Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit (Q28115545)

3 January 2017

title

Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit (English)

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LYN proto-oncogene, Src family tyrosine kinase

3 January 2017

main subject

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YES proto-oncogene 1, Src family tyrosine kinase

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SRC proto-oncogene, non-receptor tyrosine kinase

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LCK proto-oncogene, Src family tyrosine kinase

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FYN proto-oncogene, Src family tyrosine kinase

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protein tyrosine kinase activity

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author name string

Jianmin Sun

series ordinal

1

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3 January 2017

Malin Pedersen

series ordinal

2

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3 January 2017

Lars Rönnstrand

series ordinal

3

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3 January 2017

language of work or name

English

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publication date

10 October 2008

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Journal of Biological Chemistry

3 January 2017

published in

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3 January 2017

volume

283

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3 January 2017

issue

41

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3 January 2017

page(s)

27444–27451

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Signal transduction via the stem cell factor receptor/c-Kit

3 January 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M709703200

Src family kinases are involved in the differential signaling from two splice forms of c-Kit

21 January 2018

1 reference

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

21 January 2018

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The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway

21 January 2018

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The "Gab" in signal transduction.

21 January 2018

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Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

21 January 2018

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Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway

21 January 2018

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Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

21 January 2018

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Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.

21 January 2018

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Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase: effect of receptor density and ligand-requirement

21 January 2018

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Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor

21 January 2018

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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

21 January 2018

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

21 January 2018

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Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes

21 January 2018

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The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors

21 January 2018

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Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility

21 January 2018

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Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses

21 January 2018

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Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

21 January 2018

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L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition

21 January 2018

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