US20020087182A1 - Microblade array impact applicator - Google Patents
Microblade array impact applicator Download PDFInfo
- Publication number
- US20020087182A1 US20020087182A1 US09/976,763 US97676301A US2002087182A1 US 20020087182 A1 US20020087182 A1 US 20020087182A1 US 97676301 A US97676301 A US 97676301A US 2002087182 A1 US2002087182 A1 US 2002087182A1
- Authority
- US
- United States
- Prior art keywords
- piston
- penetrating member
- stratum corneum
- impact
- impacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000000434 stratum corneum Anatomy 0.000 claims abstract description 93
- 230000003213 activating effect Effects 0.000 claims abstract description 6
- 230000007246 mechanism Effects 0.000 claims description 91
- 230000000149 penetrating effect Effects 0.000 claims description 90
- 230000003116 impacting effect Effects 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 16
- 230000004913 activation Effects 0.000 claims description 7
- 230000033001 locomotion Effects 0.000 claims description 6
- 210000003491 skin Anatomy 0.000 description 36
- 239000003795 chemical substances by application Substances 0.000 description 29
- 238000005070 sampling Methods 0.000 description 14
- 230000004907 flux Effects 0.000 description 7
- 230000037317 transdermal delivery Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000012491 analyte Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000003961 penetration enhancing agent Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
- A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15107—Piercing being assisted by a triggering mechanism
- A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15142—Devices intended for single use, i.e. disposable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
- A61B5/15188—Constructional features of reusable driving devices
- A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
- A61B5/15194—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Definitions
- the invention relates to an apparatus and method for applying a penetrating member to the stratum corneum layer of the skin by impact, and more particularly, the invention relates to the use of an impact device to reproducibly penetrate the stratum corneum with a penetrating member such as a microprotrusion array for transdermal delivery or sampling of an agent.
- a penetrating member such as a microprotrusion array for transdermal delivery or sampling of an agent.
- a permeation enhancer substance when applied to a body surface through which the agent is delivered, enhances the transdermal flux of the agent such as by increasing the permselectivity and/or permeability of the body surface, and/or reducing the degradation of the agent.
- Electrotransport refers generally to the passage of a beneficial agent, e.g., a drug or drug precursor, through a body surface, such as skin, mucous membranes, nails, and the like.
- a beneficial agent e.g., a drug or drug precursor
- the transport of the agent is induced or enhanced by the application of an electrical potential, which results in the application of electric current, which delivers or enhances delivery of the agent.
- Electrotransport delivery generally increases agent delivery and reduces polypeptide degradation during transdermal delivery.
- These devices use piercing elements of various shapes and sizes to pierce the outermost layer (i.e., the stratum corneum) of the skin.
- the penetrating elements disclosed in these references generally extend perpendicularly from a thin, flat member, such as a pad or sheet.
- the penetrating elements in some of these devices are extremely small, some having dimensions (i.e., a microblade length and width) of only about 25-400 ⁇ m and a microblade thickness of only about 5-50 ⁇ m.
- Other penetrating elements are hollow needles having diameters of about 10 ⁇ m or less and lengths of about 50-100 ⁇ m.
- These tiny stratum corneum piercing/cutting elements are meant to make correspondingly small microslits/microcuts in the stratum corneum for enhanced transdermal agent delivery therethrough.
- the microslits/microcuts in the stratum corneum have a length of less than 150 ⁇ m and a width which is substantially smaller than their length.
- Skin penetrating devices are used to penetrate the outermost layer of the skin, i.e., stratum corneum, with a plurality of microprotrusions to form pathways through which an agent such as a drug can be introduced, i.e., delivered, or an agent such as a body analyte can be withdrawn, i.e., sampled.
- the perforated skin provides improved flux for sustained agent delivery or sampling through the skin.
- microprotrusion arrays are used to improve delivery or sampling of agents through the skin, consistent, complete, and repeatable penetration is desired.
- Manual application of a skin patch having microprotrusions protruding from its skin-contacting side often results in significant variation in puncture depth across the length and width of the patch.
- manual application results in large variations in puncture depth between applications due to the manner in which the user applies the array. Accordingly, it would be desirable to be able to apply a microprotrusion array to the stratum corneum with an automatic device, which provides in a consistent and repeatable manner, stratum corneum piercing not only over the length and width of the microprotrusion array but also from application of one microprotrusion array to the next.
- Some known spring loaded applicator devices for delivery of lancets for body fluid (e.g., blood) sampling are described in WO 99/26539 and WO 97/42886.
- these devices are difficult to use because they require two handed cocking of the applicator device prior to application.
- the known spring loaded lancet applicators require either two sections of the device to be pulled apart for cocking or require one part of the device to be twisted with respect to another part of the device for cocking. In both of these motions two handed cocking operation is required. Many of the patients using these devices possess neither the strength nor the manual dexterity to cock these known applicator devices.
- the present invention relates to an applicator for applying a penetrating member to the stratum corneum with impact.
- the penetrating member may be a microprotrusion array which is used to improve transport of an agent across the skin.
- the applicator includes a cocking mechanism which allows one handed cocking operation. The cocking mechanism requires minimal hand strength and dexterity since the cocking force can be applied by a user's arm.
- a device for impacting a penetrating member against the stratum corneum includes a device body for application of a penetrating member to the stratum corneum, a piston mounted within the device body for impacting the penetrating member against the stratum corneum, an impact spring between the piston and the device body for providing an impact force to the piston, and a cocking mechanism for cocking and locking the piston in a cocked position by compressing the device body and piston together using a compressing force which can be easily performed with one hand.
- a device for impacting a microblade array against the stratum corneum includes a device body, a piston mounted within the device body, the piston having a microblade array applying surface, an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade array, a cap movably mounted on the device body, a hold down spring acting between the device body and the cap, a cocking mechanism for cocking and locking the piston in a cocked position with one hand by compressing the device body and piston together, and a piston release for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
- a method of cocking a device for impacting a penetrating member against the stratum corneum includes the steps of moving a piston to a cocked position with respect to a device body by compressing the piston and device body together with only one hand, and locking the piston in the cocked position with the one hand.
- a method of impacting a penetrating member against the stratum corneum includes providing an impacting device having a device body, a piston, and an impact spring; cocking the impacting device using only one hand by moving the piston to a cocked position with respect to the device body and locking the piston in the cocked position; mounting a penetrating member on the piston; and releasing the piston to impact the penetrating member against the stratum corneum
- FIG. 1 is side cross sectional view of an applicator device in an initial configuration prior to cocking
- FIG. 2 is a side cross sectional view of the applicator device of FIG. 1 in a cocked position with a patch retainer attached to the applicator;
- FIG. 3 is a side cross sectional view of the applicator device of FIG. 1 with the patch retainer of FIG. 2 after the piston has been released to apply the patch;
- FIG. 4 is an exploded perspective view of the applicator device of FIG. 1;
- FIG. 5 is a perspective view of an alternative embodiment of an applicator device
- FIG. 6 is a side view, partially in section, of the applicator device of FIG. 5;
- FIG. 7 is a perspective view of a portion of one example of a microprotrusion array.
- the applicator device of the present invention is used for repeatable impact application of an array of microprotrusions to the stratum corneum in conjunction with transdermal therapeutic agent (e.g., drug) delivery or transdermal body analyte (e.g., glucose) sampling.
- transdermal therapeutic agent e.g., drug
- transdermal body analyte e.g., glucose
- the applicator device 10 is described for use with a certain type of microprotrusion array, it should be understood that the applicator device may also be used with other types of stratum corneum micropenetrating members.
- the applicator device can be used by patients having neither the hand strength nor the manual dexterity to cock other types of spring-loaded applicator devices. Further, the applicator device can be cocked and released with one-handed operation which provides certain advantages, for example, allowing a patient to apply a drug delivering microprotrusion array for local therapy on a site on the patient's own arm.
- FIG. 1 illustrates applicator device 10 including a device body 12 and a piston 14 movable within the device body.
- a cap 16 is provided on the device body 12 for activating the applicator to impact the stratum corneum with a microprotrusion array (not shown in FIG. 1).
- An impact spring 20 is positioned around a post 22 of the piston 14 and biases the piston downward with respect to the device body 12 .
- the piston 14 has a lower surface 18 which is substantially planar, slightly convex, or configured to a body surface (i.e., a specific skin site).
- the lower surface 18 of the piston 14 causes a microprotrusion array or a transdermal patch containing a microprotrusion array to impact and pierce the stratum corneum.
- FIG. 1 shows the piston 14 in an uncocked position
- FIG. 2 shows the piston in the cocked position.
- the locking mechanism includes a catch 26 on the post 22 and a flexible finger 28 on the device body 12 having a corresponding latch 30 .
- the catch 26 flexes the finger 28 and snaps over the corresponding latch 30 of the flexible finger 28 .
- the cocking step is performed by a single compression motion which both cocks and locks the piston 14 in the cocked position. This cocking step is easily performed with only one hand by compressing the applicator device 10 between a user's hand and another surface (e.g. a table top).
- FIG. 2 illustrates the applicator device 10 with the piston 14 in a cocked configuration.
- the catch 26 and latch 30 on the piston 14 and device body 12 are releasably engaged preventing downward motion of the piston in the device body.
- FIG. 2 also illustrates a patch retainer 34 mounted on the device body 12 .
- the retainer 34 has an annular shape with a first end 40 which is configured to engage the device body 12 .
- a second end 42 of the retainer 34 provides a stratum corneum contacting surface.
- a patch 44 is mounted between the first and second ends 40 , 42 of the retainer 34 .
- the patch 44 is suspended in the retainer 34 .
- the manner in which the patch 44 is mounted in the retainer 34 and the location of the mounted patch 44 within the retainer 34 may vary (for example, the patch 44 may be positioned adjacent the second end 42 of the retainer 34 ) it is preferred to mount patch 44 recessed some distance from both ends 40 and 42 (as shown in FIG. 1) in order to avoid inadvertent contact of the patch microprotrusions with other objects (e.g., the fingers of the user).
- the patch 44 is connected by frangible sections of patch base material to an annular ring of patch material which is adhered to the retainer ring 34 .
- the patch 44 is separated from the retainer ring 34 by the downward force of the piston 14 .
- the patch may be releasably attached to the piston 14 or positioned on the skin beneath the piston.
- the applicator device 10 can be used with a patch 44 which generally includes a microprotrusion array, an agent reservoir, and a backing. However, the applicator device 10 may also be used with a microprotrusion array without an agent reservoir. In this case, the microprotrusion array is used as a pretreatment which is followed by the application of an agent with a separate transdermal agent delivery or sampling device. Alternatively, the microprotrusion array may incorporate the agent as a coating on the microprotrusions, e.g. for delivering a vaccine intradermally.
- the application device 10 may also be used for impacting other micropiercing elements against the stratum corneum, for example those disclosed in Godshall et al, U.S. Pat. No. 5,879,326 and Zuck WO 99/29364, the disclosures of which are incorporated by reference herein.
- device 10 In addition to being able to cock the device 10 with only one hand, device 10 is also designed to be operated (i.e., to cause release of the spring-loaded piston 14 and thus causing the patch 44 to impact the skin) using only one hand.
- the activation of the applicator device 10 by releasing the locking mechanism is performed by downward force applied to the applicator cap 16 while the second end 42 of the applicator device is held against the skin.
- the cap 16 is biased upwards by a hold down spring 24 which is positioned between the device body 12 and the cap.
- the cap 16 includes a pin 46 extending downward from the cap.
- FIG. 3 illustrates the applicator device 10 after the device has been released and a patch has been applied to the stratum corneum.
- the hold down spring 24 is selected such that a predetermined hold down force must be achieved before the device is released.
- the hold down force causes the stratum corneum to be stretched by the second end 42 of the retainer 34 so that the skin is under optimal tension at the time the patch 44 impacts the skin.
- the hold down force applied by the hold down spring 24 is preferably selected to cause the second end 42 to apply a tension to the skin in the range of about 0.01 to 10 megapascals (MPa), more preferably about 0.05 to 2 MPa.
- a balance between the hold down spring 24 and the impact spring 20 allows the cocking of the piston 14 by pressing on the cap 16 without causing the finger 46 to release the locking mechanism.
- the impact spring 20 is selected to achieve a predetermined impact which is appropriate for a particular patch to provide the desired penetration. The selection of the impact and hold down springs is described further in U.S. Provisional Patent Application Serial No. 60/240,307 filed on even date herewith, which is incorporated herein by reference in its entirety.
- the retainer 34 is attached to the device body 12 after cocking of the piston 14 .
- the retainer 34 is attached by a snap in connection requiring less force to snap in than the force required to release the piston.
- the retainer 34 may also be attached to the device body by a bayonett fitting or a slide-on fitting which allows the retainer 34 to slide into the device body 12 in a direction normal to the axis of the applicator.
- FIG. 4 illustrates the cap 16 , device body 12 , and piston 14 in an exploded perspective view.
- the piston 14 includes piston retainer tabs 52 which engage a lower rim 54 (FIG. 3) of the device body 12 and prevent the piston from being expelled from the device body.
- the cap 16 includes retainer tabs (not shown) which similarly engage an upper rim 58 (FIG. 3) of the device body 12 and prevent the cap from coming off of the body.
- FIG. 4 also illustrates an optional rotational locking arrangement which allows the cap 16 to be rotated to a locked position at which activation of the applicator is not possible because the pin 46 is not aligned with the flexible finger 28 .
- An indication of the locked or unlocked position of the cap 16 is provided through a window 60 in the cap. When the cap 16 is at positions other than the unlocked position, the pin 46 is not aligned with the ramp 48 on the flexible finger 28 and thus, the applicator cannot be released. While this optional locking feature prevents inadvertent activation of the applicator device 10 , the relative rotational motion of the body 12 and the cap 16 generally requires the use of both hands, which in some cases is less desirable.
- FIGS. 5 and 6 illustrate an alternative embodiment of an applicator 80 having a different shape and somewhat different cocking arrangement which also achieves the desired result of simple one handed cocking operation.
- the user grasps an outer cylinder 81 which acts as a handle for the device.
- a piston 82 is slidably engaged within the cylinder 81 .
- An impact spring 83 shown in compression in FIG. 6 biases the piston 82 away from the top or skin distal end of cyclinder 81 .
- a releasable catch mechanism 84 (not shown in detail in FIG.
- a middle housing 87 having an indicator notch 96 .
- lower housing 88 Threaded to housing 87 is lower housing 88 which has a generally annular shape.
- a retainer 93 whose function is described in detail in U.S. Provisional Patent Application Serial No. 60/240,379 filed on even date herewith and incorporated herein by reference is screwed onto the skin proximal end of cyclinder 81 .
- an impact head 94 which is attached to piston 82 .
- Impact head 94 is adapted to hold, on its skin proximal suface, a patch having a plurality of microprotrusions (the patch is not shown in FIG. 6).
- a hold down spring 95 shown in compression in FIG. 6, is provided between cyclinder 81 and middle housing 87 . Hold down spring 95 compresses when the user grabs cylinder 81 , places edge 89 against the skin site to be pierced, and presses the device 80 against the skin site. As spring 95 is compressed, notch 96 becomes aligned with the lower edge of band 97 . In this alignment, the hold down spring 95 is in a predetermined compression which provides the necessary hold down force and skin stretching at edge 89 .
- the applicator devices 10 and 80 have been described with respect to an upright orientation in which the patch 44 is applied from a piston side of the device which is illustrated at the bottom/skin proximal end of the devices in the figures. It should be understood that the applicator devices may be used in other orientations (i.e., sideways and upside down) as long as the device is properly oriented against the skin site to be pierced.
- FIG. 7 illustrates one embodiment of a stratum corneum penetrating member for use with the present invention.
- FIG. 7 shows a plurality of microprotrusions in the form of microblades 90 .
- the microblades 90 extend at a substantially 90° angle from a metal sheet 92 having openings 94 .
- the sheet 92 may be incorporated in an agent delivery patch or an agent sampling patch which includes an agent reservoir and an adhesive for adhering the patch to the stratum corneum. Examples of agent delivery and sampling patches which incorporate a microprotrusion array are found in WO 97/48440, WO 97/48441, WO 97/48442.
- the microprotrusion array of FIG. 7 without a reservoir may also be applied alone as a skin pretreatment.
- microprotrusion refers to very tiny stratum corneum piercing elements typically having a length of less than 500 ⁇ m, and preferably less than 250 ⁇ m, which pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. However, the microprotrusions should not penetrate so deep into the dermis layer as to cause bleeding. In order to penetrate the stratum corneum, the microprotrusions preferably have a length of at least 10 ⁇ m, more preferably at least 50 ⁇ m. In general, microprotrusions penetrate the skin to a depth of no more than about 500 ⁇ m and preferably less than about 400 ⁇ m.
- the microprotrusions may be formed in different shapes, such as needles, hollow needles, blades, pins, punches, and combinations thereof.
- microprotrusion array refers to a plurality of microprotrusions arranged in an array for piercing the stratum corneum.
- the microprotrusion array may be formed by cutting a plurality of blades from a thin metal sheet and folding each of the blades out of the plane of the sheet to form the configuration shown in FIG. 7.
- the microprotrusion array may also be formed in other known manners, such as by connecting multiple strips having microprotrusions along an edge of each of the strips.
- the microprotrusion array may include hollow needles which inject a liquid formulation.
- microprotrusion arrays are described in U.S. Pat. Nos. 5,879,326 issue to Godshall, et al., 3,814,097 issued to Ganderton, et al., 5,279,544 issued to Gross, et al., 5,250,023 issued to Lee, et al., 3,964,482 issued to Gerstel, et al., Reissue 25,637 issued to Kravitz, et al., and PCT Publication Nos.
- the device of the present invention can be used in connection with agent delivery, agent sampling, or both.
- the device of the present invention is used in connection with transdermal drug delivery, transdermal analyte (e.g., glucose) sampling, or both.
- Transdermal delivery devices for use with the present invention include, but are not limited to passive devices, osmotic devices, pressure-driven devices, and electrotransport devices.
- Transdermal sampling devices for use with the present invention include, but are not limited to, passive devices, negative pressure driven devices, osmotic devices, and reverse electrotransport devices.
- the transdermal devices of the present invention may be used in combination with other methods of increasing agent flux, such as skin permeation enhancers.
- the device of the present invention may be used with a microprotrusion array included in a transdermal delivery or sampling patch having adhesive for attaching the patch to the skin.
- the microprotrusion array and delivery or sampling patch may be two separate elements with the microprotrusion array used for pretreatment prior to application of the delivery or sampling patch.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Manufacturing & Machinery (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Finger-Pressure Massage (AREA)
- Surgical Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Coating Apparatus (AREA)
- Dental Preparations (AREA)
- Pens And Brushes (AREA)
- Paper (AREA)
- Stereo-Broadcasting Methods (AREA)
- Noise Elimination (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Prostheses (AREA)
Abstract
An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44,90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.
Description
- The invention relates to an apparatus and method for applying a penetrating member to the stratum corneum layer of the skin by impact, and more particularly, the invention relates to the use of an impact device to reproducibly penetrate the stratum corneum with a penetrating member such as a microprotrusion array for transdermal delivery or sampling of an agent.
- Interest in the percutaneous or transdermal delivery of peptides and proteins to the human body continues to grow with the increasing number of medically useful peptides and proteins becoming available in large quantities and pure form. The transdermal delivery of peptides and proteins still faces significant problems. In many instances, the rate of delivery or flux of polypeptides through the skin is insufficient to produce a desired therapeutic effect due to their large size and molecular weight. In addition, polypeptides and proteins are easily degraded during and after penetration into the skin, prior to reaching target cells. Likewise, the passive transdermal flux of many low molecular weight compounds is too limited to be therapeutically effective.
- One method of increasing the transdermal delivery of agents relies on pre-treating the skin with, or co-delivering with the beneficial agent, a skin permeation enhancer. A permeation enhancer substance, when applied to a body surface through which the agent is delivered, enhances the transdermal flux of the agent such as by increasing the permselectivity and/or permeability of the body surface, and/or reducing the degradation of the agent.
- Another method of increasing the agent flux involves the application of an electric current across the body surface referred to as “electrotransport.” “Electrotransport” refers generally to the passage of a beneficial agent, e.g., a drug or drug precursor, through a body surface, such as skin, mucous membranes, nails, and the like. The transport of the agent is induced or enhanced by the application of an electrical potential, which results in the application of electric current, which delivers or enhances delivery of the agent. Electrotransport delivery generally increases agent delivery and reduces polypeptide degradation during transdermal delivery.
- There also have been many attempts to mechanically penetrate or disrupt the skin in order to enhance the transdermal flux. See for example, U.S. Pat. Nos. 5,879,326 issue to Godshall, et al., 3,814,097 issued to Ganderton, et al., 5,279,544 issued to Gross, et al., 5,250,023 issued to Lee, et al., 3,964,482 issued to Gerstel, et al., Reissue 25,637 issued to Kravitz, et al., and PCT Publication Nos.
WO 96/37155,WO 96/37256,WO 96/17648,WO 97/03718, WO 98/11937, WO 98/00193,WO 97/48440,WO 97/48441,WO 97/48442, WO 98/00193, WO 99/64580, WO 98/28037, WO 98/29298, and WO 98/29365. These devices use piercing elements of various shapes and sizes to pierce the outermost layer (i.e., the stratum corneum) of the skin. The penetrating elements disclosed in these references generally extend perpendicularly from a thin, flat member, such as a pad or sheet. The penetrating elements in some of these devices are extremely small, some having dimensions (i.e., a microblade length and width) of only about 25-400 μm and a microblade thickness of only about 5-50 μm. Other penetrating elements are hollow needles having diameters of about 10 μm or less and lengths of about 50-100 μm. These tiny stratum corneum piercing/cutting elements are meant to make correspondingly small microslits/microcuts in the stratum corneum for enhanced transdermal agent delivery therethrough. In many instances, the microslits/microcuts in the stratum corneum have a length of less than 150 μm and a width which is substantially smaller than their length. - Skin penetrating devices are used to penetrate the outermost layer of the skin, i.e., stratum corneum, with a plurality of microprotrusions to form pathways through which an agent such as a drug can be introduced, i.e., delivered, or an agent such as a body analyte can be withdrawn, i.e., sampled. The perforated skin provides improved flux for sustained agent delivery or sampling through the skin.
- When microprotrusion arrays are used to improve delivery or sampling of agents through the skin, consistent, complete, and repeatable penetration is desired. Manual application of a skin patch having microprotrusions protruding from its skin-contacting side often results in significant variation in puncture depth across the length and width of the patch. In addition, manual application results in large variations in puncture depth between applications due to the manner in which the user applies the array. Accordingly, it would be desirable to be able to apply a microprotrusion array to the stratum corneum with an automatic device, which provides in a consistent and repeatable manner, stratum corneum piercing not only over the length and width of the microprotrusion array but also from application of one microprotrusion array to the next.
- Some known spring loaded applicator devices for delivery of lancets for body fluid (e.g., blood) sampling are described in WO 99/26539 and WO 97/42886. However, these devices are difficult to use because they require two handed cocking of the applicator device prior to application. In particular, the known spring loaded lancet applicators require either two sections of the device to be pulled apart for cocking or require one part of the device to be twisted with respect to another part of the device for cocking. In both of these motions two handed cocking operation is required. Many of the patients using these devices possess neither the strength nor the manual dexterity to cock these known applicator devices.
- Accordingly, it would be desirable to provide a spring loaded applicator for a skin penetrating member which is cocked by one handed operation of the user and which requires a minimal hand strength for cocking.
- The present invention relates to an applicator for applying a penetrating member to the stratum corneum with impact. The penetrating member may be a microprotrusion array which is used to improve transport of an agent across the skin. The applicator includes a cocking mechanism which allows one handed cocking operation. The cocking mechanism requires minimal hand strength and dexterity since the cocking force can be applied by a user's arm.
- In accordance with one aspect of the present invention, a device for impacting a penetrating member against the stratum corneum includes a device body for application of a penetrating member to the stratum corneum, a piston mounted within the device body for impacting the penetrating member against the stratum corneum, an impact spring between the piston and the device body for providing an impact force to the piston, and a cocking mechanism for cocking and locking the piston in a cocked position by compressing the device body and piston together using a compressing force which can be easily performed with one hand.
- In accordance with an additional aspect of the present invention, a device for impacting a microblade array against the stratum corneum includes a device body, a piston mounted within the device body, the piston having a microblade array applying surface, an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade array, a cap movably mounted on the device body, a hold down spring acting between the device body and the cap, a cocking mechanism for cocking and locking the piston in a cocked position with one hand by compressing the device body and piston together, and a piston release for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
- In accordance with a further aspect of the invention, a method of cocking a device for impacting a penetrating member against the stratum corneum includes the steps of moving a piston to a cocked position with respect to a device body by compressing the piston and device body together with only one hand, and locking the piston in the cocked position with the one hand.
- In accordance with an additional aspect of the invention, a method of impacting a penetrating member against the stratum corneum includes providing an impacting device having a device body, a piston, and an impact spring; cocking the impacting device using only one hand by moving the piston to a cocked position with respect to the device body and locking the piston in the cocked position; mounting a penetrating member on the piston; and releasing the piston to impact the penetrating member against the stratum corneum
- The invention will now be described in greater detail with reference to the preferred embodiments illustrated in the accompanying drawings, in which like elements bear like reference numerals, and wherein:
- FIG. 1 is side cross sectional view of an applicator device in an initial configuration prior to cocking;
- FIG. 2 is a side cross sectional view of the applicator device of FIG. 1 in a cocked position with a patch retainer attached to the applicator;
- FIG. 3 is a side cross sectional view of the applicator device of FIG. 1 with the patch retainer of FIG. 2 after the piston has been released to apply the patch;
- FIG. 4 is an exploded perspective view of the applicator device of FIG. 1;
- FIG. 5 is a perspective view of an alternative embodiment of an applicator device;
- FIG. 6 is a side view, partially in section, of the applicator device of FIG. 5; and
- FIG. 7 is a perspective view of a portion of one example of a microprotrusion array.
- The applicator device of the present invention is used for repeatable impact application of an array of microprotrusions to the stratum corneum in conjunction with transdermal therapeutic agent (e.g., drug) delivery or transdermal body analyte (e.g., glucose) sampling. Although the
applicator device 10 is described for use with a certain type of microprotrusion array, it should be understood that the applicator device may also be used with other types of stratum corneum micropenetrating members. The applicator device can be used by patients having neither the hand strength nor the manual dexterity to cock other types of spring-loaded applicator devices. Further, the applicator device can be cocked and released with one-handed operation which provides certain advantages, for example, allowing a patient to apply a drug delivering microprotrusion array for local therapy on a site on the patient's own arm. - Turning now to the figures, FIG. 1 illustrates
applicator device 10 including adevice body 12 and apiston 14 movable within the device body. Acap 16 is provided on thedevice body 12 for activating the applicator to impact the stratum corneum with a microprotrusion array (not shown in FIG. 1). Animpact spring 20 is positioned around apost 22 of thepiston 14 and biases the piston downward with respect to thedevice body 12. Thepiston 14 has alower surface 18 which is substantially planar, slightly convex, or configured to a body surface (i.e., a specific skin site). Thelower surface 18 of thepiston 14 causes a microprotrusion array or a transdermal patch containing a microprotrusion array to impact and pierce the stratum corneum. - FIG. 1 shows the
piston 14 in an uncocked position, while FIG. 2 shows the piston in the cocked position. When theapplicator device 10 is cocked, thepiston 14 is pressed up inside thedevice body 12 and locked in place by a locking mechanism. The locking mechanism includes acatch 26 on thepost 22 and aflexible finger 28 on thedevice body 12 having a correspondinglatch 30. - As the
piston 14 is moved toward thedevice body 12 compressing theimpact spring 20, thecatch 26 flexes thefinger 28 and snaps over the correspondinglatch 30 of theflexible finger 28. The cocking step is performed by a single compression motion which both cocks and locks thepiston 14 in the cocked position. This cocking step is easily performed with only one hand by compressing theapplicator device 10 between a user's hand and another surface (e.g. a table top). - FIG. 2 illustrates the
applicator device 10 with thepiston 14 in a cocked configuration. As shown in FIG. 2, in the cocked position, thecatch 26 and latch 30 on thepiston 14 anddevice body 12 are releasably engaged preventing downward motion of the piston in the device body. - FIG. 2 also illustrates a
patch retainer 34 mounted on thedevice body 12. Theretainer 34 has an annular shape with afirst end 40 which is configured to engage thedevice body 12. Asecond end 42 of theretainer 34 provides a stratum corneum contacting surface. Apatch 44 is mounted between the first and second ends 40, 42 of theretainer 34. Thepatch 44 is suspended in theretainer 34. Although the manner in which thepatch 44 is mounted in theretainer 34 and the location of the mountedpatch 44 within theretainer 34 may vary (for example, thepatch 44 may be positioned adjacent thesecond end 42 of the retainer 34) it is preferred to mountpatch 44 recessed some distance from both ends 40 and 42 (as shown in FIG. 1) in order to avoid inadvertent contact of the patch microprotrusions with other objects (e.g., the fingers of the user). - According to one example, the
patch 44 is connected by frangible sections of patch base material to an annular ring of patch material which is adhered to theretainer ring 34. Thepatch 44 is separated from theretainer ring 34 by the downward force of thepiston 14. Alternatively, the patch may be releasably attached to thepiston 14 or positioned on the skin beneath the piston. - The
applicator device 10 can be used with apatch 44 which generally includes a microprotrusion array, an agent reservoir, and a backing. However, theapplicator device 10 may also be used with a microprotrusion array without an agent reservoir. In this case, the microprotrusion array is used as a pretreatment which is followed by the application of an agent with a separate transdermal agent delivery or sampling device. Alternatively, the microprotrusion array may incorporate the agent as a coating on the microprotrusions, e.g. for delivering a vaccine intradermally. Theapplication device 10 may also be used for impacting other micropiercing elements against the stratum corneum, for example those disclosed in Godshall et al, U.S. Pat. No. 5,879,326 and Zuck WO 99/29364, the disclosures of which are incorporated by reference herein. - In addition to being able to cock the
device 10 with only one hand,device 10 is also designed to be operated (i.e., to cause release of the spring-loadedpiston 14 and thus causing thepatch 44 to impact the skin) using only one hand. The activation of theapplicator device 10 by releasing the locking mechanism is performed by downward force applied to theapplicator cap 16 while thesecond end 42 of the applicator device is held against the skin. Thecap 16 is biased upwards by a hold downspring 24 which is positioned between thedevice body 12 and the cap. Thecap 16 includes apin 46 extending downward from the cap. When thecap 16 is pressed downward against the bias of the hold downspring 24, thepin 46 contacts aramp 48 on theflexible finger 28 moving the flexible finger outward and disengaging thelatch 30 of theflexible finger 28 from thecatch 26. This releases thepiston 14 and the piston moves downward impacting the stratum corneum with thepatch 44. - FIG. 3 illustrates the
applicator device 10 after the device has been released and a patch has been applied to the stratum corneum. The hold downspring 24 is selected such that a predetermined hold down force must be achieved before the device is released. The hold down force causes the stratum corneum to be stretched by thesecond end 42 of theretainer 34 so that the skin is under optimal tension at the time thepatch 44 impacts the skin. The hold down force applied by the hold downspring 24 is preferably selected to cause thesecond end 42 to apply a tension to the skin in the range of about 0.01 to 10 megapascals (MPa), more preferably about 0.05 to 2 MPa. - A balance between the hold down
spring 24 and theimpact spring 20 allows the cocking of thepiston 14 by pressing on thecap 16 without causing thefinger 46 to release the locking mechanism. Theimpact spring 20 is selected to achieve a predetermined impact which is appropriate for a particular patch to provide the desired penetration. The selection of the impact and hold down springs is described further in U.S. Provisional Patent Application Serial No. 60/240,307 filed on even date herewith, which is incorporated herein by reference in its entirety. - The
retainer 34 is attached to thedevice body 12 after cocking of thepiston 14. Theretainer 34 is attached by a snap in connection requiring less force to snap in than the force required to release the piston. Theretainer 34 may also be attached to the device body by a bayonett fitting or a slide-on fitting which allows theretainer 34 to slide into thedevice body 12 in a direction normal to the axis of the applicator. - FIG. 4 illustrates the
cap 16,device body 12, andpiston 14 in an exploded perspective view. As shown in FIG. 4, thepiston 14 includespiston retainer tabs 52 which engage a lower rim 54 (FIG. 3) of thedevice body 12 and prevent the piston from being expelled from the device body. In addition, thecap 16 includes retainer tabs (not shown) which similarly engage an upper rim 58 (FIG. 3) of thedevice body 12 and prevent the cap from coming off of the body. - FIG. 4 also illustrates an optional rotational locking arrangement which allows the
cap 16 to be rotated to a locked position at which activation of the applicator is not possible because thepin 46 is not aligned with theflexible finger 28. An indication of the locked or unlocked position of thecap 16 is provided through awindow 60 in the cap. When thecap 16 is at positions other than the unlocked position, thepin 46 is not aligned with theramp 48 on theflexible finger 28 and thus, the applicator cannot be released. While this optional locking feature prevents inadvertent activation of theapplicator device 10, the relative rotational motion of thebody 12 and thecap 16 generally requires the use of both hands, which in some cases is less desirable. - FIGS. 5 and 6 illustrate an alternative embodiment of an
applicator 80 having a different shape and somewhat different cocking arrangement which also achieves the desired result of simple one handed cocking operation. According to this embodiment, the user grasps anouter cylinder 81 which acts as a handle for the device. Apiston 82 is slidably engaged within thecylinder 81. Animpact spring 83, shown in compression in FIG. 6 biases thepiston 82 away from the top or skin distal end ofcyclinder 81. A releasable catch mechanism 84 (not shown in detail in FIG. 6) is provided whereby depression ofbutton 85 causes latch 86 to retract thereby enablingcompressed spring 83 to movepiston 82 downwardly (i.e., in a direction towards the skin). Slidably engaging the skin proximal end ofcyclinder 81 is amiddle housing 87 having anindicator notch 96. Threaded tohousing 87 islower housing 88 which has a generally annular shape. Aretainer 93, whose function is described in detail in U.S. Provisional Patent Application Serial No. 60/240,379 filed on even date herewith and incorporated herein by reference is screwed onto the skin proximal end ofcyclinder 81. Withinretainer 93 is animpact head 94 which is attached topiston 82.Impact head 94 is adapted to hold, on its skin proximal suface, a patch having a plurality of microprotrusions (the patch is not shown in FIG. 6). A hold downspring 95, shown in compression in FIG. 6, is provided betweencyclinder 81 andmiddle housing 87. Hold downspring 95 compresses when the user grabscylinder 81, places edge 89 against the skin site to be pierced, and presses thedevice 80 against the skin site. Asspring 95 is compressed,notch 96 becomes aligned with the lower edge ofband 97. In this alignment, the hold downspring 95 is in a predetermined compression which provides the necessary hold down force and skin stretching atedge 89. Once thenotch 96 is aligned with the lower edge ofband 97, the operator simply pressesbutton 85, which releases latch 86 which in turn releasespiston 82 andhead 94, causinghead 94 to impact the microprotrusion member against the patient's skin. - The
applicator devices patch 44 is applied from a piston side of the device which is illustrated at the bottom/skin proximal end of the devices in the figures. It should be understood that the applicator devices may be used in other orientations (i.e., sideways and upside down) as long as the device is properly oriented against the skin site to be pierced. - FIG. 7 illustrates one embodiment of a stratum corneum penetrating member for use with the present invention. FIG. 7 shows a plurality of microprotrusions in the form of
microblades 90. Themicroblades 90 extend at a substantially 90° angle from ametal sheet 92 havingopenings 94. Thesheet 92 may be incorporated in an agent delivery patch or an agent sampling patch which includes an agent reservoir and an adhesive for adhering the patch to the stratum corneum. Examples of agent delivery and sampling patches which incorporate a microprotrusion array are found in WO 97/48440, WO 97/48441, WO 97/48442. The microprotrusion array of FIG. 7 without a reservoir may also be applied alone as a skin pretreatment. - The term “microprotrusion” as used herein refers to very tiny stratum corneum piercing elements typically having a length of less than 500 μm, and preferably less than 250 μm, which pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. However, the microprotrusions should not penetrate so deep into the dermis layer as to cause bleeding. In order to penetrate the stratum corneum, the microprotrusions preferably have a length of at least 10 μm, more preferably at least 50 μm. In general, microprotrusions penetrate the skin to a depth of no more than about 500 μm and preferably less than about 400 μm. The microprotrusions may be formed in different shapes, such as needles, hollow needles, blades, pins, punches, and combinations thereof.
- The term “microprotrusion array” as used herein refers to a plurality of microprotrusions arranged in an array for piercing the stratum corneum. The microprotrusion array may be formed by cutting a plurality of blades from a thin metal sheet and folding each of the blades out of the plane of the sheet to form the configuration shown in FIG. 7. The microprotrusion array may also be formed in other known manners, such as by connecting multiple strips having microprotrusions along an edge of each of the strips. The microprotrusion array may include hollow needles which inject a liquid formulation.
- Examples of microprotrusion arrays are described in U.S. Pat. Nos. 5,879,326 issue to Godshall, et al., 3,814,097 issued to Ganderton, et al., 5,279,544 issued to Gross, et al., 5,250,023 issued to Lee, et al., 3,964,482 issued to Gerstel, et al., Reissue 25,637 issued to Kravitz, et al., and PCT Publication Nos. WO 96/37155, WO 96/37256, WO 96/17648, WO 97/03718, WO 98/11937, WO 98/00193, WO 97/48440, WO 97/48441, WO 97/48442, WO 98/00193, WO 99/64580, WO 98/28037, WO 98/29298, and WO 98/29365, all of which are incorporated herein by reference in their entirety.
- The device of the present invention can be used in connection with agent delivery, agent sampling, or both. In particular, the device of the present invention is used in connection with transdermal drug delivery, transdermal analyte (e.g., glucose) sampling, or both. Transdermal delivery devices for use with the present invention include, but are not limited to passive devices, osmotic devices, pressure-driven devices, and electrotransport devices. Transdermal sampling devices for use with the present invention include, but are not limited to, passive devices, negative pressure driven devices, osmotic devices, and reverse electrotransport devices. The transdermal devices of the present invention may be used in combination with other methods of increasing agent flux, such as skin permeation enhancers.
- The device of the present invention may be used with a microprotrusion array included in a transdermal delivery or sampling patch having adhesive for attaching the patch to the skin. Alternatively, the microprotrusion array and delivery or sampling patch may be two separate elements with the microprotrusion array used for pretreatment prior to application of the delivery or sampling patch.
- While the invention has been described in detail with reference to the preferred embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made and equivalents employed, without departing from the present invention.
Claims (22)
1. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body; and
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum.
2. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
wherein said body and piston are adapted to be releasably engaged by the use of a single hand.
3. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
wherein the latching mechanism includes interengaging latch members on the body and piston.
4. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
a flexible finger on said body and a stop on said piston wherein said flexible finger and said stop comprise said interengaging latch members.
5. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism.
6. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum;
wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism; and wherein said latching mechanism and said piston releasing mechanism are adapted to allow one handed operation of each mechanism.
7. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
a cap movably mounted on said body for activating the releasing mechanism when said cap moved onto said body; and wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism.
8. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum;
a cap movably mounted on said body for activating the releasing mechanism when said cap moved onto said body; and wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism; and
a hold down spring disposed between the body and the cap for resisting the activation of the release mechanism until said hold down spring has been sufficiently energized such that said hold down spring exerts a predetermined hold down force.
9. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum;
a cap movably mounted on said body for activating the releasing mechanism when said cap moved onto said body; and wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism; and
a lock mechanism for preventing movement of said cap relative to said body whereby activation of the release mechanism is prevented.
10. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum;
a cap movably mounted on said body for activating the releasing mechanism when said cap moved onto said body; and wherein said releasing mechanism is adapted to release said piston after a force is exerted upon said releasing mechanism;
a lock mechanism for preventing movement of said cap relative to said body whereby activation of the release mechanism is prevented; and
an indicator for indicating when said cap is in said locked position.
11. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
wherein said latching mechanism automatically locks said piston in a cocked position with respect to said body when said piston has been sufficiently disposed within said body.
12. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum; and
wherein said piston includes an application surface having a shape and size which provides for an effective application of the specific patch to be impacted.
13. A device for impacting a penetrating member against the stratum corneum comprising:
a body having a first end and a second end;
said first end adapted to receive the penetrating member;
a piston slidably disposed within said body for impacting the penetrating member against the stratum corneum;
an impact spring adapted to provide an impact force to the piston and bias said piston out of said first end of said body; wherein said impact spring is energized when said piston is further disposed within said body;
a latching mechanism wherein said latching mechanism releasably engages said piston with said body after said piston has been sufficiently disposed within said body;
a releasing mechanism for disengaging said latching mechanism whereby said impact spring impacts said piston against the penetrating member forcing the penetrating member into said stratum corneum;
said piston further includes an application surface having a shape and size which provides for an effective application of the specific patch to be impacted; and
wherein said application surface has a shape selected from the group consisting of a convex shape, a substantially planar shape and a shape configured to mate with a predetermined body surface site.
14. A device for impacting a microblade array against the stratum corneum, the device comprising:
a device body;
a piston mounted within the device body, the piston having a microblade array applying surface;
an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade;
a cap movably mounted on the device body;
a hold down spring acting between the device body and the cap;
a latching mechanism for locking the piston in a cocked position with one hand by compressing the device body and piston together; and
a piston release for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
15. A device for impacting a microblade array against the stratum corneum, the device comprising:
a device body;
a piston mounted within the device body, the piston having a microblade array applying surface;
an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade;
a cap movably mounted on the device body;
a hold down spring acting between the device body and the cap;
a latching mechanism for locking the piston in a cocked position with one hand by compressing the device body and piston together; and
a piston release comprising a release finger for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
16. A device for impacting a microblade array against the stratum corneum, the device comprising:
a device body;
a piston mounted within the device body, the piston having a microblade array applying surface;
an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade;
a cap movably mounted on the device body;
a hold down spring acting between the device body and the cap;
a latching mechanism for locking the piston in a cocked position with one hand by compressing the device body and piston together; and
a piston release comprising a release finger for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
17. A device for impacting a microblade array against the stratum corneum, the device comprising:
a device body;
a piston mounted within the device body, the piston having a microblade array applying surface;
an impact spring acting between the device body and the piston to impact the stratum corneum with the microblade;
a cap movably mounted on the device body;
a hold down spring acting between the device body and the cap, said hold down spring adapted to resist the activation of the piston release until a predetermined hold down force is reached;
a latching mechanism for locking the piston in a cocked position with one hand by compressing the device body and piston together; and
a piston release for releasing the piston from the cocked position to impact the stratum corneum with the microblade array when the hold down spring is compressed.
18. A method of cocking a device for impacting a penetrating member against the stratum corneum, the method comprising:
moving a piston to a cocked position with respect to a device body; and
locking the piston in the cocked position, whereby the device can be cocked and locked using only one hand.
19. A method of cocking a device for impacting a penetrating member against the stratum corneum, the method comprising:
moving a piston to a cocked position by moving the piston along the axis of the device body; and
locking said piston in the cocked position, wherein the device can be cocked and locked using only one hand.
20. A method of cocking a device for impacting a penetrating member against the stratum corneum, the method comprising:
moving a piston to a cocked position with respect to a device body; and
locking the piston in the cocked position, whereby the device can be cocked and automatically locked using only one hand.
21. A method of cocking a device for impacting a penetrating member against the stratum corneum, the method comprising:
moving a piston to a cocked position with respect to a device body; and
locking the piston in the cocked position, whereby the device can be cocked and manually locked using only one hand.
22. A method of impacting a penetrating member against the stratum corneum, the method comprising:
providing an impacting device having a device body, a piston, and an impact spring;
cocking the impacting device using only one hand by moving the piston and the device body together to a cocked position and locking the piston in the cocked position;
providing a penetrating member;
mounting said penetrating member on said piston; and
releasing said piston to impact the penetrating member against the stratum corneum.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/976,763 US20020087182A1 (en) | 2000-10-13 | 2001-10-12 | Microblade array impact applicator |
US11/251,488 US9192749B2 (en) | 2000-10-13 | 2005-10-14 | Microblade array impact applicator |
US14/949,158 US10342963B2 (en) | 2000-10-13 | 2015-11-23 | Microblade array impact applicator |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24043600P | 2000-10-13 | 2000-10-13 | |
US09/976,763 US20020087182A1 (en) | 2000-10-13 | 2001-10-12 | Microblade array impact applicator |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/251,488 Continuation US9192749B2 (en) | 2000-10-13 | 2005-10-14 | Microblade array impact applicator |
Publications (1)
Publication Number | Publication Date |
---|---|
US20020087182A1 true US20020087182A1 (en) | 2002-07-04 |
Family
ID=22906511
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/976,763 Abandoned US20020087182A1 (en) | 2000-10-13 | 2001-10-12 | Microblade array impact applicator |
US11/251,488 Active 2025-12-19 US9192749B2 (en) | 2000-10-13 | 2005-10-14 | Microblade array impact applicator |
US14/949,158 Expired - Fee Related US10342963B2 (en) | 2000-10-13 | 2015-11-23 | Microblade array impact applicator |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/251,488 Active 2025-12-19 US9192749B2 (en) | 2000-10-13 | 2005-10-14 | Microblade array impact applicator |
US14/949,158 Expired - Fee Related US10342963B2 (en) | 2000-10-13 | 2015-11-23 | Microblade array impact applicator |
Country Status (24)
Country | Link |
---|---|
US (3) | US20020087182A1 (en) |
EP (1) | EP1341442B1 (en) |
JP (1) | JP4198985B2 (en) |
KR (1) | KR100818545B1 (en) |
CN (1) | CN100391404C (en) |
AT (1) | ATE298528T1 (en) |
AU (2) | AU9682701A (en) |
BR (1) | BR0114634A (en) |
CA (1) | CA2425537C (en) |
CZ (1) | CZ20031035A3 (en) |
DE (1) | DE60111771T2 (en) |
ES (1) | ES2243564T3 (en) |
HK (1) | HK1058889A1 (en) |
HU (1) | HUP0303583A2 (en) |
IL (1) | IL155375A0 (en) |
MA (1) | MA26056A1 (en) |
MX (1) | MXPA03003301A (en) |
NO (1) | NO20031682L (en) |
NZ (1) | NZ525293A (en) |
PL (1) | PL360978A1 (en) |
PT (1) | PT1341442E (en) |
RU (1) | RU2277390C2 (en) |
WO (1) | WO2002030281A1 (en) |
ZA (1) | ZA200303632B (en) |
Cited By (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020177839A1 (en) * | 2001-04-20 | 2002-11-28 | Cormier Michel J. N. | Microprojection array having a beneficial agent containing coating |
US20030181936A1 (en) * | 2001-12-20 | 2003-09-25 | Trautman Joseph C. | Skin-piercing microprojections having piercing depth control |
US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
US20040115167A1 (en) * | 2002-09-30 | 2004-06-17 | Michel Cormier | Drug delivery device and method having coated microprojections incorporating vasoconstrictors |
US20040138610A1 (en) * | 2002-12-26 | 2004-07-15 | Michel Cormier | Active agent delivery device having composite members |
US20040236271A1 (en) * | 1997-12-10 | 2004-11-25 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
US20040265354A1 (en) * | 2003-06-30 | 2004-12-30 | Mahmoud Ameri | Formulations for coated microprojections containing non-volatile counterions |
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US20050031676A1 (en) * | 2003-08-04 | 2005-02-10 | Wong Patrick S.L. | Method and device for enhancing transdermal agent flux |
US20050084604A1 (en) * | 2001-03-16 | 2005-04-21 | Trautman Joseph C. | Method and apparatus for coating skin piercing microprojections |
US20050090009A1 (en) * | 2003-10-23 | 2005-04-28 | Cormier Michel J. | Compositions of stabilized DNA for coating microprojctions |
US20050089553A1 (en) * | 2003-10-28 | 2005-04-28 | Cormier Michel J. | Method and apparatus for reducing the incidence of tobacco use |
US20050106226A1 (en) * | 2003-10-24 | 2005-05-19 | Cormier Michel J. | Pretreatment method and system for enhancing transdermal drug delivery |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
US20050234401A1 (en) * | 2000-10-13 | 2005-10-20 | Trautman Joseph C | Apparatus and method for piercing skin with microprotrusions |
US20050256045A1 (en) * | 2004-05-13 | 2005-11-17 | Mahmoud Ameri | Apparatus and method for transdermal delivery of parathyroid hormone agents |
US20050271684A1 (en) * | 2004-04-13 | 2005-12-08 | Trautman Joseph C | Apparatus and method for transdermal delivery of multiple vaccines |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
US20060051403A1 (en) * | 2004-09-08 | 2006-03-09 | James Matriano | Microprojection array with improved skin adhesion and compliance |
US20060074377A1 (en) * | 2001-04-20 | 2006-04-06 | Cormier Michel J | Microprojection array immunization patch and method |
US20060142691A1 (en) * | 2000-10-13 | 2006-06-29 | Trautman Joseph C | Apparatus and method for piercing skin with microprotrusions |
US20060200069A1 (en) * | 2000-10-26 | 2006-09-07 | Cormier Michel J | Transdermal drug delivery devices having coated microprotrusions |
US20070060937A1 (en) * | 2005-08-30 | 2007-03-15 | Liu Chen H | Safety needle holder |
US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
US20070083151A1 (en) * | 2003-12-29 | 2007-04-12 | Carter Chad J | Medical devices and kits including same |
US20070118070A1 (en) * | 1996-06-18 | 2007-05-24 | Cormier Michel J | Device with anchoring elements for transdermal delivery or sampling of agents |
WO2007064486A1 (en) | 2005-11-30 | 2007-06-07 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
US20070293814A1 (en) * | 2005-09-12 | 2007-12-20 | Trautman Joseph C | Coatable transdermal delivery microprojection assembly |
US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
US20080039775A1 (en) * | 2006-03-15 | 2008-02-14 | Alza Corporation | Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia |
US20080195035A1 (en) * | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
US20090198189A1 (en) * | 2006-04-20 | 2009-08-06 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20100222743A1 (en) * | 2005-06-27 | 2010-09-02 | Frederickson Franklyn L | Microneedle array applicator device and method of array application |
US20110009782A1 (en) * | 2009-07-07 | 2011-01-13 | Naya Touch, Inc. | Dermal roller with therapeutic microstructures |
US7914480B2 (en) | 2004-03-24 | 2011-03-29 | Corium International, Inc. | Transdermal delivery device |
US20110319920A1 (en) * | 2010-06-24 | 2011-12-29 | Kikkawa Yasuo | Micropore forming apparatus and micropore forming method |
US8216190B2 (en) | 2000-10-16 | 2012-07-10 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
US8267889B2 (en) | 2004-11-18 | 2012-09-18 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
US8702726B2 (en) | 2000-10-16 | 2014-04-22 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
CN103857423A (en) * | 2011-10-12 | 2014-06-11 | 3M创新有限公司 | Integrated microneedle array delivery system |
US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US20150352295A1 (en) * | 2013-01-08 | 2015-12-10 | 3M Innovative Properties Company | Application For Applying A Microneedle Device To Skin |
US9498611B2 (en) | 2011-10-06 | 2016-11-22 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
US9540684B2 (en) | 2012-12-14 | 2017-01-10 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
US9682222B2 (en) | 2013-05-31 | 2017-06-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
US9687640B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Applicators for microneedles |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US9743949B2 (en) * | 2015-04-22 | 2017-08-29 | Medline Industries, Inc. | Two-dimensional needle array device and method of use |
US9872975B2 (en) | 2013-05-31 | 2018-01-23 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
US9895520B2 (en) | 2013-05-31 | 2018-02-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising a dual cover |
US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US10010707B2 (en) | 2011-10-12 | 2018-07-03 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US10245422B2 (en) | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11052231B2 (en) | 2012-12-21 | 2021-07-06 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US11452852B2 (en) | 2017-03-28 | 2022-09-27 | Cosmed Pharmaceutical Co., Ltd. | Applicator for water-soluble sheet-shaped preparation |
US11484695B2 (en) | 2016-03-16 | 2022-11-01 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch case |
US20230099617A1 (en) * | 2021-09-28 | 2023-03-30 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
USD1033641S1 (en) | 2021-12-17 | 2024-07-02 | Biolinq Incorporated | Microneedle array sensor applicator device |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
PL360978A1 (en) | 2000-10-13 | 2004-09-20 | Alza Corporation | Microblade array impact applicator |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US7635488B2 (en) | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
FR2822049B1 (en) | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | PATCH INTENDED IN PARTICULAR TO DETECT THE STATE OF SENSITIZATION OF A SUBJECT TO AN ALLERGEN, METHOD OF MANUFACTURING AND USE |
US7682318B2 (en) | 2001-06-12 | 2010-03-23 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
ATE485766T1 (en) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | ELECTRICAL ACTUATING ELEMENT FOR A LANCET |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
ATE497731T1 (en) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | DEVICE FOR INCREASING THE SUCCESS RATE OF BLOOD YIELD OBTAINED BY A FINGER PICK |
DE60234598D1 (en) | 2001-06-12 | 2010-01-14 | Pelikan Technologies Inc | SELF-OPTIMIZING LANZET DEVICE WITH ADAPTANT FOR TEMPORAL FLUCTUATIONS OF SKIN PROPERTIES |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
DE10222235A1 (en) * | 2002-05-16 | 2003-11-27 | Roche Diagnostics Gmbh | Blood Collection system |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
EP1624913B1 (en) * | 2003-05-08 | 2010-07-21 | Novo Nordisk A/S | Skin mountable injection device with a detachable needle insertion actuation portion |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
WO2005037095A1 (en) | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
EP1680154B1 (en) | 2003-10-31 | 2012-01-04 | ALZA Corporation | Self-actuating applicator for microprojection array |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
FR2866553B1 (en) * | 2004-02-19 | 2006-06-09 | Dbv Tech | NEW TYPE OF PATCH |
CN101827301B (en) | 2004-04-16 | 2016-01-20 | 杜比实验室特许公司 | For creating equipment and the method for audio scene |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
EP1845870A1 (en) * | 2004-11-18 | 2007-10-24 | 3M Innovative Properties Company | Non-skin-contacting microneedle array applicator |
US7846488B2 (en) | 2004-11-18 | 2010-12-07 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
WO2006055844A2 (en) | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
JP5178132B2 (en) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | Image processing system and image processing method |
FR2924349B1 (en) | 2007-12-03 | 2010-01-01 | Dbv Tech | ALLERGEN DISENSIBILITY METHOD |
FR2924350B1 (en) | 2007-12-03 | 2010-08-13 | Dbv Tech | METHOD AND COMPOSITIONS FOR SKIN VACCINATION |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
JP5820805B2 (en) * | 2009-04-24 | 2015-11-24 | コリウム インターナショナル, インコーポレイテッド | Process for manufacturing microprojection arrays |
US10010706B2 (en) | 2009-07-31 | 2018-07-03 | 3M Innovative Properties Company | Hollow microneedle arrays |
KR101708966B1 (en) * | 2010-03-17 | 2017-02-21 | 나노메드 디바이시즈, 인코포레이티드 | A built-in non-verbal instructional device integratable to applicators |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2013015136A1 (en) * | 2011-07-27 | 2013-01-31 | 久光製薬株式会社 | Applicator |
US9443061B2 (en) | 2011-08-16 | 2016-09-13 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9772270B2 (en) | 2011-08-16 | 2017-09-26 | Elwha Llc | Devices and methods for recording information on a subject's body |
US9286615B2 (en) * | 2011-08-16 | 2016-03-15 | Elwha Llc | Devices and methods for recording information on a subject's body |
JP6411888B2 (en) | 2011-09-07 | 2018-10-24 | スリーエム イノベイティブ プロパティズ カンパニー | Delivery system for hollow microneedle array |
WO2014059104A1 (en) | 2012-10-10 | 2014-04-17 | 3M Innovative Properties Company | Applicator and method for applying a microneedle device to skin |
US9782574B2 (en) | 2012-10-10 | 2017-10-10 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
WO2014078545A1 (en) | 2012-11-16 | 2014-05-22 | 3M Innovative Properties Company | Force-controlled applicator for applying a microneedle device to skin |
US20160271380A1 (en) * | 2013-03-22 | 2016-09-22 | 3M Innovative Properties Company | Microneedle applicator comprising a counter assembly |
US10232158B2 (en) | 2013-09-18 | 2019-03-19 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch application device and patch holder |
KR101423590B1 (en) * | 2013-12-31 | 2014-07-25 | 주식회사 라온 | Micro needle stamp |
EP3581236B1 (en) * | 2014-04-30 | 2021-03-03 | Sorrento Therapeutics, Inc. | Transdermal drug delivery apparatus |
JP2017023404A (en) | 2015-07-22 | 2017-02-02 | 日本写真印刷株式会社 | Impact-application-type applicator for microneedle patch and tip member |
WO2017110815A1 (en) * | 2015-12-21 | 2017-06-29 | 株式会社 メドレックス | Microneedle patch applicator and housing for same |
EP3416618A1 (en) | 2016-02-19 | 2018-12-26 | ZP Opco, Inc. | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
KR101746048B1 (en) | 2016-09-13 | 2017-06-12 | 주식회사 라파스 | Microneedle patch applicator |
WO2018139504A1 (en) | 2017-01-25 | 2018-08-02 | コスメディ製薬株式会社 | Microneedle patch applying device |
KR20210155817A (en) | 2017-08-23 | 2021-12-23 | 조사노 파마 코포레이션 | Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches |
US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
US11458289B2 (en) | 2017-10-17 | 2022-10-04 | Kindeva Drug Delivery L.P. | Applicator for applying a microneedle array to skin |
CA3089513A1 (en) | 2018-01-24 | 2019-08-01 | Cosmed Pharmaceutical Co., Ltd. | Tight-binding device for micro-needle |
US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
CN112888474A (en) * | 2018-08-30 | 2021-06-01 | 尼普洛株式会社 | Microneedle applicator |
JP7099189B2 (en) * | 2018-08-30 | 2022-07-12 | ニプロ株式会社 | Microneedle applicator |
JP7172293B2 (en) * | 2018-08-30 | 2022-11-16 | ニプロ株式会社 | microneedle applicator |
DE102019200563A1 (en) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applicator |
JP7491551B2 (en) | 2019-04-25 | 2024-05-28 | コスメディ製薬株式会社 | Applicator 2 for water-soluble sheet preparation |
DE102019122948A1 (en) * | 2019-08-27 | 2021-03-04 | Lts Lohmann Therapie-Systeme Ag | Applicator, application system and method for moving a stamp |
CN114748778B (en) * | 2021-01-11 | 2024-05-03 | 苏州纳生微电子有限公司 | Transmission structure, liquid feeding device applying transmission structure and use method of liquid feeding device |
US20220253917A1 (en) * | 2021-02-11 | 2022-08-11 | Christian Saxon | Method for Generating a Shopping and Educational Experience |
WO2024097385A1 (en) * | 2022-11-05 | 2024-05-10 | Kindeva Drug Delivery L.P. | Microneedle array applicator and system |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3814097A (en) * | 1972-02-14 | 1974-06-04 | Ici Ltd | Dressing |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US4628929A (en) * | 1985-08-16 | 1986-12-16 | American Hospital Supply Corporation | Retractable blade bleeding time device |
US5250023A (en) * | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5827297A (en) * | 1992-10-01 | 1998-10-27 | Medicamat S.A. | Device for transplanting small diameter hair grafts |
US5879326A (en) * | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US6030402A (en) * | 1998-04-23 | 2000-02-29 | Thompson; Ronald J. | Apparatus and methods for the penetration of tissue, and the creation of an opening therein |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US240307A (en) * | 1881-04-19 | And andrew eppler | ||
US240379A (en) * | 1881-04-19 | Portable clock | ||
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3605744A (en) * | 1969-04-22 | 1971-09-20 | Edward M Dwyer | Injection apparatus and method of injecting |
US4577630A (en) * | 1984-02-14 | 1986-03-25 | Becton, Dickinson And Co. | Reusable breach loading target pressure activated lancet firing device |
WO1996005879A1 (en) | 1994-08-18 | 1996-02-29 | Nmt Group Plc | Needle retraction mechanisms |
WO1996017648A1 (en) | 1994-12-09 | 1996-06-13 | Novartis Ag | Transdermal system |
AU5869796A (en) | 1995-05-22 | 1996-12-11 | Ned A. Godshall | Micromechanical patch for enhancing the delivery of compound s through the skin |
DE19525607A1 (en) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneal drug delivery system |
NL1002849C2 (en) * | 1996-04-12 | 1997-10-15 | Od & Me Bv | Device for processing a disc-shaped substrate as well as a station suitable for coupling with such a device. |
IL124426A (en) * | 1996-05-17 | 2000-06-01 | Mercury Diagnostics Inc | Method and apparatus for expressing body fluid from an incision |
US5613978A (en) | 1996-06-04 | 1997-03-25 | Palco Laboratories | Adjustable tip for lancet device |
US7184826B2 (en) | 1996-06-18 | 2007-02-27 | Alza Corporation | Device and method for enhancing transdermal flux of agents being delivered or sampled |
DE69722414T2 (en) | 1996-07-03 | 2004-05-19 | Altea Therapeutics Corp. | MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA |
ATE231015T1 (en) | 1996-09-17 | 2003-02-15 | Deka Products Lp | SYSTEM FOR DELIVERY OF MEDICATION THROUGH TRANSPORT |
WO1998028037A1 (en) | 1996-12-20 | 1998-07-02 | Alza Corporation | Device and method for enhancing transdermal agent flux |
DE19654391A1 (en) | 1996-12-27 | 1998-07-02 | Basf Ag | Catalyst for the selective production of propylene from propane |
ID21673A (en) | 1996-12-31 | 1999-07-08 | Shell Internationale Res Maatc | POLE WITH VERTICAL FLOW |
US6093172A (en) | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
US6607509B2 (en) * | 1997-12-31 | 2003-08-19 | Medtronic Minimed, Inc. | Insertion device for an insertion set and method of using the same |
JP3097600B2 (en) * | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | Stratum corneum puncture device |
US5964718A (en) * | 1997-11-21 | 1999-10-12 | Mercury Diagnostics, Inc. | Body fluid sampling device |
AU739616B2 (en) | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
WO1999033504A1 (en) * | 1997-12-31 | 1999-07-08 | Minimed Inc. | Insertion device for an insertion set and method of using the same |
US6086545A (en) * | 1998-04-28 | 2000-07-11 | Amira Medical | Methods and apparatus for suctioning and pumping body fluid from an incision |
WO1999064580A1 (en) | 1998-06-10 | 1999-12-16 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US6210420B1 (en) * | 1999-01-19 | 2001-04-03 | Agilent Technologies, Inc. | Apparatus and method for efficient blood sampling with lancet |
WO2000044438A1 (en) | 1999-01-28 | 2000-08-03 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
US6197040B1 (en) * | 1999-02-23 | 2001-03-06 | Lifescan, Inc. | Lancing device having a releasable connector |
US6258112B1 (en) * | 1999-11-02 | 2001-07-10 | Steven Schraga | Single use lancet assembly |
US6706159B2 (en) * | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
US6537242B1 (en) * | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
PL360978A1 (en) | 2000-10-13 | 2004-09-20 | Alza Corporation | Microblade array impact applicator |
-
2001
- 2001-10-12 PL PL01360978A patent/PL360978A1/en not_active Application Discontinuation
- 2001-10-12 CN CNB018204627A patent/CN100391404C/en not_active Expired - Fee Related
- 2001-10-12 IL IL15537501A patent/IL155375A0/en unknown
- 2001-10-12 RU RU2003110432/14A patent/RU2277390C2/en not_active IP Right Cessation
- 2001-10-12 JP JP2002533731A patent/JP4198985B2/en not_active Expired - Fee Related
- 2001-10-12 DE DE60111771T patent/DE60111771T2/en not_active Expired - Lifetime
- 2001-10-12 HU HU0303583A patent/HUP0303583A2/en unknown
- 2001-10-12 CA CA002425537A patent/CA2425537C/en not_active Expired - Fee Related
- 2001-10-12 ES ES01977733T patent/ES2243564T3/en not_active Expired - Lifetime
- 2001-10-12 WO PCT/US2001/031935 patent/WO2002030281A1/en active IP Right Grant
- 2001-10-12 CZ CZ20031035A patent/CZ20031035A3/en unknown
- 2001-10-12 US US09/976,763 patent/US20020087182A1/en not_active Abandoned
- 2001-10-12 AT AT01977733T patent/ATE298528T1/en not_active IP Right Cessation
- 2001-10-12 MX MXPA03003301A patent/MXPA03003301A/en active IP Right Grant
- 2001-10-12 EP EP01977733A patent/EP1341442B1/en not_active Expired - Lifetime
- 2001-10-12 AU AU9682701A patent/AU9682701A/en active Pending
- 2001-10-12 PT PT01977733T patent/PT1341442E/en unknown
- 2001-10-12 BR BR0114634-3A patent/BR0114634A/en not_active Application Discontinuation
- 2001-10-12 AU AU2001296827A patent/AU2001296827B2/en not_active Ceased
- 2001-10-12 KR KR1020037005242A patent/KR100818545B1/en not_active IP Right Cessation
-
2003
- 2003-04-11 NO NO20031682A patent/NO20031682L/en not_active Application Discontinuation
- 2003-04-11 NZ NZ525293A patent/NZ525293A/en unknown
- 2003-05-12 MA MA27150A patent/MA26056A1/en unknown
- 2003-05-12 ZA ZA200303632A patent/ZA200303632B/en unknown
-
2004
- 2004-03-05 HK HK04101669A patent/HK1058889A1/en not_active IP Right Cessation
-
2005
- 2005-10-14 US US11/251,488 patent/US9192749B2/en active Active
-
2015
- 2015-11-23 US US14/949,158 patent/US10342963B2/en not_active Expired - Fee Related
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3814097A (en) * | 1972-02-14 | 1974-06-04 | Ici Ltd | Dressing |
US4628929A (en) * | 1985-08-16 | 1986-12-16 | American Hospital Supply Corporation | Retractable blade bleeding time device |
US5250023A (en) * | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5827297A (en) * | 1992-10-01 | 1998-10-27 | Medicamat S.A. | Device for transplanting small diameter hair grafts |
US5879326A (en) * | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US6030402A (en) * | 1998-04-23 | 2000-02-29 | Thompson; Ronald J. | Apparatus and methods for the penetration of tissue, and the creation of an opening therein |
Cited By (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070118070A1 (en) * | 1996-06-18 | 2007-05-24 | Cormier Michel J | Device with anchoring elements for transdermal delivery or sampling of agents |
US20040236271A1 (en) * | 1997-12-10 | 2004-11-25 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US7798987B2 (en) | 2000-10-13 | 2010-09-21 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US20060142691A1 (en) * | 2000-10-13 | 2006-06-29 | Trautman Joseph C | Apparatus and method for piercing skin with microprotrusions |
US20050234401A1 (en) * | 2000-10-13 | 2005-10-20 | Trautman Joseph C | Apparatus and method for piercing skin with microprotrusions |
US8216190B2 (en) | 2000-10-16 | 2012-07-10 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
US8702726B2 (en) | 2000-10-16 | 2014-04-22 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US8663155B2 (en) | 2000-10-26 | 2014-03-04 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
US7537795B2 (en) | 2000-10-26 | 2009-05-26 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
US20060200069A1 (en) * | 2000-10-26 | 2006-09-07 | Cormier Michel J | Transdermal drug delivery devices having coated microprotrusions |
US7435299B2 (en) | 2001-03-16 | 2008-10-14 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US20050084604A1 (en) * | 2001-03-16 | 2005-04-21 | Trautman Joseph C. | Method and apparatus for coating skin piercing microprojections |
US20090143724A1 (en) * | 2001-04-20 | 2009-06-04 | Alza Corporation | Microprojection Array Immunization Patch and Method |
US20020177839A1 (en) * | 2001-04-20 | 2002-11-28 | Cormier Michel J. N. | Microprojection array having a beneficial agent containing coating |
US20060074377A1 (en) * | 2001-04-20 | 2006-04-06 | Cormier Michel J | Microprojection array immunization patch and method |
US7963935B2 (en) | 2001-04-20 | 2011-06-21 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
US20030181936A1 (en) * | 2001-12-20 | 2003-09-25 | Trautman Joseph C. | Skin-piercing microprojections having piercing depth control |
US20040115167A1 (en) * | 2002-09-30 | 2004-06-17 | Michel Cormier | Drug delivery device and method having coated microprojections incorporating vasoconstrictors |
US20040138610A1 (en) * | 2002-12-26 | 2004-07-15 | Michel Cormier | Active agent delivery device having composite members |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
US7579013B2 (en) | 2003-06-30 | 2009-08-25 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
US20040265354A1 (en) * | 2003-06-30 | 2004-12-30 | Mahmoud Ameri | Formulations for coated microprojections containing non-volatile counterions |
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US20050031676A1 (en) * | 2003-08-04 | 2005-02-10 | Wong Patrick S.L. | Method and device for enhancing transdermal agent flux |
US20050049549A1 (en) * | 2003-08-04 | 2005-03-03 | Wong Patrick S.L. | Method and device for enhancing transdermal agent flux |
US20050090009A1 (en) * | 2003-10-23 | 2005-04-28 | Cormier Michel J. | Compositions of stabilized DNA for coating microprojctions |
US20050106226A1 (en) * | 2003-10-24 | 2005-05-19 | Cormier Michel J. | Pretreatment method and system for enhancing transdermal drug delivery |
US20050089553A1 (en) * | 2003-10-28 | 2005-04-28 | Cormier Michel J. | Method and apparatus for reducing the incidence of tobacco use |
US7455654B2 (en) | 2003-10-28 | 2008-11-25 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
US20070083151A1 (en) * | 2003-12-29 | 2007-04-12 | Carter Chad J | Medical devices and kits including same |
US7914480B2 (en) | 2004-03-24 | 2011-03-29 | Corium International, Inc. | Transdermal delivery device |
US20050271684A1 (en) * | 2004-04-13 | 2005-12-08 | Trautman Joseph C | Apparatus and method for transdermal delivery of multiple vaccines |
US8361022B2 (en) | 2004-05-13 | 2013-01-29 | Alza Corporation | Apparatus for transdermal delivery of parathyroid hormone agents |
US20050256045A1 (en) * | 2004-05-13 | 2005-11-17 | Mahmoud Ameri | Apparatus and method for transdermal delivery of parathyroid hormone agents |
US7556821B2 (en) | 2004-05-13 | 2009-07-07 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
US20060051403A1 (en) * | 2004-09-08 | 2006-03-09 | James Matriano | Microprojection array with improved skin adhesion and compliance |
US8758298B2 (en) | 2004-11-18 | 2014-06-24 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
US9174035B2 (en) | 2004-11-18 | 2015-11-03 | 3M Innovative Properties Company | Microneedle array applicator and retainer |
US8267889B2 (en) | 2004-11-18 | 2012-09-18 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
US10315021B2 (en) | 2005-06-24 | 2019-06-11 | 3M Innovative Properties Company | Collapsible patch and method of application |
US20080195035A1 (en) * | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
US20100222743A1 (en) * | 2005-06-27 | 2010-09-02 | Frederickson Franklyn L | Microneedle array applicator device and method of array application |
US9789249B2 (en) | 2005-06-27 | 2017-10-17 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
US8784363B2 (en) | 2005-06-27 | 2014-07-22 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
EP2474338A1 (en) | 2005-06-27 | 2012-07-11 | 3M Innovative Properties Company | Microneedle array applicator device |
US20100152701A1 (en) * | 2005-08-05 | 2010-06-17 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
US20070078414A1 (en) * | 2005-08-05 | 2007-04-05 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
US20090187160A1 (en) * | 2005-08-05 | 2009-07-23 | Mcallister Devin V | Methods and devices for delivering agents across biological barriers |
US9561042B2 (en) | 2005-08-05 | 2017-02-07 | Valeritas, Inc. | Methods and devices for delivering agents across biological barriers |
US9011392B2 (en) | 2005-08-05 | 2015-04-21 | Valeritas, Inc. | Methods and devices for delivering agents across biological barriers |
US20070060937A1 (en) * | 2005-08-30 | 2007-03-15 | Liu Chen H | Safety needle holder |
US20070293814A1 (en) * | 2005-09-12 | 2007-12-20 | Trautman Joseph C | Coatable transdermal delivery microprojection assembly |
US8554317B2 (en) | 2005-11-30 | 2013-10-08 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
WO2007064486A1 (en) | 2005-11-30 | 2007-06-07 | 3M Innovative Properties Company | Microneedle arrays and methods of use thereof |
US20080287858A1 (en) * | 2005-11-30 | 2008-11-20 | Duan Daniel C | Microneedle Arrays and Methods of Use Thereof |
US20080039775A1 (en) * | 2006-03-15 | 2008-02-14 | Alza Corporation | Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia |
US9119945B2 (en) | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20090198189A1 (en) * | 2006-04-20 | 2009-08-06 | 3M Innovative Properties Company | Device for applying a microneedle array |
US20070293816A1 (en) * | 2006-04-25 | 2007-12-20 | Alza Corporation | Microprojection Array Application with Grouped Microprojections for High Drug Loading |
US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
US8821446B2 (en) | 2007-01-22 | 2014-09-02 | Corium International, Inc. | Applicators for microneedles |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US9452280B2 (en) | 2007-04-16 | 2016-09-27 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US9498524B2 (en) | 2007-04-16 | 2016-11-22 | Corium International, Inc. | Method of vaccine delivery via microneedle arrays |
US10238848B2 (en) | 2007-04-16 | 2019-03-26 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US20110009782A1 (en) * | 2009-07-07 | 2011-01-13 | Naya Touch, Inc. | Dermal roller with therapeutic microstructures |
US9687640B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Applicators for microneedles |
US11419816B2 (en) | 2010-05-04 | 2022-08-23 | Corium, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US10946180B2 (en) | 2010-05-04 | 2021-03-16 | Corium, Inc. | Applicators for microneedles |
US11666740B2 (en) | 2010-05-04 | 2023-06-06 | Corium Pharma Solutions, Inc. | Applicators for microneedles |
US20110319920A1 (en) * | 2010-06-24 | 2011-12-29 | Kikkawa Yasuo | Micropore forming apparatus and micropore forming method |
US9307933B2 (en) * | 2010-06-24 | 2016-04-12 | Sysmex Corporation | Micropore forming apparatus and micropore forming method |
US9498611B2 (en) | 2011-10-06 | 2016-11-22 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
CN103857423A (en) * | 2011-10-12 | 2014-06-11 | 3M创新有限公司 | Integrated microneedle array delivery system |
US10010707B2 (en) | 2011-10-12 | 2018-07-03 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
US20140236090A1 (en) * | 2011-10-12 | 2014-08-21 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
EP2766067A4 (en) * | 2011-10-12 | 2015-08-19 | 3M Innovative Properties Co | Integrated microneedle array delivery system |
US9540684B2 (en) | 2012-12-14 | 2017-01-10 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
US10995366B2 (en) | 2012-12-14 | 2021-05-04 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
EP3542850A1 (en) | 2012-12-14 | 2019-09-25 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
US11052231B2 (en) | 2012-12-21 | 2021-07-06 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US20150352295A1 (en) * | 2013-01-08 | 2015-12-10 | 3M Innovative Properties Company | Application For Applying A Microneedle Device To Skin |
US10245422B2 (en) | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
US11110259B2 (en) | 2013-03-12 | 2021-09-07 | Corium, Inc. | Microprojection applicators and methods of use |
US11565097B2 (en) | 2013-03-15 | 2023-01-31 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US10391290B2 (en) | 2013-05-31 | 2019-08-27 | 3M Innovative Properties Company | Microneedle injection apparatus comprising a dual cover |
US9895520B2 (en) | 2013-05-31 | 2018-02-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising a dual cover |
US10716926B2 (en) | 2013-05-31 | 2020-07-21 | Kindeva Drug Delivery L.P. | Microneedle injection and infusion apparatus and method of using same |
US11771878B2 (en) | 2013-05-31 | 2023-10-03 | Kindeva Drug Delivery L.P. | Microneedle injection and infusion apparatus and method of using same |
US9682222B2 (en) | 2013-05-31 | 2017-06-20 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
US10695547B2 (en) | 2013-05-31 | 2020-06-30 | 3M Innovative Properties Company | Microneedle injection apparatus comprising an inverted actuator |
US9872975B2 (en) | 2013-05-31 | 2018-01-23 | 3M Innovative Properties Company | Microneedle injection and infusion apparatus and method of using same |
US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
US9743949B2 (en) * | 2015-04-22 | 2017-08-29 | Medline Industries, Inc. | Two-dimensional needle array device and method of use |
US10070886B2 (en) * | 2015-04-22 | 2018-09-11 | Medline Industries, Inc. | Method of harvesting tissue using sequential sections of a two dimensional array of needles |
US10478212B2 (en) | 2015-04-22 | 2019-11-19 | Medline Industries, Inc. | Method and system for harvesting biological tissue |
US11819235B2 (en) | 2015-04-22 | 2023-11-21 | Medline Industries, Lp | Method and system for harvesting biological tissue |
US10743904B2 (en) | 2015-04-22 | 2020-08-18 | Medline Industries, Inc. | Two-dimensional needle array device and method of use |
US10898220B2 (en) | 2015-04-22 | 2021-01-26 | Medline Industries, Inc. | Method of harvesting tissue using sequential sections of a two dimensional array of needles |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11484695B2 (en) | 2016-03-16 | 2022-11-01 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch case |
US11633580B2 (en) | 2017-03-28 | 2023-04-25 | Cosmed Pharmaceutical Co., Ltd. | Applicator for water-soluble sheet-shaped preparation |
US11452852B2 (en) | 2017-03-28 | 2022-09-27 | Cosmed Pharmaceutical Co., Ltd. | Applicator for water-soluble sheet-shaped preparation |
US11654270B2 (en) | 2021-09-28 | 2023-05-23 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
US20230099617A1 (en) * | 2021-09-28 | 2023-03-30 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
US11672965B2 (en) * | 2021-09-28 | 2023-06-13 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
SE2350993A1 (en) * | 2021-09-28 | 2023-08-23 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
US20230310823A1 (en) * | 2021-09-28 | 2023-10-05 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
US11904127B2 (en) * | 2021-09-28 | 2024-02-20 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
SE545876C2 (en) * | 2021-09-28 | 2024-02-27 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
US11986614B2 (en) | 2021-09-28 | 2024-05-21 | Biolinq Incorporated | Microneedle enclosure and applicator device for microneedle array based continuous analyte monitoring device |
USD1033641S1 (en) | 2021-12-17 | 2024-07-02 | Biolinq Incorporated | Microneedle array sensor applicator device |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10342963B2 (en) | Microblade array impact applicator | |
AU2001296827A1 (en) | Microblade array impact applicator | |
CA2425315C (en) | Apparatus and method for piercing skin with microprotrusions | |
US7419481B2 (en) | Apparatus and method for piercing skin with microprotrusions | |
EP1341452B1 (en) | Microprotrusion member retainer for impact applicator | |
AU2001296828A1 (en) | Apparatus and method for piercing skin with microprotrusions | |
AU2001296817A1 (en) | Microprotrusion member retainer for impact applicator |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: ALZA CORPORATION, CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TRAUTMAN, JOSEPH C.;CAO, MICHAEL T.;KEENAN, RICHARD L.;SIGNING DATES FROM 20140910 TO 20141215;REEL/FRAME:034520/0296 |