Targeting NF-kappaB in hematologic malignancies (Q28299055)

Europe PubMed Central

title

Targeting NF-kappaB in hematologic malignancies (English)

0 references

0 references

6

G Kroemer

0 references

Pierre Fenaux

5

object named as

P Fenaux

0 references

author name string

T Braun

1

0 references

G Carvalho

2

0 references

C Fabre

3

0 references

J Grosjean

Cell Death & Differentiation

4

0 references

language of work or name

English

0 references

publication date

May 2006

0 references

published in

0 references

volume

13

0 references

issue

5

0 references

page(s)

748-58

0 references

cites work

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401874

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401874

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401874

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401874

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401874

21 April 2017

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappaB in cancer: from innocent bystander to major culprit

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Missing pieces in the NF-kappaB puzzle

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Nuclear factor-kappaB: the enemy within

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

B-cell lymphoma of MALT type: a review with special emphasis on diagnostic and management problems of low-grade gastric tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

MALT lymphoma: from morphology to molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Cellular origin of human B-cell lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Myeloproliferative disorders: the centrosome connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Expression of FLIPLong and FLIPShort in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Preferential induction of apoptosis for primary human leukemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Novel therapeutic approaches for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Effect of NF-kappaB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel- specific decoy oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Proteasome inhibition as a novel therapeutic target in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Properties of thalidomide and its analogues: implications for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Chemosensitization by erythropoietin through inhibition of the NF-kappaB rescue pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Signaling pathways activated by daunorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Expression of the NF-κB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

Constitutive NF-κB/Rel Activation in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Detection by the fluorescence in situ hybridization technique of MYC translocations in paraffin-embedded lymphoma biopsy samples

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

The 4th nation-wide study of adult T-cell leukemia/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Expression and prognostic significance of Bcl-2 family proteins in myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Structure and functions of the 20S and 26S proteasomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021

Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP). Updated results of a randomized study. Groupe Français des Myélodysplasies (GFM) and Groupe GOELAMS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401874

7 January 2021