KR102681358B1 - Non-invasive glucose measurement device and method for correcting glucose by reflecting temperature - Google Patents

Abstract

The present invention relates to a non-invasive glucose measurement device and method for correcting glucose by reflecting temperature.
For this purpose, the non-invasive glucose measurement device that corrects glucose by reflecting the temperature according to an embodiment of the present invention is located on one side of the inner seating portion, and has a light irradiation unit that irradiates light toward the finger inserted into the inner seating portion. ; a light receiving unit located on the other side of the inner seating part with the finger in between, and receiving the light irradiated from the light irradiation unit and passing through the finger; a temperature sensor that detects the temperature of a finger inserted into the inner seating portion; And a control unit configured to convert the current corresponding to the amount of light of the received light beam into voltage, filter the frequency of the converted voltage into a predetermined frequency band, and measure the user's glucose by compensating for the voltage of the filtered frequency. In addition, the control unit may perform glucose correction by reflecting the sensed temperature.

Description

Non-invasive glucose measurement device and method for correcting glucose by reflecting temperature {NON-INVASIVE GLUCOSE MEASUREMENT DEVICE AND METHOD FOR CORRECTING GLUCOSE BY REFLECTING TEMPERATURE}

The present invention relates to a non-invasive glucose measurement device and method for correcting glucose by reflecting temperature.

In general, it is reported that one in seven (13.8%) of the adult population over 30 years of age in Korea suffers from diabetes. As age increases, the prevalence of diabetes increases, to the extent that 3 out of 10 adults over the age of 65 are reported to have diabetes. Currently, diabetes is one of the diseases with a high prevalence.

Representative measuring devices for measuring blood sugar include invasive measuring devices and non-invasive measuring devices that measure blood sugar through a small amount of capillary blood instead of venous blood.

This conventional invasive blood sugar measurement device measures blood sugar by piercing a needle into the tip of a finger or an alternate part and using a small amount of secreted blood. The prior literature includes Korean Patent Publication No. 10-1288400.

However, in this conventional invasive blood sugar measuring device, the user pierces the skin with a needle each time a measurement is made, so the user not only feels pain each time, but there is a risk of bacteria infiltrating the skin.

Additionally, a conventional non-invasive blood glucose measurement device (e.g., Continuous Glucose Monitoring System, CGMS) measures the glucose concentration of interstitial fluid existing between tissues by inserting a needle-shaped sensor into the skin.

However, this conventional non-invasive blood sugar measurement device cannot be considered a completely non-invasive blood sugar measurement device because it requires inserting a sensor into the skin. In addition, measuring blood sugar involves a complex measurement step of injecting a certain amount of capillary blood into a test strip combined with a measuring device through a painful blood collection method using a lancing device at the tip of the finger, which can lead to hygiene issues and inconveniences in use. In addition, there is a problem of low accuracy.

In addition, conventional blood sugar measuring devices do not perform correction for glucose measurement in consideration of user conditions, such as finger temperature, and therefore have limitations in obtaining accurate measurement results.

Therefore, there is a need for a non-invasive glucose measurement device that performs correction for glucose measurement by reflecting the temperature of the finger.

Therefore, the present invention provides a non-invasive glucose measurement device and method for correcting glucose by reflecting the temperature of the finger.

Additionally, the present invention provides a non-invasive glucose measurement device that includes a light irradiation unit that irradiates light toward the finger and a light receiver that receives the light that has passed through the finger.

In addition, the present invention converts the current corresponding to the amount of light into a voltage, filters the frequency of the converted voltage into a predetermined frequency band, and compensates for the voltage of the filtered frequency to measure the user's glucose. To provide measuring devices and methods.

The objects of the present invention are not limited to the objects mentioned above, and other objects and advantages of the present invention that are not mentioned can be understood through the following description and will be more clearly understood by examples of the present invention. Additionally, it will be readily apparent that the objects and advantages of the present invention can be realized by the means and combinations thereof indicated in the patent claims.

To achieve this purpose, a non-invasive glucose measurement device that corrects glucose by reflecting temperature according to an embodiment of the present invention is located on one side of the inner seating portion and irradiates light toward the finger inserted into the inner seating portion. A light irradiation unit that does; a light receiving unit located on the other side of the inner seating part with the finger in between, and receiving the light irradiated from the light irradiation unit and passing through the finger; a temperature sensor that detects the temperature of a finger inserted into the inner seating portion; And a control unit configured to convert the current corresponding to the amount of light of the received light beam into voltage, filter the frequency of the converted voltage into a predetermined frequency band, and measure the user's glucose by compensating for the voltage of the filtered frequency. In addition, the control unit may perform glucose correction by reflecting the sensed temperature.

Additionally, in the method of a non-invasive glucose measuring device that corrects glucose by reflecting temperature according to an embodiment of the present invention, the non-invasive glucose measuring device is located on one side of the internal seating portion and is inserted into the internal seating portion. A light irradiation unit that radiates light toward the finger, and a light receiving unit located on the other side of the internal seating unit with the finger in between, and a light receiver that receives the light irradiated from the light irradiation unit and passing through the finger, the method comprising: A process of detecting the temperature of a finger inserted into the inner seating portion; Converting a current corresponding to the amount of light of the received light beam into voltage, and filtering the frequency of the converted voltage into a predetermined frequency band; And it may include a process of measuring the user's glucose by compensating for the voltage of the filtered frequency. Additionally, the method may further include a process of correcting glucose by reflecting the sensed temperature.

The non-invasive glucose measurement device according to the present invention can accurately measure glucose according to the user's conditions by correcting glucose by reflecting temperature.

Additionally, the present invention can measure an accurate temperature for glucose correction by detecting the first temperature of the upper surface of the finger and the second temperature of the lower surface of the finger.

Additionally, the present invention can accurately measure glucose by adjusting the gain to be within the digital voltage effective range.

In addition, the present invention corrects glucose through glucose measurement by multiple invasive methods and glucose measurement by multiple non-invasive methods, so that even when measuring glucose by non-invasive methods, the glucose level is the same as or negligible by the invasive method. Glucose levels of varying degrees can be obtained.

In addition, the present invention can perform correction so that accurate glucose is measured by matching the first correction reflecting temperature and the first correction result to the glucose level obtained from blood collection.

In addition, the present invention generates a glucose algorithm for the user based on the glucose obtained through secondary correction and stores the generated algorithm in memory, so that glucose measurement can be quickly performed in the future.

In addition to the above-described effects, specific effects of the present invention are described below while explaining specific details for carrying out the invention.

1 is a cross-sectional view of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 2 is a diagram showing a light irradiation unit and a light reception unit according to an embodiment of the present invention.
Figure 3 is a block diagram of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 4 is a perspective view showing the external appearance of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 5 is a perspective view showing the entrance of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 6 is an exploded perspective view of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 7 is a perspective view showing a first case according to an embodiment of the present invention.
Figure 8 is a perspective view showing a state in which a measurement guide is installed in a first case according to an embodiment of the present invention.
Figure 9 is a plan view showing a state in which a measurement guide is installed in a first case according to an embodiment of the present invention.
Figure 10 is a block diagram of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 11 is a flowchart showing the process of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention.
Figure 12 is an exemplary diagram showing a home screen displayed on the input/output unit of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 13 is an exemplary diagram showing a status bar displayed on the input/output unit of a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 14 is an exemplary diagram of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention.
Figure 15 is an exemplary diagram showing the results of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention.
Figure 16 is an exemplary diagram showing cumulative data according to the timing of glucose measurement using a non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 17 is an exemplary diagram showing a state in which light is irradiated from a light irradiation unit according to an embodiment of the present invention.
Figure 18 (a) is an exemplary view of the light irradiation unit according to an embodiment of the present invention as seen from the top.
Figure 18(b) is an exemplary cross-sectional view of a light irradiation unit according to an embodiment of the present invention.
Figure 19 is a flowchart showing the process of correcting glucose by reflecting temperature according to an embodiment of the present invention.
Figure 20 is a flowchart showing the process of correcting glucose by reflecting temperature according to an embodiment of the present invention.
Figure 21 (a) is a screen showing the environment settings of the non-invasive glucose measurement device according to an embodiment of the present invention.
Figure 21 (b) is a screen that inquires about whether blood sugar level is corrected according to an embodiment of the present invention.
Figure 22(a) is a screen regarding the time at which non-invasive glucose measurement is performed according to an embodiment of the present invention.
Figure 22 (b) is a screen showing the results of non-invasive glucose measurement according to an embodiment of the present invention.
Figure 23(a) is a screen guiding invasive glucose measurement according to an embodiment of the present invention.
Figure 23(b) is a screen displaying the glucose level measured by the invasive glucose method according to an embodiment of the present invention.
Figure 23(c) is a screen inquiring whether glucose correction is in progress according to an embodiment of the present invention.
Figure 24 is an exemplary diagram showing the correlation between finger temperature and voltage according to an embodiment of the present invention.
Figure 25 is an exemplary diagram showing the correlation between glucose levels using a non-invasive glucose measuring device and glucose levels obtained through blood collection according to an embodiment of the present invention.

The above-described objects, features, and advantages will be described in detail later with reference to the attached drawings, so that those skilled in the art will be able to easily implement the technical idea of the present invention. In describing the present invention, if it is determined that a detailed description of known technologies related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description will be omitted. Hereinafter, preferred embodiments according to the present invention will be described in detail with reference to the attached drawings. In the drawings, identical reference numerals are used to indicate identical or similar components.

Although first, second, etc. are used to describe various components, these components are of course not limited by these terms. These terms are only used to distinguish one component from another component, and unless specifically stated to the contrary, the first component may also be a second component.

Hereinafter, the “top (or bottom)” of a component or the arrangement of any component on the “top (or bottom)” of a component means that any component is placed in contact with the top (or bottom) of the component. Additionally, it may mean that other components may be interposed between the component and any component disposed on (or under) the component.

Additionally, when a component is described as being “connected,” “coupled,” or “connected” to another component, the components may be directly connected or connected to each other, but the other component is “interposed” between each component. It should be understood that “or, each component may be “connected,” “combined,” or “connected” through other components.

Throughout the specification, unless otherwise stated, each element may be singular or plural.

As used herein, singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, terms such as “consists of” or “comprises” should not be construed as necessarily including all of the various components or steps described in the specification, and some of the components or steps may include It may not be included, or it should be interpreted as including additional components or steps.

Throughout the specification, when referring to "A and/or B", this means A, B or A and B, unless specifically stated to the contrary, and when referring to "C to D", this means unless specifically stated to the contrary. Unless absent, it means C or higher and D or lower.

Below, a non-invasive glucose measurement device and method for correcting glucose measurement by reflecting temperature according to some embodiments of the present invention will be described.

Figure 1 is a cross-sectional view of a non-invasive glucose measurement device 1 according to an embodiment of the present invention. Figure 2 is a diagram showing a light irradiation unit 130 and a light reception unit 140 according to an embodiment of the present invention. Figure 3 is a block diagram of a non-invasive glucose measurement device 1 according to an embodiment of the present invention.

As shown in FIGS. 1 to 3, the non-invasive glucose measurement device 1 according to an embodiment of the present invention measures the measurement subject 180 with an internal seating portion 30 provided inside the housing portion 10. ) moves the finger 182, the light irradiation unit 130 radiates light in the direction of the finger 182, and the light receiving unit 140 disposed between the light irradiation unit 130 and the finger 182 transmits the light ray. The irradiation unit 130 measures the amount of light irradiated and transmitted through the finger 182. Then, the light receiving unit 140 transmits the measured amount of light to the control unit 150.

The non-invasive glucose measurement device 1 according to an embodiment of the present invention includes a housing part 10, an internal seating part 30, a measurement guide part 80, a light irradiation part 130, a light receiving part 140, and Includes a control unit 150. Additionally, the non-invasive glucose measurement device 1 according to an embodiment of the present invention may further include a pressure sensor 160 and a temperature sensor unit 170.

[Housing Department]

According to one embodiment, the housing unit 10 can be modified in various ways within the technical concept of having a mounting space on the inside. The housing unit 10 according to an embodiment of the present invention includes an upper case 12 and a lower case 14.

Figure 4 is a perspective view showing the external appearance of the non-invasive glucose measurement device 1 according to an embodiment of the present invention. Figure 5 is a perspective view showing the entrance of the non-invasive glucose measurement device 1 according to an embodiment of the present invention. Figure 6 is an exploded perspective view of the non-invasive glucose measurement device 1 according to an embodiment of the present invention.

As shown in FIGS. 4 to 6, the housing portion 10 further includes a side case portion 16, a case cover 18, and a housing frame 19 in addition to the upper case 12 and the lower case 14. It can be included.

According to one embodiment, the upper case 12 is installed in a shape that surrounds the upper part of the internal seating part 30 and forms the upper outer shape of the non-invasive glucose measurement device 1. The longitudinal cross-section of the upper case 12 according to an embodiment of the present invention is installed in an “L” shape.

According to one embodiment, the lower case 14 is connected to the lower side of the upper case 12 and is installed in a shape to surround the lower part of the internal seating portion 30. Additionally, the lower case 14 forms the lower outline of the non-invasive glucose measurement device 1. The longitudinal cross-section of the lower case 14 according to an embodiment of the present invention is installed in an “L” shape.

Meanwhile, the housing frame 19 forms the framework of the housing portion 10 and functions to connect the upper case 12 and the lower case 14.

According to one embodiment, the side case portion 16 is located between the upper case 12 and the lower case 14, and is located around the inlet 32 of the inner seating portion 30 and the inner seating portion 30. Various modifications are possible within the technical idea covering the sides.

According to one embodiment, the side case portion 16 has a hollow hole communicating with the inlet 32 of the internal seating portion 30, and is installed in a shape that surrounds the front and side surfaces of the internal seating portion 30. The side case portion 16 may be made of a single member, or may be separated into a plurality of members if necessary.

The cross-section of the side case portion 16 according to an embodiment of the present invention has a “ㄷ” shape, and is detachably installed on the upper case 12 and the lower case 14.

According to one embodiment, the case cover 18 is detachably installed on the side case, and various modifications are possible within the technical concept of opening and closing the inlet 32 of the internal seating portion 30. The case cover 18 according to an embodiment of the present invention has a plate shape and is located in front of the inlet 32 of the internal seating portion 30. The case cover 18 is detachably installed in front of the side case portion 16.

According to one embodiment, a first printed circuit board (PCB) 151 is fixed to the upper case 12 located on the upper side of the internal seating part 30. The first PCB 151 is installed in a horizontal direction, and a light receiving unit 140 and a temperature sensor unit 170 may be installed on the first PCB 151.

The second PCB 152 is fixed to the lower case 14 located below the internal seating portion 30. The second PCB 152 is installed in a horizontal direction, and a light irradiation unit 130, a pressure sensor 160, and a temperature sensor unit 170 may be installed on the second PCB 152.

[Internal seating part]

According to one embodiment, the internal seating part 30 is located inside the housing part 10, and various modifications can be made within the technical idea of forming a groove for seating the finger 182 of the measurement subject 180. do. The inner seating portion 30 forms a concave groove for the finger 182 to enter and is fixed to the inside of the housing portion 10.

The internal seating portion 30 according to an embodiment of the present invention includes a first case 40 and a second case 60, and the first case 40 and the second case 60 are combined to form a finger ( 182) forms a space and an entrance (32).

Figure 7 is a perspective view showing the first case 40 according to an embodiment of the present invention.

As shown in FIG. 7, the first case 40 is installed in a shape that surrounds the lower part of the finger 182 located inside the housing portion 10, and various modifications are possible within the technical idea. The first case 40 according to an embodiment of the present invention includes a first body 42, a first mounting hole portion 44, a second mounting hole portion 48, an elastic support portion 52, and a catching protrusion 54. Includes.

According to one embodiment, the first body 42 forms a curved surface on the inner side facing the finger 182 and is located below the finger 182 inserted into the internal seating portion 30. Since a curved surface is formed on the inside of the first body 42, injury due to the finger 182 coming into contact with the first body 42 can be prevented.

According to one embodiment, the first mounting hole portion 44 forms a first connection hole 46, which is a hole, in the first body 42. A light irradiation unit 130 is installed on the second PCB 152 facing the first connection hole 46.

According to one embodiment, the second mounting hole portion 48 forms a second connection hole 50 in the first body 42 and is installed at a location spaced apart from the first mounting hole portion 44. The first mounting hole part 44 is installed in the part of the first body 42 that is close to the inlet 32, and the second mounting hole part 48 is located further away from the inlet 32 than the first mounting hole part 44. is installed in

According to one embodiment, the elastic support part 52 is installed between the first mounting hole part 44 and the second mounting hole part 48 and has elasticity. The elastic support portion 52 has a plate shape installed on the upper side of the first body 42 facing the finger 182.

According to one embodiment, the catching protrusion 54 protrudes from the elastic support portion 52 to form a protrusion that catches the finger 182. The locking protrusion 54 is caught in the groove of the first joint of the finger 182 and thus guides the finger 182 to be positioned in the correct position, thereby improving measurement accuracy.

According to one embodiment, the second case 60 is connected to the first case 40 and is installed in a shape that surrounds the upper part of the finger 182 located inside the housing portion 10, and various modifications are made within the technical idea. Implementation is possible. The second case 60 according to an embodiment of the present invention includes a second body 62, a third mounting hole portion 64, and a fourth mounting hole portion 68.

According to one embodiment, the second body 62 forms a curved surface on the inner side facing the finger 182 and is located on the upper part of the finger 182 inserted into the internal seating portion 30. Since a curved surface is formed on the inside of the second body 62, injury due to the finger 182 coming into contact with the second body 62 can be prevented.

According to one embodiment, the third mounting hole portion 64 forms a third connection hole 66, which is a hole, in the second body 62. A light receiving unit 140 is installed in the first PCB 151 facing the third connection hole 66.

According to one embodiment, the fourth mounting hole portion 68 forms a fourth connection hole 70 in the second body 62 and is installed at a position spaced apart from the third mounting hole portion 64. The third mounting hole part 64 is installed in the part of the second body 62 that is close to the inlet 32, and the fourth mounting hole part 68 is located further away from the inlet 32 than the third mounting hole part 64. is installed in

According to one embodiment, the first mounting hole part 44 and the third mounting hole part 64 are installed in positions facing each other, the light irradiation part 130 is installed in the first mounting hole part 44, and the light receiving part ( 140) is installed in the third mounting hole portion 64.

According to one embodiment, the internal seating part 30 is a part into which the finger 182 is inserted and is provided with a first mounting hole part 44, which is a square hole surrounding the light irradiation part 130, which is a light source, installed on the lower side. .

In addition, the first mounting hole portion 44 and the second mounting hole portion 48 are provided with ribs that protrude to the outside of the first body 42, thereby blocking the possibility of external factors intervening in light irradiation and temperature measurement. This can improve operational reliability.

In addition, the third mounting hole portion 64 and the fourth mounting hole portion 68 have ribs protruding outward from the second body 62, thereby blocking the possibility of external factors intervening in light irradiation and temperature measurement. This can improve operational reliability.

[Measurement information section]

Figure 8 is a perspective view showing the measurement guide 80 installed in the first case 40 according to an embodiment of the present invention. Figure 9 is a plan view showing the measurement guide 80 installed in the first case 40 according to an embodiment of the present invention.

As shown in Figures 8 and 9, the measurement guide 80 is located at the entrance 32 of the internal seating part 30 and can be slidably moved on both sides of the width direction (W) of the internal seating part 30. It is installed properly. In addition, the measurement guide unit 80 can be modified in various ways within the technical idea of guiding the finger 182 moving inside the internal seating unit 30 to the center of the width direction (W) of the internal seating unit 30. .

According to one embodiment, the measurement guide portion 80 is installed on both sides of the width direction (W) of the inner seating portion 30, and can slide along the width direction (W). In addition, the measurement guide 80 is provided with a spring so that when the finger 182 is inserted into the inner seating part 30, the finger 182 is positioned in the center of the width direction (W) of the internal seating part 30. The elastic members 110 used are installed on both sides.

The measurement guide unit 80 according to an embodiment of the present invention includes a fixed case 90, a moving block unit 100, an elastic member 110, and a guide member 120.

According to one embodiment, the fixing case 90 is fixed to both sides of the internal seating portion 30 in the width direction (W). The fixing case 90 protruding outward in the width direction (W) of the internal seating part 30 is fixed to the outside of the internal seating part 30. The fixing case 90 according to an embodiment of the present invention includes a fixing body 92, a guide protrusion 94, and a side protrusion 96.

According to one embodiment, the fixing body 92 forms an empty space on the inside and is fixed to the outside of the internal seating portion 30. The guide protrusion 94 has a bar shape and is fixed to the fixing body 92. Additionally, the guide protrusion 94 extends in the width direction (W) and is inserted into the inside of the movable block unit 100 to guide the movement of the movable block unit 100 in the width direction (W).

According to one embodiment, one side of the moving block unit 100 is located inside the fixed case 90, and the other side protrudes inside the internal seating part 30. The movable block unit 100 is capable of sliding movement in the width direction (W) of the internal seating unit 30. The movable block unit 100 according to an embodiment of the present invention includes a block body 102 and a locking piece 104.

According to one embodiment, the block body 102 has a square block shape, one side of the movable block unit 100 is located inside the fixed case 90, and the other side extends inside the internal seating portion 30. The locking piece 104 is connected to one side of the movable block unit 100 and has a plate shape.

And since the locking piece 104 is caught on the locking protrusion provided in the fixing case 90, the movable block unit 100 can be prevented from being separated from the fixing case 90.

According to one embodiment, the elastic member 110 is located between the fixed case 90 and the movable block unit 100 and elastically presses the movable block unit 100 to the inside of the internal seating unit 30. The elastic member 110 according to an embodiment of the present invention uses a spring, is supported on one side by the side protrusion 96 provided on the fixed body 92, and rests on a groove provided on the block body 102. side is supported. Accordingly, the movable block portion 100 is elastically supported toward the center of the inner seating portion 30 in the width direction (W).

According to one embodiment, the guide member 120 is fixed to the end of the moving block part 100, and various modifications are made within the technical idea of guiding the movement of the finger 182 moving inside the inner seating part 30. is possible. The guide member 120 according to an embodiment of the present invention includes a first guide 122 and a second guide 124.

According to one embodiment, the first guide 122 is installed at the end of the moving block unit 100 and provides a plate-shaped guide along the moving direction of the finger 182. The first guide 122 is a plate extending in a straight line, and may be provided with a curved surface corresponding to the outside of the finger 182, if necessary.

According to one embodiment, the second guide 124 is connected to the end of the first guide 122 and is installed in a shape that gradually spreads outward toward the entrance 32, which is the direction in which the finger 182 enters. Accordingly, the finger 182 entering the inner seating portion 30 is guided to the center in the width direction (W) by the second guide 124.

[Light irradiation department]

The light irradiation unit 130 is located on one side of the internal seating unit 30, and various modifications are possible within the technical idea of irradiating light toward the finger 182. In the light irradiation unit 130, at least one light source is successively installed along the longitudinal direction D of the internal seating unit 30.

Alternatively, the light irradiation unit 130 may be provided with at least one light source having different wavelengths.

[Light receiver]

According to one embodiment, the light receiving unit 140 is located on the other side of the internal seating unit 30, and various modifications are made within the technical idea of receiving the light irradiated from the light irradiation unit 130 and passing through the finger 182. is possible. The light receiving unit 140 is installed in a position facing the light irradiating unit 130 and measures the wavelength of the light passing through the finger 182.

In the present invention, the light irradiated from the light irradiation unit 130 having a plurality of light sources is measured by the light receiving unit 140 while passing through the finger 182. The light receiving unit 140 can detect the amount of light using a photo detector.

[Control unit]

According to one embodiment, the control unit 150 is installed inside the housing unit 10 and receives the measurement value from the light receiving unit 140 to calculate the amount of glucose in the finger 182. The control unit 150 according to an embodiment of the present invention includes a first PCB 151 and a second PCB 152.

The converted value of the light into an electrical signal received from the light receiving unit 140 is transmitted to the control unit 150, and the DC voltage value converted through a filter provided in the control unit 150 is analyzed by the control unit 150 to generate the finger 182. Measure the amount of glucose inside.

In addition, the present invention further includes a temperature sensor unit 170 that measures the temperature of the finger 182 through a hole provided in the internal seating unit 30. The temperature sensor unit 170 according to an embodiment of the present invention includes a first temperature sensor 172 and a second temperature sensor 174, and is installed on the upper and lower sides of the finger 182, respectively. 182) Measure the temperature.

According to one embodiment, the pressure sensor 160 is located below the finger 182, measures the pressure caused by the finger 182 through contact with the lower part of the finger 182, and sends the measured value to the control unit 150. Deliver.

The control unit 150 of the present invention accurately senses the temperature of the finger 182 using a plurality of temperature sensors to compensate for the temperature correlation of the measurement and reflects it in the measurement calculation formula. In addition, the present invention detects pressure through the pressure sensor 160 to reduce measurement changes due to the pressure of the finger 182, and the control unit 150 increases measurement reliability by allowing measurement to be performed below a certain pressure.

Hereinafter, the operating state of the non-invasive glucose measurement device 1 according to an embodiment of the present invention will be described in detail with reference to the attached drawings.

According to one embodiment, when moving the finger 182 through the inlet 32 of the internal seating part 30 for measurement, the guide member 120 of the measurement guide 80 moves the inner seating part 30. Guides the movement of the finger 182 toward the center of the width direction (W). Since the moving block unit 100 is elastically supported by the elastic member 110, the measurement guide unit 80 presses the finger 182 toward the center of the inner seating unit 30 in the width direction (W).

According to one embodiment, with the finger 182 seated inside the internal seating unit 30, the values measured by the pressure sensor 160 and the temperature sensor unit 170 are transmitted to the control unit 150. . And the light irradiated from the light irradiation unit 130 passes through the finger 182 and is received at the light receiving unit 140.

According to one embodiment, the control unit 150 calculates the amount of glucose in the user's finger 182 by combining the input values and then transmits this to the output device. This control unit 150 includes a voltage/current converter 1010, a filter 1020, an amplifier 1030, an A/D converter 1040, a controller 1050, a memory 1060, a communication unit 1070, and an input/output unit ( 1080), and a processor 1090.

As described above, according to the present invention, the light irradiated from the light irradiation unit 130 passes through the finger 182 and is received by the light receiving unit 140 to measure glucose, so that the glucose of the measurement subject 180 is measured without blood sampling. User satisfaction can be improved by measuring quickly and accurately.

In addition, the measurement guide 80 moves in the width direction (W) of the internal seating part 30 and guides the position of the finger 182 moving inside the internal seating part 30, so that the finger 182 is set. Since the measurement is performed once the location has been reached, the accuracy of glucose measurement is improved.

Figure 10 is a block diagram of a non-invasive glucose measurement device according to an embodiment of the present invention.

Referring to FIG. 10, the non-invasive glucose measurement device 1000 according to an embodiment of the present invention includes a light radiating unit 130, a light receiving unit 140, a pressure sensor 160, a temperature sensor unit 170, and a control unit ( 150) may be included.

According to one embodiment, the control unit 150 includes a current/voltage converter 1010, a filter 1020, an amplifier 1030, an A/D converter 1040, a regulator 1050, a memory 1060, and a communication unit ( 1070), an input/output unit 1080, and a processor 1090.

The configuration of the non-invasive glucose measurement device 1000 shown in FIG. 10 is according to one embodiment, and the components of the non-invasive glucose measurement device 1000 are not limited to the embodiment shown in FIG. 10, and may be added as needed. Accordingly, some components may be added, changed, or deleted.

According to one embodiment, the light emitting unit 130 may include at least one light emitting device (eg, LED) that outputs light for glucose measurement. This light irradiation unit 130 passes light through the internal tissue of the finger 182.

This light irradiation unit 130 is located on one side (e.g., the second PCB 152) of the internal seating part 30 of the non-invasive glucose measurement device 1, and the finger inserted into the internal seating part 30 Rays can be irradiated toward (182).

According to one embodiment, the light receiving unit 140 may include a photo diode with high photosensitivity in a predetermined wavelength band (e.g., 800 nm to 940 nm) in order to receive a small amount of light. These photodiodes can have various sizes.

The light receiving unit 140 may receive the amount of light transmitted through various reactions such as reflection, absorption, scattering, and transmission with materials in the tissue of the finger 182. Mainly in the near-infrared region, the absorption of ingredients that make up the skin is minimal, and the biggest effect is scattering. Refraction and scattering of light are caused by differences in refractive index between various components that make up body tissues, and the greater the difference in refractive index between the material causing scattering and surrounding materials, the greater the degree of scattering.

For example, when the concentration of glucose in blood and interstitial fluid (ISF) increases, the refractive index increases and the difference in refractive index with surrounding materials may decrease. In this case, the scattering coefficient decreases and the intensity of the transmitted light becomes stronger.

Considering this operating principle, the angle of the irradiated light has a great influence on the blood sugar measurement results, and as the distribution of the incident angle increases, the measurement variable can increase.

Considering this, the light receiving unit 140 is located on the other side (e.g., the first PCB 151) of the internal seating unit 30 with the finger 182 in between, and is irradiated from the light irradiation unit 130 to the finger 182. ) can receive light that has passed through.

According to one embodiment, the pressure sensor 160 may measure the bending of the PCB (eg, the second PCB 152) using the finger 182. When the finger 182 is seated on the internal seating portion 30, the finger 182 comes into contact with the surface of the internal seating portion 30 and applies pressure to the PCB (e.g., the second PCB 152). The pressure The sensor 160 can measure the degree of bending of the PCB (eg, the second PCB 152) bent by such pressure. The pressure sensor 160 may transmit the measured pressure value to the control unit 150.

For example, the pressure sensor 160 may measure pressure once, or may measure pressure multiple times in real time while measuring glucose.

This pressure sensor 160 may include an ultra-low power integrated pressure sensor with a built-in analog front-end.

For example, the pressure sensor 160 may have a measurement range of 5 g to 4 kg load.

According to one embodiment, the temperature sensor unit 170 is disposed on the second PCB 151 and the first temperature sensor 172 is disposed on the first PCB 152 to measure the temperature of the upper surface of the finger 182. may include a second temperature sensor 174 that measures the temperature of the lower surface of the finger 182. The temperature sensor unit 170 may transmit the measured temperature to the control unit 150.

For example, the temperature sensor unit 170 may measure temperature once or measure glucose multiple times in real time while measuring glucose.

For example, the temperature sensor unit 170 may include at least one temperature sensor.

According to one embodiment, the control unit 150 may include a current/voltage converter 1010, a filter 1020, an amplifier 1030, an A/D converter 1040, and a regulator 1050.

According to one embodiment, the current/voltage converter 1010 may convert the input current to be measured into a corresponding voltage and output it. When light is detected, the light receiving unit 140 (eg, photo diode) generates a micro current (I _d ). The current/voltage converter 1010 converts this minute current into an output voltage through a transimpedance gain resistance (R _f ). The output voltage is obtained by multiplying the microcurrent and the gain resistance. The current/voltage converter 1010 converts the amount of light output from the light receiving unit 140 into voltage (e.g., mV) data and then provides it to the filter 1020.

According to one embodiment, the filter 1020 may filter the frequency of the voltage output from the current/voltage converter 1010. For example, the filter 1020 may include a low-pass filter. The filter 1020 may pass only frequency signals in a predetermined frequency band (e.g., 10 Hz or less), filter the remaining frequency bands, and transmit them to the amplifier 1030.

According to one embodiment, the controller 1050 may adjust the gain value to correspond to the user's conditions for measuring glucose. The amplifier 1030 may amplify the signal (e.g., amplify the voltage of the signal) by reflecting the gain value corresponding to the user's condition transmitted from the controller 1050 to the signal that has passed through the filter 1020. For example, the amplifier 1030 can amplify the voltage from 3.3V to 5V. The signal output from the amplifier 1030 may be an analog signal.

For example, finger thickness, skin color, and condition may vary from person to person. As these conditions differ, a gain value based on the user's conditions can be set to accurately measure glucose.

According to one embodiment, the A/D converter 1040 may convert the analog signal output from the amplifier 1030 into a digital signal. The A/D converter 1040 can convert an input analog signal into a digital signal at a rate of 20SPS (sampling rate per second).

According to one embodiment, the memory 1060 may include volatile memory or non-volatile memory. For example, the memory 1060 may store information, data, programs, etc. necessary for the operation of the non-invasive glucose measurement device 1. Accordingly, the processor 1090 can perform control operations described later with reference to information stored in the memory 1060.

The memory 1060 may store various platforms. The memory 1060 may be, for example, a flash memory type, a hard disk type, a multimedia card micro type, or a card type memory (e.g., SD or XD). It may include at least one type of storage medium among (memory, etc.), RAM, and ROM (EEPROM, etc.).

The memory 1060 stores various data (e.g., software, applications, programs, control logic, control signals, light receiving unit 140) acquired or used by at least one component of the non-invasive glucose measurement device 1. Light rays obtained through, information acquired through the input/output unit 1080 (e.g., touch input, voice messages, etc.), and commands related thereto may be stored.

The memory 1060 can store information, commands, software, data, programs, etc. regarding the operation of the non-invasive glucose measurement device 1. Additionally, the memory 1060 may store data input to the processor 1090, data being processed, and/or data according to processing results.

Additionally, information on the user measuring glucose using the non-invasive glucose measuring device 1 and a program for measuring glucose may be stored in advance in the memory 1060.

According to one embodiment, the communication unit 1070 may include at least one circuit capable of transmitting and receiving at least one signal, information, or data with another electronic device (not shown) (eg, a mobile terminal or a server).

In addition, the communication unit 1070 provides short-range communication (e.g., Wi-Fi (Wireless-Fidelity), Wi-Fi Direct, Wireless USB (Wireless Universal Serial Bus), Bluetooth, RFID (Radio Frequency Identification), and infrared communication. Wired or wireless communication may be performed with other electronic devices based on (at least one of Infrared Data Association), UWB (Ultra Wideband), ZigBee, NFC (Near Field Communication), and Beacon).

The communication unit 1070 may receive a program for measuring glucose from a portable terminal (not shown) or a server (not shown), and store the received program in the memory 1060 under the control of the processor 1090.

According to one embodiment, the input/output unit 1080 includes a display unit 1081 that displays or receives various information according to the operation of the non-invasive glucose measurement device 1, a speaker 1082 that outputs a voice signal, and a speaker that receives voice input. A microphone 1083, a light-emitting unit 1084 including at least one light-emitting element, and an interface unit 1085 that provides a physical connection (e.g., USB, HDMI, etc.) with other electronic devices (e.g., charger, display device, etc.) ) may include.

For example, the display unit may include a touch detection circuit that detects a user's touch input.

According to one embodiment, the processor 1090 may control components of the non-invasive glucose measurement device 1.

The processor 1090 includes application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, and microprocessors. It may be implemented with at least one physical element selected from micro-controllers and microprocessors.

The processor 1090 may have an artificial intelligence algorithm built into it. This algorithm for artificial intelligence can be implemented by the processor 1090. The artificial intelligence is a program that imitates the human brain neural network and can support deep learning algorithms that independently analyze, recognize, infer, and judge various data.

Through this, the processor 1090 can control the glucose measurement of the non-invasive glucose measurement device 1 using artificial intelligence.

In this way, the processor 1090 may include a circuit that can overall control the components of the non-invasive glucose measurement device 1.

According to one embodiment, the processor 1090 can perform an operation of measuring glucose through the non-invasive glucose measurement device 1, and a detailed description of this is as follows.

According to one embodiment, the control unit 150 converts the current for the amount of light received from the light receiving unit 140 into voltage, filters the frequency of the converted voltage into a predetermined frequency band, and filters the filtered frequency. You can measure the user's glucose by compensating for the voltage. This light receiving unit 140 may be placed in a position facing the light irradiating unit 130 with the fingers between them.

According to one embodiment, the control unit 150 includes a current/voltage converter 1010 that converts the current for the amount of light into voltage, a filter 1020 that filters the frequency of the converted voltage into the predetermined frequency band, and glucose A regulator 1050 that adjusts the gain value to correspond to the conditions of the user making the measurement, an amplifier 1030 that amplifies the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency, and converts the amplified voltage value into a digital voltage. It may include an analog to digital (A/D) converter that converts the value into a value, and a processor 1090 configured to measure the user's glucose using the converted digital voltage value.

According to one embodiment, the control unit 150 may further include an input/output unit 1080 that outputs the measured glucose. For example, the input/output unit 1080 displays various information about the operating status and operation results of the glucose measuring device 1, and the display unit 1081 receives the user's touch input, and the non-invasive glucose measuring device 1 A speaker 1082 that outputs sound for the operation status and operation results, a microphone 1083 that receives sound, a light emitting unit 1084 including at least one light emitting element, and a physical connection (or communication) with an external electronic device. It may further include an interface unit 1085 that provides connection.

According to one embodiment, the control unit 150 (e.g., processor 1090) acquires the temperature of the finger 182 through the temperature sensor unit 170 and converts the digital voltage value from the A/D converter 1040. The error rate in glucose measurement can be compensated by reflecting the temperature.

According to one embodiment, the processor 1090 identifies a change in at least one of intracellular fluid (ICF) and interstitial fluid for the finger based on the light transmitted through the finger 182, and Changes in scattering degree and refractive index due to changes in at least one of intracellular fluid and the interstitial fluid can be identified. Additionally, the processor 1090 may detect a change in the amount of light based on the change in the identified refractive index.

The concentration of this interstitial fluid has a high correlation with the concentration of sugar in the blood. Most of the components of interstitial fluid have similar characteristics, including ions, proteins, sugars, and alcohols, except for substances with high molecular weight such as lipids.

If glucose is ingested into the human body as food, it is first absorbed into the blood and delivered to the cells inside the body to be converted into energy and used. When delivered to the cells, glucose first moves into the interstitial fluid through the endothelium of the capillaries. In this process, a lag time of approximately 3 to 12 minutes may occur while the concentration is equilibrated due to a diffusion process due to the concentration difference. Therefore, when measuring glucose after consuming food, it is desirable to measure it after about 3 to 12 minutes.

The non-invasive glucose measurement device 1 according to the present invention can measure blood sugar through the influence of scattering of light passing through skin tissue.

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Figure 11 is a flowchart showing the process of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention. Figure 12 is an exemplary diagram showing a home screen displayed on the input/output unit of a non-invasive glucose measurement device according to an embodiment of the present invention. Figure 13 is an exemplary diagram showing a status bar displayed on the input/output unit of a non-invasive glucose measurement device according to an embodiment of the present invention. Figure 14 is an exemplary diagram of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention. Figure 15 is an exemplary diagram showing the results of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention. Figure 16 is an exemplary diagram showing cumulative data according to the timing of glucose measurement using a non-invasive glucose measurement device according to an embodiment of the present invention.

Hereinafter, with reference to FIGS. 11 to 16, the process of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention will be described in detail as follows.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may detect an input for glucose measurement through the input/output unit 1080 (S1110). For example, the processor 1090 can detect various inputs for glucose measurement through the input/output unit 1080.

According to one embodiment, the processor 1090 may display an initial screen measuring glucose through the input/output unit 1080 (eg, display unit 1081). The display unit 1081 may not only display various information or data, but may also include a touch detection sensor that detects a touch input.

Referring to FIG. 12, the processor 1090 may display a program (eg, a program for measuring glucose) stored in the memory 1060 through the input/output unit 1080 (eg, display unit 1081).

The processor 1090 displays various icons related to the timing of glucose measurement (e.g., wake-up icon 1211, before breakfast icon 1219, before lunch icon 1213, before dinner icon 1214, before bedtime icon ( A screen 1210 including the after-breakfast icon 1216, the after-lunch icon 1217, and the after-dinner icon 1218) can be displayed.

For example, if the user wants to measure glucose immediately after waking up in the morning, the user can measure glucose by selecting the wake-up icon 1211. Likewise, if the user wants to measure glucose after lunch, the user can measure glucose by selecting the after lunch icon 1217.

When the processor 1090 is turned on, it can display these various icons on the display unit 1081.

Each of these icons is selected by the user to enter the time point at which they measure glucose. In this way, the processor 1090 can provide an intuitive interface to the user.

Additionally, the screen 1210 may include various information regarding the current time 1219, communication activation information (e.g., Bluetooth 1220), remaining battery information 1221, and environment settings 1222.

Referring to FIG. 13, the processor 1090 may display a screen 1310 for the status bar of a program (eg, a program that measures glucose). For example, when the environment settings 1222 in FIG. 12 are selected, the processor 1090 displays a screen 1310 containing information about detailed settings of the non-invasive glucose measurement device 1 through the input/output unit 1080 ( Example: It can be displayed through the display unit 1081).

For example, the screen 1310 includes a home icon 1302 for displaying the home screen 1210, a Bluetooth icon 1303 for activating communication, a battery type 1304, and detailed information about the non-invasive glucose measurement device 10. It may include a settings icon 1305.

This screen 1310 may include the current date, home screen movement icon, Bluetooth connection status, battery charging status, and environment setting screen movement icon.

According to one embodiment, when the after-lunch icon 1217 of FIG. 12 is selected, the processor 1090 displays the screen 1410 for measuring glucose as shown in FIG. 14 through the input/output unit 1080 (e.g., the display unit). (1081)).

Referring to FIG. 14, the screen 1410 is an example of measuring glucose after lunch, including information 1413 indicating the measurement time, a home menu 1411, a measurement start menu 1412, and information indicating measurement-related information. It may include (1415) and information (1416) indicating the measurement elapse rate.

According to one embodiment, when the user selects the start measurement menu 1412 to measure glucose, the processor 1090 starts the glucose measurement process of the non-invasive glucose measurement device 1.

For example, the screen 1410 may include values of transmission amount information (e.g., DC component), temperature (e.g., 32 degrees), and pressure (e.g., 2100) and a graph 1415 for each.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may irradiate a light source through the light irradiation unit 130 (S1112). When the processor 1090 detects that the measurement start menu 1412 is selected on the screen 1410, it can operate the light irradiation unit 130 to output the light source toward the finger 182.

For example, the processor 1090 may output light having a predetermined wavelength (eg, 630 nm) through the light irradiation unit 130.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may obtain the amount of light passing through the finger 182 through the light receiving unit 140 (S1114). When light is transmitted through the finger, the light receiving unit 140 can obtain a signal value according to the change in blood flow due to contraction and expansion of the heart. When light is irradiated to the finger from the light irradiation unit 130, light is absorbed in blood, bone, and tissue, and some of the light passes through and reaches the light receiving unit 140.

The degree to which light is absorbed by a finger is proportional to the amount of skin, tissue, and blood in the path through which the light passes. Since it is a component that does not change except for changes in blood flow due to heartbeat, it is proportional to the change in the amount of light absorbed. If glucose in the blood increases, the refractive index decreases and the misalignment of light penetrating the tissue decreases, resulting in less light being absorbed.

Additionally, as the intensity of light across the finger tissue increases, it affects the amplitude of the base component (e.g., DC component) and the pulsatile component (e.g., AC component), which is a pure blood flow fluctuation, of the photoplethysmography (PPG) signal. is received, and the light receiving unit 140 can detect changes in amplitude. The AC component passes through a filter 1020 and an amplifier 1030 to remove high-frequency noise caused by the pulse.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may convert the current for the acquired amount of light into voltage (S1116). The processor 1090 converts the microcurrent (I _d ) output through the light receiving unit 140 into an output voltage (V _out ) through the current/voltage converter 1010 (e.g., transimpedance gain resistance (R _f )). I order it.

For example, the processor 1090 may obtain the output voltage (V _out ) by multiplying the microcurrent (I _d ) and the transimpedance gain resistance (R _f ) through the current/voltage converter 1010.

According to one embodiment, the non-invasive glucose measurement device (e.g., processor 1090) may filter the frequency of the converted voltage through the filter 1020 so that only a predetermined frequency band passes (S1118). The processor 1090 may filter the frequency of the output voltage (V _out ) output through the current/voltage converter 1010 through the filter 1020 so that only frequencies in a specific band pass through.

The frequency band used to measure glucose is mainly about 10 Hz or less. The processor 1090 passes a predetermined frequency band (e.g., approximately 10 Hz or less) at the frequency of the output voltage (V _out ) through the filter 1020 and filters the remaining frequency bands.

According to one embodiment, the non-invasive glucose measurement device (e.g., processor 1090) may compensate for the voltage to suit the conditions of the user performing glucose measurement (S1120). The processor 1090 obtains a gain value according to various factors such as external temperature and pressure, finger thickness of the subject, skin condition, skin color, and BMI (Body Mass Index) through the controller 1050, and through the amplifier 1030. The obtained gain value can be reflected in the frequency passing through the filter 1020 to compensate for the voltage according to the amount of light.

And, the analog value output through the amplifier 1030 is transmitted to the analog/digital (Analog to Digital) converter 1040. For example, these gain values are or may be stored in memory 1060.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may measure glucose by converting the compensated voltage value into a digital voltage value through the A/D converter 1040 (S1122). The processor 1090 can convert an analog input signal into a digital voltage value at a rate of 20 sampling per second through the A/D converter 1040.

According to one embodiment, a non-invasive glucose measurement device (e.g., processor 1090) may display information about measured glucose on the input/output unit 1080 (S1124). The processor 1090 may display information about glucose measured through the user's finger 182 through an input/output unit (eg, display unit 1081).

Referring to FIG. 14, the processor 1090 measures transmission amount information (e.g., DC component), temperature, and pressure in real time, and displays the real-time measured results through an input/output unit (e.g., display unit 1081). You can.

The screen 1410 is an example of measuring glucose after lunch, and the processor 1090 displays information 1413 indicating the measurement time, a home menu 1411, a start measurement menu 1412, and information indicating information related to the measurement ( 1415) and information 1416 indicating the measurement elapse rate.

Alternatively, the processor 1090 may output information about glucose measured through the user's finger 182 through an input/output unit (eg, speaker 1082).

Referring to FIG. 15, when the process of measuring glucose through a finger is completed for a predetermined period of time, the processor 1090 displays a screen 1510 containing information 1511 including the glucose measurement value through an input/output unit (e.g., a display unit ( It can be displayed through 1081)).

For example, the screen 1510 may include a save menu 1513 for storing measurement information (e.g., measurement time point, measurement value 1511, etc.), and a cancel menu 1512 for canceling the saving of the measurement information. You can.

For example, when the user selects the save menu 1513 to save measurement information, the processor 1090 may store the measurement information (e.g., measurement time point, measurement value 1511, etc.) in the memory 1060. .

Referring to FIG. 16 , the processor 1090 may display a screen 1610 containing accumulated data on glucose measured through the finger 182 through an input/output unit (eg, display unit 1081).

The screen 1610 displays information about the measurement time 1611 (e.g., current time) and measurement time (e.g., after waking up, before breakfast, after breakfast, before lunch, after lunch, before dinner, after dinner, before going to bed, etc. ) may include information (1612) about the number of measurements and measurement time.

As described above, the non-invasive glucose measurement device 1 according to the present invention can painlessly measure glucose without collecting blood by irradiating light to the finger and using the amount of light transmitted through the finger.

Hereinafter, a light irradiation unit according to an embodiment of the present invention will be described.

Figure 17 is an exemplary diagram showing a state in which light is irradiated from a light irradiation unit according to an embodiment of the present invention. Figure 18 (a) is an exemplary view of the light irradiation unit according to an embodiment of the present invention as seen from the top. Figure 18 (b) is an exemplary cross-sectional view of a light irradiation unit according to an embodiment of the present invention.

Referring to Figures 17 and 18 (a) and (b), the light irradiation unit 130 according to an embodiment of the present invention is located on one side ( Example: It is located in the first body 42, and light can be irradiated toward the finger inserted into the internal seating portion 30. Then, the light irradiated from the light irradiation unit 130 may pass through the finger 182 and then be detected by the light receiving unit 140 in the detection area 1750 of the light receiving unit 140. For example, the detection area 1750 may have a diameter of less than 5 mm.

According to one embodiment, the light irradiation unit 130 includes a light-emitting device 1710 that outputs light, a cover 1820 that covers the light-emitting device, a case 1740 formed in a cylindrical shape to insert the light-emitting device therein, and It may include a spherical lens 1720 disposed on the upper surface of the cover 1820 and an aspherical lens 1730 disposed inside the case 1740.

For example, the aspherical lens 1730 is a lens in which both the front and back sides are convexly aspherical, and the refractive index of the front and back may be different from each other.

According to one embodiment, the light emitting device 1710 is disposed on a PCB (e.g., the second PCB 152), and the control unit 150 is electrically connected to the PCB (e.g., the second PCB 152). ) (e.g., the processor 1090) can output light rays under control.

According to one embodiment, the cover 1820 is molded with plastic to protect the light emitting device 1710. For example, a hole 1812 is formed inside the cover 1820 to transmit light from the light emitting device 1710 to the aspherical lens 1730.

According to one embodiment, the case 1740 is formed in a cylindrical shape to allow light to pass therein. Additionally, a support portion 1801 is formed inside the case 1740 to seat and support the aspherical lens 1730. For example, the support portion 1801 is formed around the inner peripheral surface of the case 1740. Additionally, the aspherical lens 1730 may be placed on the upper surface of the support portion 1801 and fixed to the case 1740.

Additionally, the upper surface of the case 1740 (i.e., the top of the aspherical lens 1730) has an opening 1810 formed to allow parallel light rays to pass through the aspherical lens 1730.

For example, the case 1740 may be made of metal and may have a cylindrical shape. In addition, the horizontal portion 1801 of the case 1740 where the aspherical lens 1730 is seated has a hole 1811 formed to transmit light from the spherical lens 1720 to the aspherical lens 1730.

According to one embodiment, the spherical lens 1720 is disposed on the top of the light-emitting device 1710 (e.g., the top surface of the cover 1820) and transmits the light output from the light-emitting device 1710 to the aspherical lens 1730. there is. For example, the spherical lens 1720 may be disposed on the upper surface of the cover 1820 molded from plastic.

According to one embodiment, the aspherical lens 1730 is disposed on the spherical lens 1720 and can convert non-parallel light rays passing through the spherical lens 1720 into parallel rays and output them. For example, the aspherical lens 1730 has a refractive index that can convert non-parallel light rays passing through the spherical lens 1720 into a parallel angle of incidence.

To this end, the aspherical lens 1730 may be disposed at a location (e.g., inside the case 1740) spaced apart from the spherical lens 1720 by a certain distance 1712 in the upper direction of the spherical lens 1720.

According to one embodiment, the light receiving unit 140 is located on the other side (e.g., the second body 62) of the internal seating unit 30 with the finger 182 in between, and is located on the light irradiating unit 130. The light irradiated and transmitted through the finger 182 may be received.

The light receiving unit 140 can detect parallel light rays radiated from the light irradiating unit 130 and passing through the finger 182 in the detection area 1750. This light receiving unit 140 may include a photo diode 1760 that detects light.

As described above, the non-invasive glucose measurement device 1 according to the present invention is located on one side (e.g., the first body 42) of the internal seating part 30, and is inserted into the internal seating part 30. A light irradiation unit 130 that radiates light toward the finger 182 is located on the other side (e.g., the second body 62) of the internal seating part 30 with the finger 182 in between, A light receiving unit 140 receives the light irradiated from the light irradiation unit 130 and passes through the finger 182, and converts a current corresponding to the amount of light of the received light into a voltage, and adjusts the frequency of the converted voltage in advance. It may include a control unit 150 set to measure the user's glucose by filtering to a determined frequency band and compensating for the voltage of the filtered frequency. And, the light irradiation unit 130 can output parallel light beams.

According to one embodiment, the light irradiation unit 130 includes a light emitting device 1710 that outputs the light beam, a spherical lens 1720 disposed on an upper portion of the light emitting device 1710, and an upper portion of the spherical lens 1720. It may include an aspherical lens 1730 that is disposed in and outputs the non-parallel ray passing through the spherical lens 1720 as the parallel ray.

According to one embodiment, the light-emitting device 1710 is mounted on a printed circuit board (PCB) fixed to the lower case 14 of the non-invasive glucose measurement device 1, under the control of the control unit 150. Light rays can be output.

According to one embodiment, the light irradiation unit 130 further includes a case 1740 formed in a cylindrical shape so that the light emitting element 1710 is inserted therein, and the aspherical lens 1730 is installed inside the case 1740. Characterized by the formation of a support part that supports

According to one embodiment, the spherical lens 1720 may be disposed on the upper surface of the cover 1820 in which the light emitting device 1710 is molded with plastic.

According to one embodiment, the aspherical lens 1730 may be disposed at a position spaced apart from the spherical lens 1720 by a certain distance (eg, 6 mm) in the upper direction of the spherical lens 1720.

According to one embodiment, the aspherical lens 1730 is disposed inside the case 1740 and may be supported by the support portion 1801.

According to one embodiment, the light receiving unit 140 may include a photo diode 1760 that receives the light beam, and the distance between the light emitting element 1710 that outputs the light beam and the photo diode 1760 is 27 mm. It is characterized by

According to one embodiment, the light irradiation unit 130 is disposed on a PCB (e.g., a second PCB 152) fixed to the lower case 14 of the non-invasive glucose measurement device 1, and includes at least one It can be included.

According to one embodiment, the control unit 150 controls at least one of intracellular fluid (ICF) and interstitial fluid for the finger 182 based on the light transmitted through the finger 182. Set to identify changes, identify changes in scattering and refractive index due to changes in at least one of the intracellular fluid and the interstitial fluid, and detect changes in the amount of light based on the identified changes in refractive index. It can be.

As described above, the non-invasive glucose measurement device 1 according to the present invention can accurately measure glucose by having the light irradiation unit 130 output parallel light rays.

The pressure sensor according to an embodiment of the present invention may include a MEMS (Micro Electro-Mechanical Systems) type pressure sensor that has high sensitivity to pressure and can detect small changes in pressure.

This MEMS type pressure sensor is an ultra-small, highly sensitive sensor that can detect surface tension, friction, movement, and direction of movement.

Figure 19 is a flowchart showing the process of correcting glucose by reflecting temperature according to an embodiment of the present invention.

Hereinafter, with reference to FIG. 19, the process of correcting glucose by reflecting temperature according to an embodiment of the present invention will be described as follows.

According to one embodiment, the non-invasive glucose measurement device 1 may identify whether an input for correcting glucose measurement is detected (S1910). The non-invasive glucose measurement device 1 can detect input for glucose correction input by the user through the input/output unit 1080 (e.g., display unit 1081).

For example, the non-invasive glucose measurement device 1 may display a screen that receives input for glucose correction through the input/output unit 1080 (e.g., display unit 1081).

According to one embodiment, the non-invasive glucose measurement device 1 can measure the temperature of the finger (S1912). The non-invasive glucose measurement device 1 can measure the temperature of the finger through the temperature sensor unit 170 when an input for glucose correction is detected.

For example, the non-invasive glucose measurement device 1 measures the first temperature of the upper surface of the finger through the first temperature sensor 172 disposed on one side of the internal seating portion (e.g., the first PCB 151). It is possible to measure the second temperature of the lower surface of the finger through the second temperature sensor 174 disposed on the other side of the internal seating portion (e.g., the second PCB 152). The non-invasive glucose measurement device 1 can calculate the average temperature of the first temperature and the second temperature.

In addition, the non-invasive glucose measurement device 1 may apply at least one of the first temperature, the second temperature, and the average temperature of the first temperature and the second temperature to correction for the user's glucose measurement.

According to one embodiment, the non-invasive glucose measurement device 1 may adjust the gain using the amount of light obtained through the light receiving unit 140 (S1914). When an input for glucose correction is detected, the non-invasive glucose measurement device 1 operates the light irradiation unit 130 to output a light source toward the finger 182, and transmits the amount of light passing through the finger 182 to the light receiving unit 140. ) can be obtained through.

Then, the non-invasive glucose measurement device 1 converts the current for the acquired amount of light into voltage, filters and amplifies the frequency of the converted voltage, and then converts the amplified voltage (e.g., analog voltage) into a digital voltage. The gain can be adjusted based on several factors such as the thickness of the finger, skin condition, skin color, and BMI (Body Mass Index) of the subject.

For example, the non-invasive glucose measurement device 1 may adjust the gain through the regulator 1050 so that the converted digital voltage is within an effective range (eg, 400 mV to 800 mV).

According to one embodiment, the non-invasive glucose measurement device 1 can measure glucose a predetermined number of times in each of the invasive and non-invasive methods (S1916). The non-invasive glucose measurement device 1 obtains the glucose value measured in each of the invasive and non-invasive methods when the digital voltage converted based on the amount of light received through the light receiver 140 is within the effective range. can do.

For example, while the digital voltage converted based on the amount of light received through the light receiver 140 is within the effective range, the non-invasive glucose measurement device 1 performs glucose measurement by an invasive method four times. The obtained glucose level can be obtained. This invasive method measures glucose through blood sampling, and the non-invasive glucose measurement device 1 can obtain from the user the glucose level obtained by the invasive method.

In addition, the non-invasive glucose measurement device 1 can obtain the glucose level obtained by performing glucose measurement 10 times in a non-invasive manner. This non-invasive method is a method in which the user measures glucose using a non-invasive glucose measurement device (1), and the non-invasive glucose measurement device (1) can measure glucose levels through the user's finger in a non-invasive way. .

According to one embodiment, the non-invasive glucose measurement device 1 can correct glucose using actual glucose by temperature and invasive method (S1918). The non-invasive glucose measurement device 1 can first correct the digital voltage by reflecting the temperature detected by the temperature sensor unit 170 to the glucose measured non-invasively in the process (S1916). That is, the non-invasive glucose measurement device 1 can first analyze the trend of digital voltage that changes with temperature and correct the glucose measured by a non-invasive method (e.g., first correction).

Additionally, the non-invasive glucose measuring device 1 can perform secondary correction of glucose by matching the first corrected glucose with glucose actually obtained through an invasive method.

In this way, the non-invasive glucose measurement device 1 first corrects the digital voltage by reflecting the temperature detected by the temperature sensor unit 170 in the non-invasive glucose value (e.g., second glucose value), Glucose correction for the user can be performed by secondly correcting the firstly corrected digital voltage by matching it with a glucose value based on an invasive method.

In addition, the non-invasive glucose measurement device 1 performs secondary correction by matching the first corrected digital voltage to the glucose value based on the invasive method to generate a user-customized algorithm (e.g., a mathematical equation tailored to the user's conditions). This can be stored in the memory 1060.

Figure 20 is a flowchart showing the process of correcting glucose by reflecting temperature according to an embodiment of the present invention. Figure 21 (a) is a screen showing the environment settings of the non-invasive glucose measurement device 1 according to an embodiment of the present invention. Figure 21 (b) is a screen that inquires about whether blood sugar level is corrected according to an embodiment of the present invention. Figure 22(a) is a screen regarding the time at which non-invasive glucose measurement is performed according to an embodiment of the present invention. Figure 22 (b) is a screen showing the results of non-invasive glucose measurement according to an embodiment of the present invention. Figure 23(a) is a screen guiding invasive glucose measurement according to an embodiment of the present invention. Figure 23 (b) is a screen displaying the glucose level measured by the invasive glucose method according to an embodiment of the present invention. Figure 23(c) is a screen inquiring whether glucose correction is in progress according to an embodiment of the present invention. Figure 24 is an exemplary diagram showing the correlation between finger temperature and voltage according to an embodiment of the present invention. Figure 25 is an exemplary diagram showing the correlation between glucose levels using a non-invasive glucose measuring device and glucose levels obtained through blood collection according to an embodiment of the present invention.

Hereinafter, with reference to FIGS. 20 to 25, the process of correcting glucose by reflecting temperature according to an embodiment of the present invention will be described as follows.

According to one embodiment, the processor 1090 may identify whether an input for correcting glucose measurement is detected (S2010). The processor 1090 may detect input for glucose correction input by the user through the input/output unit 1080 (e.g., display unit 1081). For example, the processor 1090 may display a screen that receives input for glucose correction through the input/output unit 1080 (e.g., display unit 1081).

Referring to (a) and (b) of FIG. 21, the processor 1090 can display a screen 2110 showing the environment settings of the non-invasive glucose measurement device 1.

For example, when the environment settings 1222 are selected on the screen 1210 of FIG. 12, the processor 1090 displays the screen 2110 including a menu representing various functions related to the environment settings 1222 on the display unit 1081. ) can be displayed on the screen. The screen 2110 may include icons for various menus such as blood sugar correction (2111), date time (2112), screen change (2113), blood sugar record (2114), volume (2115), and standby mode (2116). there is.

For example, when the user selects blood sugar correction 2111 on the screen 2110, the processor 1090 may display a screen 2120 on the display unit 1081 that inquires about whether to correct blood sugar. The screen 2120 may include a confirmation 2121 of receiving an input to proceed with blood sugar correction.

According to one embodiment, the processor 1090 may radiate light through the light irradiation unit 130 (S2012). When an input for correcting glucose measurement is detected, the processor 1090 operates the light irradiation unit 130 to output a light source having a predetermined wavelength (eg, 630 nm) toward the finger 182.

According to one embodiment, the processor 1090 may measure the temperature of the finger through at least one temperature sensor (S2014).

The processor 1090 can identify the first temperature of the upper surface of the finger through the first temperature sensor 172 disposed on one side of the internal seating portion (e.g., the first PCB 151) and the other side of the internal seating portion. The second temperature of the lower surface of the finger can be identified through the second temperature sensor 174 disposed on the second PCB 152 (e.g., the second PCB 152). Additionally, the processor 1090 may calculate an average temperature of the first temperature and the second temperature.

The processor 1090 may use at least one of the first temperature, the second temperature, and the average temperature of the first temperature and the second temperature to correct the user's glucose measurement.

According to one embodiment, the processor 1090 may convert the amount of light passing through the finger into a digital voltage (S2016). The processor 1090 may acquire the amount of light that has passed through the finger 182 through the light receiving unit 140 and convert the current for the obtained amount of light into voltage. For example, the processor 1090 converts the minute current (I _d ) output through the light receiving unit 140 into an output voltage (V) through the current/voltage converter 1010 (e.g., transimpedance gain resistance (R _f )). _out ).

Additionally, the processor 1090 may filter the frequency of the converted voltage through the filter 1020 so that only a predetermined frequency band passes. For example, the processor 1090 may pass a predetermined frequency band (e.g., approximately 10 Hz or less) at the frequency of the output voltage (V _out ) through the filter 1020 and filter the remaining frequency bands.

According to one embodiment, the processor 1090 may identify whether the converted digital voltage is valid (S2018). Based on the identified amount of light, it can be identified whether the converted digital voltage is within a valid range or not within a valid range. For example, the processor 1090 determines that the digital voltage is within a valid range when the digital voltage is within 400 mV to 800 mV, and determines that the digital voltage is not within a valid range when the digital voltage is not within 400 mV to 800 mV. You can. For example, this effective range can be variably adjusted.

According to one embodiment, the processor 1090 may adjust the gain if the converted digital voltage is not valid (S2020). When measuring glucose based on non-invasive methods, the glucose level is determined based on the user's conditions (e.g. skin temperature, finger pressure, finger thickness, skin condition, skin color, body mass index (BMI)). Therefore, it may differ from the measured glucose level.

To reduce (or eliminate) the measurement error between these invasive and non-invasive methods, the processor 1090 may adjust the gain so that the digital voltage is within an effective range.

For example, the processor 1090 may irradiate a light source, determine whether the digital voltage is within a valid range based on the amount of light transmitted through the finger, and perform a one-time process of adjusting the gain.

According to one embodiment, the processor 1090 may identify whether measured glucose is obtained a predetermined number of times for each of the invasive and non-invasive methods (S2022). The processor 1090 can receive glucose levels measured four times using an invasive method. Additionally, the processor 1090 can measure glucose levels non-invasively 10 times. The above-described 4 times in the invasive method and 10 times in the non-invasive method are only examples, and the present invention can receive the glucose level by the invasive method at least once and also input the glucose level by the non-invasive method at least once. It can be measured.

For example, 4 times in the invasive method is 1 time before a meal and 3 times after a meal, and 10 times in the non-invasive method is 4 times before a meal and 6 times after a meal. In addition, the glucose measurement using the non-invasive method may be a measurement performed a predetermined time (eg, 15 to 20 minutes) after the glucose measurement using the invasive method. The above-mentioned 1 time before and 3 times after a meal in the invasive method and 4 times before and 6 times after a meal in the non-invasive method are only examples, and the present invention provides a method for measuring glucose levels by the invasive method and the non-invasive method according to various times or conditions. can be measured.

The sequence and time of glucose measurement by invasive and non-invasive methods are as follows.

For example, after the gain is adjusted, the user measures glucose by invasive and non-invasive methods (invasive: once, non-invasive: once) while fasting. After the user measures glucose using a non-invasive method, glucose is measured three times (a total of four times) using a non-invasive method every 15 minutes. Therefore, the user can measure glucose once by an invasive method and four times by a non-invasive method while fasting.

Thereafter, after eating, the user measures glucose using invasive and non-invasive methods (invasive: once, non-invasive: once). After the user measures glucose non-invasively, glucose is measured 5 times non-invasively every 15 minutes (6 times in total). Then, after measuring glucose using the invasive method, the user measures glucose twice (3 times in total) using the non-invasive method every 30 minutes. Accordingly, the user can measure glucose 3 times using an invasive method and 6 times using a non-invasive method after a meal.

In this way, glucose measurements for correction are performed 4 times in an 8-hour fasting state and 6 times after a meal.

In this way, the non-invasive glucose measurement device 1 of the present invention measures glucose non-invasively, mainly focusing on blood sugar in interstitial fluid, and measures blood sugar in the blood invasively through blood collection. The reason for measuring glucose non-invasively after a predetermined time (e.g. 15 to 20 minutes) after measuring glucose invasively through blood collection is that the time for blood sugar in the blood to be transferred to the interstitial fluid is about 15 minutes. Because it is about 20 minutes.

Referring to (a) and (b) of FIG. 22, the processor 1090 displays a screen 2210 for receiving conditions for measuring glucose by a non-invasive method on the input/output unit 1080 (e.g., display unit 1081). It can be displayed in .

The screen 2210 may include menus for fasting (2211), 1 hour after a meal (2212), 1 hour and 30 minutes after a meal (2213), and 2 hours after a meal (2214).

When glucose is measured based on these measurement conditions, the processor 1090 may display a screen containing different glucose levels for each condition on the input/output unit 1080 (e.g., display unit 1081).

As described above, when the user performs glucose measurement based on measurement conditions, the processor 1090 can obtain glucose levels according to each measurement condition and store them in the memory 1060.

Referring to (a) to (c) of FIG. 23, the processor 1090 can obtain the glucose level measured through blood sampling through the input/output unit 1080 (eg, display unit 1081). For example, the user can input the glucose level measured four times through blood sampling through the input/output unit 1080 (e.g., display unit 1081).

For example, to input the glucose level measured through blood collection, the user may touch the next 2311 on the screen 2310 and then enter the measured glucose level 2321 on the input screen 2320. there is. Thereafter, when save 2322 is selected, the processor 1090 displays a guidance screen 2330 for blood sugar correction. Then, when the user selects OK (2331), the processor 1090 performs blood sugar correction by reflecting the glucose level measured by the invasive method.

According to one embodiment, the processor 1090 may first correct glucose by first analyzing the trend of digital voltage based on temperature (S2024). The processor 1090 reflects the temperature obtained in the process (S2014) to the average of the glucose levels measured 10 times non-invasively in the process (S2022) (or the glucose levels measured at least once, or the average) to obtain a digital Primary correction can be performed to analyze voltage trends.

Referring to FIG. 24, the slope 2410 between temperature and digital voltage is approximately -68, and the processor 1090 uses this slope to correct the voltage measured first. For example, since the temperature of the finger is about 25 ^o to 35 ^o , the temperature is corrected by using 30 ^o as the reference point and subtracting the product of the temperature difference and slope at lower temperatures, and adding that much at higher temperatures.

For example, the processor 1090 can generate an algorithm using the equation below based on the temperature 2421 and the digital voltage slope 2410.

The processor 1090 can obtain information about glucose purely by reflecting the influence of temperature.

And, the processor 1090 can calculate the blood sugar level through [Equation 2] below.

In addition, when the processor 1090 substitutes the correction value into [Equation 2] above ([Equation 3] below), the final calculated value is calculated through the digital voltage value and temperature measured with the non-invasive glucose measurement device according to the present invention. The blood sugar level can be calculated, and the calculated blood sugar level can be displayed on the display unit 1081.

As described above, the non-invasive glucose measurement device 1 of the present invention can correct glucose by reflecting temperature.

For example, the digital voltage compared to temperature decreases from 1560 mV to 1400 mV when the finger temperature rises from 27 ^o to 29 ^o , and when the finger temperature rises from 30 ^o to 32 ^o , the digital voltage decreases from 1360 mV to 1320 mV. and when the temperature of the finger rises from 32 ^o to 33 ^o , the digital voltage drops from 1320 mV to 1280 mV.

Likewise, when the temperature rises, the digital voltage may drop, and this may vary depending on the user's conditions.

According to one embodiment, the processor 1090 may perform a secondary analysis of the trend of glucose by an invasive method and perform a secondary correction of the first corrected glucose (S2026). The processor 1090 performs primary correction of glucose by first analyzing the trend of digital voltage based on temperature, and then performs secondary analysis of the trend of glucose using an invasive method to additionally perform secondary correction of the first corrected glucose. there is.

This secondary correction refers to mapping the primary corrected glucose to the glucose level actually obtained through blood collection in the above process (S2022).

Referring to FIG. 25, the glucose level 2520 using the non-invasive glucose measurement device 1 according to an embodiment of the present invention is very similar to the glucose level 2510 obtained through blood collection. For example, it can be seen that the glucose level (2520) measured using the non-invasive glucose measurement device (1) around 13:40 and the glucose level (2510) obtained through blood collection are similar at about 190 mg/dL. .

According to one embodiment, the processor 1090 may generate and store an algorithm based on secondary corrected glucose (S2028). The processor 1090 may create an algorithm that maps the initially corrected glucose level to the glucose level actually obtained through blood sampling in the process (S2022) and store it in the memory 1060.

As described above, the non-invasive glucose measurement device (1) according to the present invention corrects glucose by reflecting the temperature, so that even when measuring glucose using a non-invasive method, the glucose level is close to or close to the glucose level measured by the invasive method. Alternatively, the same glucose levels can be obtained.

Each step in each flowchart described above may be operated regardless of the order shown, or may be performed simultaneously. Additionally, at least one component of the present invention and at least one operation performed by the at least one component may be implemented in hardware and/or software.

As described above, the present invention has been described with reference to the illustrative drawings, but the present invention is not limited to the embodiments and drawings disclosed herein, and various modifications may be made by those skilled in the art within the scope of the technical idea of the present invention. It is obvious that transformation can occur. In addition, although the operational effects according to the configuration of the present invention were not explicitly described and explained while explaining the embodiments of the present invention above, it is natural that the predictable effects due to the configuration should also be recognized.

1: Non-invasive glucose measurement device 130: Light irradiation unit
140: light receiving unit 150: control unit
160: pressure sensor 170: temperature sensor unit
1010: Current/voltage converter 1020: Filter
1030: Amplifier 1040: A/D converter
1050: Controller 1060: Memory
1070: Communication unit 1080: Input/output unit
1090: Processor 1710: Light emitting element
1720: Spherical lens 1730: Aspherical lens
1740: Case 1750: Detection area
1760: photo diode 1810: aperture
1820: cover 1910: substrate

Claims (15)

In a non-invasive glucose measurement device that corrects glucose by reflecting temperature,
A light irradiation unit located on one side of the inner seating portion and irradiating light toward the finger inserted into the inner seating portion;
a light receiving unit located on the other side of the inner seating part with the finger in between, and receiving the light irradiated from the light irradiation unit and passing through the finger;
a temperature sensor unit that detects the temperature of a finger inserted into the internal seating unit through a hole provided inside the internal seating unit;
A pressure sensor located below the inserted finger and measuring the pressure caused by the finger by measuring the degree of bending of the PCB (Printed Circuit Board) caused by the pressure caused by the finger.
display unit; and
A change in refractive index due to a change in at least one of intracellular fluid (ICF) and interstitial fluid for the finger based on the light irradiated toward the finger from the light irradiation unit disposed below the finger. Identify, convert the current corresponding to the amount of light transmitted through the finger into voltage, filter the frequency of the converted voltage into a predetermined frequency band, and measure the user's glucose by compensating for the voltage of the filtered frequency. It includes a control unit set to
The light irradiation unit,
A light emitting element that outputs the light ray,
A spherical lens disposed on top of the light emitting element, and
An aspherical lens is disposed on top of the spherical lens and outputs non-parallel light rays passing through the spherical lens as parallel rays - the aspherical lens converts non-parallel light rays passing through the spherical lens into parallel rays and outputs them. The refractive index of the front and the back are different so that
The control unit,
Adjusting the gain value differently depending on the thickness of the finger, compensating the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency, and amplifying the compensated voltage,
Primary correction of glucose is performed by reflecting the detected temperature to the measured glucose,
Displaying a screen through the display unit that guides the invasive glucose measurement for the finger and inputs the glucose value measured through the invasive method,
Secondary correction is performed by matching the first corrected glucose value to the glucose value obtained by the invasive method and input through the screen,
The control unit,
Acquire the temperature of the finger measured through the temperature sensor unit in real time,
Obtaining the pressure of the finger measured through the pressure sensor in real time,
A non-invasive glucose measurement device that displays a graph for each of the amount of light transmitted through the finger placed on the internal seating portion, the obtained temperature, and the obtained pressure in real time through the display unit.
According to claim 1,
The temperature sensor is,
a first temperature sensor disposed on one side of the inner seating portion and detecting a first temperature of the upper surface of the finger; and
A non-invasive glucose measurement device comprising a second temperature sensor disposed on the other side of the inner seating portion and detecting a second temperature of the lower surface of the finger.
According to clause 2,
The control unit,
A current/voltage converter that converts the current for the amount of light into voltage;
a filter that filters the frequency of the converted voltage into the predetermined frequency band;
A regulator that adjusts the gain value to correspond to the user's conditions for measuring glucose;
an amplifier that amplifies the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency;
An A/D (Analog to Digital) converter that converts the amplified voltage into a digital voltage; and
A non-invasive glucose measurement device comprising a processor configured to measure the user's glucose using the converted digital voltage.
According to clause 3,
The processor,
A non-invasive glucose measurement device configured to apply at least one of the first temperature, the second temperature, and an average temperature of the first temperature and the second temperature to correction for the user's glucose measurement.
According to clause 3,
The processor,
Identifying the amount of light of the received light beam,
A non-invasive glucose measurement device configured to obtain glucose values measured in invasive and non-invasive ways while the digital voltage converted based on the identified light amount is within the effective range.
According to clause 5,
The processor,
If the digital voltage is not within the effective range, the gain is adjusted through the regulator so that the converted digital voltage is within the effective range,
A non-invasive glucose measurement device, characterized in that the effective range is 400mV to 800mV.
According to clause 5,
A non-invasive glucose measuring device, characterized in that the number of glucose measurements by the invasive method is 4, and the number of glucose measurements by the non-invasive method is 10.
According to clause 7,
The 4 times in the invasive method are 1 time before and 3 times after a meal,
The 10 times for the non-invasive method is 4 times before and 6 times after meals,
Glucose measurement by the non-invasive method is,
A non-invasive glucose measurement device, characterized in that the measurement is performed 15 to 20 minutes after the glucose measurement using the invasive method.
delete According to clause 5,
The processor,
A non-invasive glucose measurement device configured to generate a glucose algorithm for the user based on the glucose obtained by the secondary correction and store the generated algorithm in a memory.
In a method performed in a non-invasive glucose measurement device that corrects glucose by reflecting temperature,
The non-invasive glucose measurement device,
A light irradiation unit located on one side of the internal seating unit and irradiating light toward the finger inserted into the internal seating unit, located on the other side of the internal seating unit with the finger in between, and irradiated from the light irradiation unit and passing through the finger. A light receiving unit for receiving a light beam, a temperature sensor unit for detecting the temperature of a finger inserted into the internal seating unit through a hole provided inside the internal seating unit, located at the lower part of the inserted finger, and It includes a pressure sensor that measures the pressure exerted by the finger by measuring the degree of bending of the PCB (Printed Circuit Board) due to pressure, and a display unit,
A process of detecting the temperature of a finger inserted into the inner seating portion;
A change in refractive index due to a change in at least one of intracellular fluid (ICF) and interstitial fluid for the finger based on the light irradiated toward the finger from the light irradiation unit disposed below the finger. The process of identifying;
A process of converting a current corresponding to the amount of light passing through the finger into a voltage and filtering the frequency of the converted voltage into a predetermined frequency band; and
It includes a process of measuring the user's glucose by compensating for the voltage of the filtered frequency,
The light irradiation unit,
A light emitting element that outputs the light beam,
A spherical lens disposed on top of the light emitting element, and
An aspherical lens is disposed on top of the spherical lens and outputs non-parallel rays passing through the spherical lens as parallel rays - the aspherical lens converts the non-parallel rays passing through the spherical lens into parallel rays and outputs them. The refractive index of the front and the back are different, so that
The method is:
adjusting the gain value differently depending on the thickness of the finger, compensating the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency, and amplifying the compensated voltage;
A process of first correcting glucose by reflecting the sensed temperature to the measured glucose;
A process of guiding invasive glucose measurement for the finger through the display unit;
A process of displaying, through the display unit, a screen that receives the glucose value measured through the invasive method;
Further comprising the step of performing secondary correction by matching the first corrected glucose value to the glucose value obtained by the invasive method and input through the screen,
The method is,
A process of acquiring the temperature of the finger measured through the temperature sensor unit in real time;
A process of acquiring in real time the pressure exerted by the finger measured through the pressure sensor; and
A method comprising displaying a graph for each of the amount of light transmitted through the finger resting on the internal seating portion, the obtained temperature, and the obtained pressure in real time through the display unit.
According to claim 11,
The process of correcting the glucose is,
A process of identifying the amount of light of the received light beam;
A process of determining whether the converted digital voltage is within a valid range based on the identified light quantity; and
A method comprising obtaining glucose values measured using invasive and non-invasive methods while the converted digital voltage is within the effective range.
According to claim 12,
The process of correcting the glucose is,
If the digital voltage is not within the effective range, the method includes adjusting the gain so that the converted digital voltage is within the effective range.
delete According to claim 11,
The process of correcting the glucose is,
generating a glucose algorithm for the user based on the glucose obtained by the secondary correction; and
A method including the process of storing the generated algorithm.

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