Moždani natriuretski peptid
Natriuretski peptid B | |||||||||||
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Dostupne strukture | |||||||||||
1YK1, 3N56 | |||||||||||
Identifikatori | |||||||||||
Simboli | NPPB; BNP | ||||||||||
Vanjski ID | OMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 4879 | n/a | |||||||||
Ensembl | ENSG00000120937 | n/a | |||||||||
UniProt | P16860 | n/a | |||||||||
RefSeq (mRNA) | NM_002521.2 | n/a | |||||||||
RefSeq (protein) | NP_002512.1 | n/a | |||||||||
Lokacija (UCSC) |
Chr 1: 11.92 - 11.92 Mb | n/a | |||||||||
PubMed pretraga | [1] | n/a |
Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljudi ovaj hormon uglavnom proizvode srčane komore.
BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi
Reference
[уреди | уреди извор]- ^ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1
Literatura
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Vidi još
[уреди | уреди извор]Spoljašnje veze
[уреди | уреди извор]- Brain+Natriuretic+Peptide на US National Library of Medicine Medical Subject Headings (MeSH)