The protein kinase B/Akt signalling pathway in human malignancy (Q28645742)

3 February 2017

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Europe PubMed Central

title

The protein kinase B/Akt signalling pathway in human malignancy (English)

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3 February 2017

Karleen M. Nicholson

1

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3 February 2017

Neil G. Anderson

series ordinal

2

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3 February 2017

publication date

1 May 2002

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3 February 2017

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3 February 2017

volume

14

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3 February 2017

issue

5

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3 February 2017

page(s)

381–395

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3 February 2017

cites work

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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7 January 2021

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

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7 January 2021

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

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7 January 2021

Molecular cloning of a second form of rac protein kinase

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7 January 2021

Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase

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7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Dual regulation of platelet protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of Akt/PKB activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Amplification of 19q13.1–q13.2 sequences in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PIK3CA as an oncogene in cervical cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Oncogenic kinase signalling

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The ErbB signaling network: receptor heterodimerization in development and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PTEN: life as a tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

NF-kappaB signals induce the expression of c-FLIP.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The Akt proto-oncogene links Ras to Pak and cell survival signals

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Signal transduction by the JNK group of MAP kinases

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt regulates cell survival and apoptosis at a postmitochondrial level

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Cyclin D1 protein expression and function in human breast cancer

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Multiple ras effector pathways contribute to G(1) cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

GSK-3: new thoughts on an old enzyme

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

GSK3, a master switch regulating cell-fate specification and tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt participation in the Wnt signaling pathway through Dishevelled

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The Akt kinase signals directly to endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt takes center stage in angiogenesis signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

PTEN controls tumor-induced angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

A survey of telomerase activity in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Growth retardation and tumour inhibition by BRCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Location of BRCA1 in human breast and ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

The akt kinase: molecular determinants of oncogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900271-6

7 January 2021

10.1016/S0898-6568(01)00271-6

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017