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US3608539A - Method for the biopsy of subcutaneous masses - Google Patents

Method for the biopsy of subcutaneous masses Download PDF

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US3608539A
US3608539A US773787A US3608539DA US3608539A US 3608539 A US3608539 A US 3608539A US 773787 A US773787 A US 773787A US 3608539D A US3608539D A US 3608539DA US 3608539 A US3608539 A US 3608539A
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cannula
mass
skin
stylet
biopsy
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Daniel G Miller
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample

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  • the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect.
  • the stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin. which is then punctured and the distal end of the cannula pushed through the puncture.
  • the ejector is then pushed through the proximal end of the cannula to eject the specimen.
  • the present invention relates generally to improvements in sampling methods and instruments and it relates particularly to an improved method and instrument for obtaining biopsy specimens from subcutaneous masses, such as lymph nodes or tumors.
  • Another object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens.
  • Still another object of the presentinvention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses.
  • a further object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses with a minimum of damage to the surrounding tissue and the obviation of any transfer of the sampled mass to the surrounding tissue.
  • Still a further object of the present invention is to provide a method of the above nature, characterized by its convenience, simplicity, high reliability, versatility and minimum discomforture to the subject.
  • the present invention contemplates the provision of the method for obtaining a biopsy of a subcutaneous masscomprising the steps of advancing a curved cannula through a first area of the skin, through said mass to cut and receive a specimen thereof, and thence through a second area of the skin, and thereafter ejecting said specimen from said cannula while projecting through the skin of the second area.
  • the cannula is advantageously curved and preferably arcuate with a radius of curvature advantageously between 3 and centimeters and advantageously extends between 45 and 180 preferably between 120 and 130, and is of a length between 5 and 12 centimeters.
  • the distal end of the cannula is provided with a serrated cutting edge and the proximal end is provided with finger engageable wings.
  • a similarly curved stylet is slidably received within the cannula and is provided with a proximal button and a distal pointed tip projecting through the cannula distal end.
  • a blunt ended flexible ejector is slidably received within the cannula alternatively with the stylet.
  • FIG. 1 is a front elevational view of the cannula section of an instrument embodying the present invention
  • FIG. 2 is a front elevational view of the stylet section thereof
  • FIG. 3 is a front elevational view of the ejector section thereof
  • FIG. 4 is a enlarged longitudinal sectional view of the distal end of the assembled instrument
  • FIG. 5 is an elevational view illustrating a step of preparing the site in the practice of the improved process
  • FIG. 6 illustrates the insertion of the cannula into the explored mass
  • FIG. 7 illustrates the obtaining of the biopsy specimen
  • FIG. 8 illustrates the preparation of the skin exit site
  • FIG. 9 illustrates the ejection of the biopsy specimen.
  • the improved instrument includes a cannula 11, a stylet or piercing member 12, and an ejector member 13.
  • the cannula 11 comprises an arcuate tubular body member or barrel 14, provided at its distal end with a sharp serrated cutting edge 16, as bestseen in FIG. I.
  • the bore of the cannula barrel 14 is uniform throughout its length, the outer face at the distal end being tapered to the cutting edge 16.
  • An annulus 17 is fitted over the proximal end of the barrel 14 and a wing-shaped finger piece provided with a medial opening is also fitted over the proximal border of the barrel l4 and rests on the annulus 17.
  • a standard Luer-lok receptacle or coupling collar 19 engages the distal end of the barrel l4 and is affixed to the barrel 14 with the annulus l7 and finger piece 18, by soldering, welding or the like.
  • the stylet 12 includes an accurately shaped rod 20 of the same curvature as the cannula barrel l4, and is of lesser crosssectional diameter than the bore of the barrel 14.
  • the rod 20 terminates at its distal end in an enlarged pointed tip 21 and is provided at its proximal end with a thumb rest or button 22.
  • the cannula l1 and stylet 12 are so dimensioned that when the stylet 12 is fully inserted in the cannula 11, the button 22 rests on the coupling collar 19 and the tip 21 projects through the distal end of the cannula barrel 14 with its face forming a smooth continuous surface with the outside face of the cannula barrel distal border, as seen best in FIG. 4.
  • the ejector member 13 is a flexible rod or wire of an outside diameter, about equal to the inside diameter of the barrel l4, and is provided with a blunt distal end face 23.
  • the ejector member 13 is advantageously formed of Teflon rod or other suitable material.
  • the cannula barrel 14 is formed of stainless steel with an inside diameter of 3 millimeters and an outside diameter of 4 millimeters.
  • the overall length of the cannula barrel 14 is 10 centimeters and the chord distance from end to end is about 9 centimeters. It has a radius of curvature of about 4.5 cm. and extends for about 120.
  • the taper leading to the cutting edge 16 is about 4 millimeters long.
  • the rod 20 is stainless steel of 2 millimeters diameter and the conical tip 21 is 6 millimeter long.
  • the skin S is infiltrated with procaine and from this side additional procaine is injected subcutaneously about mass M.
  • Skin S is punctured, as seen in FIG. 5, with a surgical blade 26 in an area slightly offset from the side of mass M.
  • the opening in the skin is further enlarged by stretching with a small curved hemostat or pointed scissors, not shown.
  • a tract is made to the mass M by penetration and separation of the subutaneous tissue.
  • the cannula l l with the pointed stylet 12 in place is then inserted along the prepared tract and inserted into the side of or the undersurface of the mass M, as seen in P10. 6.
  • the free hand can often assist by holding the mass.
  • the pointed stylet 12 is removed. With the thumb of the free hand, the mass M is pushed down and in this manner the open cannula ll traverses one entire diameter of the mass M, as seen in H0. 7.
  • the arc is further extended to raise the skin S at the opposite side of the mass M.
  • the specimen loaded cannula 11 emerges.
  • the clearing stylet or ejector 13 is inserted in the cannula 11, as shown in FIG. 9, and the specimen is picked up on either a square of blotting paper or with thumb forceps and dropped into a bottle containing the fixing solution.
  • the cannula 11, is easily withdrawn by reversing the direction of the arc. Pressure is applied to the punctures for 2 minutes and two Band- Aids are applied to each of the two puncture sites and left in place for 24 hours.
  • the method for obtaining a biopsy of a subcutaneous mass comprising the steps of advancing a cannula inwardly through a first area of the skin laterally of the area above the mass and through said mass to undercut and receive a specimen from said mass and thence advancing outwardly cannula with the specimen therein out through a second area of the skin, on the side of the area above the mass opposite the first area and thereafter ejecting said specimen from said cannula while projecting through said skin.

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  • Life Sciences & Earth Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

An instrument for the biopsy of subcutaneous masses includes an arcuate cannula having a serrated distal cutting end and is provided for alternative insertion, a correspondingly curved pointed stylet and a flexible ejector element. In performing a biopsy, and the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect. The stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin, which is then punctured and the distal end of the cannula pushed through the puncture. The ejector is then pushed through the proximal end of the cannula to eject the specimen.

Description

United States Patent [72] lnventor Daniel G. Miller 430 E. 86th St., New York, N.Y. 10028 [21] Appl. No. 773,787 [22] Filed Nov. 6, 1968 [45] Patented Sept. 28, 1971 [54] METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES 6 Claims, 9 Drawing Figs.
[52] 11.8. CI. 128/2, 128/314, 128/329, 128/347 [51] Int. Cl ..A61bl0/00, A61b 17/34, A61b 17/32 [50] Field of Search 128/2, 305, v 314, 329, 347
[56] References Cited UNITED STATES PATENTS 2,919,692 l/1960 v Ackermann 128/314 X 3,342,175 9/1967 Bulloch 128/2 1,485,298 2/l924 Schroyer 128/347 UX 2,865,374 12/1958 Brown et al.... 128/347 X 3,496,932 2/1970 Prisk et a1. 129/347 X Primary Examiner-Channing L. Pace Attorney-Howard C. Miskin ABSTRACT: An instrument for the biopsy of subcutaneous masses includes an arcuate cannula having a serrated distal cutting end and is provided for alternative insertion, a correspondingly curved pointed stylet and a flexible ejector element. In performing a biopsy, and the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect. The stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin. which is then punctured and the distal end of the cannula pushed through the puncture. The ejector is then pushed through the proximal end of the cannula to eject the specimen.
PATENTED SEP28I9TI 3.808.539
SHEET 1 BF 2 INVEN'I'OR. DANIEL G. MILLER AT TORNEY PATENTED SEP28 I97! 3.608.539
sum 2 0F 2 EN'I'UR. DAME MILLER ATTORNEY METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES BACKGROUND OF THE INVENTION The present invention relates generally to improvements in sampling methods and instruments and it relates particularly to an improved method and instrument for obtaining biopsy specimens from subcutaneous masses, such as lymph nodes or tumors. I
The procedures conventionally employed for obtaining biopsy specimens pose numerous drawbacks and disadvantages, particularly when applied to subcutaneous masses. They are usually accompanied by damage to the surrounding tissue as the result of surgical incision and disection, and frequently effect the transfer of some of the sampled mass to the surrounding tissue, a consequence which is highly undesirable and should be assiduously avoided. Moreover, when straight needles are employed to obtain biopsies of lymph nodes or subcutaneous masses, the plug which is impaled in the barrel, in most instances will remain in situ when the needle is withdrawn, because its distal end has not been severed from the bulk of the mass. These tissues possess an inherent elasticity and connective tissue framework, which is resilient and has sufficient strength to retain a specimen which is cut on only three sides. It is because of this common experience that needles previously used for this purpose employed various undercutting mechanisms for retaining the cut plug, e.g. a screw, a hook, compressible jaws or a side cutting device.
SUMMARY OF THE INVENTION It is a principal object of the present invention to provide an improved sampling method and instrument.
Another object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens.
Still another object of the presentinvention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses.
A further object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses with a minimum of damage to the surrounding tissue and the obviation of any transfer of the sampled mass to the surrounding tissue.
Still a further object of the present invention is to provide a method of the above nature, characterized by its convenience, simplicity, high reliability, versatility and minimum discomforture to the subject.
The above and other objects of the present invention will become apparent from a reading of the following description taken in conjunction with the accompanying drawing, which illustrates a preferred embodiment thereof.
In a sense the present invention contemplates the provision of the method for obtaining a biopsy of a subcutaneous masscomprising the steps of advancing a curved cannula through a first area of the skin, through said mass to cut and receive a specimen thereof, and thence through a second area of the skin, and thereafter ejecting said specimen from said cannula while projecting through the skin of the second area. The cannula is advantageously curved and preferably arcuate with a radius of curvature advantageously between 3 and centimeters and advantageously extends between 45 and 180 preferably between 120 and 130, and is of a length between 5 and 12 centimeters. The distal end of the cannula is provided with a serrated cutting edge and the proximal end is provided with finger engageable wings. A similarly curved stylet is slidably received within the cannula and is provided with a proximal button and a distal pointed tip projecting through the cannula distal end. A blunt ended flexible ejector is slidably received within the cannula alternatively with the stylet. According to the preferred procedure, the skin on one side of the mass is punctured and the stylet engaged cannula inserted therethrough and advanced into engagement with the mass. The stylet is then removed and the cannula advanced through The improved procedure is simple, rapid, convenient, versatile and reliable. It results in a minimum of damage to the surrounding tissue and prevents any transfer of the biopsied mass to the surrounding tissue.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a front elevational view of the cannula section of an instrument embodying the present invention;
FIG. 2 is a front elevational view of the stylet section thereof;
FIG. 3 is a front elevational view of the ejector section thereof;
FIG. 4 is a enlarged longitudinal sectional view of the distal end of the assembled instrument;
FIG. 5 is an elevational view illustrating a step of preparing the site in the practice of the improved process;
FIG. 6 illustrates the insertion of the cannula into the explored mass;
FIG. 7 illustrates the obtaining of the biopsy specimen;
FIG. 8 illustrates the preparation of the skin exit site; and
FIG. 9 illustrates the ejection of the biopsy specimen.
DESCRIPTION THE PREFERRED EMBODIMENT Referring now to the drawing, and particularly FIGS. 1 to 4 thereof, which illustrate an instrument embodying the present invention, the improved instrument includes a cannula 11, a stylet or piercing member 12, and an ejector member 13. The cannula 11 comprises an arcuate tubular body member or barrel 14, provided at its distal end with a sharp serrated cutting edge 16, as bestseen in FIG. I. The bore of the cannula barrel 14 is uniform throughout its length, the outer face at the distal end being tapered to the cutting edge 16.
An annulus 17 is fitted over the proximal end of the barrel 14 and a wing-shaped finger piece provided with a medial opening is also fitted over the proximal border of the barrel l4 and rests on the annulus 17. A standard Luer-lok receptacle or coupling collar 19engages the distal end of the barrel l4 and is affixed to the barrel 14 with the annulus l7 and finger piece 18, by soldering, welding or the like.
The stylet 12 includes an accurately shaped rod 20 of the same curvature as the cannula barrel l4, and is of lesser crosssectional diameter than the bore of the barrel 14. The rod 20 terminates at its distal end in an enlarged pointed tip 21 and is provided at its proximal end with a thumb rest or button 22. The cannula l1 and stylet 12 are so dimensioned that when the stylet 12 is fully inserted in the cannula 11, the button 22 rests on the coupling collar 19 and the tip 21 projects through the distal end of the cannula barrel 14 with its face forming a smooth continuous surface with the outside face of the cannula barrel distal border, as seen best in FIG. 4.
The ejector member 13, is a flexible rod or wire of an outside diameter, about equal to the inside diameter of the barrel l4, and is provided with a blunt distal end face 23. The ejector member 13 is advantageously formed of Teflon rod or other suitable material.
As a specific example, the cannula barrel 14 is formed of stainless steel with an inside diameter of 3 millimeters and an outside diameter of 4 millimeters. The overall length of the cannula barrel 14 is 10 centimeters and the chord distance from end to end is about 9 centimeters. It has a radius of curvature of about 4.5 cm. and extends for about 120. The taper leading to the cutting edge 16 is about 4 millimeters long. The rod 20 is stainless steel of 2 millimeters diameter and the conical tip 21 is 6 millimeter long.
Considering now the practice of the improved method employing the instrument described above, and referring to FIGS. 5-.-9 of the drawing, the skin S, about 2 centimeters from the mass M which is to be biopsied, is infiltrated with procaine and from this side additional procaine is injected subcutaneously about mass M. Skin S is punctured, as seen in FIG. 5, with a surgical blade 26 in an area slightly offset from the side of mass M. The opening in the skin is further enlarged by stretching with a small curved hemostat or pointed scissors, not shown. With the same instrument a tract is made to the mass M by penetration and separation of the subutaneous tissue. The cannula l l with the pointed stylet 12 in place is then inserted along the prepared tract and inserted into the side of or the undersurface of the mass M, as seen in P10. 6. The free hand can often assist by holding the mass. After entry has been confirmed by moving the cannula 11 and mass M as one, the pointed stylet 12 is removed. With the thumb of the free hand, the mass M is pushed down and in this manner the open cannula ll traverses one entire diameter of the mass M, as seen in H0. 7. ln some situations it is advantageous to rock the proximal end of the cannula to and fro; this turns serrated cutting edge 16 of barrel l4 and facilitates its passage through the mass M. When the mass M has been penetrated, the arc is further extended to raise the skin S at the opposite side of the mass M. With procaine, puncture and tract prepared as above, as seen in FIG. 8, the specimen loaded cannula 11 emerges. The clearing stylet or ejector 13 is inserted in the cannula 11, as shown in FIG. 9, and the specimen is picked up on either a square of blotting paper or with thumb forceps and dropped into a bottle containing the fixing solution. The cannula 11, is easily withdrawn by reversing the direction of the arc. Pressure is applied to the punctures for 2 minutes and two Band- Aids are applied to each of the two puncture sites and left in place for 24 hours.
In employing the improved instrument in the method described above, highly satisfactory biopsy specimens were obtained and the proper diagnosis made in a large number of patients. No false negative diagnosis were encountered. It is important to note that there were no complications associated with the improved procedure. The specimens biopsied represented a variety of lesions from the point of view of size, consistency and diagnosis and the improved method has proven sufficiently versatile to adapt to most of the situations encountered.
While there has been described and illustrated a preferred embodiment of the present invention, it is apparent that numerous alterations, omissions and additions may be made without departing from the spirit thereof.
What I claim is:
l. The method for obtaining a biopsy of a subcutaneous mass comprising the steps of advancing a cannula inwardly through a first area of the skin laterally of the area above the mass and through said mass to undercut and receive a specimen from said mass and thence advancing outwardly cannula with the specimen therein out through a second area of the skin, on the side of the area above the mass opposite the first area and thereafter ejecting said specimen from said cannula while projecting through said skin.
2. The method of claim 1 wherein said cannula is advanced through said first skin area to said mass, while engaged by a stylet provided with a pointed end positioned at the distal end of said cannula, and removing said stylet from said cannula prior to said cannula being advanced through said mass.
3. The method of claim 1 wherein said specimen is ejected through said cannula by advancing a plunger through said cannula.
4. The method of claim 1 including the step of puncturing said first area of said skin with a sharp instrument prior to the insertion of said cannula.
5. The method of claim 1, including the step of puncturing the skin at said second area following the penetration of the mass by the cannula and before the emergence of the cannula through said second area.
6. The method of claim 1, including the step of applying pressure to said mass through the surrounding tissue in a direction towards said cannula during the advance of said cannula through said mass.
mg? NITEE STATES PATENT @F'FECE (IERHFECATE @F GORREQTEGN Patent No. 3,608, 539 Dated Becember 13, 1971 It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
Abstract: 1. 5 "ment. In performing a biopsy, and
the skin is punctured and" Change to ment. In performing a biopsy, the skin is punctured, end-- Column 2, 1.. l9 "Fig. t is e enlarged longitudinal" Change to Fig. t is an enlarged longitudinal-- Column 4, l. i i-l5 said mess and thence advancing outwardly cannula with the specimen therein out through second area of the skin, on the Change to --said mass and thence advancing said cannula with the specimen therein outwardly through a second area of the skin, on the-- Signed and sealed this 25th day of April 1%?2.
At to e L:
MJNARD MJLEJJ EMEJR. ROBERT GOTTSCHALK Attesting Officer Commissioner of Patents

Claims (5)

  1. 2. The method of claim 1, wherein said cannula is advanced through said first skin area to said mass, while engaged by a stylet provided with a pointed end positioned at the distal end of said cannula, and removing said stylet from said cannula prior to said cannula being advanced through said mass.
  2. 3. The method of claim 1, wherein said specimen is ejected through said cannula by advancing a plunger through said cannula.
  3. 4. The method of claim 1, including the step of puncturing said first area of said skin with a sharp instrument prior to the insertion of said cannula.
  4. 5. The method of claim 1, including the step of puncturing the skin at said second area following the penetration of the mass by the cannula and before the emergence of the cannula through said second area.
  5. 6. The method of claim 1, including the step of applying pressure to said mass through the surrounding tissue in a direction towards said cannula during the advance of said cannula through said mass.
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Cited By (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870043A (en) * 1974-03-28 1975-03-11 Allan R Dunn U-shaped intravenous needle structure
US4013080A (en) * 1974-10-03 1977-03-22 Froning Edward C Cannula connector and direction indicator means for injection system
US4244370A (en) * 1978-11-20 1981-01-13 American Medical Systems, Inc. Tool for positioning implantable medical prosthetic device _and method of using same
USRE30966E (en) * 1977-09-30 1982-06-15 The Regents Of The University Of California Wick catheter pressure sensing probe and method of use
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4530359A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic perforating instrument and surgical method employing said instrument
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US4842589A (en) * 1986-11-26 1989-06-27 Sherwood Medical Company Intercavity catheter
US5025797A (en) * 1989-03-29 1991-06-25 Baran Gregory W Automated biopsy instrument
US5047040A (en) * 1987-11-05 1991-09-10 Devices For Vascular Intervention, Inc. Atherectomy device and method
US5342376A (en) * 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
US5417700A (en) * 1992-03-30 1995-05-23 Thomas D. Egan Automatic suturing and ligating device
WO1999065545A1 (en) * 1998-06-16 1999-12-23 Robbins Scientific Corporation Syringe with various needle assemblies
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US6264675B1 (en) * 2000-02-04 2001-07-24 Gregory R. Brotz Single suture structure
US6364859B1 (en) 1998-06-16 2002-04-02 Robbins Scientific Corporation Locking cap for replaceable needle assembly
US20020087189A1 (en) * 1993-02-04 2002-07-04 Bonutti Peter M. Method and apparatus for positioning a suture anchor
US6478809B1 (en) * 2000-02-04 2002-11-12 Gregory R. Brotz Suture and method of use
US6599310B2 (en) 2001-06-29 2003-07-29 Quill Medical, Inc. Suture method
US20040030354A1 (en) * 2002-08-09 2004-02-12 Leung Jeffrey C. Suture anchor and method
US20040087956A1 (en) * 2000-09-01 2004-05-06 Synthes (U.S.A) Tools and methods for creating cavities in bone
US20040210245A1 (en) * 2002-07-26 2004-10-21 John Erickson Bendable needle with removable stylet
US20040237736A1 (en) * 2001-08-31 2004-12-02 Genova Perry A. Method of forming barbs on a suture and apparatus for performing same
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US20060241695A1 (en) 2000-03-13 2006-10-26 Bonutti Peter M Method of using ultrasonic vibration to secure body tissue with fastening element
US20080027390A1 (en) * 2006-07-31 2008-01-31 Carlos Jaramillo Catheterization device and method
US20080039845A1 (en) * 2006-02-07 2008-02-14 Bonutti Peter M Methods and devices for intracorporeal bonding of implants with thermal energy
US20080071304A1 (en) * 2005-02-25 2008-03-20 Tal Michael G Varicose Vein Dissector and Removal Apparatus
US20080114399A1 (en) * 2000-05-03 2008-05-15 Bonutti Peter M Method of securing body tissue
US20080215072A1 (en) * 2007-02-15 2008-09-04 Graham Kelly Methods and apparatus for utilization of barbed sutures in human tissue including a method for eliminating or improving blood flow in veins
US20080255563A1 (en) * 2006-11-03 2008-10-16 Innovative Spine Instrumentation and method for providing surgical access to a spine
US20080281224A1 (en) * 2007-05-11 2008-11-13 Johnson Michael E Biopsy device needle tip
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US20100153335A1 (en) * 2008-12-12 2010-06-17 Microsoft Corporation Synchronizing multiple classes with disparate schemas in the same collection
US7758614B2 (en) 1998-07-08 2010-07-20 Tornier, Inc. Coupling member for knotless sutures and ligatures
US20100298871A1 (en) * 2004-05-14 2010-11-25 Quill Medical, Inc. Self-retaining wound closure device including an anchoring loop
US20100298876A1 (en) * 2002-09-30 2010-11-25 Quill Medical, Inc. Self-retaining sutures having effective holding strength and tensile strength
US7857827B2 (en) 2006-04-14 2010-12-28 Ethicon Endo-Surgery, Inc. Endoscopic device
US7998167B2 (en) 2006-04-14 2011-08-16 Ethicon Endo-Surgery, Inc. End effector and method of manufacture
US8118834B1 (en) 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8313500B2 (en) 2006-04-14 2012-11-20 Ethicon Endo-Surgery, Inc. Endoscopic device
US8496657B2 (en) 2006-02-07 2013-07-30 P Tech, Llc. Methods for utilizing vibratory energy to weld, stake and/or remove implants
US8617185B2 (en) 2007-02-13 2013-12-31 P Tech, Llc. Fixation device
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US8721681B2 (en) 2002-09-30 2014-05-13 Ethicon, Inc. Barbed suture in combination with surgical needle
US8771313B2 (en) 2007-12-19 2014-07-08 Ethicon, Inc. Self-retaining sutures with heat-contact mediated retainers
US8777987B2 (en) 2007-09-27 2014-07-15 Ethicon, Inc. Self-retaining sutures including tissue retainers having improved strength
US8793863B2 (en) 2007-04-13 2014-08-05 Ethicon, Inc. Method and apparatus for forming retainers on a suture
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
US8840621B2 (en) 2006-11-03 2014-09-23 Innovative Spine, Inc. Spinal access systems and methods
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US8845687B2 (en) 1996-08-19 2014-09-30 Bonutti Skeletal Innovations Llc Anchor for securing a suture
US8876865B2 (en) 2008-04-15 2014-11-04 Ethicon, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
US8875607B2 (en) 2008-01-30 2014-11-04 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US8932328B2 (en) 2008-11-03 2015-01-13 Ethicon, Inc. Length of self-retaining suture and method and device for using the same
US8961560B2 (en) 2008-05-16 2015-02-24 Ethicon, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
USRE45426E1 (en) 1997-05-21 2015-03-17 Ethicon, Inc. Surgical methods using one-way suture
US9060767B2 (en) 2003-04-30 2015-06-23 P Tech, Llc Tissue fastener and methods for using same
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US9125647B2 (en) 2008-02-21 2015-09-08 Ethicon, Inc. Method and apparatus for elevating retainers on self-retaining sutures
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US9149281B2 (en) 2002-03-20 2015-10-06 P Tech, Llc Robotic system for engaging a fastener with body tissue
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US9226828B2 (en) 2004-10-26 2016-01-05 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9248580B2 (en) 2002-09-30 2016-02-02 Ethicon, Inc. Barb configurations for barbed sutures
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9439642B2 (en) 2006-02-07 2016-09-13 P Tech, Llc Methods and devices for utilizing bondable materials
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US9750496B2 (en) 2002-08-27 2017-09-05 P Tech, Llc System for securing a portion of a body
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
US9888916B2 (en) 2004-03-09 2018-02-13 P Tech, Llc Method and device for securing body tissue
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
US10188384B2 (en) 2011-06-06 2019-01-29 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1485298A (en) * 1923-04-26 1924-02-26 William O Schroyer Embalming implement
US2865374A (en) * 1957-09-16 1958-12-23 Sierra Eng Co Tracheotomy instrument
US2919692A (en) * 1956-02-23 1960-01-05 Ackermann Wolfgang Vertebral trephine biopsy instruments
US3342175A (en) * 1964-11-23 1967-09-19 Robert T Bulloch Cardiac biopsy instrument
US3496932A (en) * 1967-12-22 1970-02-24 Gen Motors Corp Method and apparatus for substernal cardiac massage

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1485298A (en) * 1923-04-26 1924-02-26 William O Schroyer Embalming implement
US2919692A (en) * 1956-02-23 1960-01-05 Ackermann Wolfgang Vertebral trephine biopsy instruments
US2865374A (en) * 1957-09-16 1958-12-23 Sierra Eng Co Tracheotomy instrument
US3342175A (en) * 1964-11-23 1967-09-19 Robert T Bulloch Cardiac biopsy instrument
US3496932A (en) * 1967-12-22 1970-02-24 Gen Motors Corp Method and apparatus for substernal cardiac massage

Cited By (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870043A (en) * 1974-03-28 1975-03-11 Allan R Dunn U-shaped intravenous needle structure
US4013080A (en) * 1974-10-03 1977-03-22 Froning Edward C Cannula connector and direction indicator means for injection system
USRE30966E (en) * 1977-09-30 1982-06-15 The Regents Of The University Of California Wick catheter pressure sensing probe and method of use
US4244370A (en) * 1978-11-20 1981-01-13 American Medical Systems, Inc. Tool for positioning implantable medical prosthetic device _and method of using same
US4684369A (en) * 1982-04-14 1987-08-04 Wildemeersch Dirk A A Instrument for suprapubic drainage of the bladder, inserted through the urethra
US4493323A (en) * 1982-12-13 1985-01-15 University Of Iowa Research Foundation Suturing device and method for using same
US4530359A (en) * 1983-02-08 1985-07-23 Helfgott Maxwell A Ophthalmic perforating instrument and surgical method employing said instrument
US4842589A (en) * 1986-11-26 1989-06-27 Sherwood Medical Company Intercavity catheter
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US5047040A (en) * 1987-11-05 1991-09-10 Devices For Vascular Intervention, Inc. Atherectomy device and method
US5025797A (en) * 1989-03-29 1991-06-25 Baran Gregory W Automated biopsy instrument
US5125413A (en) * 1989-03-29 1992-06-30 Baran Gregory W Automated biopsy instrument
US5417700A (en) * 1992-03-30 1995-05-23 Thomas D. Egan Automatic suturing and ligating device
US20020087189A1 (en) * 1993-02-04 2002-07-04 Bonutti Peter M. Method and apparatus for positioning a suture anchor
US20050240227A1 (en) * 1993-02-04 2005-10-27 Bonutti Peter M Method and apparatus for positioning an anchor member
US6942684B2 (en) * 1993-02-04 2005-09-13 Bonutti Ip, Llc Method and apparatus for positioning an anchor member
US7226468B2 (en) 1993-05-03 2007-06-05 Quill Medical, Inc. Barbed bodily tissue connector
US8246652B2 (en) 1993-05-03 2012-08-21 Ethicon, Inc. Suture with a pointed end and an anchor end and with equally spaced yieldable tissue grasping barbs located at successive axial locations
US20080221617A1 (en) * 1993-05-03 2008-09-11 Quill Medical, Inc. Barbed tissue connector
US7806908B2 (en) 1993-05-03 2010-10-05 Quill Medical, Inc. Barbed tissue connector
US5342376A (en) * 1993-05-03 1994-08-30 Dermagraphics, Inc. Inserting device for a barbed tissue connector
US20070208355A1 (en) * 1993-05-03 2007-09-06 Ruff Gregory L Barbed tissue connector
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US20040093028A1 (en) * 1993-05-03 2004-05-13 Ruff Gregory L. Barbed bodily tissue connector
US8845687B2 (en) 1996-08-19 2014-09-30 Bonutti Skeletal Innovations Llc Anchor for securing a suture
USRE45426E1 (en) 1997-05-21 2015-03-17 Ethicon, Inc. Surgical methods using one-way suture
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
WO1999065545A1 (en) * 1998-06-16 1999-12-23 Robbins Scientific Corporation Syringe with various needle assemblies
US6364859B1 (en) 1998-06-16 2002-04-02 Robbins Scientific Corporation Locking cap for replaceable needle assembly
US7758614B2 (en) 1998-07-08 2010-07-20 Tornier, Inc. Coupling member for knotless sutures and ligatures
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US6264675B1 (en) * 2000-02-04 2001-07-24 Gregory R. Brotz Single suture structure
US6478809B1 (en) * 2000-02-04 2002-11-12 Gregory R. Brotz Suture and method of use
US9067362B2 (en) 2000-03-13 2015-06-30 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US8747439B2 (en) 2000-03-13 2014-06-10 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US9986994B2 (en) 2000-03-13 2018-06-05 P Tech, Llc Method and device for securing body tissue
US20060241695A1 (en) 2000-03-13 2006-10-26 Bonutti Peter M Method of using ultrasonic vibration to secure body tissue with fastening element
US9884451B2 (en) 2000-03-13 2018-02-06 P Tech, Llc Method of using ultrasonic vibration to secure body tissue
US8814902B2 (en) 2000-05-03 2014-08-26 Bonutti Skeletal Innovations Llc Method of securing body tissue
US20080114399A1 (en) * 2000-05-03 2008-05-15 Bonutti Peter M Method of securing body tissue
US20040087956A1 (en) * 2000-09-01 2004-05-06 Synthes (U.S.A) Tools and methods for creating cavities in bone
US6599310B2 (en) 2001-06-29 2003-07-29 Quill Medical, Inc. Suture method
US7857829B2 (en) 2001-06-29 2010-12-28 Quill Medical, Inc. Suture method
US8747437B2 (en) 2001-06-29 2014-06-10 Ethicon, Inc. Continuous stitch wound closure utilizing one-way suture
US8764796B2 (en) 2001-06-29 2014-07-01 Ethicon, Inc. Suture method
US20070208377A1 (en) * 2001-06-29 2007-09-06 Andrew Kaplan Suture Method
US8764776B2 (en) 2001-06-29 2014-07-01 Ethicon, Inc. Anastomosis method using self-retaining sutures
US8777988B2 (en) 2001-06-29 2014-07-15 Ethicon, Inc. Methods for using self-retaining sutures in endoscopic procedures
US8777989B2 (en) 2001-06-29 2014-07-15 Ethicon, Inc. Subcutaneous sinusoidal wound closure utilizing one-way suture
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US7913365B2 (en) 2001-08-31 2011-03-29 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US20040237736A1 (en) * 2001-08-31 2004-12-02 Genova Perry A. Method of forming barbs on a suture and apparatus for performing same
US8926659B2 (en) 2001-08-31 2015-01-06 Ethicon, Inc. Barbed suture created having barbs defined by variable-angle cut
US7996968B2 (en) 2001-08-31 2011-08-16 Quill Medical, Inc. Automated method for cutting tissue retainers on a suture
US7996967B2 (en) 2001-08-31 2011-08-16 Quill Medical, Inc. System for variable-angle cutting of a suture to create tissue retainers of a desired shape and size
US8011072B2 (en) 2001-08-31 2011-09-06 Quill Medical, Inc. Method for variable-angle cutting of a suture to create tissue retainers of a desired shape and size
US8015678B2 (en) 2001-08-31 2011-09-13 Quill Medical, Inc. Method for cutting a suture to create tissue retainers of a desired shape and size
US8020263B2 (en) 2001-08-31 2011-09-20 Quill Medical, Inc. Automated system for cutting tissue retainers on a suture
US7225512B2 (en) 2001-08-31 2007-06-05 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US8028388B2 (en) 2001-08-31 2011-10-04 Quill Medical, Inc. System for cutting a suture to create tissue retainers of a desired shape and size
US8028387B2 (en) 2001-08-31 2011-10-04 Quill Medical, Inc. System for supporting and cutting suture thread to create tissue retainers thereon
US20070187861A1 (en) * 2001-08-31 2007-08-16 Quill Medical, Inc. Method of Forming Barbs on a Suture and Apparatus for Performing Same
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
US9192395B2 (en) 2002-03-20 2015-11-24 P Tech, Llc Robotic fastening system
US10932869B2 (en) 2002-03-20 2021-03-02 P Tech, Llc Robotic surgery
US9877793B2 (en) 2002-03-20 2018-01-30 P Tech, Llc Robotic arthroplasty system
US9155544B2 (en) 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
US9149281B2 (en) 2002-03-20 2015-10-06 P Tech, Llc Robotic system for engaging a fastener with body tissue
US10959791B2 (en) 2002-03-20 2021-03-30 P Tech, Llc Robotic surgery
US9271779B2 (en) 2002-03-20 2016-03-01 P Tech, Llc Methods of using a robotic spine system
US9271741B2 (en) 2002-03-20 2016-03-01 P Tech, Llc Robotic ultrasonic energy system
US9486227B2 (en) 2002-03-20 2016-11-08 P Tech, Llc Robotic retractor system
US9585725B2 (en) 2002-03-20 2017-03-07 P Tech, Llc Robotic arthroplasty system
US9629687B2 (en) 2002-03-20 2017-04-25 P Tech, Llc Robotic arthroplasty system
US10265128B2 (en) 2002-03-20 2019-04-23 P Tech, Llc Methods of using a robotic spine system
US9808318B2 (en) 2002-03-20 2017-11-07 P Tech, Llc Robotic arthroplasty system
US10368953B2 (en) 2002-03-20 2019-08-06 P Tech, Llc Robotic system for fastening layers of body tissue together and method thereof
US10869728B2 (en) 2002-03-20 2020-12-22 P Tech, Llc Robotic surgery
US20040210245A1 (en) * 2002-07-26 2004-10-21 John Erickson Bendable needle with removable stylet
US8679158B2 (en) 2002-08-09 2014-03-25 Ethicon, Inc. Multiple suture thread configuration with an intermediate connector
US8690914B2 (en) 2002-08-09 2014-04-08 Ethicon, Inc. Suture with an intermediate barbed body
US8652170B2 (en) 2002-08-09 2014-02-18 Ethicon, Inc. Double ended barbed suture with an intermediate body
US8734486B2 (en) 2002-08-09 2014-05-27 Ethicon, Inc. Multiple suture thread configuration with an intermediate connector
US20040030354A1 (en) * 2002-08-09 2004-02-12 Leung Jeffrey C. Suture anchor and method
US8083770B2 (en) 2002-08-09 2011-12-27 Quill Medical, Inc. Suture anchor and method
US9750496B2 (en) 2002-08-27 2017-09-05 P Tech, Llc System for securing a portion of a body
US20100298876A1 (en) * 2002-09-30 2010-11-25 Quill Medical, Inc. Self-retaining sutures having effective holding strength and tensile strength
US8821540B2 (en) 2002-09-30 2014-09-02 Ethicon, Inc. Self-retaining sutures having effective holding strength and tensile strength
US8734485B2 (en) 2002-09-30 2014-05-27 Ethicon, Inc. Sutures with barbs that overlap and cover projections
US9248580B2 (en) 2002-09-30 2016-02-02 Ethicon, Inc. Barb configurations for barbed sutures
US8721681B2 (en) 2002-09-30 2014-05-13 Ethicon, Inc. Barbed suture in combination with surgical needle
US8852232B2 (en) 2002-09-30 2014-10-07 Ethicon, Inc. Self-retaining sutures having effective holding strength and tensile strength
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US9060767B2 (en) 2003-04-30 2015-06-23 P Tech, Llc Tissue fastener and methods for using same
US9962162B2 (en) 2003-04-30 2018-05-08 P Tech, Llc Tissue fastener and methods for using same
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US8032996B2 (en) 2003-05-13 2011-10-11 Quill Medical, Inc. Apparatus for forming barbs on a suture
US9888916B2 (en) 2004-03-09 2018-02-13 P Tech, Llc Method and device for securing body tissue
US8721664B2 (en) 2004-05-14 2014-05-13 Ethicon, Inc. Suture methods and devices
US20100298871A1 (en) * 2004-05-14 2010-11-25 Quill Medical, Inc. Self-retaining wound closure device including an anchoring loop
US11723654B2 (en) 2004-05-14 2023-08-15 Ethicon, Inc. Suture methods and devices
US10779815B2 (en) 2004-05-14 2020-09-22 Ethicon, Inc. Suture methods and devices
US10548592B2 (en) 2004-05-14 2020-02-04 Ethicon, Inc. Suture methods and devices
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9579129B2 (en) 2004-10-26 2017-02-28 P Tech, Llc Devices and methods for stabilizing tissue and implants
US10238378B2 (en) 2004-10-26 2019-03-26 P Tech, Llc Tissue fixation system and method
US9999449B2 (en) 2004-10-26 2018-06-19 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US11992205B2 (en) 2004-10-26 2024-05-28 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9980761B2 (en) 2004-10-26 2018-05-29 P Tech, Llc Tissue fixation system and method
US9226828B2 (en) 2004-10-26 2016-01-05 P Tech, Llc Devices and methods for stabilizing tissue and implants
US11457958B2 (en) 2004-10-26 2022-10-04 P Tech, Llc Devices and methods for stabilizing tissue and implants
US10813764B2 (en) 2004-10-26 2020-10-27 P Tech, Llc Expandable introducer system and methods
US9545268B2 (en) 2004-10-26 2017-01-17 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US9867706B2 (en) 2004-10-26 2018-01-16 P Tech, Llc Tissue fastening system
US9814453B2 (en) 2004-10-26 2017-11-14 P Tech, Llc Deformable fastener system
US11013542B2 (en) 2004-10-26 2021-05-25 P Tech, Llc Tissue fixation system and method
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US9980717B2 (en) 2005-02-22 2018-05-29 P Tech, Llc Device and method for securing body tissue
US20080071304A1 (en) * 2005-02-25 2008-03-20 Tal Michael G Varicose Vein Dissector and Removal Apparatus
WO2006093787A3 (en) * 2005-02-25 2009-04-16 Univ Yale Varicose vein dissector and removal apparatus
US8608767B2 (en) 2005-02-25 2013-12-17 Yale University Varicose vein dissector and removal apparatus
US8034070B2 (en) 2005-02-25 2011-10-11 Yale University Varicose vein dissector and removal apparatus
US10376259B2 (en) 2005-10-05 2019-08-13 P Tech, Llc Deformable fastener system
US10441269B1 (en) 2005-10-05 2019-10-15 P Tech, Llc Deformable fastener system
US11219446B2 (en) 2005-10-05 2022-01-11 P Tech, Llc Deformable fastener system
US8496657B2 (en) 2006-02-07 2013-07-30 P Tech, Llc. Methods for utilizing vibratory energy to weld, stake and/or remove implants
US9610073B2 (en) 2006-02-07 2017-04-04 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US9439642B2 (en) 2006-02-07 2016-09-13 P Tech, Llc Methods and devices for utilizing bondable materials
US11998251B2 (en) 2006-02-07 2024-06-04 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US9421005B2 (en) 2006-02-07 2016-08-23 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US9173650B2 (en) 2006-02-07 2015-11-03 P Tech, Llc Methods and devices for trauma welding
US20080039845A1 (en) * 2006-02-07 2008-02-14 Bonutti Peter M Methods and devices for intracorporeal bonding of implants with thermal energy
US10368924B2 (en) 2006-02-07 2019-08-06 P Tech, Llc Methods and devices for trauma welding
US11129645B2 (en) 2006-02-07 2021-09-28 P Tech, Llc Methods of securing a fastener
US11134995B2 (en) 2006-02-07 2021-10-05 P Tech, Llc Method and devices for intracorporeal bonding of implants with thermal energy
US9743963B2 (en) 2006-02-07 2017-08-29 P Tech, Llc Methods and devices for trauma welding
US7857827B2 (en) 2006-04-14 2010-12-28 Ethicon Endo-Surgery, Inc. Endoscopic device
US7998167B2 (en) 2006-04-14 2011-08-16 Ethicon Endo-Surgery, Inc. End effector and method of manufacture
US8313500B2 (en) 2006-04-14 2012-11-20 Ethicon Endo-Surgery, Inc. Endoscopic device
US8740853B2 (en) 2006-04-14 2014-06-03 Ethicon Endo-Surgery, Inc. Endoscopic device and method of packaging
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
US20080027390A1 (en) * 2006-07-31 2008-01-31 Carlos Jaramillo Catheterization device and method
US8882715B2 (en) * 2006-07-31 2014-11-11 Carlos Jaramillo Catheterization device and method
US20080306481A1 (en) * 2006-11-03 2008-12-11 Innovative Spine System and method for providing surgical access to a spine
US8597299B2 (en) 2006-11-03 2013-12-03 Innovative Spine, Llc Instrumentation and method for providing surgical access to a spine
US8025664B2 (en) 2006-11-03 2011-09-27 Innovative Spine, Llc System and method for providing surgical access to a spine
US8057481B2 (en) 2006-11-03 2011-11-15 Innovative Spine, Llc System and method for providing surgical access to a spine
US8632550B2 (en) 2006-11-03 2014-01-21 Innovative Spine LLC. System and method for providing surgical access to a spine
US8840621B2 (en) 2006-11-03 2014-09-23 Innovative Spine, Inc. Spinal access systems and methods
US20080255563A1 (en) * 2006-11-03 2008-10-16 Innovative Spine Instrumentation and method for providing surgical access to a spine
US10390817B2 (en) 2007-02-13 2019-08-27 P Tech, Llc Tissue fixation system and method
US9402668B2 (en) 2007-02-13 2016-08-02 P Tech, Llc Tissue fixation system and method
US11801044B2 (en) 2007-02-13 2023-10-31 P Tech, Llc Tissue fixation system and method
US8617185B2 (en) 2007-02-13 2013-12-31 P Tech, Llc. Fixation device
US10517584B1 (en) 2007-02-13 2019-12-31 P Tech, Llc Tissue fixation system and method
US20080215072A1 (en) * 2007-02-15 2008-09-04 Graham Kelly Methods and apparatus for utilization of barbed sutures in human tissue including a method for eliminating or improving blood flow in veins
US8793863B2 (en) 2007-04-13 2014-08-05 Ethicon, Inc. Method and apparatus for forming retainers on a suture
US8915943B2 (en) 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US20080281224A1 (en) * 2007-05-11 2008-11-13 Johnson Michael E Biopsy device needle tip
US8777987B2 (en) 2007-09-27 2014-07-15 Ethicon, Inc. Self-retaining sutures including tissue retainers having improved strength
US9498893B2 (en) 2007-09-27 2016-11-22 Ethicon, Inc. Self-retaining sutures including tissue retainers having improved strength
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US8771313B2 (en) 2007-12-19 2014-07-08 Ethicon, Inc. Self-retaining sutures with heat-contact mediated retainers
US8118834B1 (en) 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
US9044225B1 (en) 2007-12-20 2015-06-02 Ethicon, Inc. Composite self-retaining sutures and method
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8875607B2 (en) 2008-01-30 2014-11-04 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US9125647B2 (en) 2008-02-21 2015-09-08 Ethicon, Inc. Method and apparatus for elevating retainers on self-retaining sutures
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US8876865B2 (en) 2008-04-15 2014-11-04 Ethicon, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
US8961560B2 (en) 2008-05-16 2015-02-24 Ethicon, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
US8932328B2 (en) 2008-11-03 2015-01-13 Ethicon, Inc. Length of self-retaining suture and method and device for using the same
US10441270B2 (en) 2008-11-03 2019-10-15 Ethicon, Inc. Length of self-retaining suture and method and device for using the same
US11234689B2 (en) 2008-11-03 2022-02-01 Ethicon, Inc. Length of self-retaining suture and method and device for using the same
US20100153335A1 (en) * 2008-12-12 2010-06-17 Microsoft Corporation Synchronizing multiple classes with disparate schemas in the same collection
US11234692B2 (en) 2010-05-04 2022-02-01 Cilag Gmbh International Self-retaining system having laser-cut retainers
US10420546B2 (en) 2010-05-04 2019-09-24 Ethicon, Inc. Self-retaining systems having laser-cut retainers
US10952721B2 (en) 2010-05-04 2021-03-23 Ethicon, Inc. Laser cutting system and methods for creating self-retaining sutures
US9955962B2 (en) 2010-06-11 2018-05-01 Ethicon, Inc. Suture delivery tools for endoscopic and robot-assisted surgery and methods
US11007296B2 (en) 2010-11-03 2021-05-18 Ethicon, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US11690614B2 (en) 2011-03-23 2023-07-04 Ethicon, Inc. Self-retaining variable loop sutures
US10492780B2 (en) 2011-03-23 2019-12-03 Ethicon, Inc. Self-retaining variable loop sutures
US10188384B2 (en) 2011-06-06 2019-01-29 Ethicon, Inc. Methods and devices for soft palate tissue elevation procedures
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
US11317974B2 (en) 2015-10-21 2022-05-03 P Tech, Llc Systems and methods for navigation and visualization
US11684430B2 (en) 2015-10-21 2023-06-27 P Tech, Llc Systems and methods for navigation and visualization
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
US11744651B2 (en) 2015-10-21 2023-09-05 P Tech, Llc Systems and methods for navigation and visualization
US10765484B2 (en) 2015-10-21 2020-09-08 P Tech, Llc Systems and methods for navigation and visualization
US12023111B2 (en) 2015-10-21 2024-07-02 P Tech, Llc Systems and methods for navigation and visualization
US12096995B2 (en) 2015-10-21 2024-09-24 P Tech, Llc Systems and methods for navigation and visualization

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