Inozitol-heksakisfosfat kinaza
| Inozitol-heksakisfosfat kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.4.21 | ||||||||
| CAS broj | 176898-37-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Inozitol-heksakisfosfat kinaza (EC 2.7.4.21, ATP:1D-mio-inozitol-heksakisfosfat fosfotransferaza) je enzim sa sistematskim imenom ATP:1D-mio-inozitol-heksakisfosfat 5-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2) ATP + 1D-mio-inozitol 1,3,4,5,6-pentakisfosfat ADP + 1D-mio-inozitol difosfat tetrakisfosfat (izomerska konfiguracija je nepoznata)
Kod sisara su poznate tri izoforme.
- ↑ Saiardi, A., Erdjument-Bromage, H., Snowman, A.M., Tempst, P. and Snyder, S.H. (1999). „Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases”. Curr. Biol. 9: 1323-1326. PMID 10574768.
- ↑ Schell, M.J., Letcher, A.J., Brearley, C.A., Biber, J., Murer, H. and Irvine, R.F. (1999). „PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase”. FEBS Lett. 461: 169-172. PMID 10567691.
- ↑ Albert, C., Safrany, S.T., Bembenek, M.E., Reddy, K.M., Reddy, K.K., Falck, J.-R., Bröcker, M., Shears, S.B. and Mayr, G.W. (1997). „Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells”. Biochem. J. 327: 553-560. PMID 9359429.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.