A survival guide to early T cell development (Q36499749)

14 August 2017

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title

A survival guide to early T cell development (English)

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Juan Carlos Zuniga-Pflucker

14 August 2017

Maria Ciofani

1

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author name string

Juan Carlos Zúñiga-Pflücker

series ordinal

2

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14 August 2017

publication date

1 January 2006

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14 August 2017

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14 August 2017

volume

34

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14 August 2017

issue

2

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14 August 2017

page(s)

117-132

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IL-7 enhances the survival and maintains the size of naive T cells

14 August 2017

cites work

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12 December 2020

Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes

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12 December 2020

Haemopoietic cell growth factor mediates cell survival via its action on glucose transport

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12 December 2020

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

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12 December 2020

The common cytokine receptor gamma chain controls survival of gamma/delta T cells

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12 December 2020

Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma

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12 December 2020

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

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12 December 2020

Social controls on cell survival and cell death

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12 December 2020

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

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12 December 2020

Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell

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12 December 2020

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

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12 December 2020

BCL-XL-regulated apoptosis in T cell development

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12 December 2020

Fuel feeds function: energy metabolism and the T-cell response

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12 December 2020

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

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12 December 2020

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

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12 December 2020

Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation

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12 December 2020

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation

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12 December 2020

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

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12 December 2020

Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility

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12 December 2020

Get a ligand, get a life: integrins, signaling and cell survival

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12 December 2020

PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

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12 December 2020

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

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12 December 2020

A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo

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12 December 2020

Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

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12 December 2020

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells

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12 December 2020

Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus

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12 December 2020

IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells

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12 December 2020

The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice

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12 December 2020

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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12 December 2020

STAT proteins: From normal control of cellular events to tumorigenesis

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12 December 2020

Integrin regulation by RhoA in thymocytes

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12 December 2020

An essential role for c-FLIP in the efficient development of mature T lymphocytes

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12 December 2020

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

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12 December 2020

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

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12 December 2020

The pathophysiology of mitochondrial cell death

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12 December 2020

Thymic T cell development and progenitor localization depend on CCR7.

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12 December 2020

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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12 December 2020

Positive and negative selection of T cells

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12 December 2020

Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development

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12 December 2020

Death and Baxes: mechanisms of lymphotrophic cytokines

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12 December 2020

Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR

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12 December 2020

Thymus-derived signals regulate early T-cell development

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12 December 2020

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

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12 December 2020

Notch regulation of lymphocyte development and function.

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12 December 2020

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

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12 December 2020

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

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12 December 2020

Correlating notch signaling with thymocyte maturation

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12 December 2020

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

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12 December 2020

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

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12 December 2020

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

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12 December 2020

Characterization of TCR gene rearrangements during adult murine T cell development

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12 December 2020

Apoptosis in the regulation of immune responses.

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12 December 2020

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

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12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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12 December 2020

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

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12 December 2020

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

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12 December 2020

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

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12 December 2020

Transcription, apoptosis and p53: catch-22.

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12 December 2020

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

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12 December 2020

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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12 December 2020

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

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12 December 2020

The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

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12 December 2020

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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12 December 2020

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes

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12 December 2020

Intrathymic delta selection events in gammadelta cell development.

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12 December 2020

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

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12 December 2020

The GTPase Rho has a critical regulatory role in thymus development

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12 December 2020

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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12 December 2020

Expression and function of c-kit in hemopoietic progenitor cells

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12 December 2020

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

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12 December 2020

A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells

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12 December 2020

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

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12 December 2020

Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

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12 December 2020

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

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12 December 2020

Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival

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12 December 2020

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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12 December 2020

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

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12 December 2020

T cell-specific FADD-deficient mice: FADD is required for early T cell development

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12 December 2020

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

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12 December 2020

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

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12 December 2020

Do inducers of apoptosis trigger caspase-independent cell death?

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12 December 2020

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

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12 December 2020

T-cell development made simple

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12 December 2020

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

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12 December 2020

Regulation of lymphoid development, differentiation, and function by the Notch pathway.

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12 December 2020

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

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12 December 2020

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

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12 December 2020

The developmental fate of T cells is critically influenced by TCRgammadelta expression.

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12 December 2020

The role of BH3-only proteins in the immune system

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12 December 2020

Growth factors can influence cell growth and survival through effects on glucose metabolism

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12 December 2020

Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

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12 December 2020

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

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12 December 2020

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

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12 December 2020

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

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12 December 2020

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

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12 December 2020

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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12 December 2020

DR3 regulates negative selection during thymocyte development

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12 December 2020

MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation

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12 December 2020

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

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12 December 2020

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

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12 December 2020

Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival

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12 December 2020

Pleiotropic changes controlled by the pre-T-cell receptor

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12 December 2020

Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling

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12 December 2020

Signaling for survival and apoptosis in the immune system

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12 December 2020

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

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12 December 2020

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

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12 December 2020

NF-kappaB signaling in lymphocytes: a new cast of characters

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12 December 2020

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

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12 December 2020

Cell metabolism in the regulation of programmed cell death

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12 December 2020

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

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12 December 2020

Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity

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12 December 2020

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

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12 December 2020

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

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12 December 2020

Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2.

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12 December 2020

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

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12 December 2020

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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12 December 2020

The protein kinase B/Akt signalling pathway in human malignancy

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12 December 2020

The Pim kinases control rapamycin-resistant T cell survival and activation

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12 December 2020

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

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12 December 2020

Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.

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12 December 2020

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

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12 December 2020

Different functions of the GTPase Rho in prothymocytes and late pre-T cells

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12 December 2020

Regulation of thymus size by competition for stromal niches among early T cell progenitors

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12 December 2020

Expression and function of the interleukin 7 receptor in murine lymphocytes

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12 December 2020

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

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12 December 2020

Ontogeny and regulation of IL-7-expressing thymic epithelial cells

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12 December 2020

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

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12 December 2020

Thymopoiesis independent of common lymphoid progenitors

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12 December 2020

Bax deficiency partially corrects interleukin-7 receptor alpha deficiency

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12 December 2020

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

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12 December 2020

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

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12 December 2020

Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition

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12 December 2020

Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice

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12 December 2020

In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development

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12 December 2020

Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

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12 December 2020

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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12 December 2020

Role of the CC chemokine receptor 9/TECK interaction in apoptosis

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12 December 2020

The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways.

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12 December 2020

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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12 December 2020

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

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12 December 2020

Interleukin 7 receptor-deficient mice lack gammadelta T cells

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12 December 2020

Identifiers

DOI

10.1385/IR:34:2:117

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Dimensions Publication ID

14 August 2017

1029882194

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