Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. (Q53969139)

23 May 2018

title

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. (English)

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23 May 2018

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1

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23 May 2018

Ryohei Katayama

series ordinal

2

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23 May 2018

author name string

Rie Takikawa

series ordinal

3

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23 May 2018

Takeshi Iwatsubo

series ordinal

4

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23 May 2018

language of work or name

English

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publication date

1 June 2002

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23 May 2018

number of pages

5

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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23 May 2018

volume

520

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23 May 2018

issue

1-3

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23 May 2018

page(s)

117-121

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23 May 2018

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

cites work

1 reference

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The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

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A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902802-8

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902802-8

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902802-8

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

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APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902802-8

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

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Nicastrin binds to membrane-tethered Notch

21 January 2018

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Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2902802-8

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

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Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

21 January 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

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Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

21 January 2018

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Alzheimer's disease: genes, proteins, and therapy

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 January 2021

1 reference

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10.1016/S0014-5793(02)02802-8

7 January 2021

Identifiers

DOI

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23 May 2018

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23 May 2018