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SG10201913247XA - Antibody/t-cell receptor chimeric constructs and uses thereof - Google Patents

Antibody/t-cell receptor chimeric constructs and uses thereof

Info

Publication number
SG10201913247XA
SG10201913247XA SG10201913247XA SG10201913247XA SG10201913247XA SG 10201913247X A SG10201913247X A SG 10201913247XA SG 10201913247X A SG10201913247X A SG 10201913247XA SG 10201913247X A SG10201913247X A SG 10201913247XA SG 10201913247X A SG10201913247X A SG 10201913247XA
Authority
SG
Singapore
Prior art keywords
antibody
cell receptor
chimeric constructs
receptor chimeric
constructs
Prior art date
Application number
SG10201913247XA
Inventor
Jingwei Lu
Zhiyuan Yang
Cheng Liu
Hong Liu
Yiyang Xu
Su Yan
Vivien Wai-Fan Chan
Lucas Horan
Original Assignee
Eureka Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eureka Therapeutics Inc filed Critical Eureka Therapeutics Inc
Publication of SG10201913247XA publication Critical patent/SG10201913247XA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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  • Proteomics, Peptides & Aminoacids (AREA)
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SG10201913247XA 2015-10-23 2016-10-21 Antibody/t-cell receptor chimeric constructs and uses thereof SG10201913247XA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562245944P 2015-10-23 2015-10-23
US201662304918P 2016-03-07 2016-03-07
US201662345649P 2016-06-03 2016-06-03
US201662369694P 2016-08-01 2016-08-01

Publications (1)

Publication Number Publication Date
SG10201913247XA true SG10201913247XA (en) 2020-02-27

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SG10201913245UA SG10201913245UA (en) 2015-10-23 2016-10-21 Antibody/t-cell receptor chimeric constructs and uses thereof
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Country Status (18)

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US (6) US11421013B2 (en)
EP (2) EP3842450A1 (en)
JP (3) JP7316042B2 (en)
KR (1) KR20180063325A (en)
CN (4) CN107614519B (en)
AU (2) AU2016342041B2 (en)
CA (1) CA3001137A1 (en)
DK (1) DK3365364T5 (en)
ES (1) ES2979220T3 (en)
HK (2) HK1248243A1 (en)
IL (3) IL314725A (en)
MX (1) MX2018004721A (en)
MY (1) MY194628A (en)
PH (1) PH12018500861A1 (en)
RU (2) RU2022103665A (en)
SG (3) SG10201913247XA (en)
TW (1) TWI780031B (en)
WO (1) WO2017070608A1 (en)

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RU2762359C2 (en) 2014-12-05 2021-12-20 Мемориал Слоан-Кеттеринг Кэнсер Сентер Chimeric antigenic receptors aimed at receptor bound to g-proteins, and their application
KR102602417B1 (en) * 2014-12-05 2023-11-16 메모리얼 슬로안 케터링 캔서 센터 Antibodies targeting g-protein coupled receptor and methods of use
EP3770168A1 (en) 2015-05-18 2021-01-27 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
SG10201913247XA (en) 2015-10-23 2020-02-27 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
EP3516068A4 (en) 2016-09-19 2020-10-14 University of Southern California Non-radioactive cytotoxicity assays
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CA3001137A1 (en) 2017-04-27
PH12018500861A1 (en) 2018-11-05
US10464988B2 (en) 2019-11-05
RU2022103665A (en) 2022-03-05
US20190248865A1 (en) 2019-08-15
RU2018118652A3 (en) 2021-01-29
CN116059316A (en) 2023-05-05
KR20180063325A (en) 2018-06-11
HK1258274A1 (en) 2019-11-08
CN115927191A (en) 2023-04-07
US20220348629A1 (en) 2022-11-03
MX2018004721A (en) 2018-07-06
US20210253665A1 (en) 2021-08-19
DK3365364T5 (en) 2024-09-30
RU2767209C2 (en) 2022-03-16
AU2016342041B2 (en) 2021-12-02
IL295398A (en) 2022-10-01
US10098951B2 (en) 2018-10-16
IL258405B (en) 2022-09-01
IL314725A (en) 2024-10-01
DK3365364T3 (en) 2024-05-06
TW201730208A (en) 2017-09-01
US20200115434A1 (en) 2020-04-16
EP3365364A4 (en) 2019-08-07
US10822389B2 (en) 2020-11-03
AU2016342041A1 (en) 2018-04-19
IL258405A (en) 2018-05-31
RU2018118652A (en) 2019-11-26
EP3842450A1 (en) 2021-06-30
SG11201802895QA (en) 2018-05-30
AU2022201334A1 (en) 2022-03-31
SG10201913245UA (en) 2020-02-27
IL295398B1 (en) 2024-09-01
CN115925973A (en) 2023-04-07
TWI780031B (en) 2022-10-11
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US20190022216A1 (en) 2019-01-24
JP2019500848A (en) 2019-01-17

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