KR101680420B1 - Vascular and bodily duct treatment devices and methods - Google Patents

Abstract

The device includes a self-expanding member having a proximal end portion and a main body portion. Wherein the self-inflatable member is movable from a first delivery position to a second disposition position, wherein the inflatable member in the first delivery position is in a non-inflated position and has a nominal first diameter, And has a second nominal diameter that is larger than the first nominal diameter for placement in a patient's blood vessel or tube. The inflatable member includes a plurality of cellular structures and the inflatable member includes but is not limited to a plurality of cellular structures wherein the cellular structure in the main body portion is elongated circumferentially about a longitudinal axis of the inflatable member, The cell structure in the proximal end portion is less elongated circumferentially about the longitudinal axis of the inflatable member.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a device for treating blood vessels and body tubes,

This application is a continuation-in-part of United States patent application serial no. 12 / 499,713 filed July 8, 2009, some continuation of United States patent application serial no. 12 / 573,676 filed October 5, 2009, December 21, 2009 Some of the copending U.S. Patent Application Serial No. 12 / 643,942, filed on July 8, 2009, some continuation of U.S. Patent Application No. 12 / 832,857, filed on Feb. 4, 2011, 021,364, filed November 23, 2011, which is a continuation of United States Patent Application Serial No. 13 / 303,890.

The present application relates to an apparatus and a method for treating blood vessels and other vessels in the body.

Self-expanding prostheses, such as stents, shielded stents, vascular grafts, flow transducers, and the like, have been developed for treating tubing in the body. Many prosthetic inserts have been developed to treat occlusions in the blood vessels, as well as aneurysms originating in the brain. For example, improved treatment methods are needed to treat blood vessels such as aneurysms, stenosis, embolic occlusion, and the like and other bodily tubes.

According to one embodiment, there is provided a vessel or body tube treatment apparatus comprising an elongated magnetically-inflatable member movable from a first delivery position to a second delivery position, wherein the inflatable member at a first delivery position is inflated Wherein the inflatable member in a second position is in a radially expanded position and has a second nominal diameter greater than the first nominal diameter for deployment in a patient's blood vessel or body tube, Wherein the expandable member has a cylindrical main body portion, a proximal end portion including a proximal end, and a distal end portion having a distal end, wherein the cell structure in the main body portion comprises an inflatable member Wherein the cell structure in the proximal and distal end portions is elongated circumferentially about a longitudinal axis of the inflatable member, The outermost cell structure at the proximal end has a first and a second substantially parallel elongated cell structure extending in a two dimensional view from a location at or near the most recent upper end of the inflatable member to a distal location at or near the cylindrical main body portion, And has a recent upper linear wall segment forming a linear rail segment. In one embodiment, the self-expandable member has a longitudinal slit between the proximal end and the distal end that expands along at least a portion of the length of the self-expandable member.

In yet another embodiment, an elongated self-inflatable member includes an elongated flexible wire having a proximal end and a distal end, wherein the elongated self-inflatable member is coupled to the distal end, Wherein the inflatable member is in a non-inflated position and has a nominal first diameter in a first delivery position, the inflatable member is in a radially inflated position in a second position, Expandable member includes a plurality of cellular structures, the inflatable member having a proximal end portion having a proximal end, a cylindrical main body portion, and a proximal end portion having a proximal end, wherein the proximal end portion has a second nominal diameter greater than the first nominal diameter, The cell structure in the main body portion extending circumferentially about a longitudinal axis of the inflatable member and having a distal end portion with a distal end portion having a distal end portion with a distal end portion having a distal end portion with a distal end portion, The structure is less elongated circumferentially about the longitudinal axis of the inflatable member and the outermost cell structure within the proximal end portion extends from a position at or near the nearest upper end of the inflatable member in the two- Wherein the elongated wire including the inflatable member has a first length and has a first elongated linear wall segment forming first and second substantially linear rail segments each extending into a position The delivery catheter having a proximal end, a distal end and a lumen, the lumen advancing the unexpanded member from the proximal end to the distal end of the catheter, Expandable member has a diameter sufficient to receive the inflatable member in its unexpanded position, and the second length has a length sufficient to allow the self- Expandable member is partially or fully positioned outside of the distal end of the catheter when the expandable member and the catheter are positioned farther away from the catheter than the first length so that the self- Wherein the distal end of the self-expandable member is configured to retract proximally into the lumen of the catheter. In one embodiment, the self-expandable member has a longitudinal slit between the proximal end and the distal end that expands along at least a portion of the length of the self-expandable member.

According to one embodiment, there is provided an elongated member comprising an elongated magnetically-inflatable member movable from a first delivery position to a second disposition position, wherein the inflatable member in a first delivery position is in a non-inflated position and has a nominal first diameter , The inflatable member in the second position is in a radially expanded position and has a second nominal diameter greater than the first nominal diameter for deployment in a patient's blood vessel or body tube and the inflatable member has a plurality of generally longitudinal Wherein adjacent wavy elements are interconnected in a manner to form a plurality of obliquely disposed cell structures wherein the inflatable member has a proximal end portion, a cylindrical main body portion, and a distal end portion , The cell structure in the main body portion is circumferentially elongated about the longitudinal axis of the inflatable member and the cell structure in the proximal and distal end portions is expanded Wherein the cell structure in the proximal end portion extends from a position at or near the closest upper end of the inflatable member in a two dimensional view to a position at or near the cylindrical main body portion There is provided a body tube and an apparatus for treating an arterial vessel having a recent gastric linear wall segment forming first and second substantially linear rail segments extending therethrough. In one embodiment, the proximal inflated elongated flexible wire connected to the proximal uppermost end of the inflatable member has sufficient flexibility and length to pass through a patient's blood vessel or body tube.

In yet another embodiment, an expandable self-inflatable member is provided that is movable from a first delivery position to a second disposition position, wherein the inflatable member in a first delivery position is in a non-inflated position and has a nominal first diameter , The inflatable member in the second position being in a radially expanded position and having a second nominal diameter greater than the first nominal diameter for deployment in a patient's blood vessel, the inflatable member having a plurality of generally longitudinally wavy Wherein the adjacent wavy elements are interconnected in such a manner as to form a plurality of cell structures arranged to twist the inflatable member as the inflatable member transitions from the unexpanded to the expanded position, Having a proximal end portion, a cylindrical main body portion and a distal end portion, wherein the cell structure in the main body portion extends in a circumferential direction about a longitudinal axis of the inflatable member The cell structure in the proximal and distal end portions is elongated less circumferentially about the longitudinal axis of the expandable member and the outermost cell structure within the proximal end portion is located at or near the proximal uppermost end of the inflatable member There is provided a vascular treatment device having a recent upper linear wall segment forming first and second substantially linear rail segments each extending from a cylindrical main body portion to a position in or near the cylindrical main body portion. In one embodiment, the proximal inflated elongated flexible wire connected to the proximal uppermost end of the inflatable member has sufficient flexibility and length to pass through a patient's blood vessel or body tube.

In yet another embodiment, an expandable self-inflatable member is provided that is movable from a first delivery position to a second disposition position, wherein the inflatable member in a first delivery position is in a non-inflated position and has a nominal first diameter , The inflatable member in the second position is in a radially expanded position and has a second nominal diameter greater than the first nominal diameter for deployment in a patient's blood vessel or body tube and the inflatable member has a plurality of generally longitudinal And the adjacent wavy elements are interconnected to form a plurality of obliquely arranged cell structures, the inflatable member having a cylindrical portion and a distal end portion, the cell structure in the cylindrical portion having an expansion Wherein the cell structure in the distal end portion extends in a circumferential direction about the longitudinal axis of the expandable member, And, the main body above the last cell structure in the part of the body is provided with a tube or blood vessel treatment device having an upper end portion recently. One or more proximal upper end portions of the inflatable member have proximal inflated elongated wires having sufficient flexibility and length to pass through a patient's blood vessel or body conduit.

According to yet another embodiment, there is provided an elongated flexible wire comprising an elongated flexible wire having a proximal end and a distal end, wherein the elongated magnetically-inflatable member is attached to the distal end, Wherein the inflatable member is in a non-inflated position and has a nominal first diameter in a first delivery position, the inflatable member is in a radially inflated position in a second position, The inflatable element having a second nominal diameter greater than the first nominal diameter for placement in the closure, wherein the inflatable member comprises a plurality of generally longitudinally wavy elements, and adjacent wavy elements comprise a plurality of obliquely arranged cells Wherein the inflatable member has a proximal end portion, a cylindrical main body portion and a distal end portion, and wherein the cell structure in the main body portion comprises a tubular member Wherein the cell structure in the proximal and distal end portions is less elongated circumferentially about the longitudinal axis of the inflatable member and the outermost cell structure within the proximal end portion is expanded in a two- Having a nearest upper linear wall segment forming first and second substantially linear rail segments respectively extending from a position at or near the nearest top end of the member to a position at or near the cylindrical main body portion, Wherein the delivery wire and inflatable member have a first length and include a delivery catheter having a sufficient flexibility and a second length to pass through a vein in a patient's serpentine cranium, the delivery catheter having a proximal end, a distal end and a lumen, The lumen advances the unexpanded member from the proximal end to the distal end of the catheter and receives the inflatable member in the unexpanded position And the second length is less than the first length so that the inflatable member can be advanced distally beyond the distal end of the catheter and advanced in a distal direction so that the inflatable member is located distally of the distal end of the catheter The distal end of the inflatable member and the catheter is configured such that the inflatable member is retracted proximally into the lumen of the catheter.

According to yet another embodiment,

- (a) advancing a delivery catheter including a lumen having a proximal end and a distal end as a site of an embolus occlusion in the intracranial vein of a patient,

(b) introducing an embolic closure collection device including an elongated flexible wire having a distal end and a proximal end including an elongated self-expandable member attached to the distal end into a proximal end of the lumen of the delivery catheter, - advancing the inflatable member to the distal end of the lumen, wherein the elongated self-inflatable member is moveable from a first delivery position to a second disposition position, wherein in the first delivery position the inflatable member is non- Wherein the inflatable member in a second position is in a radially expanded position and has a second nominal diameter greater than the first nominal diameter for deployment in a patient's embolus closure, Shaped member comprises a plurality of generally longitudinally wavy elements and adjacent wavy elements are interconnected to form a plurality of obliquely arranged cell structures, The shell member has a proximal end portion, a cylindrical main body portion and a distal end portion, wherein the cell structure in the main body portion is circumferentially elongated about a longitudinal axis of the inflatable member, and the cell structure in the proximal and distal end portions is expanded Wherein the outermost cell structure in the proximal end portion is located at or near the cylindrical main body portion from a position at or near the most recent upper end of the inflatable member in a two dimensional view, Wherein the elongated wire and the inflatable member have a second length that is longer than the first length in combination, the elongate wire and the inflatable member having a first length and a second length, respectively, of the first and second substantially linear rail segments,

- (c) withdrawing the delivery catheter proximal enough to deploy the self-expanding device so that the one or more cell structures capture at least a portion of the embolic occlusion,

- (d) A method is provided for removing an embolic occlusion portion from a patient's blood vessel, comprising the steps of pulling the delivery catheter and the self-expandable member proximal to the exterior of the patient. In an alternative embodiment, the self-expandable member is partially withdrawn proximally into the delivery catheter and into the lumen of the delivery catheter prior to introducing the self-expandable member proximally into the patient ' s direction .

According to yet another embodiment there is provided an elongated member comprising an elongated magnetically-inflatable member movable from a first transmitting position to a second disposing position, wherein in the first transmitting position the inflatable member is in its unexpanded position and has a nominal first diameter The inflatable member in the second position being in a radially expanded position and having a second nominal diameter greater than the first nominal diameter for deployment in a patient's vein or tube and the inflatable member including a plurality of cellular structures The inflatable member having a proximal end portion having a proximal end and a cylindrical main body portion and the cell structure in the main body portion having a proximal end portion and a distal end portion extending circumferentially about a longitudinal axis of the inflatable member, Wherein the cell structure in the proximal end portion comprises a plurality of second intersecting struts and is disposed about the longitudinal axis of the inflatable member Wherein at least a portion of the plurality of first intersecting struts has a thickness ratio to a width greater than one.

According to yet another embodiment, there is provided an inflated self-inflating member comprising an elongated magnet-inflatable member including a delivery wire and movable from a first delivery position to a second disposition position, wherein the inflatable member in a first delivery position is in a non- The inflatable member in the second position being in a radially expanded position and having a second nominal diameter greater than the first nominal diameter for deployment in a patient's tubing or blood vessel, the inflatable member having a first nominal diameter, The inflatable member having a proximal end portion having a proximal end and a cylindrical main body portion and the proximal end having an integrally formed wire segment that is inflated with a coil disposed about the wire segment, Includes a first and a second loosely wound segment having one or more gaps, wherein within the proximal end portion, the cell structure comprises an elongate member Axis and less expansion in the circumferential direction on the periphery, the device comprising a proximal end of the wire segment attached to the distal end of the delivery wire by a binding agent in the second loosely rolled segment of the coil is provided.

According to yet another embodiment there is provided an elongated member comprising an elongated magnetically-inflatable member movable from a first transmitting position to a second disposing position, wherein in the first transmitting position the inflatable member is in its unexpanded position and has a nominal first diameter The inflatable member in the second position being in a radially expanded position and having a second nominal diameter greater than the first nominal diameter for deployment in a patient's vein or tube and the inflatable member including a plurality of cellular structures Wherein the inflatable member has a proximal end portion including a cylindrical main body portion and a proximal end, the cell structure in the main body portion is circumferentially extended about a longitudinal axis of the inflatable member, and the cell structure in the proximal end portion Is less elongated circumferentially about the longitudinal axis of the expandable member and is initially about 0.50 mm from the nominal diameter depending on the cell structure having size and material properties A radial force along the length of the inflatable member per mm of inflation during the inflation of the radial diameter range results in a total reduction of about -1.5 N to about -3.5 N and the inflation per mm of inflation during the inflation of the subsequent radial range An apparatus is provided in which a radial force along the length of the member causes a total reduction of about -0.10 N to about -0.50 N. In one embodiment, the stretched magneto-expandable member has a designated maximum second nominal diameter, and the radial force exerted by the stretched magneto-expansible member is greater than zero at inflation to a maximum second nominal diameter.

According to yet another embodiment, there is provided a coagulating and recovering device comprising: an inflated magnetically expandable member movable from a first delivery position to a second disposition position, in an inflated position at a first delivery position, An inflatable member having an inflatable member having a first diameter and a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure at a second location in a radially expanded position, Includes a plurality of generally longitudinal wave elements having adjacent wave elements interconnected in a manner to form a plurality of diagonally arranged cell structures, the inflatable member having a proximal end portion and a cylindrical main body portion, The cell structure of the main body portion, which is circumferentially expanded about the longitudinal axis of the elongate member, the cell structure of the proximal end portion includes the proximal and distal end segments The branch is circumferentially less inflated about the longitudinal axis of the inflatable means to form the first and second peripheral rails and the cell structure of the proximal end portion including the first set of cell structures disposed to form the first peripheral rail A second set of cell structures arranged to form a second set of cell structures and a second set of cell structures arranged between the first and second sets of cell structures and a fourth set of cells A first set of cell structures having a first and a second set of cell structures having a cell structure in a main body including a structure, a first set of cell structures having a circumference outermost strut member defining a first circumferential rail and a proximal end segment, At least a portion of the peripheral outermost strut member disposed to vary the first and second peripheral rails between the first width dimension of the distal end segment and the second width dimension and having a different width dimension, It is small between a second width dimension, in one embodiment, the first and second rail width ratio is no change between the wave width of the first size and the second size range is from about 20.0% to about 50.0%.

Another embodiment of a coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion and a cylindrical main body portion and has a cell structure of a main body portion that is circumferentially expanded about a longitudinal axis of the inflatable member, The cell structure of the portion may include a circle around the longitudinal axis of the expandable means to form first and second peripheral rails having proximal and distal end segments, A cell structure of a proximal end portion including a first set of cell structures arranged to form a first peripheral rail and a third set of cells located between the first and second sets of cell structures, A second set of cell structures arranged to form a second peripheral rail and a second set of cell structures having a cell structure in a main body including a fourth set of cell structures in a common, A second set of cell structures having a first set of cell structures having a circumferential outermost strut member defining a first circumferential rail and a circumferentially outermost strut member defining a proximal cell structure and a second circumferential rail, An upper shell structure, a first width dimension of the proximal end segment and a second width dimension at the distal end segment, and at least a portion of the peripheral outermost strut portion The second width dimension being less than the first width dimension, the ratio variation between the first width dimension and the second width dimension being between about 20.0% and about 50.0%, and the third set of cell structures being less than the second width dimension The fourth set of cell structures comprises a strut having a fourth width dimension less than the second width dimension and wherein the ratio difference between the first width dimension and the second width dimension comprises a strut having a third width dimension, Between about 10.0% and about 25.0%, and the ratio difference between the second and fourth width sizes is between about 10.0% and about 25.0%.

According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion and a cylindrical main body portion and has a cell structure of a main body portion that is circumferentially expanded about a longitudinal axis of the inflatable member, The cell structure of the portion may include a circle around the longitudinal axis of the expandable means to form first and second peripheral rails having proximal and distal end segments, A cell structure of a proximal end portion including a first set of cell structures arranged to form a first peripheral rail and a third set of cells located between the first and second sets of cell structures, A second set of cell structures arranged to form a second peripheral rail and a second set of cell structures having a cell structure in a main body including a fourth set of cell structures in a common, A second set of cell structures having a first set of cell structures having a circumferential outermost strut member defining a first circumferential rail and a circumferentially outermost strut member defining a proximal cell structure and a second circumferential rail, An upper shell structure, a first width dimension of the proximal end segment and a second width dimension at the distal end segment, and at least a portion of the peripheral outermost strut portion The second width dimension being less than the first width dimension, the ratio variation between the first width dimension and the second width dimension being between about 20.0% and about 50.0%, and the third set of cell structures being less than the second width dimension The fourth set of cell structures including a strut having a fourth width dimension substantially equal to a second width dimension and wherein the ratio of the second width dimension to the third width dimension comprises a strut having a third width dimension, Is between about 10.0% and about 25.0%.

 According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion and a cylindrical main body portion and has a cell structure of a main body portion that is circumferentially expanded about a longitudinal axis of the inflatable member, The cell structure of the portion may include a circle around the longitudinal axis of the expandable means to form first and second peripheral rails having proximal and distal end segments, A cell structure of a proximal end portion including a first set of cell structures arranged to form a first peripheral rail and a third set of cells located between the first and second sets of cell structures, First and second sets of cell structures having a cell structure in a main body including a fourth set and a fifth set of cell structures in a common last up cell configuration, Two sets of cell structures, a first set of cell structures having a circumferential outermost strut member defining a first circumferential rail and a cell structure of a cell structure having a circumferentially outermost strut member defining a second circumferential rail, Two sets and a recent up-cell structure, wherein the first and second peripheral rails are arranged to vary between a first width dimension of the proximal end segment and a second width dimension of the distal end segment, A strut member,

The sizes of the third and fifth sets of cell structures are substantially the same, the size of the fourth set of cell structures is larger than the size of the third set of cell structures, and the third, fourth, Fourth, and fifth struts, wherein at least some of the fourth and fifth struts or segments of the third, fourth, and fifth sets of cell structures are larger than the width dimension of the third strut, Width size.

According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion and a cylindrical main body portion and has a cell structure of a main body portion that is circumferentially expanded about a longitudinal axis of the inflatable member, The cell structure of the portion may include a circle around the longitudinal axis of the expandable means to form first and second peripheral rails having proximal and distal end segments, A cell structure of a proximal end portion including a first set of cell structures arranged to form a first peripheral rail and a third set of cells located between the first and second sets of cell structures, A second set of cell structures arranged to form a second peripheral rail and a second set of cell structures having a cell structure in a main body including a fourth set of cell structures in a common, A second set of cell structures having a first set of cell structures having a circumferential outermost strut member defining a first circumferential rail and a circumferentially outermost strut member defining a proximal cell structure and a second circumferential rail, An upper shell structure, a first width dimension of the proximal end segment and a second width dimension at the distal end segment, and at least a portion of the peripheral outermost strut portion The second width dimension being less than the first width dimension, the ratio variation between the first width dimension and the second width dimension being between about 20.0% and about 50.0%, and the third set of cell structures being less than the second width dimension The fourth set of cell structures including a strut having a fourth width dimension substantially equal to a second width dimension and wherein the ratio of the second width dimension to the third width dimension comprises a strut having a third width dimension, Is between about 10.0% and about 25.0%.

 According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion and a cylindrical main body portion and has a cell structure of a main body portion that is circumferentially expanded about a longitudinal axis of the inflatable member, The cell structure of the portion may include a circle around the longitudinal axis of the expandable means to form first and second peripheral rails having proximal and distal end segments, A cell structure of a proximal end portion including a first set of cell structures arranged to form a first peripheral rail and a third set of cells located between the first and second sets of cell structures, First and second sets of cell structures having a cell structure in a main body including a fourth set and a fifth set of cell structures in a common last up cell configuration, Two sets of cell structures, a first set of cell structures having a circumferential outermost strut member defining a first circumferential rail and a cell structure of a cell structure having a circumferentially outermost strut member defining a second circumferential rail, Two sets and a recent up-cell structure, wherein the first and second peripheral rails are arranged to vary between a first width dimension of the proximal end segment and a second width dimension of the distal end segment, A strut member,

The sizes of the third and fifth sets of cell structures are substantially the same, the size of the fourth set of cell structures is larger than the size of the third set of cell structures, and the third, fourth, Fourth, and fifth struts, wherein the width dimension of the third strut is less than the second width dimension, and at least some of the fourth and fifth struts or segments thereof are substantially equal to the second width dimension Width size.

 According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion, a cylindrical main body portion, and a distal end portion, wherein the expandable member includes a plurality of generally longitudinal wave elements having a proximal end portion, a cylindrical main body portion and a distal end portion, The structure, the cell structure of the proximal end portion and the distal end portion, is configured to define first and second peripheral rails having proximal and distal end segments A cell structure of a proximal end portion including a first set of cell structures deployed circumferentially about a longitudinal axis of the inflatable means and arranged to form a first peripheral rail, A second set of cell structures arranged to form a second peripheral rail, a main body structure including a fourth set and a fifth set of cell structures in a common, A first set of cell structures having first and second sets of cell structures, a cell structure of a distal end portion including cell sets of a sixth set, a first set of cell structures having a peripheral outermost strut member defining a first peripheral rail, A second set of cell structures having a cell structure and a recent up-cell structure, a peripheral structure defining a second peripheral rail, and a second set of cell structures having a first width dimension and a second width at a distal end segment of the proximal end segment, size The first and second standing around the rail and arranged to change a second width smaller than the size at least in part around the outermost strut member, the first width dimension of a size having a different width. In one embodiment, the first and second surrounding rails are undamped and the ratio variation between the first width size and the second width size is between about 20.0% and about 50.0%.

According to yet another embodiment, the coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion, a cylindrical main body portion, and a distal end portion, wherein the expandable member includes a plurality of generally longitudinal wave elements having a proximal end portion, a cylindrical main body portion and a distal end portion, The structure, the cell structure of the proximal end portion and the distal end portion, is configured to define first and second peripheral rails having proximal and distal end segments A cell structure of a proximal end portion including a first set of cell structures deployed circumferentially about a longitudinal axis of the inflatable means and arranged to form a first peripheral rail, A second set of cell structures arranged to form a second peripheral rail, a main body structure including a fourth set and a fifth set of cell structures in a common, A first set of cell structures having first and second sets of cell structures, a cell structure of a distal end portion including cell sets of a sixth set, a first set of cell structures having a peripheral outermost strut member defining a first peripheral rail, A second set of cell structures having a cell structure and a recent up-cell structure, a peripheral structure defining a second peripheral rail, and a second set of cell structures having a first width dimension and a second width at a distal end segment of the proximal end segment, size Wherein at least some of the peripheral outermost strut members disposed to vary the first and second peripheral rails and having different width dimensions, the sizes of the third, fifth, and sixth sets of cell structures are substantially the same, The sizes of the four sets of cell structures are larger than the sizes of the third, fifth, and sixth sets of cell structures, and the third, fifth, and sixth sets of cell structures are third, fourth, fifth, And at least some of the fourth and fifth struts or segments thereof have a width dimension greater than the width dimension of the third and sixth struts.

Another embodiment of a coagulation recovery apparatus is provided comprising:

An elongated, self-expanding member movable from a first delivery position to a second delivery position, an inflatable member at a non-inflated position at the first delivery position and an inflatable member at the nominal first diameter, and a radially- An inflatable member having a second nominal diameter greater than a first nominal diameter for placement in a patient's embolus closure, the inflatable member comprising an adjacent wave element interconnected in a manner to form a plurality of diagonally arranged cell structures, Wherein the inflatable member has a proximal end portion, a cylindrical main body portion, and a distal end portion, wherein the expandable member includes a plurality of generally longitudinal wave elements having a proximal end portion, a cylindrical main body portion and a distal end portion, The structure, the cell structure of the proximal end portion and the distal end portion, is configured to define first and second peripheral rails having proximal and distal end segments A cell structure of a proximal end portion including a first set of cell structures deployed circumferentially about a longitudinal axis of the inflatable means and arranged to form a first peripheral rail, A second set of cell structures arranged to form a second peripheral rail, a main body structure including a fourth set and a fifth set of cell structures in a common, A first set of cell structures having first and second sets of cell structures, a cell structure of a distal end portion including cell sets of a sixth set, a first set of cell structures having a peripheral outermost strut member defining a first peripheral rail, A second set of cell structures having a cell structure and a recent up-cell structure, a peripheral structure defining a second peripheral rail, and a second set of cell structures having a first width dimension and a second width at a distal end segment of the proximal end segment, size Wherein at least some of the peripheral outermost strut members disposed to vary the first and second peripheral rails and having different width dimensions, the sizes of the third, fifth, and sixth sets of cell structures are substantially the same, The sizes of the four sets of cell structures are larger than the sizes of the third, fifth, and sixth sets of cell structures, and the third, fifth, and sixth sets of cell structures are third, fourth, fifth, And at least some of the fourth and fifth struts or segments thereof have a width dimension substantially equal to the width dimension of the second strut.

In another embodiment, the embolization closure collection device is provided comprising:

An inflatable member in a first delivery position is in an unexpanded position and has a nominal first diameter and the inflatable member in a second position is in a radial direction Wherein the inflatable member has a second nominal diameter greater than the first nominal diameter for deployment in a patient's embolus closure, the inflatable member having an adjacent, interconnected, Wherein the inflatable element has a proximal antenna, a proximal end portion and a cylindrical main body portion, and the cellular structure of the main body portion is configured to expand about a longitudinal axis of the inflatable member, The cell structure at the proximal and distal ends is inflated less than the perimeter around the longitudinal axis of the inflatable member, The outermost cell structure of the minor portion has a recent upper wall segment forming first and second rail segments that respectively expand from a position at or near the closest upper end of the inflatable member to a position at or near the cylindrical main body portion , The most recent up-cell structure of the proximal end portion includes first and second outer struts that are expanded from the proximal antenna, and at least one portion of each of the first and second outer struts in the two-dimensional layout comprises a straight segment Each straight segment is co-inflated with the proximal antenna.

In another embodiment, the embolization closure collection device is provided comprising:

An inflatable member in a first delivery position is in an unexpanded position and has a nominal first diameter and the inflatable member in a second position is in a radial direction Wherein the inflatable member has a second nominal diameter greater than the first nominal diameter for deployment in a patient's embolus closure, the inflatable member having an adjacent, interconnected, Wherein the inflatable element has a proximal antenna, a proximal end portion and a cylindrical main body portion, and the cellular structure of the main body portion is configured to expand about a longitudinal axis of the inflatable member, The cell structure at the proximal and distal ends is inflated less than the perimeter around the longitudinal axis of the inflatable member, The outermost cell structure of the first set of parts has a recent upper wall segment forming a non-ephemeral rail segment that respectively expands from a position at or near the closest upper end of the inflatable member to a position at or near the cylindrical main body portion, The outermost cell structure of the body 2 set of end portions has a recent upper wall segment forming a non-ephemeral rail segment that respectively expands from a location at or near the closest upper end of the inflatable member to a location at or near the cylindrical main body portion .

In another embodiment, the embolization closure collection device is provided comprising:

Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal end, a proximal end portion and a cylindrical main body portion including a proximal and distal section, the cell structure of the cylindrical main body portion including a longitudinal axis of the inflatable member, The cell structure of the proximal end portion is inflated less than the perimeter around the longitudinal axis of the inflatable member and the distal section of the cylindrical main body portion in the inflated configuration is less than the average diameter of the proximal section of the cylindrical main body portion And has a large average diameter.

In some embodiments, the average length of the cell structure of the distal section of the cylindrical main body portion is greater than the average length of the cell structure of the proximal section of the cylindrical main body portion, and the average length of the cell structure of the proximal section of the cylindrical main body portion is greater than the average length of the proximal Is greater than the average length of the cell structure of the end portion and the ratio of the average length to width of the cell structure of the proximal end portion and the cylindrical main body portion is greater than when the self-expandable member has a limited and unrestricted configuration.

In another embodiment, the embolization closure collection device is provided comprising:

Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal antenna, a proximal end portion and a cylindrical main body portion including a proximal and distal section, wherein the cellular structure of the cylindrical main body portion includes a longitudinal axis of the inflatable member, The cell structure of the proximal end portion is inflated to less than the perimeter around the longitudinal axis of the inflatable member and the ratio of the average length to width of the cell structure of the distal section of the cylindrical main body portion is greater than that of the cylindrical main body portion Is greater than the ratio of the average length to width of the cell structure of the proximal section and the proximal sector of the cylindrical main body portion The ratio of the average length to width of the cell structure of the proximal end portion is greater than the ratio of the average length to the width of the cell structure of the proximal end portion and the ratio of the average length to width of the cell structure of the proximal end portion is such that the self- Lt; / RTI >

In another embodiment, the embolization closure collection device is provided comprising:

Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal antenna, a proximal end portion and a cylindrical main body portion, the cellular structure of the cylindrical main body portion is expanded about a longitudinal axis of the inflatable member, The cell structure of the end portion is inflated less than the perimeter around the longitudinal axis of the inflatable member and the cell structure of the distal section of the cylindrical main body portion is expanded to a pair of diagonal lines and spaced proximally and circumferentially Shaped V-shaped structure, wherein the proximal and distal V-shaped structures have a first average width And has a pair of diagonally expanded and circumferentially spaced struts having a second mean width dimension greater than the first mean width dimension.

In another embodiment, the embolization closure collection device is provided comprising:

Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal end, a proximal end portion and a cylindrical main body portion including a proximal and distal section, the cell structure of the cylindrical main body portion including a longitudinal axis of the inflatable member, The cell structure of the proximal end portion is inflated to less than the perimeter around the longitudinal axis of the inflatable member and the cell structure of the cylindrical main body portion is expanded to a pair of diagonal lines and interconnected by strut spaced apart. A V-shaped structure that faces the proximal and distal sides of the diaphragm, and is diagonally inflated A circumferentially spaced apart strut includes a first and a second end segment and an intermediate segment disposed between the first and second end segments, wherein the first end segment is connected to the proximal V-shaped structure and the second end segment is distal Wherein the proximal and distal V-shaped structures have a first average width dimension, the middle segments of the struts extending diagonally and spaced apart have a second average width dimension greater than the first average width dimension, The first and second end segments of the strut that are diagonally expanded and circumferentially spaced have a third average width dimension that is greater than the first average width dimension and less than the second average width dimension.

In another embodiment, the embolization closure collection device is provided comprising:

Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal end, a proximal end portion and a cylindrical main body portion including a proximal and distal section, the cell structure of the cylindrical main body portion including a longitudinal axis of the inflatable member, The cell structure of the proximal end portion is inflated to less than the perimeter around the longitudinal axis of the inflatable member and the cell structure of the cylindrical main body portion is expanded to a pair of diagonal lines and interconnected by strut spaced apart. Shaped structure that is expanded in a pair of diagonal lines, At least a portion of the spaced apart struts have one or more wires or ribbons wound to enhance the average deflection strength of all or a portion of the cylindrical main body portion when the self-expandable member is in a radially expanded configuration.

Alternative embodiments of the present invention are described herein with reference to the accompanying drawings.
IA is a plan view of an inflatable member of a treatment device in one embodiment.
1B is an isometric view of the inflatable member shown in FIG. 1A;
Figure 2 shows a distal wire segment extending in a distal direction from an inflatable member in one embodiment.
3 shows a distal end of an inflatable member having an exotic tip;
Figure 4a is a top view of an inflatable member of a treatment device in yet another embodiment.
Fig. 5 is an enlarged view of a recent upper segment of the inflatable member shown in Fig. 4a. Fig.
6A is a plan view of an inflatable member of a treatment device in yet another embodiment.
6B is an isometric view of the inflatable member shown in Fig. 6A. Fig.
Figure 7a is a top view of an inflatable member of a treatment device in yet another embodiment.
Figure 7b is an isometric view of the inflatable member shown in Figure 7a.
8 is a plan view of an inflatable member of a treatment device in yet another embodiment.
8 is a view of an inflatable member in an inflated position having a bulge or increased diameter portion;
10 is a plan view of an inflatable member of a treatment device in another embodiment.
11A is a plan view of an inflatable member of a treatment device in yet another embodiment.
11B is an isometric view of the inflatable member shown in Fig.
12 is a plan view of an inflatable member of a treatment device in another embodiment.
Figures 13A-13C illustrate a method for recovering an embolus closure in accordance with one embodiment.
Figure 14 is a plan view of an inflatable member of a treatment device in another embodiment.
15 is a plan view of an inflatable member of a treatment device in another embodiment.
16 is an isometric view of an inflatable member having an inner wire segment in another embodiment.
17 is an isometric view of an inflatable member having an outer wire segment in yet another embodiment.
18 is an isometric view of an inflatable member having a distal embolization device in another embodiment.
19 is a plan view of an inflatable member of a treatment device in yet another embodiment.
Figure 20 is a view of the expandable member of Figure 19 with longitudinal slits.
Figure 21 is a view of the expandable member of Figure 19 having a helical slit.
Figure 22 is a view of the expandable member of Figure 19 with partial spiral slits.
23 is a plan view of an inflatable member of a treatment device in yet another embodiment.
24A is a plan view of an inflatable member of a treatment device in yet another embodiment.
Figure 24B is a top view of an inflatable member of a treatment device in yet another embodiment.
25 illustrates how a wire segment extending in the proximal direction of an inflatable device is attached to a delivery wire in one embodiment.
26 is a plan view of an inflatable member of a treatment device in yet another embodiment.
27A and 27B are a side view and a top view of the inflatable member shown in Fig. 26;
28A and 28B illustrate a proximal wire segment and a distal wire segment of an inflatable member in one embodiment.
29 is a graph showing the curvature of the radial force of an inflatable member according to one embodiment.
30 is a plan view of the solid-liquid recovery device according to some embodiments
31 is a plan view of a solid-liquid recovery device according to some embodiments;
32A-C are cell structures according to a portion of the embodiment of FIG.
33A is a plan view of a solid-liquid recovery device according to some embodiments.
33B and 33C are top and side isometric views of the apparatus shown in Fig. 33A. Fig.
34A is a plan view of a solid-liquid recovery device according to some embodiments.
Figures 34B and 34C are top and side isometric views of the apparatus shown in Figure 34A.
35A is a plan view of a solid-liquid recovery device according to some embodiments.
35B and 35C are top and side isometric views of the apparatus shown in Fig. 35A. Fig.
36 is a plan view of a solid-liquid recovery device according to some embodiments;
37 is a plan view of a solid-liquid recovery device according to some embodiments.
38 is a plan view of a solid-liquid recovery device according to some embodiments;
39 is a plan view of a solid-liquid recovery device according to some embodiments.
40A is a plan view of a solid-liquid recovery device according to an embodiment.
40B is a perspective view of the solid-liquid recovery device of Fig. 40A. Fig.
41 is a plan view of a solid-liquid recovery device according to some embodiments.
42A is a plan view of a solid-liquid recovery device according to some embodiments.
42B is an enlarged plan view of the proximal tapered end portion of the recovery device shown in FIG. 45A;
Figure 43 is a top plan view of a recent up-cell structure in accordance with some embodiments.
44 is a plan view of a recent up-cell structure in accordance with some embodiments.
45A-C are plan views of a solid-liquid recovery device in accordance with some embodiments.
46 is a plan view of a solid-liquid recovery device according to some embodiments;
47A is a plan view of a distal end of a coagulum recovery device according to some embodiments.
47B is a perspective view of the distal end shown in Fig. 47A. Fig.
48A is a plan view of a solid-liquid recovery device according to some embodiments.
48B is a perspective view of the solid-liquid recovery device shown in Fig. 48A. Fig.
49 is a plan view of a solid-liquid recovery device according to some embodiments;
50 is a plan view of a distal segment of a collection device according to some embodiments.
51A-D are top views of a collection device according to some embodiments.
52A and 52B are plan views of a collection device according to some embodiments.
53 is a plan view of the collecting device according to some embodiments;
54 is a plan view of a collection apparatus according to some embodiments;
55 is a plan view of a collecting apparatus according to some embodiments.
56A and 56B are plan views of a collecting device according to some embodiments.
Figure 57 is a top view of a collection device according to some embodiments.
58A is a top view of a collection apparatus according to some embodiments.
58B is an enlarged view of the cell structure shown in FIG. 58A; FIG.
59A is a side view of a mating member according to one embodiment.
59B is a cross-sectional view of the coupling member shown in Fig. 59A. Fig.
60A and 60B are wire attachment configurations according to some embodiments.

Figures 1A and 1B illustrate an apparatus 10 for treating a vessel or body tube in accordance with one embodiment of the present invention. The device 10 is particularly suitable for accessing and treating an intracranial vascular in a patient, such as, for example, treating an aneurysm or capturing and removing an embolic obstruction. However, the device 10 may be used for accessing and treating the vasculature, and also for other areas within other bodily tubes. Other uses include, for example, stenosis and other types of vascular diseases and disorders. Figure 1A shows a top view of the device 10 with the device cut and laid flat on the surface. 1B shows a device in a tubular shape that has been manufactured and / or expanded. The device 10 includes a self-expandable member 12 attached to or attached to an elongate flexible wire 40 expanded proximally from the inflatable member 12. The self- In one embodiment, the inflatable member 12 is made of a shape memory material, such as Nitinol, and is preferably laser cut from the tube. In one embodiment, the inflatable member 12 has a wire segment 42 that is formed integrally and extends in a proximal direction, which is used to connect the elongated flexible wire 40 to the inflatable member 12. In one embodiment, In this embodiment, the flexible wire 40 may be joined to the wire segment 42 using soldering, welding, adhesive, or any other known attachment method. In an alternative embodiment, the proximal end of the flexible wire 40 is attached directly to the proximal end 20 of the inflatable member 12. In one embodiment, the distal end of the wire 40 has a flat profile with a width of about 0.005 inches and a width of about 0.0063 and about 0.0035 inches in width and thickness of the wire segment 42.

In one embodiment, the distal end of the wire 40 is attached to the proximal extension of the wire segment 42 by the following method, thereby forming the joint shown in Fig. In one embodiment, the coil 41 is disposed over the wire segment 42 and the coil includes a tightly wound segment 41a contacting the proximal end of the inflatable member 12 and a loosely wound And a segment 41b. The size of the one or more spacing 41c is at least large enough to allow at least the bonding agent to flow into the inner cavity of the coil segment 41b. In one embodiment, coil 41 and wire segment 42 have the same length. In one embodiment, the length of the wire segment 42 is 4.0 mm and the coil 41 is the same length. The distal end of the wire 40 is disposed within the coil segment 41b and contacts and overlaps with the proximal end portion of the wire segment 42. The coils 41, The bonding agent is then applied through the gap 41c of the coil 41 to bond the wire 40 to the wire segment 41. [ The bonding agent may be an adhesive, solder, or any suitable bonding agent. When the bonding agent is solder, the preceding step in the process includes coating the distal end portion of the wire 40 with the proximal end portion of the wire segment 42 with tin or another suitable wetting agent. In one implementation, the solder is gold and used to enhance the radiopacity of the joint so that the joint can be provided as a proximal radiopaque marker. In addition to the use of gold, all or a portion of the coil may be made of a radiopaque material to further enhance the radiopacity of the joint. According to one embodiment, the overlap length between wire 40 and wire segment 42 is 0.75 mm to 1.0 mm. In the same or other implementation, the length of the coil segment 41b may be the same as, or substantially the same as, the overlap length of the wire 40 and the wire segment 42. In an alternative embodiment, instead of using a single coil 41, two or more coils in an adjacent state may be used, for example, a first tight-wound coil may be used to connect the proximal end 20 of the inflatable member 12 ), And the second loosely wound coil is disposed in an interval formed proximate to the tightly wound coil. Although not shown in the figures, in one embodiment, the distal end length of the wire 40 tapers in a proximal direction with a reduced profile from the nominal diameter. A distal wire coil of constant outside diameter is provided that is not tapered along this length. According to one embodiment, the diameter of the coil 41 has the same outer diameter as the distal wire coil.

One advantage of the joint structure is its resistance to buckling and the device is pressurized through the delivery catheter and at the same time the device is flexible enough to be delivered through the patient's tortuous anatomy. In addition, the joint can withstand high tensile and torque loads without breaking. In the load test, the joints of the embodiments described above can withstand tensile stresses in excess of two pounds. In one embodiment, the coil 41 is also made of a radiopaque material to serve as a proximal radiopaque marker.

Figure 28A illustrates an optional proximal wire segment structure. As shown, the proximal wire segment 4002 has a first section 4002a and a second section 4002b, and the second section 4002b has a width W that is greater than the width of the first section. In one embodiment, the tapered transition section 4003 couples the first and second sections 4002a and 4002b. In one embodiment, the first section 4002a is approximately 0.0063 inches and the width W of the second section is approximately 0.0085 inches to approximately 0.0105 inches. The length L between the proximal end 4005 of the inflatable member 4004 and the second section 4002b of the wire segment 4002 is from about 0.017 to about 0.022 inches. The advantage of including the second section 4002b is that the wider width dimension is greater for widening the wire segment 4002 relative to the elongated wire 40 used for the infeed and delivery of the elongated member from the patient & Surface area. In one embodiment, the first section 4002a has a circular or substantially circular structure, and the second section 4002b has a flat profile formed by a pressing / coining operation.

1a and 1b, the inflatable member 12 includes a plurality of generally longitudinally-wedge-shaped elements 24, adjacent wedge-shaped elements are out of phase with each other, and a plurality of diagonal- To form a cell structure (26). The inflatable member 12 includes a proximal end portion 14, a cylindrical main body portion 16 and a distal end portion 18 and the cell structure 26 in the main body portion 16 includes an inflatable member 12 In the circumferential direction. The cell structure 26 in the proximal end portion 14 and the distal end portion 18 is elongated less and less circumferentially about the longitudinal axis 30 of the inflatable member 12.

In one embodiment, the inflatable member 12 has a total length of about 33.0 mm, the main body portion 16 has a length of about 16.0 mm and the proximal and distal end portions 14, 18 each have a length of about 7.0 mm Respectively. In alternative embodiments, the length of the main body portion 16 is generally about 2.5 to about 3.5 times longer than the length of the proximal and distal end portions 14, 18.

In use, the inflatable member 12 advances through the patient's ganglionic vasculature or body tube in a non-expanding or compressed state (not shown) of a first nominal diameter in a treatment flush, And can be moved in a radially expanded state of a second nominal diameter larger than the first nominal diameter for deployment. In an alternate exemplary embodiment, the first nominal diameter (e.g., the average diameter of the main body portion 16) ranges from about 0.017 to about 0.030 inches, while the second nominal diameter (e.g., (The average diameter of the first layer 16) is in the range of about 2.5 mm to about 5.0 mm. In one embodiment, the size and material properties of the cell structure 26 disposed in the main body portion 16 of the inflatable material 12 are such that the embolization disposed within the vessel in a manner that permits partial or total removal of the embolization closure from the patient. Is selected to create sufficient radial forces and contact interactions to contact the closure and the cell structure (26). In an alternate embodiment, the size and material properties of the cell structure 26 in the main body portion 16 may range from about 0.005 N / mm to about 0.050 N / mm, preferably from about 0.010 N / mm to about 0.050 N / mm , And more preferably from about 0.030 N / mm to about 0.050 N / mm, to produce a radial force per unit length. In one embodiment, in the fully expanded state, the diameter of the main body portion 16 is about 4.0 mm, and the cell pattern, strut size, and material is about 0.040 N / mm 0.0 > N / mm, < / RTI > In an identical or alternative embodiment, the cell pattern, strut size, and material (s) may be selected so as to produce a radial force of about 0.010 N / mm to about 0.020 N / mm when the diameter of the main body portion decreases to 3.0 mm Is selected.

1A and 1B, each cell structure 26 is shown having the same size, and each cell structure includes a pair of short struts 32 and a pair of long struts 34 do. In an exemplary embodiment, the struts 32 have a length of from about 0.080 to about 0.100 inches, the struts 34 have a length of from about 0.130 to about 0.140 inches, and each strut 32, 34 has a length of about 0.003 inches To about 0.0045 inches, respectively, and have width and thickness, respectively, after polishing from about 0.0022 inch to about 0.0039 inch. The integration of the strut into the embolization closure is facilitated by the advantage that the strut thickness ratio to width exceeds 1. In an alternate embodiment, the width and thickness sizes after polishing vary between about 0.0020 inches and about 0.0035 inches and about 0.0030 inches and about 0.0040 inches, respectively, and the ratio of thickness to width is about 1.0 to about 2.0, And varies from about 1.25 to about 1.75.

In one embodiment, only the strut elements of the main body portion 16 have a thickness to size ratio of greater than one. In yet another embodiment, only strut elements of main body portion 16 and distal end portion 18 have a thickness to size ratio of greater than one. In yet another embodiment, only a portion of the strut element has a thickness to thickness ratio of greater than one. In yet another embodiment, the strut elements in different parts of the inflatable member have a ratio of the thickness to the thickness of the different widths, and in each part the ratio exceeds one. By way of example, because the radial forces exerted by the distal end portion 18 and the proximal end portion 14 of the inflatable member 12 may be generally less than the radial forces exerted by the main body portion 16, The strut element at the distal and / or proximal end portions may have a ratio of thickness to width greater than the ratio of the thickness to the width of the strut within the main body portion 16. According to the advantage of such a structure, the inflatable member 12 can be integrated into the embolization closure and becomes more uniform along the length of the inflatable member.

In yet another embodiment, the particular or all strut elements have a tapered shape and the outer surface of the strut has a width dimension less than the width dimension of the inner surface of the strut. In another alternative embodiment, the inflatable member 12 may include a strut element having a tapered shape and a strut element having a generally rectangular cross-section.

It is important that the present invention is not limited to an expandable member 12 having a uniform cell structure, but rather a specific size characteristic. By way of example, in alternative embodiments, the cell structure 26 in the distal and / or proximal end portions 14, 18 is larger or smaller than the cell structure 26 in the main body portion 16. In one embodiment, the cell structure 26 in the proximal and distal end portions 14, 18 is larger in size than in the main body portion 16 so that the radial forces exerted on the end portions 14, Is less than the radial force exerted within the main body portion 16.

The radial force along the length of the inflatable member 12 can be varied in various ways. One method is to vary the mass (e.g., width and / or thickness) of the strut along the length of the inflatable member 12. [ Another method is to change the size of the cell structure 26 along the inflatable member 12. [ The use of a smaller cell structure generally results in a larger radial force than a larger cell structure. Changing the applied radial force along the length of the inflatable member may be particularly preferred for use in retrieving and entrapping the embolic occlusion. For example, in one embodiment, the radial forces in the distal section of the main body portion 16 of the inflatable member 12 in the inflated state are greater than the radial forces in the proximal section of the main body portion 16 . With this configuration, the distal section of the main body portion 16 relative to the proximal section promotes greater radial expansion into the embolic occlusion. Because the expandable member 12 is pulled in the proximal direction during removal of the embolic occlusion from the patient, the shape described above reduces the likelihood of particles being removed from the embolic occlusion during its removal. In an alternative embodiment, the radial forces in the proximal section of the main body portion 16 of the inflatable member 12 in the inflated state are greater than the radial forces in the proximal section of the main body portion 16. In another embodiment, the main body portion 16 of the inflatable member 12 includes a proximal section, a middle section, a distal section, and radial forces in the proximal and distal sections cause the inflatable member 12 to expand Is greater than the radial force in the middle section when in the engaged state.

9, the main body portion 16 may include an increased diameter portion or bulge 70 to increase the ability to capture or otherwise contact the embolus closure. In an alternative embodiment, have. In FIG. 9, a single increased diameter portion 70 is provided in the middle section of the main body portion 16. In an alternate embodiment, the increased diameter portion 70 may be positioned distal or proximal to the middle section. In yet another embodiment, two or more increased diameter portions 70 are provided along the length of the main body portion 16. In one embodiment, in another embodiment, two or more increased diameter portions 70 may be provided along the length of the main body portion 16. In one embodiment, the two or more increased diameter portions 70 have substantially the same nominal diameter. In yet another embodiment, the most extreme increased diameter portion 70 has a larger nominal diameter than the increased diameter portion disposed proximal. In an alternate exemplary embodiment, the nominal diameter of the increased diameter portion 70 is about 25.0 to about 45.0 percent greater than the nominal diameter of the main body portion. For example, in one embodiment, the expanded nominal diameter of the main body portion 16 is about 3.0 mm, and the nominal diameter of the increased diameter portion 70 is about 4.0 mm. In another embodiment, the expanded nominal diameter of the main body portion 16 is about 3.50 mm, and the nominal diameter of the increased diameter portion 70 is about 5.00 mm. In one embodiment, the one or more increased diameter portions are formed by disposing an inflatable mandrel within the internal lumen of the main body portion 16 and inflating the mandrel to form an increased diameter portion 70 of the desired diameter . In yet another embodiment, one or more increased diameter portions 70 may be formed by placing a mandrel of a given width and diameter into the main body portion 16 and then by at least a portion of the main body portion 16 being pressed against the mandrel As shown in FIG.

In one embodiment, the strut element in the increased diameter portion or portion 70 has a ratio of the thickness magnitude to the width magnitude that is greater than the ratio of the thickness to the width of the other struts in the main body portion 16. In yet another embodiment, the strut element in the increased diameter portion or portion 70 has a ratio of the thickness dimension to the width dimension that is less than the ratio of the thickness to the width of the other strut in the main body portion 16 .

The distal wire segment 50 attached to or formed integrally with the inflatable member 12 extends in a distal direction from the distal end 22 of the inflatable member 12, To guide delivery of the inflatable member to the inflatable member. 2 shows a distal wire segment in one embodiment having a second section 54 having a distal tapered cross-section and a first section 52 of uniform cross-section. In one embodiment, the first section 52 has a length of about 3.0 mm and a cut cross section size of about 0.0045 inches times about 0.003 inches, while the second section 54 has a length of about 4.0 mm and has a length of about 0.002 Inch times the tangent to the farthest in a cut cross-sectional dimension of about 0.003 inches. The post-polishing of the device is generally accompanied by an etching process, resulting in a cut cross-sectional size reduction of 40% to 50%. 3, the distal wire segment 50 is defined by a spring member 57 of constant diameter and is mounted with an atruamatic distal tip 58. In this embodiment, In an alternative embodiment, the spring element 57 and / or the outer tip 58 are made of or coated with a radiopaque material such as, for example, platinum.

Figure 28b shows an optional distal wire segment structure. As shown, the distal wire segment 4010 includes a first section 4011a and a second section 4011b and the second section 4011b includes a width W that is greater than the width of the first section 4011a. Respectively. In one embodiment, the tapered transition section 4012 couples the first and second sections 4011a and 4011b. In one embodiment, the width W of the second section is between about 0.003 inches and about 0.004 inches, and between the second section 4011b of the wire segment 4010 and the distal end 4013 of the inflatable member 4014 The length L is from about 0.015 inches to about 0.020 inches. As a benefit of the second section 4011b, the larger width size provides a larger surface area for coupling the coil / spring segment 57 to the wire segment 4010. [ In one embodiment, the first section 4011a has a circular or substantially circular configuration, and the second section 4011b has a flat profile formed by the pressing / coining operation.

In one embodiment, as will be described in greater detail below, the inflatable member 12 is delivered to the treatment site of the patient through the lumen of the delivery catheter already disposed at the treatment site. In an alternate embodiment, the vascular treatment device 10 can be introduced in a proximal direction so that the inflatable member 12 is assumed to be in an inflated state, and the inflatable member 12 is compressed As shown in FIG.

In one embodiment, in the expanded state, the inflatable member 12 may contact the embolization closure placed on the treatment site, for example, by being embedded into the closure itself, and the inflatable member 12 and the embolus closure Can be removed from the patient by pulling a portion of the elongate flexible wire 40 that is placed on the exterior of the patient until at least a portion is removed from the patient.

The use of interconnected, out-of-phase wavy elements to form at least a portion of the cell structure 26 in alternative embodiments provides several advantages. First, the flexibility of the inflatable member 12 is increased during delivery through the patient's serpentine anatomy, depending on the curvilinear characteristics of the cell structure 26. In addition, a more compact overlap of the inflatable member elements is possible due to the out-of-phase relationship between the wavy elements, so that the inflatable member 12 can have a very small compressed diameter. The elements of the inflatable member can be arranged in succession according to the various embodiments described herein and the particular advantage of the inflatable member strut pattern shown in Figure 1A so that the inflatable member can be partially or fully deployed And may then be withdrawn into the lumen of the delivery catheter. Also, because of the translational movement of the expanding member 12 between the expanded and compressed states that help the inflatable member better contact with the embolic occlusion in an out-of-phase relationship, the oblique orientation of the cell structure 26 is twisted Sting operation can be caused. In an alternate embodiment, the cell structure 26 of the inflatable member 12 is arranged to produce a desired twisting action, particularly while the inflatable member 12 is being inflated. In this way, different inflatable members having different twisting operations can be used, for example, to treat different types of embolic occlusion.

To enhance the visibility of the device under a mold light, the inflatable member may be coated completely or partially with a radiation-impermeable material such as tungsten, platinum, platinum / iridium, tantalum, and gold. Alternatively, or in conjunction with the use of a radiopaque coating, the radiopaque marker 60 may be placed on the selected inflatable member strut segment and / or along the distal and proximal wire segments 42, 50 and / At or near the proximal and distal ends 20,22. In one embodiment, the radiopaque marker 60 is a radiopaque coil, such as a platinum coil.

FIG. 4A shows an apparatus 100 for treating an artery in a plan view in still another embodiment of the present invention. In its manufactured and / or expanded tubular shape, the device 100 has a structure similar to the device 10 shown in FIG. 1B. The device 100 includes a self-expandable member 112 that is coupled to the elongated flexible wire 140, such as the device 10 described above in accordance with Figures 1A and 1B. The expandable member 112 includes a proximal end portion 114, a cylindrical main body portion 116, and a distal end portion 118. As described above, delivery of the inflatable member 112 from the unexpanded state to the patient ' s treatment site can be accomplished by deploying the inflatable member 112 into the proximal end of the delivery catheter and deploying the inflatable member 112 to the treatment site Is performed by pushing the inflatable member 112 through the lumen of the delivery catheter until the distal end of the catheter pre-positioned across the treatment site is reached. The proximal extension of the flexible wire 140 coupled to or attached to the proximal end 120 of the expandable member 112 is configured to transmit the applied pushing force to the point of connection with the elongated flexible member 112 Is designed. As shown in more detail in Figures 4A and 4B, the apparatus 100 is configured such that the recent up-cell structure 128, 130 within the proximal end portion 114 is sized to have a width dimension < RTI ID = 0.0 > And a strut element having a wider width W1 than the width W2 of the strut element W1. As shown, the upper, upper wall sections 160, 162, 164 of the cell structure 128 are made of struts having a width W1. In addition, all struts of the upper cell structure 130 have an increased width W1. Some advantages are provided by including and arranging struts with width W1. One advantage is that the pushing force exerted by the distal end of the elongated wire 140 at the proximal end 120 of the elongated member 112 as it progresses through the patient's serpentine anatomy, As shown in FIG. A more uniformly distributed pressing force minimizes the formation of local high force components that can act on individual or multiple strut elements in the inflatable member 112 that bend them. Further, as the strut of width W1 is included in the peripheral region of the proximal end portion 114, the strut significantly prevents the tendency of the proximal end portion 114 to bend under the applied pressure exerted by the elongated wire 140. [ In one exemplary embodiment, the cut width size W1 is about 0.0045 inches and the cut width size W2 is about 0.003 inches. As described above, the post-polishing of the apparatus is generally accompanied by an etching process to reduce the cut cross-sectional size by 40% to 50%.

Although width size W1 is shown to be the same among all struts with increased width, this is not necessary. For example, in one embodiment, the wall segment 158 may have an increased width dimension that is greater than the increased width of the wall segment 160, and the wall segment 160 may have an increased width dimension A width greater than the width, and the like. In addition, the inner strut element 166 of the upper shell structure 130 may have an increased width dimension that is less than the increased width dimension of the strut 158. Further, in alternate embodiments, the radial thickness magnitude of the struts 158, 160, 162, 164, etc. may be increased instead of the magnitude of the width or a combination thereof.

5, at the distal end portion 118 of the inflatable member 112, some strut elements 180 may extend beyond the strut 180 as the device 100 advances to the patient's treatment site. Have masses greater than those of the other struts to prevent bending and possible destruction. In the illustrated embodiment, the strut 180 is sized to have the same width as the distal wire segment 150. In alternate embodiments, the thickness magnitude of the strut 180 may be increased instead of the magnitude of the width or a combination thereof.

6A and 6B illustrate an apparatus 200 for treating an artery according to another embodiment of the present invention. 6A shows an apparatus 200 in plan view wherein the apparatus is cut and placed on a surface. Figure 6b shows the manufactured and / or expanded tubular shape of the device. The apparatus 200 includes an inflatable member 212 having a proximal end portion 214, a cylindrical main body portion 216 and a distal end portion 218 and the elongated flexible wire 240 includes an inflatable member 212, Or attached to the proximal end 220 of the proximal end. The structure of device 200 is similar to that of FIG. 4A except that proximal wall segment 260 of cell structure 228, 230 is linear or includes a substantially linear strut element as shown in the two- And is similar to device 100 described above. In one embodiment, the linear strut element 260 includes a continuous and substantially linear rail segment 270 extending from the proximal end 220 of the proximal end portion 214 to the proximal upper end of the main body portion 216 (Again, as shown in the plan view of Fig. 6A) to be formed, preferably of the same size but of different lengths. When the pattern of Figure 6a is applied to a laser cutting a tubular structure, the resulting expanded member shape is as shown in Figure 6b. As shown in FIG. 6B, the rail segment 270 is substantially non-linear, curved and non-wavy. According to this configuration, there is preferably provided a rail segment 270 free of wavy portions, whereby the ability of the rail segment to prevent bending and distribute the force when the pressing force is applied thereto. In an optional preferred embodiment, the angle [theta] between wire segment 240 and rail segment 270 ranges from about 140 [deg.] To about 150 [deg.]. In one embodiment, one or both of the linear rail segments 270 have a width dimension W1 that is greater than the width dimension of the adjacent strut segment of the cell structure 228,230. The increased width dimension W1 of one or both of the linear rail segments 270 further increases the ability of the rail segment to prevent bending and to distribute force when a pressing force is applied thereto. In yet another embodiment, one or both of the linear rail segments 270 are provided with an increased thickness dimension rather than an increased width dimension to achieve the same or similar results. In yet another embodiment, the width and / or thickness dimension of each rail segment 270 is greater than the width and / or thickness dimension of the proximal end portion 214 of the inflatable member 212 when mounted or withdrawn into the delivery catheter or sheath (not shown) The way to cause more uniform compression is different.

FIGS. 7A and 7B illustrate an apparatus 100 for treating blood vessels according to another embodiment of the present invention. Figure 7A shows an apparatus 300 in plan view wherein the apparatus is cut and placed on a surface. Figure 7b shows the manufactured and / or expanded tubular shape of the device. Apparatus 300 includes an inflatable member 312 having a proximal end portion 314, a cylindrical main body portion 316 and a distal end portion 318 and the elongated flexible wire 340 includes an inflatable member 312, Or attached to the proximal end 320 of the endoscope. The structure of the device 300 is similar to the device 200 described above with reference to Figures 6A and 6B except that the upper cell structure 330 includes a substantially diamond shape as shown in the two- similar. The substantially diamond-shaped cellular structure includes a pair of outer strut elements 358 and a pair of inner strut elements 360, and has an increased width and / or width as described above in accordance with the embodiment of Figs. / RTI > and / or increased thickness, respectively. In an optional preferred embodiment, the inner strut element 360 intersects the outer strut element 358 at an angle beta between about 25.0 [deg.] And about 45.0 [deg.], As shown in the plan view of Figure 7a. By maintaining the angular orientation between the inner strut and the outer strut within this range, a very small compressed diameter during delivery can be assumed to have a substantially unimpeded effect on the ability of the inflated member and the inflation of the inflated member 312 The possibility increases.

In one embodiment, the inner strut element 360 is sized to be smaller than the mass of the outer strut element 358 so that the strut element can be easily bent as the inflatable member 312 is transformed from the expanded state to the compressed state. . This helps to achieve very small compressed diameters. 7C, inner strut element 360 may be curved (not shown) that may more easily bend inner strut element 360 when inflatable member 312 is compressed into its delivery position. In other embodiments, Is coupled to the outer strut element (358) by an element (361).

FIG. 8 shows an alternative embodiment of the vascular care device 400. The apparatus 400 is similar to the apparatus 400 of Figure 6A except that the inflatable member 412 of the apparatus 400 is connected to the two distally expanded elongate flexible wires 440 and 441 at its proximal end portion 414. [ And a structure similar to that of the device 200 shown in Fig. 6B. As shown, the wire 440 is attached or otherwise coupled to the proximal end portion 414 of the proximal end portion 414 and the wire 441 is connected to the proximal end portion 414 at the junction with the rail segment 470, To the farthest end 422 of the base portion 422. [ In yet another embodiment, a further elongated flexible wire (not shown) may be attached to the uppermost end 424. The use of two or more elongate flexible wires 440, 441 to provide a pressing force on the proximal end portion 414 of the elongated member 412 preferably includes a proximal end portion 414 Quot;) < / RTI >

FIG. 10 shows a top view of an apparatus for treating vascular diseases 500, which is another embodiment of the present invention. In the embodiment of FIG. 10, the inflatable member 512 includes a plurality of generally longitudinally-shaped wavy elements 524, adjacent wavy-type elements are out of phase with each other, To form a structure 526. The inflatable member 512 includes a cylindrical portion 516 and a distal end portion 518 and the cell structure 526 in the main body portion 516 extends around a longitudinal axis 530 of the inflatable member 512 In the circumferential direction. The cell structure 526 in the distal end portion 518 is elongated less and less circumferentially about the longitudinal axis 530 of the inflatable member 512. [ The proximal inflated elongate flexible wire 540 is attached or otherwise bonded to the up-stell cell structure 528. The use of a plurality of elongate flexible wires 540 allows the pressing force exerted on the proximal end of the inflatable member 512 to be more evenly distributed around its proximal circumference. 10, the upper strut element 528 has a width and / or thickness greater than that of the strut at other portions of the inflatable member 512. In another embodiment, This feature contributes to an even distribution of the pressing force around the circumference of the inflatable member 512 and also prevents the strut element receiving the pressing force from being bent.

11A and 11B illustrate an apparatus 600 for treating an artery according to another embodiment of the present invention. Figure 11A shows a device 600 in plan view wherein the device is cut and laid flat on the surface. Fig. 11b shows a device of its manufactured and / or expanded tubular shape. 11A and 11B, the inflatable member 612 includes a plurality of generally longitudinal wavy elements 624 and adjacent wavy elements are disposed about the length of the inflatable member 612 And are interconnected by a plurality of curved connectors 628 to form a plurality of closed- In the illustrated embodiment, the inflatable member 612 includes a cylindrical portion 616 and a proximal end portion 614 and the cell structure 626 in the cylindrical portion 616 extends in the longitudinal direction of the inflatable member 612 And is continuous and circumferentially stretched around axis 630. The cell structure 626 in the proximal end portion 614 is elongated less and less circumferentially about the longitudinal axis 630 of the expandable member 612. [ In an alternative embodiment, the inflatable member 612 includes a proximal end portion, a cylindrical portion, and a distal end portion that are substantially similar to the inflatable member 12 shown in Figs. 1A and 1B. In this embodiment, the cell structure 626 in the distal end portion of the inflatable member has a circumferential shape about the longitudinal axis 630 of the inflatable member 612 in a manner similar to the proximal end portion 614 shown in Fig. Lt; / RTI > In addition, the inflatable members of Figures 1A, 4A, 6A, 7A, 7C, 10, 14, 15 and 19-24 can be removed in a manner that removes the distal end portion (e.g., distal end portion 18 in Figure 1) So that there is only a proximal end portion and a main body portion similar to those of Figure 11a.

12 shows an apparatus 700 for treating an artery according to another embodiment of the present invention. Figure 12 shows an apparatus 700 in plan view in which the device is cut and laid flat on the surface. 12, inflatable member 712 includes a plurality of generally longitudinally wedge shaped elements 724, adjacent wedge shaped elements having a plurality of And are interconnected by a plurality of curved connectors 728 to form a closed-cell structure 726. In the illustrated embodiment, the inflatable member 712 includes a cylindrical portion 716 and a distal end portion 718, and the cell structure 726 in the cylindrical portion 716 extends in the longitudinal direction of the inflatable member 712 And is continuously and circumferentially stretched around axis 730. The cell structure 726 in the distal end portion 718 is elongated less and less circumferentially about the longitudinal axis 730 of the inflatable member 712. In a manner similar to the method described in accordance with the embodiment of Fig. 10, the proximal inflated elongated flexible wire 740 is attached to or otherwise coupled to a recent up-cell structure 728. According to this arrangement, the pressing force applied to the proximal end of the inflatable member 712 can be more evenly distributed around its proximal circumference. 12, the upper strut element 730 has a width and / or thickness greater than that of the strut at other portions of the inflatable member 712. In other embodiments, This feature contributes to an even distribution of the pressing force around the circumference of the inflatable member 712 and also prevents the strut element that receives the pressing force from being bent.

As described above, in use, the inflatable member of the present invention advances through a tortuous vascular structure of the annulus to a treatment site, such as an embolic occlusion site, in a non-inflated or compressed state of a first nominal diameter, Can be moved from the unexpanded state to the radially expanded state of the second nominal diameter larger than the first nominal diameter for deployment. One way of transferring and disposing the inflatable member 912 at the site of embolus closure 950 is shown in Figures 13A-13C. 13A, the delivery catheter 960 with the lumen 962 advances to the site of the embolus closure 950 so that its distal end 964 is placed on a circle with respect to the closure. After the delivery catheter 960 is in place in the embolic closure 950 a retrieval device 900 introduces the inflatable member 912 into the proximal end of the delivery catheter Is placed into the delivery catheter by advancing the inflatable member 912 through the lumen of the delivery catheter by applying a backward force to the flexible wire 940. [ By using a radiopaque marking and / or coating disposed on the delivery catheter 960 and the device 900, the inflatable member 912 is positioned at the distal end of the delivery catheter 960, as shown in FIG. 13b So that the main body portion 916 is longitudinally aligned with the closure 950. The deployment of the inflatable member 912 is implemented by withdrawing the delivery catheter 960 in the proximal direction while the inflatable member 912 is held in a fixed position as shown in Figure 13c. If the inflatable member 912 is placed in the inflated position within the closure 950, the inflatable member 912 is introduced into the patient's exterior with the delivery catheter 960. In one embodiment, the inflatable member 912 is first partially inserted into contact with the distal end 964 of the delivery catheter 960 prior to fully withdrawing the device from the patient.

In one embodiment, when the inflatable member 912 is inflated in the closure 950, it exists for a predetermined period of time to form a perfusion channel through the closure to allow the closure to dissolve by the resulting blood flow through the closure . In this embodiment, the inflatable member 912 need not capture a portion of the closure 950 for restoration outside the patient. When the sufficient portion of the closure 950 is dissolved to form the desired flow channel through the closure or the complete removal of the closure is achieved by the resulting blood flow, the inflatable member 912 is introduced into the delivery catheter 960 Can be withdrawn and then removed from the patient.

In another embodiment, the inflatable member 912 may be inflated in the closure 950 and the embolism closure may be more easily captured by the inflatable member and / or the embolus closure may be more easily removed from the patient ' And is maintained for a predetermined period of time to create a perfusion channel through the closure to cause the resulting flow to act on the closure in such a way that it can be removed. For example, the blood flow generated through the embolic occlusion can flow through the occlusion for a time sufficient to change the shape of the occlusion so that it can be more easily captured and / or separated from the vessel wall by the expandable member have. As in the above-described method, tissue is also protected as blood flow is created across the closure 950. In one embodiment, blood flow through the occlusion can be used to dissolve the occlusion. However, in the modified method, dissolution of the closure is performed for the purpose of allowing the closure portion to be more easily captured by the expandable member 912. [ The closure 950 may be formed by forming a distal portion 964 of the delivery catheter 940 such that the expandable member 912 is in contact with the closure 960 when properly formed, for example, by forming the desired nominal inner diameter closure 950. [ . Removal of all or a portion of the closure 950 from the patient is then performed in a manner similar to that described above.

In another embodiment, when the inflatable member 912 is delivered and inflated within the closure 950, the inflatable member can be disengaged from the elongated wire 940 to be permanently disposed within the patient. In this embodiment, the two parts can be separated from each other, depending on how the stretched wire 940 is attached to the inflatable member 912. [ This may be implemented, for example, using a corrosion-resistant electrolytic junction or mechanical interlock between the elongate member 912 and the elongated wire 940.

As described herein, the inflatable members of the various embodiments may or may not include a distal wire segment attached to the distal end. In an optional preferred embodiment, the vascular treatment device configured to permanently deploy the inflatable member at the site of the embolus closure does not include a distal wire segment attached to the distal end of the inflatable member.

One advantage associated with the inflatable member cell pattern of the present invention is that the flexible wire presses the inflatable member with a smaller inflated diameter as the inflatable member is pulled out by applying a pulling force on the proximal stretched wire, And at the same time withdrawing from the patient, the tendency of the wound to the vessel wall is reduced. Also, as the profile of the inflatable member decreases during clot retrieval, the cell structure collapses and agglomerates the lumps to improve lump recovery efficiency. Another advantage is that the inflatable member can be introduced into the lumen of the delivery catheter after the cell pattern is partially or fully deployed. As such, at any given time, the inflatable member can be fully or partially disposed at the appropriate location, which can be retracted into the distal end of the delivery catheter and relocated to the correct position.

Referring to Figure 14, a modified version of the vascular treatment device 200 of Figure 6A includes a thin strut 228 that intersects at least a portion of the cell structure 226 located in the cylindrical main body portion 216 of the inflatable member 212. [ Elements. The thin strut element 280 is sized to have a width less than the strut element 282 forming the cell structure 226. In an alternate exemplary embodiment, the strut element 280 has a cut or polished width dimension that is less than about 25% to about 50% less than the cut or polished width dimension of each of the struts 262. When used for lump collection purposes, the purpose of the thin strut 280 is to enhance the ability of the expandable member to capture and contact the embolic occlusion. This is done according to several factors. First, depending on the thinner width size of the strut 280, the strut can easily penetrate into the closure. Second, it serves to grasp a portion of the structure captured with respect to the outer and wider strut elements 282 as the inflation-facing member is disposed within the enclosure. Third, it can be used to locally improve the radial forces acting on the closure. The use of the thin strut element 280 is not limited to use within the cellular structure 226 that lies within the cylindrical main body portion 216 of the inflatable member 212. This can be arranged primarily in any cell structure or both of the inflatable members. In addition, the use of the strut element 280 is not limited to the embodiment of FIG. 6, but can be applied to all of the various embodiments disclosed herein. 15, a plurality of thin strut elements 280 are provided in one or more of the cell structures 226 and are also provided with a single thin strut element, / ≪ / RTI > or a cell structure having a cell structure.

When treating the aneurysm, when the treatment device is used for the purpose of switching the flow, the density of the cell structure 226 is sufficient to effectively convert the flow from the aneurysm color (sack). Alternatively, in an alternative embodiment, or in combination with adjusting the density of the cell structure 226, an intermediate strut element similar to the strut element 280 of FIGS. 14 and 15 increases the effective wall surface of the inflatable member Is used. In these embodiments, the intermediate strut element may be equal to, less than, or greater than the size characteristic of the strut of the cell structure, or any combination thereof. Conversely, when used in the treatment of an aneurysm to place a coil or other similar structure within the color of the aneurysm, the size of the cell structure 226 is sufficient to facilitate movement of the coil through the cell structure.

Figure 16 illustrates a treatment device in accordance with the embodiment of Figures 6A and 6B wherein the pushability of the inflatable member 212 during advancement to the patient ' s treatment site is determined by the distal end of the inflatable member 212 222 and the proximal end 220. The inner wire segment 241 extends between the proximal end 222 and the proximal end 220, In this manner, the applied force exerted by the elongated wire 240 is transmitted to both the proximal and distal ends of the inflatable device. The inner wire segment may be an individual element attached to the distal and proximal ends of the inflatable member, or preferably it may be a co-stretchable portion of the elongated flexible wire 240. The inner wire segment 241 is configured to receive the distal end 222 of the expandable member 222 in a substantially straight or linear shape (e.g., a substantially straight or linear shape) to properly distribute at least a portion of the biasing force to the distal end 222 of the inflatable member, while the inflatable member 212 is delivered to the treatment site, Lt; / RTI > When the inflatable member 212 is inflated, it tends to shrink, causing it to loosen within the inner wire segment 241, which forms a long-pitch spiral in the inflatable member, as shown in Fig. A further benefit associated with the use of the inner wire segment 241 is that the formation of an inner spiral upon inflation of the inflatable member 212 helps to trap the embolic occlusion.

17, the possibility of pressing the inflatable member 212 during advancement to the treatment region of the patient is less likely to occur between the distal end 222 and the proximal end 220 of the inflatable member 212, Lt; RTI ID = 0.0 > 243 < / RTI > In this manner, the applied force exerted by the elongated wire 240 is transmitted to both the proximal and distal ends of the inflatable device. The outer wire segment may be an individual element attached to the distal end and proximal end of the inflatable member, or preferably it may be a co-stretchable portion of the elongated flexible wire 240. The outer wire segment 243 may be configured to receive the distal end 222 of the expandable member 222 in a substantially straight or linear shape (e.g., a substantially straight or linear shape) to properly distribute at least a portion of the biasing force to the distal end 222 of the expandable member, while the inflatable member 212 is delivered to the treatment site, Lt; / RTI > When the inflatable member 212 is inflated, it tends to shrink, causing it to loosen within the outer wire segment 243 as shown in Fig. A further benefit associated with the use of the outer wire segment 243 is that the inflatable member 212 is inflated such that the formation of the inner spiral upon inflation expedites the capture and contact of the embolus closure.

In another embodiment, the distal embolization capture device 251 is disposed on the distal wire segment 250 or otherwise attached to the distal end 222 of the inflatable member 212 as shown in FIG. The function of the distal embolization capture device 251 is to capture the embolus that can be displaced from the embolus closure during inflation of the inflatable member 212 or during removal from the patient to prevent angulation. In Fig. 18, the distal embolization device is shown as a coil. In an alternative embodiment, a basket, embolization filter, or other known embolization device can be attached to the distal wire segment 250 or distal end 222 of the inflatable member 12.

Again, as in the embodiment of Figs. 14 and 15, the features described with reference to Figs. 16, 17 and 18 are not limited to the embodiment of Fig. 6 and can be applied to all the various embodiments described herein.

Fig. 19 shows a body tube or vessel treatment apparatus 1000 according to another embodiment of the present invention. 19 shows an apparatus 1000 in plan view in which the apparatus is cut and placed on a surface. Apparatus 1000 includes an inflatable member 1012 having a proximal end portion 1014, a cylindrical main body portion 1016 and a distal end portion 1018 and the elongated flexible wire 1014 includes an inflatable member Or attached to the proximal end 1020 of the proximal end 1020. FIG. The structure of device 1000 is similar to that of device 1000 except that cell structure 1018,1024 in proximal end portion 1024 is arranged in a more symmetrical configuration than cell structure at proximal end portion 214 of device 200, Lt; RTI ID = 0.0 > 200 < / RTI > Into the lumen of the delivery catheter or sheath (not shown) to more evenly collapse by the proximal end portion 1024 during compression in accordance with a more substantial symmetrical arrangement of the cell structure at the proximal end portion 1024 of the device 1000. [ So that it is easy to mount or recover the mold member 1012. The proximal wall segment 1016 of the cell structures 1018, 1019 includes a linear or substantially linear strut element, as shown in the plan view of FIG. In one embodiment, the linear strut element 1016 is continuous and substantially continuous extending from the proximal end 1020 of the proximal end portion 1024 with respect to the main body portion 1026 (as shown in plan in Figure 19) To form a linear rail element. In an alternate embodiment, the angle [theta] between wire segment 1014 and rail segment 1017 ranges from about 140 [deg.] To about 150 [deg.]. In one embodiment, one or both of the linear rail segments 1017 have a width dimension W1 that is greater than the width dimension of adjacent strut segments of the cell structures 1018,1019, 1030. The ability of the rail segment to prevent bending and to distribute the force is further increased when the pressing force is applied thereto in accordance with the increased width dimension W1 of one or both of the linear rail segments 1017. [ In yet another embodiment, one or both of the linear rail segments 1017 are provided with an increased thickness dimension rather than an increased width dimension to achieve the same or similar result. In yet another embodiment, the width and / or thickness dimension of each rail segment 1017 is greater than the width and / or thickness dimension of the proximal end portion 1024 of the inflatable member 1012 when mounted or withdrawn into the delivery catheter or sheath (not shown) The way to cause more uniform compression is different.

Although the following description relates to the embodiment of Fig. 19, as all of the vascular treatment devices described herein and the various embodiments and variants thereof, as provided with the slits, as contemplated by the embodiments of Figs. Lt; / RTI >

Referring now to FIG. 20, treatment device 1000 of FIG. 19 is shown having a longitudinal slit 1040 extending from proximal end 1020 to distal end 1022 of inflatable member 1012. The individual strut elements 1031 of the inflatable member 1012 during compression of the inflatable member 1012 as the cell structures 1018,1019 and 1030 are mounted or retrieved into the delivery catheter or sheath in accordance with the slit 1040 They can be moved relative to each other in such a way that bending is prevented. In an alternate embodiment, the slit 1040 is configured to extend below the entire length of the inflatable member 1012 and to prevent bending of the significantly important strut elements that effectively mount or pull the inflatable member into the delivery catheter or sheath . For example, in one embodiment, the slit 1040 is provided only at the proximal end portion 1024 of the inflatable member 1012 where the strut 1032 most flexes or curves. In another embodiment, slit 1040 is provided on both the cylindrical main body portion 1026 and proximal end portion 1024 of the inflatable member 1012.

Figure 21 shows the treatment device 1000 of Figure 19 with an oblique orientation / spiral slit 1050 extending along the entire circumference of the expandable member 1012. [ In one embodiment, the helical slit 1050 is oriented at a point or distal position adjacent the distal position of the proximal end portion 1024 of the inflatable member 1012, as shown in FIG. For an embodiment having a linear rail segment, the spiral slit 1050, like the linear rail segment 1017 of Fig. 19, may be located at a point adjacent to the linear rail segment 1017 in a < Desc / 0.0 > 1021 < / RTI > of one of the segments 1017. Testing of the various vascular treatment devices described herein is shown to cause bending in a strut element positioned adjacent a distal position of the proximal end portion of the inflatable member. This phenomenon worsens in an expandable member having a proximal end portion including a linear rail segment. 21, the orientation point of the helical slit 1050 is located at or adjacent to the distal portion 1021 of one of the linear rail segments 1017. The advantage of being arranged in the oblique direction of FIG. 21 and / or of the helical slit shape is that the bend is further oriented to prevent bending of the strut element 1032 along the length of the inflatable member 1012 and to exhibit bending. As shown in FIG. 22, in alternative embodiments, the slit 1050 extends in an oblique direction along only a portion of the circumference of the cylindrical main body portion 1026 of the inflatable member 1012. 22, the slit 1050 extends in an oblique direction along only a portion of the circumference of the cylindrical main body portion 1026 of the linear rail segment 1017. In the embodiment of FIG. 22, the slit 1050 is oriented at a distal position 1021 of the linear rail segment 1017. The flexure of the individual strut element 1032 is oriented at a portion other than the distal portion of the proximal end portion 1024 of the inflatable member 1012 and the orientation point of the slit 1050 is oriented at the orientation of the flexure (No slit 1050) and is elongated in the longitudinal direction from the distal direction.

23 shows an apparatus 2000 for treating a vessel or body tube according to an embodiment of the present invention. 20 shows an apparatus 2000 in plan view in which the device is cut and laid flat on the surface. Apparatus 2000 includes a self-expandable member 2012 that is attached to or bonded to an elongated flexible wire 2040 that is expanded proximally from the inflatable member 2012. In one embodiment, the inflatable member 2012 is made of a shape memory material, such as Nitinol, and is preferably laser cut from the tube. In one embodiment, the inflatable member 2012 has a wire segment 2042 that is formed integrally and extends in a proximal direction that is used to connect the elongated flexible wire 2040 to the inflatable member 2012. In this embodiment, the flexible wire 2040 can be coupled to the wire segment 2042 using soldering, welding, adhesives, or any other known attachment method. In an alternative embodiment, the proximal end of the flexible wire 2040 is attached directly to the proximal end 2020 of the inflatable member 2012.

23, the inflatable member 2012 includes a plurality of generally longitudinally wavy elements 2024, and adjacent wavy elements form a plurality of circumferentially disposed cell structures 2026. In one embodiment, . The inflatable member 2012 includes a proximal end portion 2013, a cylindrical main body portion 2014 and a distal end portion 2015 and the cell structure 2026 in the main body portion 2014 includes an inflatable member 2012 In the circumferential direction. The cell structure in the proximal end portion 2013 and the distal end portion 2015 is elongated less and less circumferentially about the longitudinal axis 2032 of the inflatable member 2012. [ The proximal wall segment 2016 of the cell structures 2027, 2028, 2029, 2030 includes a linear or substantially linear strut element as shown in the plan view of FIG. In one embodiment, the linear strut element 2016 includes a continuous and substantially linear rail segment 2017 extending from the proximal end 2020 of the proximal end portion 2013 to the proximal upper end of the main body portion 2014 (Again, as shown in the plan view of Figure 23), and are preferably the same length. As described above with reference to Figs. 6A and 6B, the rail segments are not substantially linear but are curved and non-wavy.

According to this configuration, a rail segment 2017, preferably without a wavy portion, is provided, whereby the ability of the rail segment to prevent bending and distribute force when the pressing force is applied thereto. In an optional preferred embodiment, the angle [theta] between the wire segment 2041 or 2040 and the rail segment 2017 ranges from about 140 [deg.] To about 150 [deg.]. In one embodiment, the linear rail segment 2017 has a width dimension W1 that is greater than the width dimension of adjacent strut segments of the cell structures 2027, 2028, 2029, 2030, The increased width dimension W1 of the linear rail segment 2017 further increases the ability of the rail segment to prevent bending and to distribute force when a pressing force is applied thereto. In yet another embodiment, the linear rail segment 2017 is provided with an increased thickness dimension rather than an increased width dimension to achieve the same or similar result. In yet another embodiment, the width and / or thickness dimension of each rail segment 2017 is increased to achieve the same or similar result.

In one embodiment, the width and / or thickness of the inner strut element 2080 of the up-stern cell structure 2027 also helps to prevent bending of these elements while the inflatable member is entering through the sheath or delivery catheter. In one exemplary embodiment, the "cut" nominal width of the strut elements 2016, 2080 is about 0.0045 inches and the "cut" nominal width of the other strut elements is about 0.003 inches.

24A and 24B illustrate an apparatus 3000 for treating an artery according to another embodiment of the present invention. 24A shows a plan view of the apparatus 3000 with the apparatus cut and laid flat on the surface. Figure 24b shows an apparatus in a tubular shape that has been manufactured and / or expanded. The overall design of the apparatus 3000 is similar to that of the apparatus 2000 described and illustrated with reference to FIG. The main difference between the two designs is the ratio of the length "L" to the width "W" of the cell structures 2026, 2027, 2028, 2029, The ratio of the length to the width of the cell structure of Fig. 24A is generally greater than the ratio of the length to the width of each cell structure of Fig. As shown, the length "L" of the cell structure of the device of Figure 24A in the "cut" shape is generally greater than the length of each cell structure of Figure 23, Is smaller than the width of each cell structure. As a result, the slope of each strut element 2040 in the cell structure of Fig. 24A is generally less than the slope of each strut element in the cell structure of Fig. By reducing the slope of the strut element 2040 and keeping other other size and material properties constant, the effective radial force along the length of the strut 2040 is reduced. The effect of this reduction is that the sum of the axial force components along line A-A in Fig. 24 more closely matches the sum of the radial force components along line B-B compared to the device of Fig. The inventors have determined that the longitudinal radial force, depending on the ratio of the length of the " cut "cell structure to the width of greater than about 2.0 and the ratio of the" The longitudinal radial forces are thus distributed, so that preferably the ability of the inflatable member is pulled into and through the lumen of the delivery catheter.

Figs. 26, 27A and 27B show another embodiment of the inflatable member 5000. Fig. The inflatable member 5000 includes a plurality of generally longitudinal wavy elements 5024 and adjacent wavy elements are arranged in a plurality of oblique directions arranged in each direction at about 40.0 to about 50.0 degrees relative to each other Lt; RTI ID = 0.0 > 5026 < / RTI > In one embodiment, the cell structure is moved in an oblique direction along a line approximately 45.0 degrees. The inflatable member 5000 includes a proximal end portion 5014, a cylindrical main body portion 5026 and a distal end portion 5018 and a cell structure 5026 within the main body portion 5016 includes an inflatable member 5000 In the circumferential direction. Within the proximal end portion 5014 and the distal end portion 5018, the cell structure 5026 is less elongated circumferentially along the longitudinal axis of the inflatable member 5000. In one embodiment, the inflatable member has a designated maximum implantable diameter of about 4.0 mm and a non-inflated or crimped nominal diameter of about 1.0 mm.

In one embodiment, the inflatable member 5000 has a total length dimension A of about 36.0 ± 2.0 mm and the main body portion 5016 has a length P of about 19.0 ± 2.0 mm. In one embodiment, the strut width size N and thickness O in the main body portion 5016 are about 0.0021 +/- 0.0004 inches and about 0.0032 +/- 0.0005 inches, and the strut width size L of the proximal rail 5030 is about < RTI ID = Is about 0.0039 +/- 0.004 inches.

During use, the inflatable member 5000 advances through the patient ' s ganglion vessel structure or body tube in a non-inflated or compressed state (not shown) of the first nominal diameter in a treatment flush, And can be moved in a radially expanded state of a second nominal diameter larger than the first nominal diameter for deployment. In an alternate exemplary embodiment, the first nominal diameter (e. G., The average diameter of the main body portion 5016) ranges from about 0.017 to about 0.030 inches, while the second nominal diameter (e. (The average diameter of the second layer 5016) is in the range of about 2.5 mm to about 5.0 mm. In one embodiment, the size and material properties of the cell structure 5026 disposed in the main body portion 5016 of the inflatable material 5000 is determined by the size and material properties of the embolization disposed within the vessel in a manner that allows for the removal of some or all of the embolus closure from the patient Is selected to generate sufficient radial force and contact interaction to contact the closure and the cell structure 5026. [ In an alternate embodiment, the size and material properties of the cell structure 5026 in the main body portion 5016 may range from about 0.005 N / mm to about 0.050 N / mm, preferably from about 0.010 N / mm to about 0.050 N / mm , And more preferably from about 0.030 N / mm to about 0.050 N / mm, to produce a radial force per unit length. In one embodiment, the diameter of the main body portion 5016 in the fully expanded implanted condition is about 4.0 mm, and the cell pattern, strut size, and material are about 0.030 N / mm to about 0.050 N / mm. < / RTI > In an identical or alternative embodiment, the cell pattern, strut size, and material (s) may be such that the diameter of the main body portion is reduced to 3.0 mm to produce a radial force of about 0.010 N / mm to about 0.020 N / mm Is selected.

In one embodiment, as shown in the graph of FIG. 29, the cell structure has a length of the expanded member 5000 of from about 1.50 N to about 2.50 N when the inflatable member 5000 is in a compressed or crimped state To produce a total radial force that is applied along the radial direction. A total reduction of about -1.5 N to about -3.5 N of the radial force along the length of the expandable member per mm of expansion results in an initial 0.50 mm radial extent of expansion from the compressed or crimped state. After a radial extent of expansion of about 0.5 mm, a total reduction of about -0.1 to about -0.50 N of the radial force along the length of the inflatable member per mm of inflation is less than the value of the non-zero radial force It occurs when implemented and until the specified maximum diameter is implemented. Preferably, the inflatable member 5000 is configured such that the inflatable member 5000 applies a relatively high radial force during initial inflation to allow the strut of the inflatable member to contact the closure in the patient ' s tubing when the device is initially deployed Increase trend. In addition, the rate at which the radial force is reduced is significantly greater during the initial expansion of the device than during subsequent expansion. In the exemplary embodiment shown in Fig. 29, the initial velocity of the reduction in radial force during about 0.5 mm inflation is about 20.0 to about 30.0 times the rate of decrease during subsequent inflation. The advantage of the radial force characteristic is that the high radial force value can be realized while the inflatable member is initially deployed to improve the integration of the strut of the inflatable perfume member into the tube closure and the radial force after the initial inflation is significantly reduced , And a significant reduction is facilitated or improved in that undesirable interactions with the tube are limited (i. E., Damage to the vessel wall, etc.) and the occlusion can be removed from the patient ' s tube without complexity. Another advantage of the radial force characteristics shown in Fig. 29 is that it provides an indication of the level of radial force applied to the inflated member diameter at which the decreasing rate of the radial force along the length of the inflatable member during subsequent inflation is different In a linear-like manner at a further reduced rate. Also, preferably, the radial force exerted by the inflatable member is designed to implement a non-zero value when the inflatable member is the designated maximum implantable diameter.

Figure 30 illustrates, among other features, the solidification recovery apparatus 6000 according to another embodiment in which the strut elements of the rail segments 6001, 6002 have a width magnitude change. Figure 30 shows the coagulating and collecting device in a plan view as if the device were cut and laid flat on the surface. Fig. 30 shows a constituent device manufactured (cut). In one embodiment, the rail segment 6001 is transitioned from a proximal end 6014 or a minimum width size near it to an end or distal end 6015. In the same manner, the rail segment 6002 is converted to a minimum width size of the distal end 6016 at or near the proximal end 6014 or a maximum width dimension near it. As noted above, the width dimension of the rail segment is selected to enhance the ability to distribute force and resist buckling when a push force is applied to the proximal end 6014 of the angioplasty device. In some embodiments, the ratio variation between the maximum rail width size and the minimum rail width size is between about 20.0% and about 50.0%. In another embodiment, the ratio change between the maximum rail width size and the minimum rail width size is between about 25.0% and about 45.0%. In another embodiment, the ratio change between the maximum rail width size and the minimum rail width size is between about 35.0% and about 45.0%. In an exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0027 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches. In another exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0037 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches. As discussed above, post-polishing of the apparatus generally involves an etching process with a reduction of 40% to 50% of the cut cross-sectional size.

30 shows the undamped rail segment, it is understood that the rail portion as shown in FIGS. 1A and 4A is also contemplated, as discussed above. Further, a number of features and / or characteristics of the vascular care apparatus disclosed in the previous Figs. 1-29, which are different from the above-described rail width characteristics, can be incorporated into the solid-liquid recovery apparatus 6000 according to Fig.

In some embodiments, the width of the rails 6001, 6002 is tapered along the length (or portion thereof) in a substantially uniformly reduced form. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a transition taper used to join the rail portions of different widths. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a stepwise transition between different rail portions of width. In another embodiment, two or more of the width conversion methods are used. Although not required, it is preferred that the width transition occurs in a portion along the rail strut that is different from the joint of the strut (e. G., Joint 6030).

In some embodiments, the struts 6012, 6013 of most proximal cell structures 6018, as described above, also have a maximum rail width and a maximum radial width 6012 for the purpose of enhancing the push capability of the solid- And has an enhanced width dimension that can be equal to or less than. In some embodiments, it is provided with a reinforced width dimension that is less than the overall length of the struts 6012 and 6013. [ For example, in some embodiments, the reinforced width portion is inflated at the uppermost end of the struts 6012, 6013 and ends at a distance prior to the abutment 6026. The configuration of the struts 6012 and 6013 can be changed in the above-described manner.

30, all or a portion of the struts 6003 and 6004 (optionally, the entire or proximal portion of the struts 6005 and 6006) may have a width dimension between about 0.0045 inches and about 0.0050 inches All or portions of the struts 6007 and 6008 (optionally the entire or distal portion of the struts 6005 and 6006) have a width dimension between about 0.0035 inches and about 0.0036 inches and a width between about 0.0027 inches and about 0.0034 inches All or portions of the struts 6009 and 6010 (optionally the entire or distal portion of the struts 6007 and 6008), together with the substantial portion of the strut elements of the remaining portions of the device (portions A, B and C) Inch to about 0.0035 inch. In one or more of the above embodiments, the width dimension of the struts 6012, 6013 is between about 0.0033 inch and 0.0047 inch, preferably between about 0.0033 inch and 0.0040 inch. It should be understood that the size as described above in connection with the exemplary embodiment is subject to conventional manufacturing tolerances, and variations in size are possible and are also contemplated.

Although not required, the width transition preferably occurs at a portion along the strut itself other than at the strut's joint (e. G., Joints 6030 and 6032).

In one exemplary embodiment, struts 6003-6006 have a width dimension of about 0.0047 inches and struts 6007 and 6008 and a proximal portion of strut 6010 have a width dimension of about 0.0036 inches, 6011 and struts 6010 have a width dimension of about 0.0035 inches and struts 6012-6013 have a width dimension of about 0.0027 inches with a total or substantial portion of the remaining strut elements of the processing apparatus having a width dimension of about 0.0027 inches It has a width dimension of 0.0036 inches.

The test is performed in a proximal tapered region of the treatment device of FIG. 30 having good force transfer characteristics according to good radial force characteristics, such as sheathing and re-sheathing, well within the introducer sheath and / Lt; / RTI >

In another embodiment, struts 6003-6006 have a width dimension of about 0.0047 inches and struts 6007 and 6008 and a proximal portion of strut 6010 have width dimensions of about 0.0036 inches and struts 6009 and 6011 ) And the distal portion of the strut 6010 have a width dimension of about 0.0035 inches and the struts 6012-6013 have a width dimension of about 0.0036 inches and the remaining strut elements of section A of the coagulum recovery apparatus have a width dimension of about 0.0033 inches Width size, and the remaining strut elements generally located in sections B and C of the coagulating and recovering device have a width dimension of about 0.0027 inches. The increased width size of the struts in section A advantageously reduces the likelihood of strut buckling in the proximal taper region of the coagulum recovery apparatus and also increases the radial strength of the proximal taper region.

In another exemplary embodiment, struts 6003-6006 have a width dimension of about 0.0047 inches and struts 6007 and 6008 and a proximal portion of strut 6010 have a width dimension of about 0.0036 inches, , 6011 and the strut 6010 have a width dimension of about 0.0035 inches and the remaining strut elements of section D of the processing apparatus have a width dimension of about 0.0033 inches and the remaining struts of sections B and C of the processing apparatus The element has a width dimension of about 0.0027 inches. The increased width size of the struts in section A advantageously reduces the likelihood of strut buckling in the proximal taper region of the coagulum recovery apparatus during delivery to the patient ' s treatment area and also increases the radial strength of the proximal taper region.

In another exemplary embodiment, struts 6003-6006 have a width dimension of about 0.0047 inches and struts 6007 and 6008 and a proximal portion of strut 6010 have a width dimension of about 0.0036 inches, 6011 and struts 6010 have a width dimension of about 0.0035 inches and struts 6012-6013 have a width dimension of about 0.0036 inches and have strut elements generally located in section C of the coagulum recovery apparatus Has a width dimension of about 0.0033 inches and the remaining strut elements of sections A and B of the coagulating and recovering apparatus have a width dimension of about 0.0027 inches. The increased width size of the struts in section C advantageously reduces the likelihood of strut buckling within the distal taper region of the coagulum recovery apparatus during delivery to the patient ' s treatment area. The increased width size also increases the radial strength of the proximal tapered region, which enhances the ability of the distal taper region to remain open while the coagulum recovery device is withdrawn from the patient. This feature is particularly advantageous for allowing the distal taper section to remain open when the coagulation recovery apparatus is used for coagulation removal and to clear the remainder of the coagulation when the coagulum recovery apparatus is withdrawn from the patient.

In some embodiments, the coagulating and recovering apparatus 6000 according to FIG. 30 is a laser cut from a tube having an internal diameter of 2.667 mm and a wall thickness of between about 0.102-0.126 mm. In use, the coagulating and collecting device 6000 according to the embodiment shown in FIG. 30 may be operated from a complicated blood vessel dissection or through a tube in the patient's body to a treatment chamber of a first nominal diameter in an unexpanded or compressed state, Can be moved to a radially expanded state of a second nominal diameter larger than the first nominal diameter for placement in the process chamber.

In an alternative embodiment, the second nominal diameter (e. G., The average diameter of the main body portion) is about 4.0 +/- 0.5 mm. In some embodiments, the size and material properties of the cell structure 6020, which is generally present in the main body (section B) of the inflatable material, is present in the blood vessel in a manner that allows the embolization closure to be partially or completely removed from the patient. To provide sufficient interfacial interaction and sufficient radial force to connect the cell structure 6020 with the embolic occlusion /

In some embodiments, the size and material properties of the element as a function of the expansion length of the collecting device are such that the radial force per unit length between about 0.030 N / mm and 0.055 N / mm when the outer diameter of the collecting device is limited to 1.5 mm . In some embodiments, the size and material properties of the element along its inflation length are such that when the outer diameter of the collection apparatus is limited to 1.5 mm, a radial force per unit length of between about 0.035 N / mm and 0.050 N / mm Is selected. In some embodiments, the size and material properties of the element along the inflation length may be adjusted to produce a radial force per unit length between about 0.037 N / mm and 0.049 N / mm when the outer diameter of the retrieval apparatus is limited to 1.5 mm Is selected.

In the same or alternative embodiment, the size and material properties of the element with respect to the expansion length of the collecting device are in the radial direction between about 0.010 N / mm and 0.020 N / mm when the nominal diameter of the main body is about 3.0 0.5 mm It is chosen to generate force.

In the embodiment of FIG. 30, most of the cell structures (except at least partially formed by rail segments 6001 and 6002) are formed by a plurality of short struts 6022 and a long strut 6023, Cell structure. According to some embodiments, the cell area is 4.00 + - 0.5 mm < ^{2 &} gt ;. In an exemplary embodiment, the cell area is about 4.2 mm ² . In an exemplary embodiment, short struts 6022 to be staggered relative to the circumference of the processing apparatus have a length between 0.080 and 0.100 inches, and long struts 6023 have a length between 0.130 and 0.140 inches. In some embodiments, the overall length of the expanded portion of the coagulating and recovering device has a length of about 35.0-45.0 mm and the main body portion (section B) has a length of between about 20.0 - 25.0 mm. In one exemplary embodiment, the total length of the expansion portion of the solid-liquid recovery device has a length of about 42.7 mm, and the proximal and distal taper regions have lengths of about 12.4 mm and 8.6 mm, respectively.

Fig. 31 shows a solidification recovery apparatus 6050 according to another embodiment having another feature. The strut elements of the rail segments 6051 and 6052 have various width sizes. The coagulation recovery apparatus 6050 is configured for the treatment of silver, especially of small diameter vessels / tubes. In one embodiment, as shown in Figure 31, the circumference of the main body portion (section A) includes but is not limited to three cell structures 6080. Fig. 31 shows a solidification recovery apparatus 6050 in a plan view as if the apparatus is cut and laid flat on the surface. Figure 31 shows a device in a constructed (cut) configuration. In one embodiment, the rail segment 6051 is converted from a maximum width dimension at or near the proximal end portion 6053 to a minimum width dimension at or near the distal end portion 6054. In the same manner, the rail segment 6052 is converted from a maximum width size at or near the proximal end 6053 to a minimum width size at or near the distal end 6055. [ As discussed above, the width dimension of the rail segment is selected to enhance the ability to disassemble the force and resist buckling when a push force is applied to the proximal end 6053 of the vessel treatment device. In some embodiments, the ratio change between the maximum rail width size and the minimum rail width size is between about 20.0% and 30.0%, and preferably between 20% and 25%. In an exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0036 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches.

Fig. 31 shows the rail segments 6051 and 6052 in the undamped state as described above, but it is understood that rail segments such as those shown in Figs. 1A and 4A are also considered. Further, a processing apparatus having a number of features and / or characteristics (e.g., dimension, space, relationship, etc.) different from the above-described rail width characteristics as shown in Figs. 1-29, May be integrated into the collection device 6050.

In some embodiments, the width of the rails 6051, 6052 is tapered along the length (or portion thereof) in a substantially uniformly decreasing fashion. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with the transition taper only when used to join different rail portions with different widths. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a step transition between rail portions of different widths. In another embodiment, two or more of the width conversion methods are used. It is preferred, but not required, that width transitions occur at portions along the strut joint (e. G., Junction 6064) and other rail struts.

In some embodiments, the struts 6056, 6057 of most of the proximal cell structures may also be reinforced with the same or less than the maximum rail width for the purpose of enhancing the push capability of the solid- Width size. In some embodiments, it is provided with a reinforced width dimension that is less than the overall length of the struts 6056, 6057. For example, in some embodiments, the reinforced width portion is inflated at the uppermost end of the struts 6056, 6057 and ends at a distance prior to the abutment 6058. The configuration of the struts 6056 and 6057 may also be modified in the manner described above.

31, rail portions 6060 and 6061 have a width dimension of about 0.0047 inches, rail portions 6062 and 6063 have width dimensions of about 0.0036 inches, and device 6050 Lt; / RTI > has a width dimension of about 0.0027 inches. In other exemplary embodiments, the rail portions 6060 and 6061 have a width dimension of about 0.0047 inches, the rail portions 6062 and 6063 have a width dimension of about 0.0036 inches, and the distal portion of the device The strut of strut 6070 has a width dimension of about 0.0023 inches and the remainder of the strut has a width dimension of about 0.0027 inches. The reduced width dimension of the distal portion 6070 allows for more surface interaction between the vessel / vessel and distal portion 6070 to prevent or minimize damage to the vessel / vessel wall while the coagulating and collecting device is withdrawn adjacent from the patient Minimization in a small vessel or tube produces a region of lower radial force.

The test may be performed using a proximal taper of the coagulum recovery device 6050 having good force transfer characteristics in accordance with good radial force characteristics, such as sheathing and re-sheathing, in the introducer sheath and / Area.

31 in some embodiments is a laser cut from a tube having an inner diameter of about 2.130 mm and a wall thickness of between about 0.128-0.10 mm. In use, the coagulating and collecting device 6050 according to the embodiment shown in FIG. 31 may be operated from a complicated blood vessel dissection or through a tube in the patient's body to a treatment chamber of a first nominal diameter in an unexpanded or compressed state, Can be moved to a radially expanded state of a second nominal diameter larger than the first nominal diameter for placement in the process chamber.

In an alternative embodiment, the second nominal diameter (e. G., The average diameter of the main body portion) is about 3.0 +/- 0.5 mm. In some embodiments, the size and material properties of the cell structure (6080) present in the main body (section A) may be determined by a combination of embolization closure / coagulation present in the blood vessel The cell structure 6020 is selected to provide contact interaction and sufficient radial force to engage.

In some embodiments, the size and material properties of the element as a function of the expansion length of the collecting device are such that the radial force per unit length between about 0.015 N / mm and 0.035 N / mm when the outer diameter of the collecting device is limited to 1.5 mm . In some embodiments, the size and material properties of the element along its inflation length are such that when the outer diameter of the collecting device is limited to 1.5 mm, a radial force per unit length of between about 0.017 N / mm and 0.033 N / mm Is selected. In an identical or alternative embodiment, the size and material properties of the element with respect to the expansion length of the collecting device may be in the radial direction between about 0.010 N / mm and 0.020 N / mm when the nominal diameter of the main body is about 2.0 0.5 mm It is chosen to generate force.

In the embodiment of FIG. 31, most of the cell structure (except at least partially formed by rail segments 6051 and 6052) includes a pair of short struts 6081 joined by connector region 6083 and a long strut 6081 6082). ≪ / RTI > 32A-C), the short strut 6081 has a linear length (L ₁ ) of about 0.055 +/- 0.010 inches and the long strut 6082 has a length of about 0.128 +/- 0.010 inches Has a linear length (L ₂ ), and the connector region 6083 has a linear length (L ₃ ) of about 0.0371 ± 0.010 inch. In one or more embodiments, the cell structure 6080 has a region of about 4.5 +/- 5.5 mm < ^{2 &} gt ;. In one exemplary embodiment, the cell structure 6080 has a region of about 5.0 mm ² . In an exemplary embodiment, the overall length of the expanded portion of the coagulating and collecting device has a length of about 25.0 - 35.0 mm and the main body portion (section A) has a length of between about 10.0 - 15.0 mm. In one exemplary embodiment, the total length of the expanded portion of the coagulating and collecting device has a length of about 30.7 mm, the main body portion (section A) has a length of about 13.1 mm, the proximal and distal taper regions are about 10.9 mm 6.7 mm in length.

In Fig. 33A, an alternative embodiment of the above-described solidification recovery apparatus related to Fig. 30 is shown. 33B and 33C are a plan perspective view and a side view of the solidification recovering apparatus 7000 of Fig. 33A. The sections of the processing apparatus 7000, generally identified as areas E and G, are similar in some respects and in some cases identical in many respects to the same general area of the collection apparatus 6000 described above. For example, the width dimension of the struts generally located in region G may have different values to form the various desired distal taper characteristics described above in other embodiments. Region E may also assume one of the various embodiments described above with reference to the collecting device of FIG. 33A, the size of the cell structure 7002 in the central region F of the device 7000 is generally larger than that of the device 6000 described above. The advantage of the reduced strut density of the central region F of the apparatus 7000 is to enhance the integration of embolic occlusion / coagulation in the region F of the apparatus. 33, a large cell structure is used to form the selected long strut 6022 of the device 6000 of Figure 30 to form a cell structure 7002 having an area that doubles the size of the cell 7024. [ Lt; / RTI > In one embodiment, the cell structure 7020 has a region between about 8.0 mm ² and 8.5 mm ² . In one exemplary embodiment, the cell structure 7020 has an area of about 8.3 mm ² . It is important to note that other methods can be used to form large cell structures. A particular advantage of the embodiment of FIG. 33 is that good strut overlap properties are preserved to facilitate the low profile delivery of the device 7000.

The reduction in the strut density of the region generally results in a lower radial strength in the region. The reduction in the coagulation recovery device can adversely affect the ability of the device to integrate with embolic occlusion / solidification. To compensate for the reduction in radial strength, the selection strut portion 7006 (shown in phantom) located generally within the area F of the collection device in some embodiments has a width dimension (indicated by solid lines) of the strut portion 7004 A larger width size is provided. The width dimension of the strut portion 7006, according to some embodiments, is selected to be similar to the fact that the overall radial strength per unit length of the expansion portion of the collection device is such that the struts are not removed to form a large sized cell structure. For example, in some of the embodiments described above in which the reduced strut density is achieved by missing a particular long strut 6022 of the device of Figure 30, the width of the strut 7006 is greater than the total radial direction per unit length of the inflation portion of the retrieval device The intensity is selected to resemble the device described above.

For example, in some embodiments, the strut portion 7004 may be formed so that the total radial intensity per unit length of the inflation portion is approximately equal to the same area of the collecting device having a substantially uniform cell size and a strut width size of about 0.0027 inches. With a strut portion 7006 having a width dimension of 0.0035 inches, and a width dimension of about 0.0027 inches.

Although it is not essential, as shown in FIG. 33A, it is preferable that the strut width change occurs at a position (denoted by "X") different from the joint 7008. Although not required, width transitions preferably include a taper that provides a relatively smooth transition between different width sizes.

The strut portion of the reinforced width 7006 is one way to produce the desired total radial force per unit length. Other methods can be used. For example, the strut portion 7006 may instead have an enhanced thickness dimension over the strut portion 7004, or may have a combination of enhanced thickness and width dimensions. In another embodiment, most of the width dimension, substantially all of the struts in section F in general, is reinforced to compensate for the reduction in strut density.

Referring to Figure 34A, there is shown an alternative embodiment of the coagulum recovery apparatus described above in conjunction with Figure 30. [ Figures 34B and 34C are exemplary perspective and side views of the solidification recovery apparatus 7020 of Figure 34A. The sections of the processing apparatus 7020, generally identified as regions E and G, are similar in some respects and in some respects identical in many respects to the same general area of the solidification recovery apparatus 6000 described above. For example, the width dimension of the strut of region G may have different values to form the various desired distal taper features described above in other embodiments. Region E may also assume one of the various embodiments described above with reference to the collecting device of FIG. Some of the dimensions of the cell structure 7022 in the central region J of the device 7020, as in Figure 34A, are reduced by a reduced strut density < RTI ID = 0.0 > As compared to the embodiment of the apparatus 6000 described above in order to provide a region to be circumferentially expanded. In the processing arrangement 7020 of FIG. 34, a large cell structure is formed by missing a selected long strut 6022 of the device 6000 of FIG. 30 to form a cell structure 7002 having an area twice the size.

One example cell structure 7022 has an area of about 8.3 mm ² . It is important to note that one of many other methods can be used to form large cell structures. A particular advantage of the embodiment of FIG. 34 is that good strut nesting properties are preserved to facilitate the low profile delivery state of the device 7020.

As described above, the reduction of the strut density of the region generally causes the intensity in the radial direction within the region to be lowered. The reduction in the coagulation recovery device can adversely affect the ability of the device to integrate with embolic occlusion / solidification. A selection strut portion 7026 (shown in phantom) generally located within the area J of the collection device to compensate for the reduction in radial strength has a width dimension greater than the width dimension of the strut portion 7025 / RTI > According to some embodiments, the width dimension of the strut portion 7026 is selected to be similar to the fact that the total radial strength per unit length of the expansion portion of the retrieval device does not remove the struts to form a large sized cell structure. For example, in the above-described embodiment in which the reduced strut density is achieved by missing a particular long strut 6022 of the device of Figure 30, the width of the strut 7026 is greater than the total radial strength per unit length of the inflation portion of the retrieval device Is selected to resemble device 6000 described above.

For example, in some embodiments, the strut portion 7025 may have a total radial intensity per unit length of the expanded portion of about < RTI ID = 0.0 > about < / RTI > Has a width dimension of about 0.0027 inches with a strut portion 7026 having a width dimension of 0.0035 inches.

In some embodiments, as shown in Figure 34A, some or all of the strut widths may be changed such that, in another embodiment, a transition of some or all of the strut width occurs at a different location than the abutment 7028, Lt; / RTI > Although not required, width transitions preferably include tapers that provide a relatively smooth transition between different width sizes.

The strut portion of the reinforced width 7026 is one way to create the desired total radial force in the region J. [ Other methods can be used. For example, the strut portion 7026 may have an enhanced thickness dimension over the strut portion 7025, or may have a combination of enhanced thickness and width dimensions.

Referring to Fig. 35, there is shown an alternative embodiment of the solidification recovery apparatus described above in conjunction with Fig. 35B and 35C are exemplary perspective and side views of the solidification recovery apparatus 7050 of FIG. 35A. The sections of the processing apparatus 7050, generally identified as regions E and G, are similar in some respects and in some cases identical in many respects to the same general area of the solidification recovery apparatus 6000 described above. For example, the width dimension of the struts generally located in region G may have different values to form the various desired distal taper characteristics described above in other embodiments. Region E may also assume one of the various embodiments described above with reference to the collecting device of FIG. Some of the dimensions of the cell structure 7052 in the central region K of the device 7052, as in Figure 35A, are of a reduced strut density, generally separated by the heat expanded into the circumference of the unexpanded cell structure 7054 Which is larger than the embodiment of the apparatus 6000 described above in order to provide a circumferential expansion region. 35, a large cell structure is used to form the selected long strut 6022 of the device 6000 of FIG. 30 to form a cell structure 7052 having twice the size of the cell 7054. [ Lt; / RTI > One example cell structure 7052 has an area of about 8.3 mm ² . It is important to note that one of many other methods can be used to form large cell structures. A particular advantage of the embodiment of FIG. 35 is that good strut nesting properties are preserved to facilitate the low profile delivery state of the device 7050.

As described above, the reduction of the strut density of the region generally causes the intensity in the radial direction within the region to be lowered. The reduction in the coagulation recovery device can adversely affect the ability of the device to integrate with embolic occlusion / solidification. A selection strut portion 7056 (shown in dashed lines) generally located within the area K of the collection device to compensate for the reduction in radial strength has a width dimension greater than the width dimension of the strut portion 7055 / RTI > According to some embodiments, the width dimension of the strut portion 7056 is selected to be similar to the fact that the total radial strength per unit length of the expansion portion of the retrieval device does not remove the struts to form a large sized cell structure. For example, in the above-described embodiment in which the reduced strut density is achieved by missing a particular long strut 6022 of the device of FIG. 30, the width of the strut 7056 is greater than the total radial strength per unit length of the inflation portion of the retrieval device Is selected to resemble device 6000 described above.

For example, in some embodiments, the strut portion 7055 may be formed from the same area of the collecting device 6000 having a substantially uniform cell size per unit length of the inflation portion and a strut width size of about 0.0027 inch With a width dimension of about 0.0027 inches with a strut portion 7056 having a width dimension of about 0.0035 inches.

In some embodiments, the width of strut 7059 has a width dimension of between about 0.0031 inches and about 0.0033 inches, similar to those described above for some embodiments of apparatus 6000. [

Although it is not necessary, as shown in FIG. 35A, it is preferable that the strut width change occurs at a position different from the joint 7058. Although not required, width transitions preferably include a taper that provides a relatively smooth transition between different width sizes.

The strut portion of the reinforced width 7056 is one way to produce the desired total radial force per unit length. Other methods can be used. For example, the strut portion 7056 may instead have an enhanced thickness dimension across the strut portion 7055, or may have a combination of enhanced thickness and width dimensions.

Fig. 36 shows a solidification recovery device 6090 similar in size to cell structure 6091 whose size difference is generally located in region B of the device. As shown in FIG. 36, the cell structure 6091 is larger than the cell structure 6020 of the device shown in FIG. As noted above, the advantage of a large size cell structure in the main body portion of the recovery device is that it enhances solidification integrity in the main body portion when the radial strength of the main body portion is suitably provided. A strut 6092 (shown in phantom) generally located within region B for the purpose of providing sufficient radial strength in region B of apparatus 6090 has an enhanced width dimension of about 0.0035 inches in one embodiment. In one embodiment, the width dimension of the struts 6092, which is generally located in region B, is greater than the width dimension of the rail segments 6001 and / or 6002 (having the same or similar width dimension of one or more struts 6009, 6010, and 6011) Same as or similar to the width of the section. Although it is not essential, it is preferable that the width size change occurs at a position different from the joint 6045 as shown in Fig.

Figure 37 shows, among other features, the solidification recovery apparatus 8000 according to another embodiment in which the strut elements of the rail segments 8001, 8002 have a width magnitude change. Figure 37 shows the coagulating and collecting device in a plan view as if the device were cut and laid flat on the surface. Figure 37 shows a constructed (cut) configuration device. In one embodiment, the rail segment 8001 is transitioned from a proximal end 8014 or a minimum width size near it to an end or near distal end 8015. In the same manner, the rail segment 8002 is converted to a minimum width size of the distal end 8016 at or near the proximal end 8014 or a maximum width dimension at or near the proximal end. As noted above, the width dimension of the rail segment is selected to improve the ability to distribute force and resist buckling when a push force is applied to the proximal end 8014 of the vessel treatment device. In some embodiments, the ratio variation between the maximum rail width size and the minimum rail width size is between about 20.0% and about 35.0%. In another embodiment, the ratio change between the maximum rail width size and the minimum rail width size is between about 25.0% and about 30.0%. In an exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0027 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches. In another exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0034 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches.

Figure 37 shows the undamped rail segment, but as discussed above, it is understood that the rail portion as shown in Figures 1A and 4A is also contemplated. In addition, a plurality of features and / or characteristics of the vascular treatment apparatus disclosed in Figs. 1-29, which are different from the above-described rail width characteristics like the apparatus of Fig. 30 described above, are provided in the coagulating and recovering apparatus 8000 Can be integrated.

In some embodiments, the width of the rails 8001, 8002 is tapered along the length (or a portion thereof) in a substantially uniformly reduced form. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a transition taper used to join the rail portions of different widths. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a stepwise transition between different rail portions of width. In another embodiment, two or more of the width conversion methods are used. Although not required, the width transition preferably occurs at a portion along the rail strut that is different from the strut's joint (e. G., Joint 8030).

In some embodiments, the struts 8012, 8013 of most proximal cell structures 8018, as described above, also have a maximum rail width and a maximum radial width for the purpose of enhancing the push capability of the solid- And has an enhanced width dimension that can be equal to or less than. In some embodiments, it is provided with a reinforced width dimension that is less than the overall length of the struts 8012 and 8013. [ For example, in some embodiments, the reinforced width portion is inflated at the uppermost end of the struts 8012, 8013 and ends at a distance prior to the abutment 8026. [ The configuration of the struts 8012 and 8013 can be changed in the above-described manner.

37, all or a portion of the struts 8003, 8004 (optionally the entire or proximal portion of the struts 8005, 8006) may have a width dimension between about 0.0045 inches and about 0.0050 inches All or portions of struts 8007 and 8008 (optionally all or part of struts 8005 and 8006) have a width dimension between about 0.0036 inches and 0.0040 inches, and all or part of struts 8009 and 8008, (Optionally all or part of the struts 8007, 8008) has a width dimension between about 0.0034 inches and 0.0036 inches. In some embodiments, the remainder of the strut generally located in the region M of the device has a width dimension of about 0.0027 inches and the remainder of the strut generally located in the region N of the device has a width dimension of about 0.0036 inches With the remainder of the struts generally located in the region O of the device having a width dimension of about 0.0031-0.033 inches. It should be understood that the size as described above in connection with the exemplary embodiment is subject to conventional manufacturing tolerances, and variations in size are possible and are also contemplated.

Although not required, the width transition preferably occurs at a portion along the strut other than at the strut's joint (e. G., Joints 8030 and 8032).

As shown in FIG. 37, the strut density of an area generally identified as "N" is significantly less than the strut density of an area generally identified as "M" and "O". As a result, the cell structure 8020 generally located in the region N is generally larger than the cell structure 8021 located in the regions "N" and "O ". As mentioned above, the advantage of the large size cell structure in the main body portion of the recovery device is to enhance coagulation integration into the main body portion (region N) when the radial strength of the main body portion is suitably provided.

In order to provide sufficient radial strength in the region N of the device, the struts in the region are strengthened relative to the cell struts typically present in region M (except struts 8003-8013) Width dimension. In one embodiment, the width dimension of the struts in the region N is similar or equal to the width dimension of the distal struts 8009, 8010, and 8011 of the rail segments 8001 and / or 8002.

In another exemplary embodiment, the struts 8003-8006 have a width dimension of about 0.0047 inches and the proximal portions of the struts 8007 and 8008 and the strut 8010 have a width dimension of about 0.0040 inches, , 8011 and the distal portion of the strut 8010 have a width dimension of about 0.0034 inches and the struts 8012-8013 have a width dimension of about 0.0040 inches. In some embodiments, the remaining strut element of the apparatus has a width dimension of about 0.0027 inches, the strut of area N has a width dimension of about 0.0034 inches, and the strut of area O has a width dimension of about 0.0031 inches. The increased width size of the struts of section O advantageously reduces the likelihood of strut buckling in the distal taper region of the coagulum recovery apparatus during delivery to the patient ' s treatment area. The increased width size also increases the radial strength of the proximal tapered region, which enhances the ability of the distal taper region to remain open while the coagulum recovery device is withdrawn from the patient. This feature allows the distal taper section to remain open when the coagulation recovery device is used for coagulation removal and can clear the remainder of the coagulation when the coagulum recovery device is withdrawn from the patient.

37 is a laser cut from a tube having an inner diameter of 3.77 mm and a wall thickness of between about 0.097 and 0.131 mm. In use, the coagulating and collecting device 8000 according to the embodiment shown in FIG. 37 may be operated from a complicated blood vessel dissection or through a tube in a patient's body to a treatment chamber of a first nominal diameter in an unexpanded or compressed state, Can be moved to a radially expanded state of a second nominal diameter larger than the first nominal diameter for placement in the process chamber.

In an alternative embodiment, the second nominal diameter (e. G., The average diameter of the main body portion) is about 5.5 0.5 mm. In some embodiments, the size and material properties of the cell structure 8020, which is generally present in the main body (section N) of the inflatable material, is present in the blood vessel in a manner that allows the embolization closure to be partially or completely removed from the patient. To provide sufficient abutting interaction and sufficient radial force to connect the cell structure 8020 with the embolic closure /

In some embodiments, the size and material properties of the element as a function of the expansion length of the collecting device are such that the radial force per unit length between about 0.040 N / mm and 0.065 N / mm when the outer diameter of the collecting device is limited to 1.5 mm . In some embodiments, the size and material properties of the element along its inflation length may be adjusted to produce a radial force per unit length between about 0.045 N / mm and 0.060 N / mm when the outer diameter of the retrieval apparatus is limited to 1.5 mm Is selected. In some embodiments, the size and material properties of the element along the inflation length may be adjusted to produce a radial force per unit length between about 0.050 N / mm and 0.060 N / mm when the outer diameter of the collection apparatus is limited to 1.5 mm Is selected. In some embodiments, the size and material properties of the element along its inflation length are such that when the outer diameter of the collection apparatus is limited to 1.5 mm, a radial force per unit length of between about 0.049 N / mm and 0.057 N / mm Is selected. In an identical or alternative embodiment, the size and material properties of the element with respect to the expansion length of the collecting device may be in the radial direction between about 0.010 N / mm and 0.020 N / mm when the nominal diameter of the main body is about 4.5 0.5 mm It is chosen to generate force.

In the embodiment of FIG. 37, the cell structure of regions "M" and " O "(except at least partially formed by rail segments 8001 and 8002) comprises a pair of short struts 8022 and a long strut 8023, Lt; RTI ID = 0.0 > a < / RTI > pair. Region of the cell structure 8021 in an exemplary embodiment is between 4.5mm ² -5.5mm ^2. Region of the cell structure 8021 in an exemplary embodiment is 5.0mm ² -5.2mm ^2. In one embodiment, the cell structure 8020, which is generally located in the region N, includes a form consisting of two contiguous cell structures 8021 with long struts 8024 missing from these cells. Although another type of large cell structure is considered, an advantage of the cell structure shown in FIG. 37 is that the collecting device has a good nesting ability to achieve a small transfer profile.

In some embodiments, the total length of the expanded portion of the coagulating and collecting device has a length of about 55.0-65.0 mm, the main body portion (section N) has a length of between about 25-35 mm, and the proximal and distal taper regions are And has a length of between about 10.0 mm and 20.0 mm. In one exemplary embodiment, the total length of the expanded portion of the coagulating and collecting device has a length of about 58.4 mm, the main body portion (section N) has a length of about 29.3 mm, the proximal and distal taper regions are each about 16.6 mm And 12.5 mm in length.

38 shows a solidification recovery apparatus 8500 according to another embodiment having another feature. The strut elements of the rail segments 8051 and 8052 have various width sizes. 38 shows the solidification recovery apparatus 6050 in a plan view as if the apparatus was cut and laid flat on the surface. Figure 38 shows a device in a constructed (cut) configuration. In one embodiment, the rail segment 8051 is switched from a maximum width dimension at or near the proximal end 8066 to a minimum width dimension at or near the distal end 8067. [ In the same manner, the rail segment 8052 is converted from a maximum width dimension at or near the proximal end 8066 to a minimum width dimension at or near the distal end 8077. As discussed above, the width dimension of the rail segment is selected to enhance the ability to disassemble the force and resist buckling when a push force is applied to the proximal end 8064 of the vessel treatment device. In some embodiments, the ratio change between the maximum rail width size and the minimum rail width size is between about 20.0% and 35.0%. In another embodiment, the ratio change between the maximum rail width size and the minimum rail width size is between about 22.0% and 27.0%. In an exemplary embodiment, the width dimension of the rail segment is converted to a minimum width dimension of about 0.0035 +/- 0.0004 inches at a maximum width dimension of about 0.0047 +/- 0.0004 inches.

Figure 38 shows the rail segments in the undamped state as described above, but it is understood that rail segments such as those shown in Figures 1A and 4A are also contemplated. Further, a processing apparatus having a number of features and / or characteristics (e.g., dimension, space, relationship, etc.) different from the above-described rail width characteristics as shown in Figs. 1-29, May be integrated into the collection device 8050.

In some embodiments, the width of the rails 8051 and 8052 is tapered along the length (or a portion thereof) in a substantially uniformly decreasing fashion. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with the transition taper only when used to join different rail portions with different widths. In some embodiments, the individual portions of the rails have a substantially uniform width dimension with a step transition between rail portions of different widths. In another embodiment, two or more of the width conversion methods are used. It is preferred, but not required, that width transitions occur at portions along the strut joint (e. G., Junction 8070) and other rail struts.

In some embodiments, the struts 8064, 8065 of most proximal cell structures in the above-described manner may also have the same or smaller maximum rail width for the purpose of enhancing the push capability of the solid- Lt; RTI ID = 0.0 > width. ≪ / RTI > In some embodiments, the struts 8064 and 8065 are provided with a reinforced width dimension less than the overall length. For example, in some embodiments, the reinforced width portion is inflated at the uppermost end of the struts 8064, 8065 and ends at the pre-joining distance. Also, the configuration of the struts 8064 and 8065 can be changed by the above-described method.

38, all portions or portions (and optionally all or portions of struts 8055 and 8056) of struts 8053 and 8054, in the exemplary embodiment, have a width dimension of from about 0.0045 inches to about 0.0050 inches All portions or portions (and optionally all or portions of struts 8055, 8056, 8059, 8060) of struts 8057 and 8058 have width dimensions of about 0.0036 inch to about 0.0040 inch, struts 8059 All portions or portions (and optionally all or portions of the struts 8061, 8062, 8063) have a width dimension of from about 0.0034 inches to about 0.0036 inches.

In some embodiments, the remainder of the strut generally located in the region P of the device has a width dimension of about 0.0027 inches, and the strut generally located in the region Q has a width dimension of 0.0034 inches to about 0.0036 inches , The strut generally located in the region R has a width dimension of 0.0031 inches to about 0.0033 inches. In one or more of the above-described embodiments, the width dimension of the struts 8064, 8065 is between 0.0036 inches and about 0.0047 inches. It should be understood that the size as described above in connection with the exemplary embodiment is subject to conventional manufacturing tolerances, and variations in size are possible and are also contemplated.

Although not required, the width transition preferably occurs at a portion along the strut itself other than at the strut's joint (e. G., Joints 8070 and 8071).

As shown in FIG. 38, the strut density of an area generally identified as "Q " is significantly less than the strut density of an area generally identified as" P " As a result, cell structure 8080, which is generally located in region Q, is generally larger than cell structure 8081 located in regions "P" and "R ". As noted above, the advantage of a large size cell structure in the main body portion of the recovery device is to enhance coagulation integrity into the main body portion (region Q) when the radial strength of the main body portion is suitably provided.

In order to provide sufficient radial strength to the region Q of the device, struts in the region are strengthened relative to cell struts generally present in region P (except struts 8053-8065) Width dimension. In one embodiment, the width dimension of the struts in the area Q is similar or equal to the width dimension of the rails 8051 and / or 8052 (e.g., 8061, 8062 and / or 8063).

In another exemplary embodiment, the proximal portions 8055 and 8056 of the struts 8003-8006 and the struts 8055 have width dimensions of about 0.0047 inches and the struts 8057 and 8058 and the struts 8055,8056 and 8059 , 8060 have a width dimension of about 0.0040 inches each and the distal portions of struts 8009, 8011 and strut 8010 have width dimensions of about 0.0034 inches, struts 8012-8013 With a width dimension of about 0.0040 inches, the distal portions of struts 8061, 8062, 8063 and struts 8059, 8060 have a width dimension of about 0.0035 inches.

In some embodiments, the remainder of the strut generally located in the region P of the device has a width dimension of about 0.0027 inches, the strut generally located in the region Q has a width dimension of 0.0035 inches, R) has a width dimension of 0.0031 inches. The increased width size of the strut of section R advantageously reduces the likelihood of strut buckling in the distal taper region of the coagulum recovery device during delivery to the patient ' s treatment area. The increased width size also increases the radial strength of the proximal tapered region, which enhances the ability of the distal taper region to remain open while the coagulum recovery device is withdrawn from the patient. This feature allows the distal taper section to remain open when the coagulation recovery device is used for coagulation removal and can clear the remainder of the coagulation when the coagulum recovery device is withdrawn from the patient.

38 is a laser cut from a tube having an inner diameter of 3.77 mm and a wall thickness of between about 0.097 and 0.131 mm. In use, the coagulating and collecting device 8050 according to the embodiment shown in FIG. 38 may be operated from a complicated blood vessel dissection or through a tube in the patient's body to a treatment chamber of a first nominal diameter in a non- Can be moved to a radially expanded state of a second nominal diameter larger than the first nominal diameter for placement in the process chamber.

In an alternative embodiment, the second nominal diameter (e. G., The average diameter of the main body portion) is about 6.0 +/- 0.5 mm. In some embodiments, the size and material properties of the cell structure 8080, which is generally present in the main body (section Q) of the inflatable material, is present in the blood vessel in such a way as to partially or completely remove the embolus closure from the patient To provide sufficient abutting interaction and sufficient radial force to allow the embolic closure / clot to be connected to the cell structure 8080.

In some embodiments, the size and material properties produce a radial force per unit length of the expansion portion of the coagulation apparatus between about 0.010 N / mm and 0.010 N / mm when the diameter of the main body is reduced to about 5.0 +/- 0.5 mm .

In the embodiment of FIG. 38, the cell structure (except at least partially formed by rail segments 8051 and 8052) generally located in regions "P" Is shown to have a similar form to the cell structure 8081 comprising a pair of struts 8084. In an exemplary embodiment, the area of the cell structure 8081 is 9.2 mm ² . In one embodiment, the cell structure 8080, which is generally located in the region Q, includes a form consisting of two contiguous cell structures 8081 with long struts 8084 missing from these cells. Although another type of large cell structure is considered, an advantage of the cell structure shown in FIG. 38 is that the collecting device has a good nesting ability to achieve a small transfer profile.

In some embodiments, the overall length of the expansion portion of the coagulating and recovering device has a length of about 65.0-75.0 mm and the main body portion (section Q) has a length of between about 25-35 mm. In one exemplary embodiment, the total length of the expanded portion of the coagulating and collecting device has a length of about 71.9 mm, the main body portion (section Q) has a length of about 32.3 mm, the proximal and distal taper regions are each about 22.5 mm And 17.1 mm in length.

39 is a plan view of a tube closed part collection device 370 according to another embodiment. As part of another embodiment described above, the collection device 370 includes a proximal tapered end 371, a cylindrical main body portion 372, and a distal tapered end 373. The difference in the distal tapered end 373 relative to the distal tapered end portion described above is that the distal tapered end 373 has less than three total rows of cell structures to reduce the length of the distal taper. In the example of Figure 39, the distal tapered end portion includes two full column cell structures 374 and 375 and some column cell structures 376. (For the sake of clarity, although column 375 in the embodiment of Figure 39 includes a single cell structure, it is sometimes considered a single column cell structure.)

The inclusion of the distal taper end portion of the retrieval device ending in the distal antenna provides many advantages over the withdrawal device ending at the blunt end.

One advantage is that once the collection device is deployed and deployed in a patient's blood vessel, the tapered end provides a large range of positioning through the collection device with its blunt end. Another advantage is that the distal taper end portion is less traumatic than the blunt end. The reduced taper length achieved by limiting the configuration of the distal tapered ends 373 to less than three columns of the cell structure is more stable and more traumatic than having the entire row of cell structures ) ≪ / RTI > In a collecting device having different sized cell structures, such as cell structures 376 and 377, it is preferred that the cells of the entire row of distal tapered end portions 373 are included in all small sized cell structures 377 as shown in FIG. 39 .

The length of the distal tapered end portion 373 in the cut-away state according to some embodiments is less than or equal to about 30% of the length of the main body portion 372, and preferably less than or equal to about 25%. In one embodiment, the lengths of the main body portion 372 and the distal tapered end portion 373 can be about 26 mm and 6 mm, respectively. In another embodiment, the distal tapered end 373 has a length between about 4.5 mm and 5.0 mm. In some embodiments, the combined length of distal taper end 373 and distal antenna 379 is less than about 10 mm.

40A is a plan view of a tube closed part collection device 380 according to another embodiment. Similar to the collection device 370 shown in FIG. 39, the collection device 380 includes a distal tapered end portion that includes fewer rows than three full column cell structures. The collection device 380 includes a first set of cell structures 387 ending at a first cell of the cell structure 386 ending at the first distal antenna 388 and a second distal antenna 389 at the distal tapered end portion Differs from the collecting device 370 in that it includes a cell structure that branches into a first set of cell structures 386 and a second set of cell structures 387. [ 40B is a perspective view of the collection device 380 with reference numeral 383 showing the distal tapered end portion of the device. As shown in FIG. 40B, distal antennas 388 and 389 are coupled to form a collection device having a distal tapered end portion with a closed end.

Although it is described that the collection device 370, 380 includes a distal antenna, it is important that it is provided without a distal antenna in other embodiments, such as a collection device. The same applies to the embodiments of the present invention. 40, in one embodiment only one distal antenna is selected and provided between the distal antenna 388 and the distal antenna 389 in another embodiment. In this embodiment, the collection device has an open distal end with a second set of cell structures 387 that can be withdrawn to the process container to capture the material to be removed.

41 is a plan view of a tube closure retrieval apparatus 390 according to another embodiment that includes a distal tapered end portion that includes fewer than three entire columns of the cell structure.

The distal tapered end portion of the retrieval device 390, similar to the retrieval device 380, includes a first cell of the cell structure 396 ending at the first distal antenna 398 and a second cell of the second set 392 terminating at the second distal antenna 399. [ The first set of cell structures 396 having a cell structure 397 of the first set and the cell structure 395 branching into the second set of cell structures 397. 41, the first and second distal antennas 398 and 399 are set apart from each other in the longitudinal direction. In one embodiment, the radiopaque material, features (e.g., flare struts) or components (e.g., coils) are disposed on the first and second antennas, respectively. By virtue of the offset configuration, radiopaque components, for example, the distal end of the retrieval device and the distal tapered end portion of the retrieval device at each antenna can be visually depicted during the surgical procedure.

 42A is a plan view of the tube closed part collection apparatus 450 according to another embodiment. The recovery device 450 includes an expansion member having a proximal tapered end portion 451, a cylindrical main body portion 452, and a distal tapered end portion 453. The outermost cell structure of the proximal tapered end portion has an outer wall segment that defines first and second rail segments 454 and 455, respectively. Each rail segment 454 and 455 may be inflated from the uppermost end of the inflation member to a location at or near the proximal end of the cylindrical main body portion 452. [ In the embodiment of Figure 42, each rail segment 454, 455 has a wave. Adjacent antenna 457 is expanded adjacent in a recent up-cell structure 456.

The recent up-cell structure 456 shown in more detail in FIG. 42B includes first and second outer struts 460, 461 and first and second inner struts 462, 463, respectively. The first portion 461a of the first outer strut 460 and the second outer strut 461 is straight while the first inner strut 462 and the second inner strut 463 are straight, And the second portion 461b of the strut 461 are curved. In the as-manufactured condition, the first portion 461a of the first outer strut 460 and the second outer strut 461 is curved and wave-free. As the proximal antenna is similarly inflated and tilted to the proximal end of the expanding member, the straight strut segment of the upper cell structure 456 is now transmitted through dissection compared to a collection device having a recent up-cell structure having only struts that are curved Thereby enhancing the pushing capability of the collection device 450.

In some embodiments, the total length L1 of the struts 460, 462 and the total length L2 of the struts 461, 463 facilitate the nesting of the strut when the expanding member is switched from the inflated state to the inflated state Substantially the same.

In other embodiments, the length difference between L1 and L2 is less than 1.0%, while the length difference between L1 and L2 according to some embodiments is less than 5.0%.

FIG. 43 shows a modification of the recent up-cell structure 456. FIG. As shown, the struts 460, 461 each have a region of reduced width 464, 465 that is located adjacent the junction 466 with a proximal antenna 457. The inclusion of the reduced width regions 464, 465 enhances the ability of the recent up-cell structure to collapse by reducing the amount of force required to initiate and validate collapse. Thus, when the withdrawal device 450 first withdraws the introducer or delivery catheter to the introducer catheter for placement in the delivery catheter, for example after the expanding member is deployed within the patient, the area of the reduced width 464 and 465 Causes the abutment 466 to fold more easily into the region with less force when struts 460, 461 need to have no area of reduced width. This allows the collection device 450 to be managed by a medical professional when the collection device 450 is first introduced into the delivery catheter, thereby reducing the likelihood of damage to the collection device during the introduction process. As described above, there may be a case where the collection device 450 is introduced into the patient's tube and inflated, and then the collection device is pulled back to the delivery catheter. This can occur, for example, at the completion of a recovery procedure or in a collection device that is improperly placed in the pipe. In this case, several advantages are achieved since less force is required to disintegrate the expansion member of the recovery device, respectively. One advantage is that the possibility of the collection device 450 acting on the delivery catheter can be reduced in a way that weaves the careless placement of the delivery catheter within the patient's duct. Another advantage is that it is possible to reduce the possibility of excessive force being exerted on the attachment between the inflation wire (e.g., the inflation wire 40 shown in FIG. IA) and the proximal antenna 457, which causes failure of the abutment.

In the embodiment of FIG. 43, the regions of reduced width 464 and 465 include tapered shapes. The reduced width region of another embodiment is indicated by a stepwise decrease in strut width. The extent to which the widths are reduced in regions 464 and 465 depends on the nominal width of struts 460 and 461. In some cases, it is important that the amount of reduction in width be consistent with the structural integrity requirements of the radial forces and expansion members. It has been found that the reduction in width of the cut manufactured state between about 20.0% and about 5.0% is preferably suitable for struts having a nominal width between about 0.0057 inches and about 0.0027 inches in the range between about 10.0% and 20.0% . In one embodiment, the width dimension W1 of the struts 460, 461 is 0.0053 inches with a minimum width dimension of the reduced width area of 0.0046 inches.

In some embodiments, the cut edge of the struts 460, 461 is different from the width dimension of each area of the other reduced width 464, 465. For example, in one embodiment struts 460 have a width dimension of about 0.0050 inches, struts 461 have a width dimension of about 0.0057 inches, and areas of reduced widths 464 and 465 each have a width dimension of about 0.0042 Inch and a width dimension of about 0.0046 inch.

Figure 44 shows a further variation of a recent up-cell structure 457 in which the outer struts 460 and 461 include a proximal section 467, a middle section 468 and a wind section 469. The width dimension of the outer struts 460, 461 of the upper cell structure 456 is generally made larger than the majority of the struts of the remainder of the collection apparatus 450 for the purpose of enhancing the push- The mass of material at the joints 471, 472, which are generally located at the distal end of the strut, interferes with the collapsing ability of the expanding member. 44, the distal section 469 has a reduced width dimension to reduce the amount of material occupying the abutment regions 471 and 472. In this embodiment, Figure 44 shows a proximal section with a reduced width size (similar to that described above), but in some embodiments is different. The reduced width sections in the manner described above may include tapered and / or stepped configurations.

Another advantage of the embodiment shown in FIG. 44 is that the middle section 468 of the struts 460, 461, which otherwise could be assumed to be in the inflated state, And can be provided with a sufficient width to improve the visibility of the device. According to one embodiment, the width dimension of the middle section 468 of the struts 460, 461 is about 0.0053 inch and the minimum width dimensions of the proximal and distal sections 467, 469 are 0.0047 inch and 0.0041 inch, respectively. In some embodiments of FIG. 43 and in some embodiments of FIG. 44, the width dimension of the struts 460, 461 is different from the width dimension of one or more of the other respective proximal, middle and distal sections.

45A is a plan view of a tube closed part collection device 800 according to another embodiment. The recovery device 8000 includes an expansion member having a proximal tapered end portion 801, a cylindrical main body portion 802, and a distal tapered end portion 803. The outermost cell structure of the proximal tapered end portion has an outer wall segment forming a non-wave-like rail segment 804 on one side and a wave-rail segment 805 on the other side. Each rail segment 804 and 805 can be inflated from the uppermost end of the inflation member to a location at or near the proximal end of the cylindrical main body portion 802. [ The proximal antenna 806 is inflated proximately from the stomach cell structure 807, while the distal antenna 808 is inflated over the circle at the distal end of the distal taper section 803. The distal taper section 803 is similar to that described above in conjunction with FIG. In some embodiments, recent up-cell structure 807 has the same features and characteristics as recent up-cell structure 456 in the embodiment of Figures 42-44.

As a result of the transverse displacement of the cell structure of the recovery device, the straight length through which the rails 804 and 805 pass is the cut manufacturing state with a linear length passing along the rail 804 longer than the straight length passing along the rail 805 .

The linear configuration of the rails 804 combined with the wave configuration of the rails 805 allows the rails 804 and 805 to have a length approaching closer to each other when the collecting device is in the non-inflation / delivery state. According to one embodiment, rails 804 and 805 are configured to achieve substantially the same length when the collecting device is in the non-inflation / delivery state. In some embodiments, the length difference between the rails 804, 805 is between about 0% and about 5% when the collection device 800 is in the non-expansion / delivery state.

As noted above, the collecting device disclosed and contemplated herein is generally a laser cut from a tube, and generally comprises the same structural tube in an actual three dimensional configuration. Figure 45, similar to most of the other drawings, shows a plan view of the device being cut and laid flat on the surface. With this in mind, referring to FIG. 45B, the cell structure may be a polygon including a plurality of struts. As shown, the rail segments 804 and 805 are constructed by the outer walls of the outermost cell structures 807, 810 and 811 of the proximal taper section. Wave rail segment 804 is formed by the first outer wall 812 of the upper cell structure and the outer wall 814 of the outer cell structure 810 while the non-vibrating rail segment 804 is formed by the outer cell structure 811 and a second outer wall 813 of a recent up-cell structure.

As shown in Figure 45B, outer wall 814 is a curve and outer wall 815 is straight. As will be appreciated, when in the tubular form, the rail 804 expansion member is curved, assuming an inflated condition, but non-collapsed nonetheless. The rail 805 is assumed to have additional curvature when it is in a conformation, but the rail 804 otherwise includes waves.

The advantage of the proximal taper section 801 design is that the wave rail segment 805 can be used to provide multiple symmetrical polygons in the section 801 and / RTI > and / or nearly symmetrical polygons. The inclusion of an increased number of symmetrical and / or nearly symmetrical polygons in the distal tapered end portion 801 improves the ability to assume a non-expanded or compressed condition and also provides a more uniform and simple configuration. The above advantages are achieved by the increased number of opposing cell structures disposed within the proximal tapered end portion 801 because the symmetrical cell structure has a better nesting tendency than the asymmetrical counterpart.

 Another advantage of the proximal tapered end portion with one non-pulsating rail segment 804 and one pulley rail segment 805 is that the inclusion of the wave rail segment can result in a reduction in cell structure To provide a greater degree of freedom in the design of the device. As shown in Figure 45B, the outer shell structure 811 in which the non-wave rail segment 804 is formed includes a structure that is considerably more patching than the example shown in Figure 30. [

According to an embodiment with reference to Figure 45C, the collector device 800 has the following cut size characteristics: L1 = 56.44 mm ± 0.50 mm; L2 = 26.85 mm ± 0.50 mm; L3 = 2.0 mm +/- 0.1 mm; L4 = 4.0 mm + - 0.3 mm; W1 = 0.0054 inch +/- 0.0004 inch; W2 = 0.0056 inch 占 0.0004 inch; W3 = 0.0047 inch 占 0.0004 inch; W4 = 0.0047 inch 占 0.0004 inch; W5 = 0.0040 inch 占 0.0004 inch; W6 = 0.0027 inch 占 0.0004 inch; W7 = 0.0034 inch 占 0.0004 inch; W8 = 0.0031 inch +/- 0.0004 inch; W9 = 0.010 inch 占 0.007 inch; W10 = 0.0035 inch +/- 0.0004 inch; W11 = 0.0025 inch +/- 0.0004 inch. In one embodiment, the lengths of the proximal tapered end portion and the distal tapered end portion are about 13 mm and about 7 mm, respectively.

46 shows a closure collection apparatus 830 according to another embodiment. A portion 833 of a portion of the strut 832 of the distal tapered end 831 of the collection device is incinerated to improve the radiation impermeability of the distal region of the device. In some embodiments, during the fabrication process, each portion 833 is laser cut to have a reinforced width dimension for the remaining struts 832. In addition to enhancing the radiation impermeability on its own, the flared portion (or reinforced width portion) provides a good platform for accommodating a radiopaque coating, such as, for example, a gold coating. In the embodiment of Figure 46, the flare portion 88 is disposed at a sufficient distance from the strut joint 834 so as not to impede the recovery device from being compressed. In the embodiment of Figure 46, the flare portion 833 is also staggered so that the single flare portion 833 no longer occupies the vertical position when the recovery device 830 is in the compressed state. This configuration reduces the impact that the flare portion 833 may have along the distal tapered end portion 831 at a diameter size that is the lowest achievable by the collection apparatus.

In the embodiment of Figure 46, the flared portion includes a node having a diameter of about 0.015 inches in one embodiment. In another embodiment, the flared portion 833 is essentially longitudinal and occupies a significant length of the strut 832. [ In such an embodiment, the flared portion 833 may have a width between about 0.0035 inches and 0.0045 inches.

47A and 47B illustrate the distal segment of the closure collection device 480 according to one embodiment. 47A shows a plan view of the recovery device cut along its length and laid flat on the surface. Figure 47A shows the device 480 in a cut configuration, while the perspective view of Figure 47B shows the device 480 in its manufactured state after being cut.

Referring to Figure 47A, the distal segment of device 480 includes a plurality of distal cell structures 481-482 with a set of antennas 481, 482, 483 extending from the junction regions 492-494 of cell structures 488-491, (488-491). In some embodiments, tabs 485-487 or other enhanced size features may be used for purposes of identifying the distal end of the device by fluoroscopic diagnosis, due to the enhanced size feature and / or given a radiopaque material Is provided at one or more ends of the most upstanding cell structure. As shown in Figure 47A, in some embodiments, the top-most cell structure is smaller than the adjacent cell structure of the main body portion of device 480. [

47B, after the device 480 is cut by the laser, the distal ends of the antennas 481, 482, and 483 provide the inner cavity of the device 480 with the closed end at the junction 484 do. In fact, the closed end forms a basket that facilitates collection of particles, such as embolic material, that can be removed during the recovery process. In some embodiments, the junction 484 is formed by soldering the distal ends of the antennas 481-483 together. In some embodiments, the distal ends of the antennas 481-483 may be provided with a coil spring or other perforated structure, such as a solder or other adhesive applied to the encasement joining the distal ends of the antennas 481-483 together, Lt; / RTI > In some embodiments, the container includes a round non-atraumatic distal tip. In some embodiments, the container comprises a radiopaque material.

48A and 48B illustrate a closure collection device 850 according to one embodiment. 48A shows a plan view of the collection device 850 cut along its length and laid flat on the surface. 48A shows device 850 in a cut configuration and FIG. 48B shows a device 480 in a manufactured state after cutting. The device includes a proximal antenna 851, a proximal tapered portion 852, a main body portion 853, and a wedge portion 855. In the cut fabrication state, the main body portion 853 and the windward portion 855 have the same or substantially the same diameter. At a point after the device 850 has been severed, such as by laser cutting, the device 850 is formed such that the unconstrained configuration of the winch portion 855 has a larger diameter than the unconstrained main body portion 853 . The post-cut configuration of the device 850 may be accomplished using known methods and mandrels or other tools. In some embodiments, the ratio of the unconstrained diameter of the rounded portion 855 (except for the transition portion 854) to the non-constrained diameter of the main body portion 853 is between 2.0 / 1.0 and 1.2 / 1.0. For example, according to one embodiment, the average unconstrained diameter of the main body portion 853 is about 2.0 mm, and the average restraining diameter of the turnable portion 855 is about 4.0 mm, without the transition portion 864. According to some embodiments, the ratio of the unconstrained length of the main body portion to the free portion 855 (except for the diversion portion 854) is between about 0.2 and about 0.7. For example, according to one embodiment, the unconstrained length of the main body portion 855 is between about 15 mm and 25 mm, and the restraint length of the distal portion (excluding the transition portion 854) is between about 5 mm and 10 mm.

According to some embodiments described in FIG. 48A, the cell structure of the main body portion 853 is larger than the rounded portion 855. The low strut density of the main body portion 853 facilitates the integration of the collection device 850 within the closure. The high strut density of the windward portion 855 facilitates grabbing and removing particles as will be described in detail below. In some embodiments, in a manner that results in a radial eccentric force exerted by the main body portion 853, which is greater than the radial force exerted by the distal portion 855 when the retrieval device 850 is disposed within the patient ' . In this embodiment, the main body portion 853 is positioned to capture the closure, while the distal portion 855 is positioned further to the wall of the tube above the closure to hold the portion of the closure that is removed during and after capture It works smoothly. According to one such method, the collection device 850 is disposed in the treatment area of the patient by using the aforementioned delivery catheter. The collection device 850 is located at the distal end of the delivery catheter so that it is located in an area with a closure where the main body portion 853 is withdrawn. The main body portion 853 and the distal portion 855 have the same or substantially the same diameter when stored in the delivery catheter. Thereafter, the delivery catheter has a collection device constrained to the treatment area so that the main body portion 853 at least partially enters the closure and at least a portion of the distal portion 855 is laid more smoothly against the tube wall on the circle relative to the closure To the nearest point. When the closure is captured within the main body portion 853 of the device 850, the device may be removed from the patient in a manner consistent with one or more of the methods described above. During this removal, the collection device is pulled to sweep along the wall to collect a portion of the closure where the distal portion 855 is removed. Thanks to the enhanced diameter dimension, the windward portion 855 maintains contact with the tube wall during the entire removal procedure or portion. As noted above, the low strut density of the main body portion 853 facilitates the integration of the collection device 850 within the closure. However, in some embodiments, the collection device is constrained in a manner that results in a radial force exerted by the main body portion 853, which is greater than the radial force exerted by the distal portion 855 when placed in the patient's tubing. To achieve such radial force variations, the width dimension of the strut of the main body portion 853 of the retrieval device may be adjusted to have a greater width dimension of at least a portion or the entirety of the distal portion 855 Is cut.

As shown in FIGS. 48A and 48B, in some embodiments, the strut density of the distal segment 855 is further enhanced by including at least a portion of the nonlinear strut 860 of the cell structure. In some embodiments, the nonlinear strut may expand between the proximal end 864 and the distal end 866 of the cell structure. In some embodiments, the nonlinear strut 860 includes a proximal end 864 of the cell structure with a nonlinear strut 861 having substantially the same length as the upper strut 861 and / or the lower strut 862 of the cut configuration. And the free end 866 of the free end. This structure enhances the nesting ability of the cell structure struts due to the low attainable reduced diameter of the collecting device. In some embodiments, the nonlinear strut 861 is positioned between the proximal end 864 and the distal end 866 of the cell structure with respective upper and lower non-linear struts 860, 862, and 861 having the same length of the cut configuration / RTI > So that in some embodiments the nonlinear strut 860 has a width dimension that is less than the width dimension of the upper and lower struts 861 and 862 by not significantly affecting the radial eccentric force generated in the distal segment 855. [ In some embodiments, the ratio of the width dimension of the struts 860 to the width dimension between each of the upper and lower struts 861, 862 is between about 0.70 and 0.80. For example, according to one embodiment, each upper and lower strut 361, 362 has a width dimension of about 0.0035 inches, while a strut 360 has a width dimension of about 0.0025 inches.

Figure 49 shows a variant of the cut configuration shown in Figure 48A. 49, the recovery device 870 includes a proximal portion 871, a main body portion 872, and a distal portion 873, the distal portion of which is shorter than that shown in Figure 48A.

Figure 50 illustrates a distal segment of the retrieval device similar to that shown in Figures 47A and 47B having one or more radiopaque wires or ribbons 495 wrapped around the strut forming the cell structure 488-492. Throughout the remainder of the description, the term "wire" is used extensively in wire, ribbon or similar structures. Although the entirety of the cell struts forming the cell structures 488-492 can be wrapped with one or more radiopaque wires 495 as shown in Figure 50, in other embodiments, only a selected number of struts can be wrapped with radiation Impermeable wire windings. The advantage of incorporating the radiopaque wire winding in the distal segment of the retrieval device is to enhance the visibility of the distal end of the device by fluoroscopy. Further, when a sufficient number of distal struts are provided with wire windings as shown in Fig. 50, the wire windings can improve the rigidity of the distal portion. An advantage of increasing the stiffness of the distal portion is that the retrieval device inhibits the escape of the distal segment that proceeds through the delivery catheter or patient ' s tubing. In one embodiment, the one or more wires comprise platinum. However, a number of other radiopaque materials may be used. The one or more wires may include a toroidal structure such as stainless steel cladded or coated with a radiopaque material. The one or more wires may penetrate the radiopaque material, or may include a coated or doped polymer structure. In some embodiments, the cross-sectional area of the one or more wires is varied to provide a variation in radiation impermeability and / or stiffness within the distal segment. In some embodiments, the diameter or width dimension of the one or more wires 495 is in the range between about 20% and about 50% less than the width dimension of the struts forming the distal segment.

Although not shown in FIG. 50, in some embodiments, a small recess is provided in at least a portion of the strut of the cell structure 488-492 for the purpose of guiding the placement of the wire windings in the designated location. Preferably, the recess is sized to receive only a portion of the outer sheath such that only a portion of the wire is within the recess and a portion of the wire is outside the recess.

Figures 51 - 51A illustrate other aspects of the solidification recovery apparatus 550 according to some methods similar to the recovery apparatus 850 shown in Figures 48A and 48B. Figures 51A-51D illustrate an apparatus 550 of plan view cut along a length and laid flat on a surface. The device includes a proximal antenna 561, a proximal tapered portion 551, a main body portion 552a, and a winded portion 552b. The main body portion 552a and the distal portion 552b in the cut manufacturing state have the same or substantially the same diameter. At a point in time after the device 550 is severed by laser cutting, the device 550 has a larger diameter than the unconstrained main body portion 552a in the unrestrained configuration of the distal portion 552b. The post-cut formation of the device 550 can be accomplished by using a method of air surgery and other tools or mandrels.

In some embodiments, the ratio of the unconstrained diameter of the rounded portion 552b to the main body portion 552a is between 2.0 / 1.0 and 1.2 / 1.0. For example, according to one embodiment, the average unconstrained diameter of the main body portion 552a is about 2.0 mm, and the average restraining diameter of the rounded portion 552a is about 4.0 mm. According to some embodiments, the ratio of the unconstrained length of the rounded portion 552a to the main body portion is between about 0.2 and about 0.7. For example, according to one embodiment, the unconstrained length of the main body portion 552a is between about 15 mm and 25 mm, and the constraining length of the distal portion is between about 5 mm and 10 mm.

According to some embodiments, the structure of the cells of the proximal tapered portion 551, the main body portion 552 and the distal portion 552b may be of different sizes. In the example of FIG. 51A, the cell size is a multiple of the cell structure 555 including the same area as the three cell structures, and the cell structure 554 including the area almost the same as the two cell structures 553. It is important that cell sizes, which are multiples of one another, are not required. 51B shows a length dimension L1 and a width dimension W1 of the cell structure 553. [ 51C shows a length dimension L2 and a width dimension W2 of the cell structure 554. [ 51D shows a length dimension L3 and a width dimension W3 of the cell structure 555. FIG.

In some embodiments, the cell structures 553, 554, and 555 each have a larger average length to width ratio when the collecting device is in the unexpanded state and when the collecting device is in the expanded state. The ability of the cell structures 553, 554, 55 to maintain an average length-to-width ratio greater than one blocks the cell from collapsing in the longitudinal direction as the device 550 progresses through the delivery catheter or patient's tubing. That is, the cell structure of device 550 blocks lengthwise collapse in the form of an accordion due to a length-to-width ratio greater than unity.

Another aspect is reflected in the length L3 of the cell structure 555 of the distal portion 552b of the device. Because the distal portion 552b is estimated at an expansion diameter that is greater than the expanded diameter of the rest of the device, the length dimension L3 is such that when the collection device 550 switches from the unexpanded state to the expanded state, Is selected to be sufficiently long compared to the width dimension W3 to ensure that the width dimension W3 is maintained at a length dimension greater than the width dimension.

In some embodiments, the width ratio to the average length of the cell structure of the distal portion 552b of the cylindrical main body portion is greater than the width ratio to the average length of the cell structure of the proximal portion 552a of the cylindrical main body portion, The width ratio of the proximal portion 552a of the main body portion to the average length of the cell structure is greater than the width ratio of the proximal end portion 551 to the average length of the cell structure and the average of the cell structure of the proximal end portion 551 The ratio of width to length is greater than when the self-expanding member is a non-expanding and expanding configuration.

In some embodiments, in a manner that results in a radial eccentric force exerted by the main body portion 552a, which is greater than the radial force exerted by the distal portion 552b when the collection device 550 is disposed in the patient's tubing, Device 550 is constrained. In this embodiment, the main body portion 552a is positioned to capture the closure, while the distal portion 552b is positioned relative to the wall of the tube above the closure to hold the portion of the closure that is removed during and after capture It works smoothly. According to one such method, the collection device 550 is disposed in the treatment area of the patient by using the above-described delivery catheter. The collection device 550 is located at the distal end of the delivery catheter so that it is located in an area with a closure to which the main body portion 552a is withdrawn. The main body portion 552a and the distal portion 552b have the same or substantially the same diameter when stored in the delivery catheter. Thereafter, the delivery catheter has a collection device constrained to the treatment area such that the main body portion 552a at least partially enters the closure and at least a portion of the distal portion 552b is laid more smoothly against the tube wall on the circle relative to the closure To the nearest point. When the closure is captured within the main body portion 552a of the device 550, the device can be removed from the patient in a manner consistent with one or more of the methods described above. During this removal, the collection device is pulled to sweep along the wall to collect a portion of the closure where distal portion 552b is removed. Owing to the enhanced diameter dimension, the sweep portion 552b maintains contact with the tube wall during the entire removal procedure or portion.

As noted above, the low strut density of the main body portion 552a (as compared to the strut density of the proximal tapered portion 551) facilitates the integration of the collection device 550 within the closure. However, in some embodiments, the collection device is constrained in a manner that results in a radial force exerted by the main body portion 552a that is greater than the radial force exerted by the distal portion 552b when placed in the patient's tubing. To achieve such radial force variations, in some embodiments, the width dimension of the strut of the main body portion 552a of the retrieval apparatus may be such that the width dimension of at least a portion or the entirety of the distal portion 552b Is cut.

As shown in Figure 51A, in some embodiments, the strut density of the distal segment 552b is further enhanced by including at least some non-linear struts 562 of the cell structure. In some embodiments, the nonlinear strut 562 may be expanded between the proximal end 556 and the distal end 557 of the cell structure. In some embodiments, nonlinear struts 562 (or intermediate struts) may be used to form the upper struts 558 and / or the lower struts 559 of the cell structure together with the nonlinear struts 562 having substantially the same length as the lower struts 559 of the cut configuration. Extending between the proximal end 556 and the distal end 557. This structure enhances the nesting ability of the cell structure struts due to the low attainable reduced diameter of the collecting device. So that in some embodiments the nonlinear strut 562 has a width dimension that is less than the width dimension of the upper and lower struts 558 and 559 by not significantly affecting the radial eccentric force generated in the distal segment 855. [ In some embodiments, the ratio of the width dimension of the strut 562 to the width dimension between each of the upper and lower struts 558, 559 is between about 0.70 and 0.90. For example, according to one embodiment, each upper and lower strut 558, 559 has a width dimension of about 0.0035 inches, while a strut 562 has a width dimension of about 0.0025 inches.

Although not shown in Figures 51A-51D, in some embodiments, the cell structure of the distal segment 552b may be selected through struts to impart the intended radiopacity and / or stiffness to the distal segment, As shown in FIG.

In some embodiments, a plurality of antennas 560a, 560b, and 560c are inflated to a circle with the uppermost circumferential row of the cell structure of distal segment 552b. In the manner described above in connection with the apparatus of Figures 47A and 47B, the distal ends of the antennas 560a, 560b and 560c are joined together to provide an inner cavity of the device 550 having a partially closed end. In fact, the closed end forms a basket that facilitates the collection of particles, such as embolic materials, that can be removed during the recovery procedure. In some embodiments, the connections of antennas 560a, 560b and 560c are formed by soldering the distal ends of the antennas together. In some embodiments, the distal end of the antenna is positioned in a container, such as a coil spring or other perforated structure, with solder or other adhesive applied to the encasement joining the distal end of the antenna together. In some embodiments, the container includes a round non-atraumatic distal tip. In some embodiments, the container comprises a radiopaque material.

Figure 52A shows a collection device similar to that disclosed in Figures 51A-51D. The difference resides in the configuration of the nonlinear / intermediate strut 570 that is disposed in the distal segment cell structure 555. As shown in Figure 52A, the intermediate strut 570 includes first and second curved elements 571 and 572, respectively, with branch struts 573a and 573b between them. An advantage of the strut 570 configuration is that it provides additional benefits to support the collection of embolism fragments compared to the strut 562. [ In some embodiments, the nonlinear strut is expanded between the proximal end 556 and the distal end 557 of the cell structure 555. In some embodiments, the nonlinear strut 570 has a length substantially equal to the length of the lower strut 559 of the cut configuration

With the combined length of the elements 571, 572 and 573b and / or the combined length of the elements 571, 572 and 573b having the same length as the upper strut 558, (Not shown). So that in some embodiments the nonlinear strut 570 has a width dimension that is less than the width dimension of the upper and lower struts 558 and 559 by not significantly affecting the radial eccentric force generated in the distal segment 552b. In some embodiments, the ratio of the width dimension of the struts 570 to the width dimension between each of the upper and lower struts 558, 559 is between about 0.70 and 0.90. For example, according to one embodiment, each upper and lower strut 558, 559 has a cut width dimension of about 0.0035 inches, while a strut 560 has a width dimension of about 0.0025 inches.

52B shows the difference in the size of the cell structure 579 of the proximal section 575 of the cylindrical main body portion and the difference in the size of the cell structure 579 of the distal section 576 of the cylindrical main body portion, A modification of the recovery device is shown.

As shown in FIG. 52B, the cell structure 579 is sized to have a size (as shown in FIG. 52A) that is smaller than the similarly positioned cell structure of the collecting device of FIG. 52A due to the additional struts added to reduce the size of the cell structure in half Is small.

As noted above, another difference is that it includes a cell structure 577 at the distal end of the collection device to provide a device with a substantially uniform circumferential end. In one embodiment, the intermediate strut 578 expands between the opposite ends of the cell structure 577 in a manner similar to that described above for the intermediate strut 562. [

Figure 53 shows a collection device 580 that includes cell structures of different sizes along a length similar to that described above in combination with the collection device 550 shown in Figures 51A-51D. 53 shows an apparatus 580 in plan view cut along its length and laid flat on the surface.

The device includes a proximal antenna 581, a proximal tapered portion 582, a main body portion 583, and a turn portion 584. In the cut-away manufacturing state, the main body portion 583 and the distal portion 584 have the same or substantially the same diameter. At a point in time after the device 580 is severed by laser cutting, the device 580 has a larger diameter than the unconstrained main body portion 583 in the unconstrained configuration of the distal portion 584. The post-cut formation of the device 580 can be accomplished by using a method of air surgery and other tools or mandrels.

In some embodiments, the ratio of the unconstrained diameter of the rounded portion 584 to the main body portion 583 is between 2.0 / 1.0 and 1.2 / 1.0. For example, according to one embodiment, the average unconstrained diameter of the main body portion 583 is about 2.0 mm, and the average restraining diameter of the rounded portion 584 is about 4.0 mm.

53, the cell structures of the proximal tapered portion 582, the main body portion 583, and the swivel portion 584 may be of different sizes. In the example of FIG. 53, the cell size is a cell structure 587 including approximately the same area as the three cell structures 585, a cell structure 586 including approximately the same area as the two cell structure 585, Relationship. It is important that cell sizes, which are multiples of one another, are not required.

By having the cell structure 553, 554 and 555 of the apparatus 550 described above, the cell structures 585, 586 and 587 can be arranged in such a manner that when the collecting apparatus 580 is in an unexpanded state and when the collecting apparatus 580 is expanded State, a larger average length-to-width ratio. The ability of the cell structure to maintain an average length-to-width ratio greater than 1, as described above, prevents the cells from collapsing in the longitudinal direction through the delivery catheter or through the patient's duct as the collection device advances. That is, the cell structure of the device 580 blocks lengthwise collapse in the form of an accordion due to a length-to-width ratio greater than unity.

Another aspect is reflected in the length of the cell structure 587 of the distal portion 584 of the device. Because the distal portion 584 is estimated to be an expanded diameter that is larger than the expanded diameter of the rest of the device, the length dimension of the cell structure 587 is such that the withdrawal device 580 is in a non- Is chosen to be sufficiently long relative to the width dimension to ensure that the cell structure maintains a length dimension greater than the width dimension.

In some embodiments, in a manner that results in a radial echo force exerted by the main body portion 583, which is greater than the radial force exerted by the distal portion 584 when the collection device 580 is disposed within the patient ' Device 580 is constrained. In this embodiment, the main body portion 583 is positioned to capture the closure, while the distal portion 584 is positioned relative to the wall of the tube above the closure to hold the portion of the closure that is removed during and after capture It works smoothly. By such a method, the collection device 580 is placed in the treatment area of the patient by using the delivery catheter described above. The collection device 580 is located at the distal end of the delivery catheter so that it is located in an area with a closure to which the main body portion 583 is withdrawn. The main body portion 583 and the distal portion 584 have the same or substantially the same diameter when stored in the delivery catheter. Thereafter, the delivery catheter has a retrieval device constrained to the treatment area so that the main body portion 583 at least partially enters the occlusion and at least a portion of the distal portion 584 is placed more smoothly against the tube wall in the circle against the occlusion To the nearest point. When the closure is captured within the main body portion 583 of the device 580, the device may be removed from the patient in a manner consistent with one or more of the methods described above. During this removal, the collection device is pulled to sweep along the wall to collect the portion of the closure where the distal portion 584 is removed. Thanks to the enhanced diameter dimension, the rounded portion 584 maintains contact with the tubular wall during the entire removal procedure or portion.

Although not shown in FIG. 53, in some embodiments, the cell structure of the distal segment 584 may be selected via struts to impart the intended radiopacity and / or stiffness to the distal segment described above in connection with FIG. As shown in FIG.

54 is similar to device 580 with a difference in the manner in which cell structures 587 are interconnected. The cell structure 587 has a proximal side 591, a distal side 592, an upper side 593 and a lower side 594. As shown in FIG. 54, the cell structure 587 is joined with an adjacent cell structure 586 along at least a portion of the proximal side 591. However, the upper and lower sides 593 and 594 of the cell structure 587 are not attached. As noted above, the length-to-width ratio of the cell structure 587 is preferably maintained greater when the collection device 590 moves through the patient's conduit or delivery catheter. By stripping the upper and lower sides of the cell structure, the force normally applied to the cell structure is applied to the cell structure to expand the width during expansion. This ensures that the ratio of the length to width of the cell structure 587 remains greater when the device 590 is estimated to be in the expanded state. As shown in FIG. 55, the selection of a cell structure with a small size is accommodated due to the removal of the outermost column of the cell structure. For example, as shown in FIG. 55, the topmost column of the cell structure 596 may include a cell structure that is the same as or similar to the adjacent positioned cell structure 586. However, the size and shape of the top row of the cell structure need not mimic the adjacent cell structure.

Now, at 56A, the recovery device 630 is shown having a configuration similar to the device 800 of Figure 45A, despite the fact that there is almost no cell structure and a smaller diameter bezel / tube. 56A is a plan view of a collection apparatus 630 according to another embodiment.

The collection device 630 includes an expansion member having a proximal tapered end portion 631, a cylindrical main body portion 632, and a distal tapered end portion 633. The outermost cell structure of the proximal tapered end portion has an outer wall segment forming a non-wave-like rail segment 636 on one side and a wave-rail segment 637 on the other side. Each rail segment 636 and 637 may be inflated from the uppermost end of the inflation member to a position at or near the proximal end of the cylindrical main body portion 632. [ The proximal antenna 634 is inflated proximately from the stomach cell structure 638, while the distal antenna 635 is inflated over the circle at the distal end of the distal taper section 633. The cell structure 640 of the cylindrical main body portion 632 may include faced and distal flexure elements 641 and 632 that generally include convex and / or concave structures such as, for example, V-shaped and U- . The proximal and distal flexure elements 641 and 632 are interconnected by struts 643 and 644 that extend in a pair of diagonal lines and circumferentially spaced.

Figure 56B illustrates the cut width dimension of the various strut inch sizes of the proximal tapered end portion 631 according to one embodiment. Each size has a tolerance of ± 0.0004 inches. According to one embodiment, the strut of the proximal tapered end portion 631 has a cut thickness size of about 0.0045 +/- 0.0004 inches.

As discussed above, the cylindrical main body portion 632 preferably has sufficient radial strength to allow at least partial integration of the struts into the desired closure for total or partial removal. However, the radial strength of the cylindrical main body portion 632 should be low enough to prevent excessive damage to the bezel or tube being treated. In order to achieve the desired radial strength, the cross-sectional area and / or width and / or thickness of the strut forming the cylindrical main body portion 632 should be formed to an appropriate size.

Another feature to consider is flexibility. The cylindrical main body portion 632 should be flexible enough to allow the collection device 630 to enter and exit through the complex dissection of the patient. However, the cylindrical main body portion 632 must also have sufficient stiffness to allow it to pass through the delivery catheter and the patient ' s tube without collapsing on its own.

It has also been found that the stiffness is also deployed and serves as a factor in the ability of the withdrawal device to be withdrawn to the delivery catheter. As noted above, as the collection device is in the wrong position in the patient's tubing, sometimes the collection device is completely or partially drained back to the delivery catheter when the collection device is removed from the patient. It has been found that it is difficult to evacuate the collection device back to the delivery catheter once it has been deployed without the requisite stiffness of the cylindrical main body portion. The test shows a situation where, under certain circumstances, all struts in the cylindrical main body portion are of such a size that the struts achieve a sufficient radial force when they have a uniform cross-sectional insufficient cross-section.

The diagonal struts 643 and 644 are located within the cylindrical main body portion 632 while the cross sections of the flexure elements 641 and 642 most closely affect the radial forces of the cylindrical main body portion 632 It has been found that it hardly contributes to the provided radial forces. In accordance with some embodiments, the cross-sections of the flexure elements 641 and 642 are different from the cross-sections of the struts 643 and 644, in order to achieve sufficient coupling of sufficient strength and stiffness within the cylindrical main body portion 632. The width dimension of the strut 643 diagonally disposed with the flexure elements 641 and 642 varies to achieve the desired radial force and stiffness characteristics, since in many instances the collection apparatus is cut from a uniform thickness tube . However, it should be acknowledged that the width and other dimensions may vary to achieve the same or similar results.

According to some embodiments, all of the struts of the cylindrical main body portion 632 have flexure elements 641, 642 having a first average width dimension and a diagonal line having a second average width dimension greater than the first average width dimension, And the struts 643 and 644 disposed in the same direction. To compensate for the lack of rigidity that may occur if the second average width size is equal to the first average width size, the second average width size may be sufficiently large. In some embodiments, the severed second mean width magnitude is in the range of about 1.1 - 2.0 times the magnitude of the first mean width severed. In another embodiment, the severed second mean width size is in the range of about 1.5 - 1.5 times the first mean width size cut. In one experiment, the first average width size was about 0.032 inches and the second average width size was about 0.00040 inches. The results show that as the width dimension of the diagonally arranged struts 643 and 644 increases from 0.0032 inch to 0.0040 inch, the average deflection stiffness of the cylindrical main body portion 632 increases from about 40% to 75% .

 FIG. 57 shows a collecting device 650 similar to the collecting device 630 having divergent arrangement of the struts 643 and 644. As shown, the struts 643 and 644 of the recovery device 630 are curved while the struts 643 and 644 of the recovery device 650 are straight.

According to some embodiments, the width dimension of the diagonally arranged struts 643 and 644 is uniform along the length. For this exemplary size, the total length of the struts 643 and 644 means an average width size of 0.0040 inches. In other embodiments, struts 643 and 644 may include a middle segment disposed between opposed proximal and distal end segments having a proximal end segment that engages a proximal flexure element and a distal end segment that engages a distal flexure element . Using the same example sizes, the flexure elements 641 and 642 along the proximal and distal segments of the struts 643 and 644 have an average width dimension of 0.0032 while the middle segments of the struts 643 and 644 have an average width dimension of 0.0040 inches Lt; RTI ID = 0.0 > width < / RTI >

 In other embodiments, struts 643 and 644 may have opposing proximal tapered end segments coupled to proximal flexure element 641 and opposed proximal and distal tapered end portions having distal tapered end segments coupled to the free flexure element 642. In other embodiments, And an intermediate segment disposed between the segments. Using the same exemplary sizes as above, the flexure elements 641 and 642 have an average width dimension of 0.0032 inches, the middle segments of the struts 643 and 644 have an average width dimension of 0.0040 inches, and the proximal and distal tapers The average width size of the end segments is changed from 0.0032 inches to 0.0040 inches.

The process of weaving / winding the wire or ribbon around the strut of the collecting device, as described in the description of the apparatus shown in Figure 50, may be used for the purpose of improving the radiation impermeability of the apparatus and affecting the rigidity of the apparatus. . This embodiment is limited to integrating these functions in the distal segment of the collection device. The next is an explanation that involves using such wire windings in different parts of the device.

58A shows a collection device 630 having a structure similar to the collection device 650 shown in Fig. The collection device 660 includes wires wound around the optional struts for the purpose of improving the radiation impermeability of the device 660 and / or affecting the stiffness of one or more portions of the device. 58A, the three radiopaque wires (or ribbons) 661, 662, and 663 essentially enhance the radiation impermeability of the device along the entire length and the rigidity of the cylindrical main body portion 666 Lt; RTI ID = 0.0 > a < / RTI > In the embodiment of Figure 58A, the wires 661-663 are positioned such that only the short legs of the flexure element 670 670a have diagonal downward struts (viewed from left to right) of the cylindrical main body portion 666 ). As shown in detail in Figure 58B, the long leg 670b of the flexure element 670 has no or substantially no wire windings. The advantage of the winding configuration is that it can be applied to the cylindrical main body portion 666 in a manner that allows the wire to be applied to the collection device, in particular, in a manner that imbalances rigidity and radial forces. For example, the average biasing stiffness of the cylindrical main body portion 666 can be adequately increased without corresponding increase in radial force exerted by the cylindrical main body portion 666 when in the unexpanded state. The prototype shows that the average deflection stiffness of the cylindrical main body portion 666 can be increased to 50% without increasing the radial force.

According to one exemplary embodiment, the strut of the cylindrical main body portion 666 has a cut thickness size of about 0.0045 inches with each strut 670a, 670b, 671 having width dimensions of 0.0032 and 0.0040 inches, respectively . In one embodiment, the wire comprises platinum with a width and / or diameter between about 0.0020 inches to about 0.0025 inches with an average of 1-10 turns per stratum and more typically 1-5 turns per strut. It will be appreciated that single or multiple wires can be used instead of the three wire configurations shown in Figure 58A. It is also important to note that when reinforcing radio-opacity, as discussed in connection with Figure 50, the wire may comprise a combination of radiopaque materials and materials. Where wire windings are applied only for purposes that affect stiffness, the wire may comprise any material suitable for use, for example, metals, polymers and composite materials. In some embodiments, the cross-sectional area of the one or more wires can be varied to provide a change in radiopacity and / or stiffness with the length of the device.

According to some embodiments, the cylindrical main body portion 666 includes a first average bias intensity without one or more wires or ribbons 661-663, a second average bias intensity with one or more wires or ribbons 661-663, , The size and material properties of one or more wires or ribbons (661-663), and between about 1.2-1.8 where the eccentric force exerted by the cylindrical main body portion is unequally lowered when the second average biasing intensity is unexpanded Of the circumferentially spaced struts of the cylindrical main body portion selected to be greater than the first average deflection strength by a factor < RTI ID = 0.0 > of: < / RTI >

According to some embodiments, the proximal and distal segments of wires 661-663 are coupled to a collection device 660, as shown in Figures 59 and 60, respectively. It is important to note that other attachment / bonding configurations are possible. Figure 59A shows proximal attachment of wires 661-663 to a location where an elongated wire 40 (see Figure 1A for example) is attached to proximal antenna 675. [ In one embodiment, the distal portion of wire 40 has a flat profile with a width and thickness of about 0.005 inches with a width and thickness of proximal antenna 675 of about 0.0063 inches and 0.0005 inches, respectively. Figure 59B shows that in one embodiment the proximal end of the wire 661-663 is on the lower side of the adjacent antenna 675 and the distal end of the elongated wire 40 is in cross section of the junction at the top of the adjacent antenna 675 / RTI >

In one embodiment, the distal end of the elongated wire 40, the proximal end of the wires 661-663, and the proximal antenna 675 are coupled together within the coil structure 680. In one embodiment, the coil structure 680 has a closely wrapped distal segment 680a and a loosely wrapped proximal segment 680c that includes one or more gaps 680b. In one embodiment, the lengths of the proximal antenna 675 and the coil 680 are substantially the same. At the coil 680 disposed over the overlapping component, the adhesive is applied to the inner cavity of the coil 680 to join the elongated wire 40, proximal antenna 675 and wires 661-663 with at least a portion of the coil . In one embodiment, the end segments 661-663 of the wire are generally present in the winding coil segment 680a. The bonding means may be an adhesive, braze, or other suitable bonding agent. When the bonding means includes soldering, the preceding steps of the process may include coating the various components with tin or other suitable wetting agent. In one embodiment, the solder is gold and is used to enhance the radiopacity of the junction so that the junction can serve as a proximal radiopaque marker. This embodiment is particularly applicable when the wires 661-663 are non-radiopaque. In addition to the use of gold, all or a portion of the coil may be made of a radiopaque material to further improve the radiopacity of the joint. In another embodiment, instead of using a single coil 680, two or more coils in an adjacent relationship, for example a closely wound coil on a circle and a proximal loosely wound coil with a gap lying adjacent to the closely wound coil, Is used.

60A and 60B illustrate various ways in which the distal end segments of wires 661-663 may be attached to the distal antenna 676. FIG. 60A, the distal ends of wires 661-663 are bonded directly to the distal antenna using adhesive means such as solder or adhesive. 60B shows another embodiment in which the distal end of the wires 661-663 is interposed between the distal antenna 676 and the coil 685 surrounding it. In this embodiment, the adhesive means may be introduced into the interior of the coil 685 to enable coupling of the coil 685, the distal antenna 676 and the wires 661-663.

Although the foregoing description includes a plurality of contents, these contents are not intended to limit the scope of the invention and are merely examples of preferred embodiments. For example, sizes other than those described above are contemplated. For example, a collection device having a length of up to 5.0 to 10.0 centimeters and an expanded diameter of 1.0 to 100.0 mm is contemplated. In addition, many of the features disclosed herein may be compatible among various embodiments. Other possible variations within the spirit and scope of the invention will be apparent to those skilled in the art. In addition, the delivery of an angioplasty device of the embodiments disclosed herein permits subsequent placement of the inflatable member at the catheter, sheath or vein treatment site, and any subsequent delivery of the inflatable member and device to the treatment site in a compressed state Or any other device of the < / RTI > The angioplasty site may include (1) a neck of an aneurysm for facilitating placement and / or diversion of a coil or other similar structure within the color of the aneurysm, (2) an aneurysm neck for the purpose of eliminating the embolus closure The location of the embolus closure, and (3) the area of the stenosis to dilate the stenosis to increase blood flow through the blood vessel, etc.

Claims (41)

delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete An embolus closure part recovery device,
Wherein the elongate self-expandable member has a radially expanded configuration and a radially unexpanded configuration, the inflatable member having a plurality of diagonally arranged cell structures interconnected in a manner to form a cell structure, Wherein the inflatable member has a proximal antenna, a proximal end portion and a cylindrical main body portion, the cellular structure of the cylindrical main body portion is expanded about a longitudinal axis of the inflatable member, The cell structure of the end portion is inflated less than peripherally about the longitudinal axis of the inflatable member and the cell structure of the cylindrical main body portion is expanded by a pair of diagonal lines and the proximal and distal flexure elements are interconnected by circumferentially spaced struts Wherein the proximal and distal flexure elements have first and second legs, respectively, , At least a portion of the diagonally expanded and circumferentially spaced apart struts has one or more wires or ribbons wound to enhance the average deflection strength of all or a portion of the cylindrical main body portion when the self-inflatable member is in a radially expanded configuration Wherein the first leg of the proximal and distal flexure elements comprises no or substantially no winding or wound ribbon. 31. An embolus closure collection device according to claim 30, wherein at least one outer ear or ribbon comprises a radiopaque material. 31. An embolus closure collection device according to claim 30, wherein the at least one outer ear or ribbon comprises a metallic material. 31. An embolus closure collection device according to claim 30, wherein at least one outer ear or ribbon comprises a polymeric material. 32. The method of claim 30, wherein the cylindrical main body portion in the radially expanded configuration comprises a first average deflection intensity without one or more wires or ribbons, a second average deflection intensity with one or more wires or ribbons, Having a number of turns per unit length of diagonally extending circumferentially spaced struts selected to be larger than the first average deflection strength by a factor between about 1.2 and about 1.8 Characterized in that the embolization closure withdrawal device. 31. The device of claim 30, wherein at least a portion of the diagonally extending, circumferentially spaced struts has at least one winding guide feature. 37. The embolization closure collector of claim 35, wherein the at least one winding guide feature has a recess capable of receiving only a portion of at least one wire or ribbon. 31. The device of claim 30, further comprising a long flexible wire connected to the proximal antenna and extending to a first proximal end. 38. The device of claim 37, wherein the end of the at least one wire or ribbon is connected to the proximal antenna at a connection point of a long flexible wire extending first proximal with the proximal antenna. 32. The method of claim 30, wherein the cylindrical main body portion in the radially expanded configuration comprises a first average deflection intensity without one or more wires or ribbons, a second average deflection intensity with one or more wires or ribbons, Having a number of turns per unit length of diagonally extending circumferentially spaced struts selected to be greater in magnitude and material properties and a second average deflection strength at a first multiplication factor than the first average deflection strength,
In the radially unexpanded configuration, the cylindrical main body portion applies a first radial force without one or more wires or ribbons, applies a second radial force with one or more wires or ribbons, And a second number of windings per unit length of diagonally extending circumferentially spaced struts selected so that the second radial force is greater than the first radial force at a second multiplication factor, Wherein the multiplication factor is smaller than the first multiplication factor. 40. The embolus closure collection device according to claim 39, wherein the first multiplication factor is 1.2 to 1.8. The embolus closure collection device according to claim 30, wherein the first leg is longer than the second leg.

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