SNF8

SNF8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2ZME, 3CUQ
Dynodwyr
Cyfenwau	SNF8, Dot3, EAP30, VPS22, ESCRT-II complex subunit, SNF8 subunit of ESCRT-II
Dynodwyr allanol	OMIM: 610904 HomoloGene: 5239 GeneCards: SNF8
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • protein N-terminus binding; • transcription factor binding; • protein C-terminus binding; • channel regulator activity; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • recycling endosome; • cytosol; • endosome; • bilen; • late endosome membrane; • transcription regulator complex; • Cellbilen; • nucleoplasm; • perinuclear region of cytoplasm; • endosome membrane; • extracellular exosome; • cnewyllyn cell; • ESCRT II complex;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • GO:1903364 positive regulation of protein catabolic process; • multivesicular body sorting pathway; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • multivesicular body assembly; • regulation of multivesicular body size involved in endosome transport; • transcription, DNA-templated; • endosomal transport; • regulation of protein complex stability; • GO:1901313 positive regulation of gene expression; • early endosome to late endosome transport; • endocytic recycling; • GO:1903362 regulation of protein catabolic process; • protein transport; • regulation of MAP kinase activity; • positive regulation of exosomal secretion; • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; • macroautophagy; • regulation of molecular function; • GO:0015915 transport;
	Sources:Amigo / QuickGO
Orthologau
	11267
	n/a
	ENSG00000159210
	n/a
	Q96H20
	n/a
	NM_007241; NM_001317192; NM_001317193; NM_001317194
	n/a
	NP_001304121; NP_001304122; NP_001304123; NP_009172
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SNF8 yw SNF8 a elwir hefyd yn SNF8, ESCRT-II complex subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SNF8.

Dot3
EAP30
VPS22

Llyfryddiaeth

"Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. ". J Lipid Res. 2013. PMID 23667179.
"RILP interacts with the VPS22 component of the ESCRT-II complex. ". Biochem Biophys Res Commun. 2006. PMID 16857164.
"Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. ". Exp Cell Res. 2008. PMID 18031739.
"Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense. ". PLoS Pathog. 2017. PMID 29084253.
"Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death.". Mol Biol Cell. 2014. PMID 25232011.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] SNF8 - Cronfa NCBI

[1]

[2]