US6835189B2 - Controlled deployment balloon - Google Patents
Controlled deployment balloon Download PDFInfo
- Publication number
- US6835189B2 US6835189B2 US10/271,830 US27183002A US6835189B2 US 6835189 B2 US6835189 B2 US 6835189B2 US 27183002 A US27183002 A US 27183002A US 6835189 B2 US6835189 B2 US 6835189B2
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- United States
- Prior art keywords
- balloon
- inflation
- diameter
- inflation profile
- central region
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
Definitions
- the present invention relates to novel balloon catheters for use in the treatment of vascular diseases and to methods of making and using the same.
- Balloon catheters are employed in a variety of medical procedures.
- One such procedure is angioplasty which is a well known medical practice used in the treatment of diseased arteries in the vasculature of a patient.
- angioplasty procedures alone, however, involves a risk of re-restenosis of the artery, which may necessitate another angioplasty procedure, a surgical bypass procedure, or some method of repairing or strengthening the area. Therefore, it has become more common practice to use a catheter-delivered stent to prevent restenosis and to reinforce and strengthen weakened vessel walls.
- a physician can implant an intravascular device, i.e. a stent, to maintain vascular patency at the site of a lesion.
- a stent is typically a generally cylindrical, radially expandable device which is introduced into the vasculature of a patient using a catheter delivery assembly which typically includes an elongate shaft with a dilatation balloon mounted on its distal portion. The stent is then mounted over the dilatation balloon. The stent is maneuvered through the vasculature of the patient in a generally reduced diameter configuration, i.e. crimped. Once it has been delivered to the site of the lesion, the stent is then expanded from its reduced diameter configuration to support and reinforce the vessel walls while maintaining the vessel in an open, unobstructed condition.
- Stents are well-known and widely available in both self-expanding and inflation expandable varieties.
- Self-expanding stents are typically maintained under positive external pressure in order to maintain their reduced diameter configuration during delivery of the stent to its deployment site.
- Inflation expandable stents i.e. balloon expandable stents, are crimped to their reduced diameter about the inflation member of the stent delivery catheter and once positioned at the deployment site are expanded to a larger diameter for implantation in the vasculature by providing inflation fluid to the inflation member thus expanding the inflation member thus expanding the stent.
- watermelon seeding In which the stent has been known to slide off the balloon during expansion.
- Various methods have been employed in order overcome the possibility of stent slippage during expansion.
- the present invention relates to novel dilatation balloons which exhibit first and second inflation profiles, and to methods of producing the novel balloons of the present invention.
- the balloon has a body portion, cones and waist portions.
- the body of the balloon further has a proximal region and a distal region which are separated by the central region of the body. The length of the body, and the taper angle of the cone portions change from one inflation profile to the next as the pressure is increased.
- the balloon has a first inflation profile achieved by inflating the balloon to a first inflation pressure and a second inflation profile which is achieved by increasing the inflation pressure to a second, higher pressure.
- the central region in the first inflation profile of the balloon, is inflatable to a diameter D 1 and at least one of the proximal and distal regions of the body portion of the balloon are inflatable to a second diameter which is less than D 1 , D 1 ′.
- the diameter D 1 ′ may be taken at any of an infinitesimal number of locations between the central region of the balloon body and the cone portions. As the point at which D 1 ′ is taken approaches the central region of the body portion, the value of D 1 ′ will approach the value of D 1 .
- the central region is inflatable to a diameter D 1 ′′ and the proximal and/or distal ends of the body portion of the balloon are inflatable to a diameter D 1 ′′ which is substantially equal to D 1 . It is important to note that D 1 may increase some nominal amount from the first inflation profile to the second inflation profile.
- the proximal region, the distal region or both, and the central region of the body portion have inflation diameters which are substantially constant along the length of the balloon body.
- the proximal and/or distal ends of the body region taper into the cone regions.
- the inflation of the balloon to its first inflation profile is achieved by inflation to a first pressure
- inflation to the second inflation profile is achieved by inflation to a second pressure higher than the first pressure
- the present invention further relates to a method of making the same, the method including a first molding step wherein the second inflation profile or configuration is formed and a second molding step wherein the first inflation profile or configuration is formed.
- the balloon In a first molding step at a temperature T 1 , the balloon is formed to have a body having a length L 1 and tapered cones which have an angle ⁇ 1 relative to the longitudinal axis of the balloon and in a second molding step at a temperature T 2 which is less than T 1 but higher than the T g of the material from which the balloon is being formed, the balloon is remolded to have a body with a length L 2 which is less than L 1 and tapered cones which have an angle ⁇ 2 relative to the longitudinal axis of the balloon which is less than ⁇ 1 .
- the balloon exhibits the configuration formed during the second molding step at a first pressure, and exhibits the configuration formed during the first molding step at a second higher pressure.
- the balloon is thus said to have two inflation profiles, the first inflation profile being the second remolded configuration and the second inflation profile being the first molded configuration.
- the first inflation profile or configuration is exhibited.
- the balloon reaches its fully expanded configuration and exhibits its second inflation profile or configuration.
- the dilation balloons of the present invention may be used in various medical procedures and thus come in a large range of sizes and may therefore be suitably dimensioned for their intended purpose.
- the balloon catheters of the present invention are particularly useful for the delivery and implantation of stents for use in the treatment of stenotic vascular disease. Furthermore, the present invention is particularly suitable for use with inflation expandable stents wherein enhanced stent securement and safer stent loading are of concern.
- the dilatation balloon of the present invention in combination with the stent, is positioned adjacent a treatment site in a body vessel where it is first inflated to its first inflation profile at a first pressure wherein the central region is inflated to a diameter D 1 and at least one of the proximal and distal ends of the body of the balloon is inflated to a diameter D 1 ′ which is less than D 1 .
- the diameter D 1 ′ may be taken at any infinitesimal number of points between the central region of the body and the cone portions.
- the balloon is then inflated to its second inflation profile at a second higher pressure wherein the central region of the body is inflated to D 1 , and the proximal and distal regions of the body are inflated to a diameter D 1 ′′ which is substantially equal to D 1 .
- D 1 in the second inflation profile, may be nominally larger than in the first inflation profile.
- the balloon of the present invention may be employed in combination with various devices including catheter delivery devices and stents, for example, and may be employed in the treatment of various diseases.
- FIG. 1 shows a balloon with its second inflation profile in an expanded high pressure configuration.
- FIG. 2 shows a balloon with its first inflation profile (dashed line) in an expanded low to medium pressure configuration and its second inflation profile (solid line) in an expanded higher pressure configuration.
- FIG. 3 shows a balloon with its first inflation profile in an expanded low medium pressure configuration.
- FIG. 4 shows a balloon of the present invention having an alternative first inflation profile.
- FIG. 1 shows generally at 10 , a dilatation balloon of the present invention in its second inflation profile.
- the balloon has a uniform cylindrical body portion 14 having a central region 30 , a proximal end 32 , and a distal end 34 , and short cones 12 .
- This second inflation profile of the balloon is formed as a result of a first balloon formation or first molding step as employed in the method of the present invention.
- the balloon is in a fully expanded, high pressure profile and has a central region 30 with a diameter D 1 and the proximal end 32 and distal end 34 of the body each have a diameter D 1 ′′ which is substantially equal to D 1 .
- the diameter D 1 may exhibit a nominal increase from the first lower pressure configuration to the second higher pressure configuration.
- the balloon formation may be carried out in any conventional manner with conventional extrusion and blowing techniques.
- the formation method can include the steps of extruding a tubular preform, blow molding the balloon and annealing the balloon. Each of these major process steps may in turn include a number of sub-steps.
- the preform may be axially stretched before it is blown. Techniques for balloon formation are discussed in U.S. Pat. No. 4,490,421 to Levy and in U.S. Pat. No. 5,348,538 issued Sep. 20, 1994 to Wang et al.
- Typical molding temperatures for this first molding step are typically about 90° C. to about 100° C., and more typically about 95° C. However, this may vary depending on the type of material employed.
- the balloon is typically shrunk at a temperature that is less than the temperature of the first molding step.
- One method of doing this is to place the balloon in a hot water bath after the initial molding step and shrink at a temperature less than that of the first molding step.
- the temperature of the water bath may be varied depending on how much shrinkage is desired. The higher the temperature, the more shrinkage that the balloon will exhibit. However, it is desirable that the temperature of the hot water bath be somewhat less than that of the initial molding temperature. No pressure is typically applied during the shrinking step.
- the greater the shrinkage of the balloon the later during the inflation pressure cycle that the balloon may distend.
- Typical temperatures for this secondary process may be between about 80° C. and 85° C., more typically about 80° C. and 82° C. It is desirable that the remolding temperature is at least above the T g of the polymer, but less than the molding temperature employed in the first molding step.
- the pressure employed during this step is conventional in the art.
- FIG. 2 One embodiment of a first inflation profile 10 a of the balloon of the present invention resulting from the second molding process is represented in FIG. 2 by the solid lines and may be compared to the second inflation profile 10 (also shown in FIG. 1, resulting from the first molding process, which is represented by the dotted lines in FIG. 2 .
- the same first inflation profile is shown generally at 14 a in FIG. 3 .
- the proximal and distal ends 32 , 34 of the body portion taper into the cones portions 12 a.
- the second inflation profile of the balloon is formed with a body which has a central region 30 having a diameter D 1 , a proximal end 32 , and a distal end 34 which have a diameter D 1 ′ which is substantially equal to D 1 , and tapered cones 12 .
- the diameter D 1 of the central region of the body 30 remains substantially unchanged while the diameter D 1 ′′ of the proximal and/or distal ends 32 , 34 of the body decreases to D 1 ′.
- D 1 ′ has been taken at a point A which is somewhat central between the central region of the body 30 and the cone portions 12 a .
- D 1 ′ may be taken at any of an infinitesimal number of points between the cone portions 12 and the central region 30 of the body portion and will be less than D 1 .
- the closer that the point at which D 1 ′ is taken gets to the central region 30 of the body portion the closer the value of D 1 ′ will become to D 1 .
- the distal and/or proximal regions can actually taper into the cone portions of the balloon.
- the balloon will exhibit the first inflation profile in its first lower pressure configuration and will exhibit the second inflation profile in its second higher pressure configuration.
- the balloon in the first inflation profile, the balloon will have a body having a central region with a diameter D 1 and at least one of the proximal and distal-ends exhibit a diameter D 1 ′′ which is less than D 1 .
- the central region 30 of balloon body In the second higher pressure inflation profile, the central region 30 of balloon body has a diameter D 1 and at least one of the proximal and distal ends has a diameter D 1 ′′ which is substantially equal to, but which may be slightly larger than D 1 .
- the first inflation profile i.e. the configuration formed during the second molding step, opens at first use when subjected to a first pressure.
- the remolded body section which may be said to now become part of the tapered cones, 10 a rapidly expands returning the balloon to first molded balloon configuration or the second inflation profile at a second higher pressure shown generally at 10 in FIG. 1 .
- the central region and the proximal and distal ends have a substantially constant diameter along the length of the body.
- the balloon may be said to retain memory of the second molded configuration and therefore returns to this shape upon full expansion at higher pressures.
- a typical pressure at which the first inflation profile is exhibited may be about 2-4 atmospheres while typical pressures at which the second inflation profile is exhibited may be about 5-12 atmospheres with 6 being typical. These ranges are for illustrative purposes only, and depending on the characteristics of the material from which the balloon is formed, the pressure of the first and second inflation profile could be higher.
- the length of the taper of the cone portion of the balloon is increased, and the angle of the taper of the cone section relative to the longitudinal axis of the ballon is changed accordingly.
- Taper angles for a ballon of a typical 20 mm length, L 1 is in the range of about 10° to about 45°, suitably about 15° to about 45°, although these angles may reach a perpendicular 90°.
- the taper angle may drop to between about 2° to about 14°, and more typically in the range of about 8° to ab t 10°.
- the taper angle of the cone section of the balloon relative to the longitudinal axis 20 is represented by ⁇ 1 in FIG. 2 while the taper angle of the cone section relative to the longitudinal axis after the second molding process is represented by ⁇ 2 in FIG. 2 .
- the balloon will exhibit the taper angle, ⁇ 2 , during its first inflation profile and the balloon will exhibit the taper angle ⁇ 1 during its second inflation profile.
- the taper angles represented in FIG. 2 are intended to be for illustrative purposes only, and are not intended to be actual angles which may be exhibited by catheter dilatation balloons.
- L 1 may vary between about 10 mm and about 30 mm, while L 2 may vary between about 3 mm and 10 mm.
- FIG. 4 shows generally at 10 b , a balloon of the present invention having an alternative inflation profile.
- the proximal end 32 of the balloon only and not the distal end 34 has the remolded configuration.
- the second inflation profile is shown in FIG. 1 .
- the balloon is similar in other respects to the embodiments described above.
- the balloons of the present invention may be formed using any materials known to those of skill in the art.
- Some examples of balloon materials which find utility herein include, but are not limited to, polyolefins, polyesters, polyethers, polyimides, polyamides, ionomeric polymers, polyurethanes, polycarbonates, polyvinyl chlorides, polyphenylene sulfides, block copolymer elastomers, and so forth.
- useful polyolefins include, but are not limited to, polyethylenes and polypropylenes and any copolymers thereof.
- materials useful in making the balloons of the present invention include, but are not limited to, polyethylene terephthalate, acrylonitrile-butadiene-styrene copolymers, polyether-polyester copolymers, polyether polyamide copolymers, polyether block amides, and so on and so forth.
- Balloon catheters embodying additional features known in the vascular dilatation art including, but not limited to, implantable stents which are employed in various vessels in the body, drug delivery, perfusion and dilatation features, or any combination of such features may be used in combination with the dilatation balloon of the present invention.
- the balloons of the present invention find particular utility for the deployment of balloon expandable stents which have what is referred to in the art as an “open cell” design.
- the use of the dilatation balloon with any stent design is contemplated herein.
- balloons in accordance with the present invention may be used in any and all vascular systems or cavities in the body. They may be employed in the implantation of stents in blood vessels which have collapsed, are partially occluded, blocked, weakened, or dilated for maintaining them in an open unobstructed state as well as for implanting stents in the urinary tract, bile ducts, alimentary tract, tracheobronchial tree, cerebral aqueducts, genitourinary system, prostatic urethra, fallopian tubes, as well as other regions of the body.
- the size of the stent as well as the balloon will depend on the application to which they are being put.
- the balloon is formed of a PEBAX® 7033 polyether-block-amide.
- the balloon is initially molded at a temperature of about 95° C. and has a body length L 1 of about 20 mm and the tapered portion of the cone section has an angle ⁇ 1 of about 15° relative to the longitudinal axis of the balloon.
- the balloon is then placed in a hot water bath at a temperature between about 80° C. and about 82° C., and remolded at the same temperature.
- the balloon now has a body length L 2 of about 6.5 mm and the tapered portion of the cone section has an angle ⁇ 2 of about 9°.
- the balloon is then inflated using increasing pressure. At 2-3 atmospheres, the balloon exhibits an inflation profile wherein the body has a length L 2 of about 6.5 mm and the tapered portion of the cone section has an angle ⁇ 2 of about 9°.
- the balloon exhibits a second inflation profile wherein the body has a length L 1 of about 20 mm and the tapered portion of the cone section has an angle ⁇ 1 of about 15° relative to the longitudinal axis of the balloon.
- a balloon was formed using TRAYTUF® 7357 polyethyleneterephthalate (PET).
- PET polyethyleneterephthalate
- the balloon was initially molded at a temperature of about 95° C. and had a body length, L 1 , of about 20 mm and the tapered portion of the cone section had an angle ⁇ 1 of about 15° relative to the longitudinal axis.
- the balloon was then placed in a water bath at a temperature of 80° C. for about 10 seconds and then remolded at a pressure of 125 psi for about 45 seconds to a shape where L 2 is about 6.5 mm and the tapered portion of the cone section had an angle of about 9° relative to the longitudinal axis.
- the balloon was then inflated at 37° C. by increasing the pressure.
- the balloon At a pressure of between about 8 atm and 10 atm, the balloon exhibited its second inflation profile wherein the body had a length, L 1 , of about 20 mm and the tapered portion of the cone section had an angle ⁇ 1 of about 15° relative to the longitudinal axis.
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Abstract
Description
Claims (5)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/271,830 US6835189B2 (en) | 2002-10-15 | 2002-10-15 | Controlled deployment balloon |
AU2003259779A AU2003259779A1 (en) | 2002-10-15 | 2003-08-12 | Controlled deployment balloon |
DE60310597T DE60310597T2 (en) | 2002-10-15 | 2003-08-12 | BALLOON FOR CONTROLLED DEVELOPMENT |
EP03808949A EP1556118B1 (en) | 2002-10-15 | 2003-08-12 | Controlled deployment balloon |
CA002497908A CA2497908A1 (en) | 2002-10-15 | 2003-08-12 | Controlled deployment balloon |
JP2004545236A JP2006502801A (en) | 2002-10-15 | 2003-08-12 | Expansion control type balloon |
PCT/US2003/025216 WO2004035128A1 (en) | 2002-10-15 | 2003-08-12 | Controlled deployment balloon |
AT03808949T ATE348645T1 (en) | 2002-10-15 | 2003-08-12 | BALLOON FOR CONTROLLED UNFOLDING |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/271,830 US6835189B2 (en) | 2002-10-15 | 2002-10-15 | Controlled deployment balloon |
Publications (2)
Publication Number | Publication Date |
---|---|
US20040073165A1 US20040073165A1 (en) | 2004-04-15 |
US6835189B2 true US6835189B2 (en) | 2004-12-28 |
Family
ID=32069196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/271,830 Expired - Lifetime US6835189B2 (en) | 2002-10-15 | 2002-10-15 | Controlled deployment balloon |
Country Status (8)
Country | Link |
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US (1) | US6835189B2 (en) |
EP (1) | EP1556118B1 (en) |
JP (1) | JP2006502801A (en) |
AT (1) | ATE348645T1 (en) |
AU (1) | AU2003259779A1 (en) |
CA (1) | CA2497908A1 (en) |
DE (1) | DE60310597T2 (en) |
WO (1) | WO2004035128A1 (en) |
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Also Published As
Publication number | Publication date |
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ATE348645T1 (en) | 2007-01-15 |
EP1556118A1 (en) | 2005-07-27 |
DE60310597T2 (en) | 2007-04-05 |
US20040073165A1 (en) | 2004-04-15 |
JP2006502801A (en) | 2006-01-26 |
AU2003259779A1 (en) | 2004-05-04 |
WO2004035128A1 (en) | 2004-04-29 |
CA2497908A1 (en) | 2004-04-29 |
EP1556118B1 (en) | 2006-12-20 |
DE60310597D1 (en) | 2007-02-01 |
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