the ingested protein is utilized in the body. One report shows that blood albumin levels are related to the exercise capacity of the elderly. That is, about 300 independent elderly people with an average of 71 years old, as a result of continuous investigation of changes in maximum walking speed, which is one of the indices of physical fitness, for 8 years, the lower the serum albumin level, the greater the decrease in speed Was shown (Non-patent Document 3).

  Furthermore, when hospitalization due to diseases or the like is added to the undernutrition state, lack of exercise is added to this. Insufficient exercise causes further loss of appetite, which can further exacerbate nutritional conditions and lead to bedridden conditions. Therefore, recently, doctors, nurses and nutritionists have formed a Nutrition Support Team (NST) in hospitals and nursing homes, and are actively working on improving the nutrition of patients. The importance of diet in Japan is recognized.

  As a composition for improving the undernutrition state, for example, a food and drink containing protein and fat is disclosed (Patent Document 1). However, food and drink containing protein and fats and oils are no different from conventional food and drink.

  On the other hand, growth hormone is one that promotes protein synthesis in the body. Growth hormone, as the name suggests, is a hormone that is secreted during the growth phase and promotes the growth of bones and muscles, but the secretion of this hormone decreases with age.

  Ornithine is known to promote the secretion of growth hormone when ingested (Non-patent Document 4). In addition, since changes in body composition such as a decrease in body fat percentage (Non-Patent Document 5) have been reported, elderly people whose growth hormone secretion amount in the body is decreased particularly due to ingestion of food containing ornithine. Suggests the possibility of obtaining an effect of inhibiting muscle degradation and improving body composition.

International Publication No. 2002/094039 Pamphlet

Shibata, H. et al., Nutrition for the Japanese elderly. Nutrition and Health. 8,165-175,1992 Osamu Kumagai et al. Geriatric Social Science, 16.1995 http://www.keep-act.jp/houhou/eiyou/eiyou04.html Bucci L. et al. Nutrition research.10: 239-45,1990 Elam RP. Journal of Sports Medicine & Physical Fitness. 28 (1): 35-9,1988

  An object of the present invention is to provide a composition for improving body composition comprising ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins as active ingredients.

The present invention relates to the following (1) to (19).
(1) A composition for improving body composition comprising ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins as active ingredients.
(2) The composition for improving body composition according to (1), wherein ornithine or a salt thereof is 10 to 70% by mass of ornithine as a protein amount (including amino acids) contained in the composition. .
(3) The composition for improving body composition according to (1) or (2), wherein ornithine or a salt thereof is ornithine in an amount of 5 to 45% by mass based on the total amount of the composition.
(4) The composition for improving body composition according to any one of (1) to (3), wherein the weight composition ratio of ornithine or a salt thereof and glutamine or a salt thereof is 1: 4 to 9: 4 as ornithine and glutamine.
(5) The composition for body composition improvement according to any one of (1) to (4), wherein the weight composition ratio of ornithine or a salt thereof and zinc is 70: 3 to 10: 1 as ornithine and zinc.
(6) The body composition improving composition as described in (1), which is packaged so that the amount per ingestion or administration is 2.0 to 8.0 g.
(7) The composition for improving body composition according to (6), wherein ornithine or a salt thereof is contained in an amount of 800 to 1700 mg as ornithine.
(8) The composition for improving body composition according to (6), wherein glutamine or a salt thereof is contained in an amount of 100 to 2000 mg as glutamine.
(9) The body composition improving composition as described in (6), wherein 0.1 to 15 mg of zinc is contained.
(10) The composition for improving body composition according to (6), wherein the vitamin contains one or more vitamins selected from the group consisting of vitamin A and vitamin C.
(11) The composition for improving body composition according to (10), wherein 10 to 600 μg of vitamin A is contained.
(12) The composition for improving body composition according to (10), wherein vitamin C is contained in an amount of 24 to 500 mg.
(13) The composition for improving body composition according to (12), wherein the weight composition ratio of ornithine or a salt thereof and vitamin C is 3: 2 to 7: 2 as ornithine and vitamin C.
(14) The composition for improving body composition according to any one of (1) to (13), wherein the composition is a powder or a granule.
(15) The composition for improving body composition according to any one of (1) to (14), further comprising an acidulant.
(16) The composition for improving body composition according to (15), wherein the acidulant is citric acid.
(17) A beverage comprising, mixing and dissolving the composition for improving body composition according to any one of (1) to (16).
(18) The beverage according to (17), which has a pH of 3.0 to 4.0.
(19) A method for improving body composition, wherein a subject who needs to improve body composition, ornithine or a salt thereof, glutamine or a salt thereof in an amount sufficient to improve the body composition of the subject Ingesting or administering zinc and vitamins.

  According to the present invention, a composition for improving body composition comprising ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins as active ingredients can be provided. The composition can be used for prevention, suppression, improvement, postoperative recovery, etc. of pressure ulcers.

FIG. 1 shows the transition of the average value of the total DESIGN-R score of pressure ulcer patients who took the composition of the present invention. * Indicates that there is a significant difference (*: p <0.05, **: p <0.01, Wilcoxon signed rank sum test, n = 10) when compared to the start of the test (0W). FIG. 2 shows the transition of the average value of urinary 3-methylhistidine excretion of pressure ulcer patients who took the composition of the present invention. The p value 8 weeks after ingestion when compared with the start of the study (0 W) was 0.057 (1 sample t-test, n = 10). FIG. 3 shows the transition of the mean value of the blood prealbumin value of pressure ulcer patients who took the composition of the present invention. Numerical values are shown in the figure. (N = 10). FIG. 4 shows the transition of the average value of the blood albumin level of female pressure ulcer patients who took the composition of the present invention. * Indicates that there is a significant difference (*: p <0.05, 1-sample t-test, n = 10) when compared with the start of the test (0W).

  Examples of ornithine used in the present invention include L-ornithine and D-ornithine, with L-ornithine being preferred. Ornithine used in the present invention may be obtained by any production method. Examples of the production method of L-ornithine include chemical synthesis [Col. Czechoslov. Chem. Commun. , 24, 1993 (1959)], fermentation methods (Japanese Patent Laid-Open Nos. 53-24096 and 61-119194), and the like.

  L-ornithine and D-ornithine can also be purchased from Sigma-Aldrich. Examples of ornithine salts include acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts, and the like. Acid addition salts include inorganic acid salts such as hydrochloride, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, malate, lactate, α-ketoglutarate And organic acid salts such as gluconate and caprylate.

  Examples of the metal salt include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as magnesium salt and calcium salt, aluminum salt and zinc salt. Examples of ammonium salts include salts such as ammonium and tetramethylammonium. Examples of the organic amine addition salt include salts of morpholine, piperidine and the like. Examples of amino acid addition salts include salts of glycine, phenylalanine, lysine, aspartic acid, glutamic acid and the like. Of the above ornithine salts, hydrochloride, citrate, malate, α-ketoglutarate and aspartate are preferably used, but other salts or two or more salts may be used in appropriate combination. Good.

  The compounding amount of ornithine or a salt thereof in the composition of the present invention is appropriately selected, but usually 10 to 70% by mass with respect to the amount of protein (including amino acids) contained in the composition as ornithine, Preferably it is 20-60 mass%, Most preferably, it is 30-50 mass%.

  The blending amount of ornithine or a salt thereof in the composition of the present invention is appropriately selected. As ornithine, it is usually 5 to 45% by mass, preferably 15 to 35% by mass, particularly preferably based on the total amount of the composition. It is 20-30 mass%.

  Examples of glutamine used in the present invention include L-glutamine and D-glutamine, with L-glutamine being preferred. The glutamine used in the present invention may be obtained by any production method, and examples of the production method of L-glutamine include methods such as WO2007 / 074857.

  L-glutamine and D-glutamine can also be purchased from Sigma-Aldrich. Examples of glutamine salts include acid addition salts, metal salts, ammonium salts, organic amine addition salts, amino acid addition salts, and the like. Acid addition salts include inorganic acid salts such as hydrochloride, sulfate, nitrate, phosphate, acetate, maleate, fumarate, citrate, malate, lactate, α-ketoglutarate And organic acid salts such as gluconate and caprylate.

  The weight composition ratio of ornithine or a salt thereof and glutamine or a salt thereof in the composition of the present invention is not particularly limited as ornithine and glutamine, but is preferably 1: 4 to 9: 4, and 3: 4 to 7: 4. Is more preferable, and 5: 4 is particularly preferable.

  The zinc used in the present invention is not particularly limited as long as it is edible so that zinc ions can be supplied to the composition. However, a salt containing zinc or a microorganism such as yeast containing a high amount of zinc. Can be mentioned. Particularly preferable zinc ion additives include zinc gluconate.

  The weight ratio of ornithine or a salt thereof and zinc in the composition of the present invention is not particularly limited as ornithine and zinc, but is preferably 70: 3 to 10: 1, more preferably 20: 1 to 40: 3. 50: 3 is particularly preferred.

  Examples of vitamins used in the present invention include coenzyme Q10, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin E and the like, and vitamin A and vitamin C are particularly preferable. Examples of vitamin A include retinol (vitamin A1), 3-dehydroretinol (vitamin A2), retinal, 3-dehydroretinal, retinoic acid, 3-dehydroretinoic acid, their acetates, and palmitic acid derivatives. Can do. Examples of vitamin C include L-ascorbic acid, sodium L-ascorbate, and L-ascorbic acid stearate.

  The weight composition ratio of ornithine or a salt thereof and vitamin C in the composition of the present invention is not particularly limited as ornithine and vitamin C, but is preferably 3: 2 to 7: 2, preferably 2: 1 to 3: 1. More preferred is 5: 2.

  As the composition of the present invention, ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins can be ingested or administered as they are, but it is usually desirable to provide them in various product forms or preparations.

  The product or preparation contains ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins as active ingredients, but may further contain any active ingredient. The product or preparation is produced by any method well known in the technical field of pharmaceutics by mixing the active ingredient with one or more pharmaceutically acceptable carriers.

  The intake or administration form of the product or preparation is desirably the most effective in improving body composition, and includes oral intake or administration, or parenteral administration such as intravenous, intraperitoneal or subcutaneous administration. Oral intake or administration is preferred.

  Examples of forms or dosage forms for ingestion or administration include tablets, powders, granules, pills, suspensions, emulsions, soaking / decoction, capsules, drinks, liquids, elixirs, extracts, tinctures, fluids Any of oral preparations such as extracts, parenteral preparations such as injections, infusions, creams, suppositories, etc. may be used, but they are preferably used as oral preparations.

  Liquid preparations such as drinks suitable for ingestion or oral administration include water, sucrose, sorbitol, sugars such as fructose, glycols such as polyethylene glycol, propylene glycol, oils such as sesame oil, olive oil, soybean oil And preservatives such as p-hydroxybenzoates, paraoxybenzoic acid derivatives such as methyl paraoxybenzoate, preservatives such as sodium benzoate, and flavors such as strawberry flavor and peppermint. it can.

  Also suitable for oral ingestion or administration, such as tablets, powders and granules are saccharides such as lactose, sucrose, glucose, sucrose, mannitol, sorbitol, starch such as potato, wheat, corn, calcium carbonate, calcium sulfate, Inorganic substances such as sodium hydrogen carbonate and sodium chloride, excipients such as crystalline cellulose, plant powder such as licorice powder, gentian powder, starch, agar, gelatin powder, crystalline cellulose, carmellose sodium, carmellose calcium, calcium carbonate, carbonic acid Disintegrants such as sodium hydrogen and sodium alginate, magnesium stearate, talc, hydrogenated vegetable oil, macrogol, silicone oil and other lubricants, polyvinyl alcohol, hydroxypropylcellulose, methylcellulose, ethylcellulose, carmellose, gera Emissions, starch binders glue solution and the like, surfactants such as fatty acid esters can be formulated by adding a plasticizer such as glycerin.

  In addition, product forms or preparations suitable for oral ingestion or administration include additives generally used in foods and drinks such as sweeteners, coloring agents, preservatives, thickening stabilizers, antioxidants, color formers, bleaching agents, An antifungal agent, gum base, bittering agent, enzyme, brightener, acidulant, seasoning, emulsifier, reinforcing agent, manufacturing agent, fragrance, spice extract and the like may be added.

  In addition, product forms or preparations suitable for oral ingestion or administration include, for example, tablets, powders, granules, pills, suspensions, emulsions, soaking agents, etc. It can be processed and manufactured into a decoction, capsule, drink, liquid, elixir, extract, tincture, and flow extract. For example, “unit packaging form per ingestion” is a form in which the amount to be ingested per time is determined in advance, and “unit packaging form per week to 3 months” is from 1 week to 3 It is a form that includes the amount consumed every month. As a unit packaging form, the form which prescribes | regulates a fixed quantity with a pack, a packaging, a bottle etc. is mentioned, for example.

  For example, “unit packaging form per ingestion” is a composition obtained by granulating a composition containing ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins when the product form or preparation is a granule. The form put in the pack etc. with the form per ingestion as a thing is mentioned.

  In addition, for example, in the case of a form that is put in a pack or the like in a form per ingestion as a granulated composition, it is selected as appropriate, but the granulated composition is contained in an appropriate amount of beverage, mixed, The form which is easy to melt | dissolve normally is 2.0g-8.0g, Preferably it is 3.0-7.0g, Most preferably, it is 4.0-6.0g.

  The ingestion or administration frequency of the composition of the present invention varies depending on the ingestion or administration form, the age of the person who needs the ingestion or administration, the body weight, the nature or severity of the condition to be treated, The required amount of the composition of the present invention is taken or administered 1 to 5 times, preferably twice.

  The intake or dose of ornithine or a salt thereof is appropriately selected, but is usually 800 to 1700 mg, preferably 1000 to 1500 mg, particularly preferably 1200 to 1300 mg as ornithine per one intake or administration. If it is less than 800 mg, the effects derived from ornithine may be less likely to occur, and if it is more than 1700 mg, the total nitrogen intake with other proteins (including amino acids) included in the present invention will be high. May be undesirable from the viewpoint of nitrogen load applied to

  The intake or dose of glutamine or a salt thereof is appropriately selected, but is usually 100 to 2000 mg, preferably 500 to 1600 mg, particularly preferably 900 to 1200 mg as glutamine per intake or administration. If it is less than 100 mg, the effects derived from glutamine may be less likely to occur, and if it is more than 2000 mg, the total amount of nitrogen intake with other proteins (including amino acids) included in the present invention will be high. This may be undesirable from the viewpoint of the nitrogen load to be applied.

  The intake or dose of zinc is appropriately selected, but is usually 0.1 to 15 mg, preferably 3.0 to 12.0 mg, particularly preferably 6.0 to 9.0 mg per intake or administration. is there. If it is less than 0.1 mg, there is a possibility that the wound healing effect derived from zinc is less likely to occur, and if it is more than 15 mg, it exceeds the amount of nutrients contained in the daily intake standard amount that is the standard for nutritional functional foods It will be.

  The intake or dosage of vitamins is appropriately selected. In the case of vitamin A, it is usually 10 to 600 μg (600 μg is equivalent to 2000 IU), preferably 100 to 400 μg, particularly preferably 135 to 200 μg per time. If it is less than 10 μg, the effects of collagen synthesis and epithelial generation derived from vitamin A may be less likely to occur. If it is less than 135 μg, the nutritional components contained in the daily intake standard amount that is the standard for nutritional functional foods If the amount is less than 450 IU and more than 600 μg, it will exceed the amount of nutrient component 2000 IU included in the daily intake standard amount that is the standard for nutritional functional foods.

  The intake or dose of vitamin C is usually 24-1000 mg, preferably 100-750 mg, particularly preferably 150-500 mg per dose. If it is less than 24 mg, it may be less than the amount of nutrients contained in the daily intake standard amount, which is the standard for functional nutritional foods, and it may be difficult to produce an effect derived from vitamin C. Meet nutritional requirements. 150 to 500 mg is appropriate as a necessary daily amount at the time of pressure ulcer development. When it is more than 1000 mg, it exceeds the amount of nutrient components contained in the daily intake standard amount that is the standard for functional nutritional foods.

  The intake or administration period is not particularly limited, but is usually 1 day to 1 year, preferably 1 week to 3 months.

  The composition for improving body composition of the present invention can be applied to the prevention, suppression, improvement and postoperative recovery of pressure ulcers.

  The present invention also includes a method for improving body composition. The method of the present invention allows a subject in need of improving body composition to ingest sufficient amounts of ornithine or salt thereof, glutamine or salt thereof, zinc and vitamins to improve the subject's body composition. Or a step of administering.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Production of ornithine-containing powder Powders were produced by the conventional method with the formulation shown in Table 1. The ingredients were mixed in groups A and B at the same time, and then the ingredients in group C were blended to give 5 g. It was found that a powder having good solubility in beverages and the like can be obtained by simultaneously mixing the A group and the B group.

Production of ornithine-containing beverage 5 g of the powder obtained in Example 1 was blended in 10, 50, 80, 100, 120, 240, and 500 ml of drinking water, and the solubility and taste of each were evaluated.

  The evaluation of the solubility is as follows: 1: dissolution does not occur, precipitation occurs, 2: dissolution occurs to some extent, but there is a little undissolved, 3: dissolution does not cause any problem, 4: dissolution occurs. 5: Evaluated in 5 grades: very good dissolution.

The evaluation of the taste is 1: very bad, 2: bad, 3: normal, no particular problem, 4: good. 5: Evaluated in 5 grades: extremely good.

  As shown in Table 2, when the amount was less than 10 ml, it was difficult to dissolve the composition, and 50 ml or more was dissolved without any problem. Moreover, it was able to ingest well in 80-240 ml from a viewpoint of taste.

Production of ornithine-containing soft drink 5 g of the powder obtained in Example 1 was blended into 100 ml of sports drink and black tea (straight tea). About each, solubility and taste are favorable (As the same evaluation as Example 2, sports drink was solubility 3, taste 3, and black tea was solubility 3, taste 3.) It was possible to mix and drink with drinking water.

  Below, the test example which investigated the body composition improvement effect of ornithine or its salt, glutamine or its salt, zinc, and vitamins is shown.

Test Example For subjects with pressure ulcers of Shea classification stage II or higher, in addition to a normal meal, 5 g of the powder of the composition of the present invention obtained in Example 1 was taken as 1 sachet, 2 sachets per day (morning dinner, 1 Ingested for 8 weeks. The age and symptoms of the test subjects are as shown in Table 3.

  As shown in FIG. 1, when the composition of the present invention was ingested for 8 weeks, DESIGN-R, which is an index showing the progress of pressure ulcer, in all subjects was improved compared to before the start of the test.

  Moreover, as shown in FIG. 2 and FIG. 3, in addition to the decrease in the amount of 3-methylhistidine which is a somatic protein catabolism marker, the blood prealbumin level was compared with that at the start of ingestion at 4th and 8th weeks of ingestion. The eye showed a high price.

  Furthermore, as shown in FIG. 4, the blood albumin level at the end of ingestion at the 8th week is significant in women whose acne progression was relatively mild compared to men, compared to before the start of ingestion. It was improved.

  As described above, the composition of the present invention promotes body protein synthesis in patients with pressure ulcers that are suggested to have problems with nutritional status, thereby healing the pressure ulcer site and improving body composition. Proven to get.

  According to the present invention, it is possible to provide a composition containing ornithine or a salt thereof, glutamine or a salt thereof, zinc and vitamins, which is useful for improving body composition such as prevention, suppression, improvement and postoperative recovery of pressure ulcers. .

Claims (2)

As an active ingredient, ornithine or a salt thereof, glutamine or a salt thereof, only zinc and vitamins are packaged so that the amount per intake or administration is 2.0 g to 8.0 g, In addition, the number of intakes or administrations per day is 1 to 2 times, and the total DESIGN-R score is significantly improved by ingestion or administration for 1 week or more compared to before intake or administration. A composition for promoting body protein synthesis, wherein the amount of ornithine or a salt thereof per one intake or administration is 800 to 1700 mg, and the amount of glutamine or a salt thereof is 100 to 2000 mg. Composition . The composition for promoting body protein synthesis according to claim 1, wherein the number of intakes or administrations per day is two.